JP2005514053A5 - - Google Patents
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- Publication number
- JP2005514053A5 JP2005514053A5 JP2003559425A JP2003559425A JP2005514053A5 JP 2005514053 A5 JP2005514053 A5 JP 2005514053A5 JP 2003559425 A JP2003559425 A JP 2003559425A JP 2003559425 A JP2003559425 A JP 2003559425A JP 2005514053 A5 JP2005514053 A5 JP 2005514053A5
- Authority
- JP
- Japan
- Prior art keywords
- mab
- variable region
- identity
- polypeptide
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 28
- 229920001184 polypeptide Polymers 0.000 claims 25
- 102000004196 processed proteins & peptides Human genes 0.000 claims 25
- 150000001413 amino acids Chemical class 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 claims 4
- 108010013639 Peptidoglycan Proteins 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 241000192125 Firmicutes Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000001662 opsonic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34350301P | 2001-12-21 | 2001-12-21 | |
| US60/343,503 | 2001-12-21 | ||
| PCT/US2002/041033 WO2003059260A2 (en) | 2001-12-21 | 2002-12-23 | Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008003302A Division JP2008179634A (ja) | 2001-12-21 | 2008-01-10 | グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514053A JP2005514053A (ja) | 2005-05-19 |
| JP2005514053A6 JP2005514053A6 (ja) | 2005-08-04 |
| JP2005514053A5 true JP2005514053A5 (enExample) | 2006-02-16 |
Family
ID=23346384
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003559425A Pending JP2005514053A (ja) | 2001-12-21 | 2002-12-23 | グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体 |
| JP2008003302A Pending JP2008179634A (ja) | 2001-12-21 | 2008-01-10 | グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008003302A Pending JP2008179634A (ja) | 2001-12-21 | 2008-01-10 | グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040052779A1 (enExample) |
| EP (1) | EP1463479A4 (enExample) |
| JP (2) | JP2005514053A (enExample) |
| AU (2) | AU2002359794A1 (enExample) |
| CA (1) | CA2469715C (enExample) |
| WO (1) | WO2003059260A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610293B1 (en) * | 1997-06-16 | 2003-08-26 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
| US7250494B2 (en) | 1998-06-15 | 2007-07-31 | Biosynexus Incorporated | Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria |
| GB2408573A (en) * | 2003-11-25 | 2005-06-01 | Univ Leicester | Assay for the interaction of L-Ficolin with lipoteichoic acid |
| WO2005072778A2 (en) * | 2004-01-29 | 2005-08-11 | Biosynexus, Inc. | Use of amino-oxy functional groups in the preparation of vaccines conjugates |
| EA018030B1 (ru) * | 2006-06-06 | 2013-05-30 | Круселл Холланд Б.В. | Связывающие молекулы человека, имеющие убивающую активность против стафилококков, и их применения |
| EA016717B1 (ru) | 2006-06-06 | 2012-07-30 | Круселл Холланд Б.В. | Моноклональное антитело человека, обладающее опсонизирующей фагоцитарной киллерной активностью в отношении enterococcus и staphylococcus aureus, и его применение |
| AU2012268821B2 (en) * | 2006-06-06 | 2016-06-02 | Janssen Vaccines & Prevention B.V. | Human binding molecules having killing activity against staphylococci and uses thereof |
| WO2008116118A2 (en) * | 2007-03-20 | 2008-09-25 | Avanir Pharmaceuticals | Fully human antibodies to gram positive bacteria |
| WO2010074991A1 (en) * | 2008-12-22 | 2010-07-01 | Children's Hospital & Research Center At Oakland | Ex-vivo passive protection bacteremia assay |
| US20100260752A1 (en) * | 2009-01-23 | 2010-10-14 | Biosynexus Incorporated | Opsonic and protective antibodies specific for lipoteichoic acid of gram positive bacteria |
| US8647621B2 (en) | 2009-07-27 | 2014-02-11 | Fina Biosolutions, Llc | Method of producing protein-carbohydrate vaccines reduced in free carbohydrate |
| KR101635795B1 (ko) | 2009-12-17 | 2016-07-04 | 피나 바이오솔루션스, 엘엘씨 | 다당류/단백질 접합체 백신의 제조에 있어서 시안화제인 1-시아노벤조트리아졸 (1-cbt)을 통한 다당류의 활성화 |
| EP2560738B8 (en) | 2010-04-23 | 2019-09-25 | Serum Institute of India Private Limited | Simple method for simultaneous removal of multiple impurities from culture supernatants to ultralow levels |
| CA2856085C (en) | 2011-11-18 | 2020-06-30 | National Research Council Of Canada | Clostridium difficile lipoteichoic acid and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4596769A (en) * | 1984-03-05 | 1986-06-24 | Temple University | Monoclonal antibodies to peptidoglycan and methods of preparing same |
| CA1341235C (en) * | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
| ES2091684T3 (es) * | 1992-11-13 | 1996-11-01 | Idec Pharma Corp | Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b. |
| US5624904A (en) * | 1993-11-17 | 1997-04-29 | Massachusetts Institute Of Technology | Method for treating gram positive septicemia |
| US5686600A (en) * | 1994-06-28 | 1997-11-11 | Novartis Finance Corporation | Antibodies which bind to insect gut proteins and their use |
| WO1996039518A1 (en) * | 1995-06-05 | 1996-12-12 | Bionebraska, Inc. | Lead binding polypeptides and nucleotides coding therefor |
| MA24512A1 (fr) * | 1996-01-17 | 1998-12-31 | Univ Vermont And State Agrienl | Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose |
| US6610293B1 (en) * | 1997-06-16 | 2003-08-26 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
| US7250494B2 (en) * | 1998-06-15 | 2007-07-31 | Biosynexus Incorporated | Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria |
-
2002
- 2002-12-20 US US10/323,926 patent/US20040052779A1/en not_active Abandoned
- 2002-12-23 CA CA2469715A patent/CA2469715C/en not_active Expired - Fee Related
- 2002-12-23 EP EP02794357A patent/EP1463479A4/en not_active Ceased
- 2002-12-23 JP JP2003559425A patent/JP2005514053A/ja active Pending
- 2002-12-23 WO PCT/US2002/041033 patent/WO2003059260A2/en not_active Ceased
- 2002-12-23 AU AU2002359794A patent/AU2002359794A1/en not_active Abandoned
-
2008
- 2008-01-10 JP JP2008003302A patent/JP2008179634A/ja active Pending
-
2009
- 2009-07-08 AU AU2009202762A patent/AU2009202762B2/en not_active Ceased
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