JP2005515476A5 - - Google Patents
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- Publication number
- JP2005515476A5 JP2005515476A5 JP2003562632A JP2003562632A JP2005515476A5 JP 2005515476 A5 JP2005515476 A5 JP 2005515476A5 JP 2003562632 A JP2003562632 A JP 2003562632A JP 2003562632 A JP2003562632 A JP 2003562632A JP 2005515476 A5 JP2005515476 A5 JP 2005515476A5
- Authority
- JP
- Japan
- Prior art keywords
- reference standard
- group
- drug
- detectable complex
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940079593 drug Drugs 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 239000003153 chemical reaction reagent Substances 0.000 claims 6
- 238000003018 immunoassay Methods 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- -1 nitro, amino Chemical group 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 229940049706 benzodiazepine Drugs 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- KEQGZUUPPQEDPF-UHFFFAOYSA-N 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione Chemical compound CC1(C)N(Cl)C(=O)N(Cl)C1=O KEQGZUUPPQEDPF-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000001557 benzodiazepines Chemical class 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- XTHPWXDJESJLNJ-UHFFFAOYSA-N chlorosulfonic acid Substances OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000003381 solubilizing effect Effects 0.000 claims 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 1
- SORGEQQSQGNZFI-UHFFFAOYSA-N [azido(phenoxy)phosphoryl]oxybenzene Chemical compound C=1C=CC=CC=1OP(=O)(N=[N+]=[N-])OC1=CC=CC=C1 SORGEQQSQGNZFI-UHFFFAOYSA-N 0.000 claims 1
- 239000000908 ammonium hydroxide Substances 0.000 claims 1
- 239000012280 lithium aluminium hydride Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/057,762 US7029918B2 (en) | 2002-01-25 | 2002-01-25 | Water-soluble derivatives of lipophilic drugs |
| PCT/EP2003/000655 WO2003062819A2 (en) | 2002-01-25 | 2003-01-23 | Water- soluble derivatives of lipophilic drugs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005515476A JP2005515476A (ja) | 2005-05-26 |
| JP2005515476A5 true JP2005515476A5 (enExample) | 2005-12-22 |
| JP3828891B2 JP3828891B2 (ja) | 2006-10-04 |
Family
ID=27609480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003562632A Expired - Fee Related JP3828891B2 (ja) | 2002-01-25 | 2003-01-23 | 親油性薬物の水溶性誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7029918B2 (enExample) |
| EP (1) | EP1468295A2 (enExample) |
| JP (1) | JP3828891B2 (enExample) |
| AU (1) | AU2003215543A1 (enExample) |
| CA (1) | CA2473498A1 (enExample) |
| WO (1) | WO2003062819A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005059547A2 (en) * | 2003-12-12 | 2005-06-30 | Inverness Medical Switzerland Gmbh | Assay |
| WO2006088894A2 (en) * | 2005-02-15 | 2006-08-24 | Elan Pharma International Limited | Aerosol and injectable formulations of nanoparticulate benzodiazepine |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH568996A5 (enExample) | 1968-05-07 | 1975-11-14 | Hoffmann La Roche | |
| US3819602A (en) * | 1968-05-07 | 1974-06-25 | Hoffmann La Roche | 7-chloro-5-(2-fluorophenyl)-1-(2-hydroxyethyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one and esters thereof |
| US3567710A (en) | 1968-06-03 | 1971-03-02 | Hoffmann La Roche | Process for the preparation of 1,3-dihydro-2h-1,4-benzodiazepin-2-ones |
| US4046636A (en) | 1974-06-20 | 1977-09-06 | Syva Company | Diazepam enzyme conjugates |
| US4043989A (en) | 1975-09-11 | 1977-08-23 | Syva Company | Oxazepam derivatives for immunoassay reagents |
| US4083948A (en) | 1977-04-04 | 1978-04-11 | Hoffmann-La Roche, Inc. | Benzodiazepine radioimmunoassay using I125-label |
| US4243654A (en) | 1978-09-11 | 1981-01-06 | Syva Company | Oxazepam derivatives for immunoassay reagents |
| US4717582A (en) | 1986-05-22 | 1988-01-05 | The Dow Chemical Company | Method and apparatus for controlling the density of a foam |
| ATE132974T1 (de) * | 1986-10-24 | 1996-01-15 | Abbott Lab | Test, indikatoren, immunogene und antikörper für benzodiazepine |
| US5219747A (en) * | 1987-01-27 | 1993-06-15 | Hoffmann-La Roche Inc. | Immunoassay for tetrahydrocannabinol metabolites |
| US5144030A (en) | 1987-02-17 | 1992-09-01 | Abbott Laboratories | Fluorescene polarization immunoassay for tetrahydrocannabinoids |
| US4777169A (en) | 1987-07-24 | 1988-10-11 | Hoffmann-La Roche Inc. | Benzodiazepine derivatives |
| US5521215A (en) * | 1989-11-07 | 1996-05-28 | Ramot University Authority For Applied Research And Industrial Development Ltd. | NMDA-blocking pharmaceuticals |
| US5237057A (en) | 1992-04-06 | 1993-08-17 | Biosite Diagnostics, Inc. | Tetrahydrocannabinol derivatives and protein and polypeptide tetrahydrocannabinol derivative conjugates and labels |
| CA2167362A1 (en) | 1995-02-10 | 1996-08-11 | Alexei Dmitri Klimov | Apparatus and method for conducting a binding assay on an absorbent carrier material |
| EP1066523A2 (en) | 1998-03-27 | 2001-01-10 | Microgenics Corporation | Confirmatory assays for small molecule drugs |
| US5847128A (en) | 1998-05-29 | 1998-12-08 | Virginia Commonwealth University | Water soluble derivatives of cannabinoids |
| KR20030008153A (ko) | 2000-06-22 | 2003-01-24 | 파모스 코포레이션 | 신규 비-향정신성 카나비노이드 |
-
2002
- 2002-01-25 US US10/057,762 patent/US7029918B2/en not_active Expired - Fee Related
-
2003
- 2003-01-23 JP JP2003562632A patent/JP3828891B2/ja not_active Expired - Fee Related
- 2003-01-23 EP EP03731624A patent/EP1468295A2/en not_active Withdrawn
- 2003-01-23 CA CA002473498A patent/CA2473498A1/en not_active Abandoned
- 2003-01-23 WO PCT/EP2003/000655 patent/WO2003062819A2/en not_active Ceased
- 2003-01-23 AU AU2003215543A patent/AU2003215543A1/en not_active Abandoned
-
2005
- 2005-09-22 US US11/231,403 patent/US20060024832A1/en not_active Abandoned
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