JP2005515992A - 眼病治療のための多環式フェノール化合物の使用方法 - Google Patents

眼病治療のための多環式フェノール化合物の使用方法 Download PDF

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Publication number
JP2005515992A
JP2005515992A JP2003548815A JP2003548815A JP2005515992A JP 2005515992 A JP2005515992 A JP 2005515992A JP 2003548815 A JP2003548815 A JP 2003548815A JP 2003548815 A JP2003548815 A JP 2003548815A JP 2005515992 A JP2005515992 A JP 2005515992A
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compound
cell death
pharmaceutical composition
cells
effective
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Japanese (ja)
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JP2005515992A5 (https=
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ディケンズ、ジェームズ・アラン
ゴードン、キャサリン
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ミトコー、インク
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Publication of JP2005515992A5 publication Critical patent/JP2005515992A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2003548815A 2001-12-05 2002-12-05 眼病治療のための多環式フェノール化合物の使用方法 Pending JP2005515992A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33659901P 2001-12-05 2001-12-05
PCT/US2002/039098 WO2003047559A1 (en) 2001-12-05 2002-12-05 Use of polycyclic phenolic compounds for the treatment of opthalmic diseases

Publications (2)

Publication Number Publication Date
JP2005515992A true JP2005515992A (ja) 2005-06-02
JP2005515992A5 JP2005515992A5 (https=) 2006-01-26

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ID=23316822

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003548815A Pending JP2005515992A (ja) 2001-12-05 2002-12-05 眼病治療のための多環式フェノール化合物の使用方法

Country Status (6)

Country Link
US (1) US20030105167A1 (https=)
EP (1) EP1463494A1 (https=)
JP (1) JP2005515992A (https=)
AU (1) AU2002359635A1 (https=)
CA (1) CA2468342A1 (https=)
WO (1) WO2003047559A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070213310A1 (en) * 2002-04-01 2007-09-13 Laszlo Prokai Prodrugs for Use as Ophthalmic Agents
US7300926B2 (en) * 2002-04-01 2007-11-27 University Of Florida Research Foundation, Inc. Steroidal quinols and their use for estrogen replacement therapy
US7186707B2 (en) * 2002-04-01 2007-03-06 University Of Florida Prodrugs for use as ophthalmic agents
ES2279946T3 (es) * 2002-04-01 2007-09-01 University Of Florida Research Foundation, Inc. Quinoles esteroideos como profarmacos de antioxidantes.
US7578996B2 (en) * 2004-04-07 2009-08-25 Advanced Medical Optics, Inc. Cetylpyridinium chloride as an antimicrobial agent in ophthalmic compositions
US6973795B1 (en) * 2004-05-27 2005-12-13 American Standard International Inc. HVAC desiccant wheel system and method
US20060188492A1 (en) * 2005-01-13 2006-08-24 Chronorx Llc, An Alaska Limited Liability Company Topical management of ocular and periocular conditions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554601A (en) * 1993-11-05 1996-09-10 University Of Florida Methods for neuroprotection
US6350739B1 (en) * 1999-08-11 2002-02-26 University Of Florida Resarch Foundation, Inc. Methods of prevention and treatment of ischemic damage
US6197833B1 (en) * 1995-07-24 2001-03-06 Apollo Biopharmaceutics, Inc. Neuroprotective effects of polycyclic phenolic compounds
US5877169A (en) * 1993-11-05 1999-03-02 University Of Florida Research Foundation, Inc. Methods of treatment of ischemic damage
US6319914B1 (en) * 1993-11-05 2001-11-20 Apollo Biopharmaceuticals, Inc. Cytoprotective effect of polycyclic phenolic compounds
US5859001A (en) * 1996-01-11 1999-01-12 University Of Florida Research Foundation, Inc. Neuroprotective effects of polycyclic phenolic compounds
DE19654750A1 (de) * 1996-12-30 1998-07-02 Helmut Dr Med Zander Verwendung von Wirkstoffen mit Östrogen-Wirkung zur Vorbeugung und Behandlung von Makuladegeneration
EP0977578B1 (en) * 1997-01-16 2004-03-31 University Of Florida Research Foundation, Inc. Compositions to enhance the cytoprotective effects of polycyclic phenolic compounds through the synergistic interaction with anti-oxidants
US6011023A (en) * 1997-08-27 2000-01-04 Alcon Laboratories, Inc. Angiostatic steroids
EP1032397A1 (en) * 1997-11-24 2000-09-06 University Of Florida Research Foundation, Inc. Testosterone inhibitors and use for the protection of neurons
CA2321560C (en) * 1998-03-13 2007-05-22 Johns Hopkins University School Of Medicine The use of a protein tyrosine inhibitor such as genistein in the treatment of diabetic retinopathy or ocular inflammation
US6326365B1 (en) * 1999-07-20 2001-12-04 Apollo Biopharmaceutics, Inc. Methods of prevention and treatment of ischemic damage
US6339078B1 (en) * 1999-07-20 2002-01-15 University Of Florida Research Foundation, Inc. Methods of prevention and treatment of ischemic damage
US6420378B1 (en) * 1999-10-15 2002-07-16 Supergen, Inc. Inhibition of abnormal cell proliferation with camptothecin and combinations including the same
EP1177787A3 (en) * 2000-07-28 2003-09-10 Pfizer Products Inc. Use of an estrogen agonist/antagonist for treating cataracts
ES2287184T3 (es) * 2000-11-03 2007-12-16 Washington University Estructuras aromaticas modificadas con sustituyentes hidroxi-, que tienen actividad citoprotectora.

Also Published As

Publication number Publication date
AU2002359635A1 (en) 2003-06-17
CA2468342A1 (en) 2003-06-12
US20030105167A1 (en) 2003-06-05
EP1463494A1 (en) 2004-10-06
WO2003047559A1 (en) 2003-06-12

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