JP2005514053A - グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体 - Google Patents

グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体 Download PDF

Info

Publication number
JP2005514053A
JP2005514053A JP2003559425A JP2003559425A JP2005514053A JP 2005514053 A JP2005514053 A JP 2005514053A JP 2003559425 A JP2003559425 A JP 2003559425A JP 2003559425 A JP2003559425 A JP 2003559425A JP 2005514053 A JP2005514053 A JP 2005514053A
Authority
JP
Japan
Prior art keywords
mab
lta
variable region
antibodies
light chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003559425A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005514053A5 (enExample
JP2005514053A6 (ja
Inventor
スティンソン,ジェフリー,アール.
シューマン,リチャード,エフ.
モンド,ジェームズ,ジェイ.
リーズ,アンドリュー
フィシャー,ジェラルド,ウォルター
Original Assignee
バイオシネクサス インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオシネクサス インコーポレーテッド filed Critical バイオシネクサス インコーポレーテッド
Publication of JP2005514053A publication Critical patent/JP2005514053A/ja
Publication of JP2005514053A6 publication Critical patent/JP2005514053A6/ja
Publication of JP2005514053A5 publication Critical patent/JP2005514053A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2003559425A 2001-12-21 2002-12-23 グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体 Pending JP2005514053A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34350301P 2001-12-21 2001-12-21
US60/343,503 2001-12-21
PCT/US2002/041033 WO2003059260A2 (en) 2001-12-21 2002-12-23 Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008003302A Division JP2008179634A (ja) 2001-12-21 2008-01-10 グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体

Publications (3)

Publication Number Publication Date
JP2005514053A true JP2005514053A (ja) 2005-05-19
JP2005514053A6 JP2005514053A6 (ja) 2005-08-04
JP2005514053A5 JP2005514053A5 (enExample) 2006-02-16

Family

ID=23346384

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003559425A Pending JP2005514053A (ja) 2001-12-21 2002-12-23 グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体
JP2008003302A Pending JP2008179634A (ja) 2001-12-21 2008-01-10 グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008003302A Pending JP2008179634A (ja) 2001-12-21 2008-01-10 グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体

Country Status (6)

Country Link
US (1) US20040052779A1 (enExample)
EP (1) EP1463479A4 (enExample)
JP (2) JP2005514053A (enExample)
AU (2) AU2002359794A1 (enExample)
CA (1) CA2469715C (enExample)
WO (1) WO2003059260A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539360A (ja) * 2006-06-06 2009-11-19 クルセル ホランド ベー ヴェー ブドウ球菌に対する殺活性を有するヒトの結合分子及びその使用方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610293B1 (en) * 1997-06-16 2003-08-26 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
US7250494B2 (en) 1998-06-15 2007-07-31 Biosynexus Incorporated Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria
GB2408573A (en) * 2003-11-25 2005-06-01 Univ Leicester Assay for the interaction of L-Ficolin with lipoteichoic acid
EP1713508A2 (en) * 2004-01-29 2006-10-25 Biosynexus Incorporated Use of amino-oxy functional groups in the preparation of vaccine conjugates
KR20220031126A (ko) 2006-06-06 2022-03-11 얀센 백신스 앤드 프리벤션 비.브이. 장내구균에 대한 사멸활성을 갖는 인간결합분자 및 그것의 용도
AU2012268821B2 (en) * 2006-06-06 2016-06-02 Janssen Vaccines & Prevention B.V. Human binding molecules having killing activity against staphylococci and uses thereof
WO2008116118A2 (en) * 2007-03-20 2008-09-25 Avanir Pharmaceuticals Fully human antibodies to gram positive bacteria
US8663940B2 (en) * 2008-12-22 2014-03-04 Children's Hospital & Research Center Oakland Ex-vivo passive protection bacteremia assay
US20100260752A1 (en) * 2009-01-23 2010-10-14 Biosynexus Incorporated Opsonic and protective antibodies specific for lipoteichoic acid of gram positive bacteria
WO2011017101A2 (en) 2009-07-27 2011-02-10 Fina Biosolutions, Llc Method for producing protein-carbohydrate vaccines reduced in free carbohydrate
DK2513056T3 (da) 2009-12-17 2022-05-23 Serum Inst Of India Pvt Ltd Kemiske reagenser til aktivering af polysaccharider i fremstillingen af konjugatvacciner
NZ602971A (en) 2010-04-23 2014-11-28 Serum Inst India Ltd Simple method for simultaneous removal of multiple impurities from culture supernatants to ultralow levels
WO2013071409A1 (en) 2011-11-18 2013-05-23 National Research Council Of Canada (Nrc) Clostridium difficile lipoteichoic acid and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596769A (en) * 1984-03-05 1986-06-24 Temple University Monoclonal antibodies to peptidoglycan and methods of preparing same
CA1341235C (en) * 1987-07-24 2001-05-22 Randy R. Robinson Modular assembly of antibody genes, antibodies prepared thereby and use
DE69303494T2 (de) * 1992-11-13 1997-01-16 Idec Pharma Corp Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
US5624904A (en) * 1993-11-17 1997-04-29 Massachusetts Institute Of Technology Method for treating gram positive septicemia
US5686600A (en) * 1994-06-28 1997-11-11 Novartis Finance Corporation Antibodies which bind to insect gut proteins and their use
WO1996039518A1 (en) * 1995-06-05 1996-12-12 Bionebraska, Inc. Lead binding polypeptides and nucleotides coding therefor
MA24512A1 (fr) * 1996-01-17 1998-12-31 Univ Vermont And State Agrienl Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
US6610293B1 (en) * 1997-06-16 2003-08-26 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
US7250494B2 (en) * 1998-06-15 2007-07-31 Biosynexus Incorporated Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539360A (ja) * 2006-06-06 2009-11-19 クルセル ホランド ベー ヴェー ブドウ球菌に対する殺活性を有するヒトの結合分子及びその使用方法

Also Published As

Publication number Publication date
JP2008179634A (ja) 2008-08-07
CA2469715A1 (en) 2003-07-24
CA2469715C (en) 2013-02-12
EP1463479A2 (en) 2004-10-06
WO2003059260A3 (en) 2004-01-15
AU2002359794A1 (en) 2003-07-30
EP1463479A4 (en) 2006-02-22
AU2009202762A1 (en) 2009-07-30
US20040052779A1 (en) 2004-03-18
WO2003059260A2 (en) 2003-07-24
AU2009202762B2 (en) 2012-08-16

Similar Documents

Publication Publication Date Title
JP4691225B2 (ja) グラム陽性細菌のリポテイコ酸に特異的なオプソニン的かつ防御的モノクローナルおよびキメラ抗体
US7777017B2 (en) Nucleic acids encoding opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
JP2008179634A (ja) グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体
AU2009210372B2 (en) Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria
JP2016507470A (ja) S.アウレウス(S.aureus)表面決定基に対する抗体
US7169903B2 (en) Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria
JP2005514053A6 (ja) グラム陽性細菌のリポタイコ酸に特異的なオプソニン性モノクローナルおよびキメラ抗体
JP2006514636A (ja) 抗ブドウ球菌療法およびワクチンの標的としての壁テイコイン酸
JP2002513398A (ja) フィブロネクチン結合タンパク質組成物および使用法
JP2004514423A (ja) トランスジェニックxenomouse(登録商標)から獲得されるpeudomonasaeruginosalpsに対するヒト抗体
KR910002373B1 (ko) 슈도모나스 에루기노사 편모에 대한 단일클론항체
US10100103B2 (en) Opsonic and protective monoclonal antibodies against gram-positive pathogens
AU2012254925B2 (en) Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
AU2006203322A1 (en) Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
AU2012201369A1 (en) Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20051222

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20051222

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070710

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20071004

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20071012

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080110

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080226

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080520

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080527

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080825

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090602

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091002