JP2005514063A5 - - Google Patents
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- Publication number
- JP2005514063A5 JP2005514063A5 JP2003560167A JP2003560167A JP2005514063A5 JP 2005514063 A5 JP2005514063 A5 JP 2005514063A5 JP 2003560167 A JP2003560167 A JP 2003560167A JP 2003560167 A JP2003560167 A JP 2003560167A JP 2005514063 A5 JP2005514063 A5 JP 2005514063A5
- Authority
- JP
- Japan
- Prior art keywords
- canine
- cdr
- variable domain
- chain variable
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000282465 Canis Species 0.000 claims 38
- 108060003951 Immunoglobulin Proteins 0.000 claims 23
- 102000018358 immunoglobulin Human genes 0.000 claims 23
- 229920001184 polypeptide Polymers 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 150000001413 amino acids Chemical class 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 238000000034 method Methods 0.000 claims 6
- 241000282472 Canis lupus familiaris Species 0.000 claims 5
- 108020004705 Codon Proteins 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 229940072221 immunoglobulins Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108091034057 RNA (poly(A)) Proteins 0.000 claims 1
- 101000980463 Treponema pallidum (strain Nichols) Chaperonin GroEL Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34487401P | 2001-12-21 | 2001-12-21 | |
| PCT/US2002/041362 WO2003060080A2 (en) | 2001-12-21 | 2002-12-20 | Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005514063A JP2005514063A (ja) | 2005-05-19 |
| JP2005514063A5 true JP2005514063A5 (https=) | 2006-01-05 |
Family
ID=23352425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003560167A Pending JP2005514063A (ja) | 2001-12-21 | 2002-12-20 | イヌ免疫グロブリン可変ドメイン、イヌ化抗体、ならびにそれらを作製および使用する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7261890B2 (https=) |
| EP (1) | EP1485126A4 (https=) |
| JP (1) | JP2005514063A (https=) |
| AU (1) | AU2002359851A1 (https=) |
| CA (1) | CA2469833C (https=) |
| WO (1) | WO2003060080A2 (https=) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101270829B1 (ko) * | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
| CN101370831B (zh) * | 2006-01-13 | 2013-06-19 | Irm责任有限公司 | 用于治疗过敏性疾病的针对胸腺基质淋巴细胞生成素受体的抗体 |
| MX2010003718A (es) | 2007-10-19 | 2010-04-21 | Genentech Inc | Anticuerpos anti-tenb2 producidos por ingenieria de cisteina y conjugados de farmaco y anticuerpo. |
| BRPI0910509B8 (pt) | 2008-07-10 | 2021-05-25 | Toray Industries | uso do anticorpo, anticorpo e composição farmacêutica |
| PT2319533T (pt) * | 2008-07-10 | 2017-07-20 | Toray Industries | Agente indutor de imunidade e método para detetar cancro |
| AU2014200771B2 (en) * | 2008-09-04 | 2016-05-26 | Vet Therapeutics, Inc. | Monoclonal antibodies |
| EP2725037A1 (en) * | 2008-09-04 | 2014-04-30 | Vet Therapeutics, Inc. | Monoclonal antibodies binding canine CD20 |
| WO2010110838A2 (en) * | 2009-03-25 | 2010-09-30 | Vet Therapeutics Inc. | Antibody constant domain regions and uses thereof |
| WO2010117448A2 (en) * | 2009-04-05 | 2010-10-14 | Provenance Biopharmaceuticals Corp. | Chimeric immunocytokines and methods of use thereof |
| WO2010128372A1 (en) | 2009-05-08 | 2010-11-11 | Allergosystem S.R.L. | A device for protecting pets from allergy |
| JP5911813B2 (ja) * | 2010-03-04 | 2016-04-27 | ベット・セラピューティクス・インコーポレイテッドＶｅｔ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | Ｃｄ２０に対するモノクローナル抗体 |
| US9616120B2 (en) | 2010-03-04 | 2017-04-11 | Vet Therapeutics, Inc. | Monoclonal antibodies directed to CD20 |
| BR112012022342A2 (pt) | 2010-03-04 | 2017-02-14 | Vet Therapeutics Inc | anticorpos monoclonais dirigidos a cd52 |
| JP5998060B2 (ja) | 2010-03-04 | 2016-09-28 | マクロジェニクス，インコーポレーテッド | Ｂ７−ｈ３と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用 |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| BR112012030311A2 (pt) | 2010-06-08 | 2017-01-24 | Genentech Inc | anticorpo |
| US9505829B2 (en) | 2010-08-19 | 2016-11-29 | Zoetis Belgium S.A. | Anti-NGF antibodies and their use |
| GB201114858D0 (en) * | 2011-08-29 | 2011-10-12 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of using the same |
| GB2504887B (en) * | 2011-05-06 | 2016-02-03 | Nvip Pty Ltd | Anti-Nerve growth factor antibodies and methods of preparing and using the same |
| CA2835094C (en) * | 2011-05-06 | 2020-12-22 | David Gearing | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| GB2504889C (en) * | 2011-05-06 | 2015-08-26 | Nvip Pty Ltd | Therapeutic canine immunoglobulins and methods of using the same |
| LT3498732T (lt) * | 2011-05-06 | 2022-01-10 | Zoetis Services Llc | Anti-nervų augimo faktorių antikūnai ir jų paruošimo ir naudojimo būdai |
| GB2528401A (en) * | 2011-05-06 | 2016-01-20 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| EP2723380B1 (en) | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| HK1201281A1 (en) * | 2011-10-13 | 2015-08-28 | Nexvet Australia Pty Ltd | Canine/feline cd20 binding epitope and compositions for binding thereto |
| WO2013119419A1 (en) | 2012-02-08 | 2013-08-15 | North Carolina State University | Treatment of allergic diseases with recombinant antibodies |
| EP2859018B1 (en) | 2012-06-06 | 2021-09-22 | Zoetis Services LLC | Caninized anti-ngf antibodies and methods thereof |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| JP6701079B2 (ja) | 2013-12-20 | 2020-05-27 | インターベット インターナショナル ベー． フェー． | ヒトｐｄ−１に対するイヌ化マウス抗体 |
| MX2017003123A (es) | 2014-09-12 | 2017-05-12 | Genentech Inc | Anticuerpos y conjugados modificados geneticamente con cisteina. |
| US9758575B2 (en) | 2015-04-06 | 2017-09-12 | Yung Shin Pharmaceutical Industrial Co. Ltd. | Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof |
| US11116795B2 (en) | 2015-07-10 | 2021-09-14 | The Trustees Of The University Of Pennsylvania | Treatment of a canine CD20 positive disease or condition using a canine CD20-specific chimeric antigen receptor |
| WO2017102920A1 (en) * | 2015-12-18 | 2017-06-22 | Intervet International B.V. | Caninized human antibodies to human and canine il-4r alpha |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| TWI781098B (zh) | 2016-04-15 | 2022-10-21 | 美商宏觀基因股份有限公司 | 新穎的ｂ７-ｈ３-結合分子、其抗體藥物綴合物及其使用方法 |
| JP7127859B2 (ja) | 2016-11-09 | 2022-08-30 | ノース カロライナ ステート ユニバーシティ | キメラタンパク質を用いたアレルギー疾患の治療 |
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| GB2561352B (en) * | 2017-04-10 | 2023-01-18 | Genome Res Ltd | Animal models and therapeutic molecules |
| JP2021517461A (ja) | 2018-03-12 | 2021-07-26 | ゾエティス・サービシーズ・エルエルシー | 抗ｎｇｆ抗体およびその方法 |
| CA3093539A1 (en) | 2018-03-16 | 2019-09-19 | Zoetis Services Llc | Interleukin-31 monoclonal antibodies for veterinary use |
| AU2019236328B2 (en) | 2018-03-16 | 2025-10-09 | Zoetis Services Llc | Peptide vaccines against Interleukin-31 |
| WO2019183437A1 (en) | 2018-03-23 | 2019-09-26 | North Carolina State University | Methods and compositions for antibody to high affinity receptor for ige |
| GB2578867A (en) * | 2018-10-09 | 2020-06-03 | Genome Res Ltd | Animal models and therapeutic molecules |
| AU2019382505B2 (en) | 2018-11-19 | 2026-02-05 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-PD-1 antibodies and uses thereof |
| WO2020176871A1 (en) * | 2019-02-28 | 2020-09-03 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Kawasaki disease antibodies identify hepacivirus peptides |
| CA3145347A1 (en) * | 2019-07-15 | 2021-01-21 | Intervet International B.V. | Caninized antibodies to human and canine ctla-4 |
| CN114174337B (zh) * | 2019-07-15 | 2024-10-25 | 英特维特国际股份有限公司 | 针对犬ctla-4的犬源化抗体 |
| CA3147809A1 (en) * | 2019-08-29 | 2021-03-04 | Shyr Jiann Li | Anti-il31 antibodies for veterinary use |
| US20220119513A1 (en) | 2020-06-08 | 2022-04-21 | Zoetis Services Llc | Anti-tgfb antibodies and therapeutic uses thereof |
| MX2023004020A (es) | 2020-10-07 | 2023-07-07 | Zoetis Services Llc | Anticuerpos anti-ngf y métodos para su uso. |
| WO2022226102A1 (en) * | 2021-04-21 | 2022-10-27 | The Trustees Of The University Of Pennsylvania | Canine monoclonal antibodies against canine cytotoxic t lymphocyte associated protein 4 (ctla-4) |
| WO2023049917A1 (en) * | 2021-09-27 | 2023-03-30 | Zoetis Services Llc | ANTI- TGFβ1,2,3 ANTIBODIES AND THERAPEUTIC USES THEREOF |
| WO2025245516A1 (en) * | 2024-05-24 | 2025-11-27 | Invetx, Inc. | Anti-actrii antibodies and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JP2811089B2 (ja) * | 1989-08-25 | 1998-10-15 | 財団法人化学及血清療法研究所 | イヌ×マウスヘテロハイブリドーマおよびイヌ免疫グロブリンλ鎖の定常領域をコードする遺伝子断片 |
| JP2811096B2 (ja) * | 1989-09-30 | 1998-10-15 | 財団法人化学及血清療法研究所 | イヌ免疫グロブリンκ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体 |
| AU640397B2 (en) * | 1989-08-25 | 1993-08-26 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Dog-mouse heterohybridoma and gene fragment coding for constant region of canine immunoglobulin |
| JP2837240B2 (ja) * | 1990-06-07 | 1998-12-14 | 財団法人化学及血清療法研究所 | イヌ免疫グロブリンγ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体 |
| US5330883A (en) * | 1992-06-29 | 1994-07-19 | Lsi Logic Corporation | Techniques for uniformizing photoresist thickness and critical dimension of underlying features |
| US5622842A (en) * | 1994-11-09 | 1997-04-22 | Merck & Co., Inc. | DNA encoding canine immunoglobulin A |
| AU1146897A (en) * | 1995-12-08 | 1997-06-27 | Idexx Laboratories, Inc. | Methods and compositions concerning allergy in dogs |
| JPH09169795A (ja) | 1995-12-22 | 1997-06-30 | Hitachi Chem Co Ltd | イヌ免疫グロブリンｅペプチド断片、それをコードするｄｎａ、そのｄｎａを含む組換えベクター、その組換えベクターを含む形質転換体及び抗イヌ免疫グロブリンｅ抗体の製造法 |
| ES2234180T3 (es) * | 1998-04-09 | 2005-06-16 | Idexx Laboratories, Inc. | Proteinas de fijacion especifica para el tratamiento de la alergia canina. |
| US6504013B1 (en) * | 2000-02-01 | 2003-01-07 | Idexx Laboratories, Inc. | Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody |
| WO2001077332A2 (en) | 2000-04-07 | 2001-10-18 | Heska Corporation | Compositions and methods related to canine igg and canine il-13 receptors |
-
2002
- 2002-12-20 EP EP02794415A patent/EP1485126A4/en not_active Withdrawn
- 2002-12-20 CA CA002469833A patent/CA2469833C/en not_active Expired - Fee Related
- 2002-12-20 WO PCT/US2002/041362 patent/WO2003060080A2/en not_active Ceased
- 2002-12-20 AU AU2002359851A patent/AU2002359851A1/en not_active Abandoned
- 2002-12-20 US US10/327,598 patent/US7261890B2/en not_active Expired - Fee Related
- 2002-12-20 JP JP2003560167A patent/JP2005514063A/ja active Pending
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