JP2005514004A5 - - Google Patents
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- Publication number
- JP2005514004A5 JP2005514004A5 JP2003523634A JP2003523634A JP2005514004A5 JP 2005514004 A5 JP2005514004 A5 JP 2005514004A5 JP 2003523634 A JP2003523634 A JP 2003523634A JP 2003523634 A JP2003523634 A JP 2003523634A JP 2005514004 A5 JP2005514004 A5 JP 2005514004A5
- Authority
- JP
- Japan
- Prior art keywords
- cell mass
- inner cell
- cells
- mass
- feeder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 66
- 238000000034 method Methods 0.000 claims 54
- 210000002459 blastocyst Anatomy 0.000 claims 19
- 210000001671 embryonic stem cell Anatomy 0.000 claims 12
- 210000001161 mammalian embryo Anatomy 0.000 claims 8
- 239000002609 medium Substances 0.000 claims 7
- 238000012258 culturing Methods 0.000 claims 6
- 238000000608 laser ablation Methods 0.000 claims 6
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 5
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 5
- 239000003636 conditioned culture medium Substances 0.000 claims 5
- 210000002744 extracellular matrix Anatomy 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 210000004340 zona pellucida Anatomy 0.000 claims 4
- 238000001574 biopsy Methods 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- 235000020776 essential amino acid Nutrition 0.000 claims 1
- 239000003797 essential amino acid Substances 0.000 claims 1
- 230000004720 fertilization Effects 0.000 claims 1
- 239000012091 fetal bovine serum Substances 0.000 claims 1
- 229940126864 fibroblast growth factor Drugs 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 150000003839 salts Chemical group 0.000 claims 1
- 229940054269 sodium pyruvate Drugs 0.000 claims 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31432301P | 2001-08-23 | 2001-08-23 | |
| PCT/IN2002/000168 WO2003018783A1 (en) | 2001-08-23 | 2002-08-20 | ISOLATION OF INNER CELL MASS FOR THE ESTABLISHMENT OF HUMAN EMBRYONIC STEM CELL (hESC) LINES |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007311763A Division JP2008099706A (ja) | 2001-08-23 | 2007-11-30 | ヒト胚性幹細胞（ｈＥＳＣ）株の樹立のための内部細胞塊の単離 |
| JP2008115762A Division JP2008194055A (ja) | 2001-08-23 | 2008-04-25 | ヒト胚性幹細胞（ｈＥＳＣ）株の樹立のための内部細胞塊の単離 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005514004A JP2005514004A (ja) | 2005-05-19 |
| JP2005514004A5 true JP2005514004A5 (https=) | 2006-01-05 |
Family
ID=23219502
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003523634A Pending JP2005514004A (ja) | 2001-08-23 | 2002-08-20 | ヒト胚性幹細胞（ｈＥＳＣ）株の樹立のための内部細胞塊の単離 |
| JP2007311763A Pending JP2008099706A (ja) | 2001-08-23 | 2007-11-30 | ヒト胚性幹細胞（ｈＥＳＣ）株の樹立のための内部細胞塊の単離 |
| JP2008115762A Pending JP2008194055A (ja) | 2001-08-23 | 2008-04-25 | ヒト胚性幹細胞（ｈＥＳＣ）株の樹立のための内部細胞塊の単離 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007311763A Pending JP2008099706A (ja) | 2001-08-23 | 2007-11-30 | ヒト胚性幹細胞（ｈＥＳＣ）株の樹立のための内部細胞塊の単離 |
| JP2008115762A Pending JP2008194055A (ja) | 2001-08-23 | 2008-04-25 | ヒト胚性幹細胞（ｈＥＳＣ）株の樹立のための内部細胞塊の単離 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7294508B2 (https=) |
| EP (1) | EP1421181A1 (https=) |
| JP (3) | JP2005514004A (https=) |
| KR (1) | KR20040030161A (https=) |
| CN (1) | CN1545549A (https=) |
| AU (1) | AU2002334378B2 (https=) |
| BR (1) | BR0212098A (https=) |
| CA (1) | CA2458362A1 (https=) |
| IL (2) | IL160351A0 (https=) |
| RU (1) | RU2291703C2 (https=) |
| SG (1) | SG172471A1 (https=) |
| WO (1) | WO2003018783A1 (https=) |
| ZA (1) | ZA200304132B (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050170506A1 (en) * | 2002-01-16 | 2005-08-04 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
| US20050090004A1 (en) * | 2003-01-16 | 2005-04-28 | Sayre Chauncey B. | Stem cell maturation for all tissue lines |
| US20030134422A1 (en) * | 2002-01-16 | 2003-07-17 | Sayre Chauncey Bigelow | Stem cell maturation for all tissue lines |
| BRPI0408733A (pt) * | 2003-03-12 | 2006-03-07 | Reliance Life Sciences Pvt Ltd | derivação de neurÈnios dopaminérgicos terminalmente diferenciados de células tronco embriÈnicas humanas |
| US7820439B2 (en) * | 2003-09-03 | 2010-10-26 | Reliance Life Sciences Pvt Ltd. | In vitro generation of GABAergic neurons from pluripotent stem cells |
| US20050272149A1 (en) | 2004-06-02 | 2005-12-08 | Life & Brain Gmbh | Therapeutic delivery of adenosine into a tissue |
| DE102004062184B4 (de) | 2004-12-23 | 2013-08-01 | Wolfgang Würfel | Embryonenerhaltende Gewinnung pluripotenter embryonaler Stammzellen, derart gewonnene Stammzellen und Verwendung derselben |
| WO2006091766A2 (en) | 2005-02-24 | 2006-08-31 | Jau-Nan Lee | Human trophoblast stem cells and use thereof |
| EP1893748A1 (en) * | 2005-05-17 | 2008-03-05 | Reliance Life Sciences Pvt., Ltd. | Establishment of a human embryonic stem cell line using mammalian cells |
| US20060269985A1 (en) * | 2005-05-31 | 2006-11-30 | Yasuhiko Kitayama | Method for constructing array blocks, and tissue punching instrument and tissue blocks used therefor |
| JP5560391B2 (ja) * | 2005-06-22 | 2014-07-23 | アステリアス バイオセラピューティクス インコーポレイテッド | ヒト胚性幹細胞の懸濁培養法 |
| GB2445338A (en) * | 2005-10-07 | 2008-07-02 | Cellartis Ab | A method for obtaining a xeno-free HBS cell line |
| WO2007079533A1 (en) * | 2006-01-10 | 2007-07-19 | South Eastern Sydney And Illawarra Area Health Service | Method for establishing and proliferating human esc by co-culturing with allogeneic feeder cells in serum-free media |
| AU2009205886B2 (en) | 2008-01-18 | 2015-08-27 | Katholieke Universiteit Leuven | Stem cell aggregates and methods for making and using |
| WO2010114193A1 (ko) | 2009-03-29 | 2010-10-07 | Kim Chang-Hyun | 내부 세포 덩어리의 분리 방법 및 이를 이용한 배아 줄기 세포주의 제조 방법 |
| WO2011011477A1 (en) | 2009-07-21 | 2011-01-27 | Abt Holding Company | Use of stem cells to reduce leukocyte extravasation |
| WO2011011500A1 (en) | 2009-07-21 | 2011-01-27 | Abt Holding Company | Use of stem cells to reduce leukocyte extravasation |
| JP5115762B2 (ja) * | 2010-02-12 | 2013-01-09 | 有機合成薬品工業株式会社 | ４−ホルミルピペリジンアセタール誘導体の製造方法 |
| SG183498A1 (en) | 2010-02-25 | 2012-09-27 | Abt Holding Co | Modulation of angiogenesis |
| DK2539436T3 (da) | 2010-02-25 | 2021-10-18 | Abt Holding Co | Modulering af makrofagaktivering |
| SG185526A1 (en) | 2010-05-12 | 2012-12-28 | Abt Holding Co | Modulation of splenocytes in cell therapy |
| WO2011158125A2 (en) | 2010-06-17 | 2011-12-22 | Katholieke Universiteit Leuven | Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells |
| WO2012012803A2 (en) | 2010-07-23 | 2012-01-26 | Advanced Cell Technology, Inc. | Methods for detection of rare subpopulations of cells and highly purified compositions of cells |
| EP2609191B1 (en) | 2010-08-24 | 2017-11-22 | Regents Of The University Of Minnesota | Non-static suspension culture of cell aggregates |
| WO2012048276A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| WO2012068170A2 (en) | 2010-11-15 | 2012-05-24 | Jau-Nan Lee | Generation of neural stem cells from human trophoblast stem cells |
| US8748178B2 (en) | 2010-11-23 | 2014-06-10 | The New York Stem Cell Foundation | Method for producing pluripotent stem cells |
| CA2826386C (en) | 2011-02-08 | 2020-04-28 | FUJIFILM Cellular Dynamics, Inc. | Hematopoietic precursor cell production by programming |
| PL2718416T3 (pl) | 2011-06-06 | 2020-05-18 | ReGenesys BVBA | Namnażanie komórek macierzystych w bioreaktorach włóknisto-kapilarnych |
| GB201119335D0 (en) | 2011-11-09 | 2011-12-21 | Univ Leuven Kath | Hepatitis virus infectable stem cells |
| CN102600507B (zh) * | 2012-03-08 | 2014-08-20 | 天津大学 | 一种细胞培养支架材料及其制备方法 |
| WO2014085493A1 (en) | 2012-11-30 | 2014-06-05 | Jau-Nan Lee | Methods of differentiating stem cells by modulating mir-124 |
| IL289870B2 (en) | 2013-04-12 | 2023-03-01 | Lafrancesca Saverio | Improving organs for transplantation |
| AU2014266935B2 (en) | 2013-04-30 | 2020-06-11 | Katholieke Universiteit Leuven | Cell therapy for myelodysplastic syndromes |
| WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| US10202598B2 (en) | 2014-05-30 | 2019-02-12 | Todd Frank Ovokaitys | Methods and systems for generation, use, and delivery of activated stem cells |
| AU2015266594A1 (en) | 2014-05-30 | 2017-01-19 | Todd Frank OVOKAITYS | Method and system for generation and use of activated stem cells |
| US10384985B2 (en) | 2014-06-06 | 2019-08-20 | B.K. Consultants, Inc. | Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants |
| WO2015187974A1 (en) | 2014-06-06 | 2015-12-10 | Ovokaitys Todd Frank | Methods and compositions for increasing the bioactivity of nutrients |
| US9808490B2 (en) | 2014-11-26 | 2017-11-07 | Accelerated Biosciences Corp. | Induced hepatocytes and uses thereof |
| CN104982419B (zh) * | 2015-07-29 | 2017-01-11 | 广西壮族自治区水牛研究所 | 一种结合激光破膜的水牛胚胎冷冻方法 |
| WO2017210537A1 (en) | 2016-06-02 | 2017-12-07 | The Cleveland Clinic Foundation | Complement inhibition for improving cell viability |
| TWI772790B (zh) | 2019-05-06 | 2022-08-01 | 美商加速生物科學有限公司 | 前驅調節滋胚內層細胞及其用途 |
| US12246037B2 (en) | 2020-12-08 | 2025-03-11 | Todd Frank Ovokaitys | Methods and systems for increased production of stem cells |
| CN117716227A (zh) * | 2021-04-27 | 2024-03-15 | 多伦多纳米仪器有限公司 | 用于检测并对其他生物结构和胚泡的细胞结进行3d成像的系统和方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6015671A (en) * | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
| US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5945577A (en) * | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US6875607B1 (en) * | 1998-11-09 | 2005-04-05 | Es Cell International Pte Ltd | Embryonic stem cells |
| WO2001068815A1 (en) * | 2000-03-14 | 2001-09-20 | Es Cell International Pte Ltd | Embryonic stem cells and neural progenitor cells derived therefrom |
-
2002
- 2002-08-20 EP EP02796348A patent/EP1421181A1/en not_active Withdrawn
- 2002-08-20 WO PCT/IN2002/000168 patent/WO2003018783A1/en not_active Ceased
- 2002-08-20 IL IL16035102A patent/IL160351A0/xx unknown
- 2002-08-20 CA CA002458362A patent/CA2458362A1/en not_active Abandoned
- 2002-08-20 JP JP2003523634A patent/JP2005514004A/ja active Pending
- 2002-08-20 KR KR10-2004-7002520A patent/KR20040030161A/ko not_active Ceased
- 2002-08-20 AU AU2002334378A patent/AU2002334378B2/en not_active Ceased
- 2002-08-20 SG SG2006043418A patent/SG172471A1/en unknown
- 2002-08-20 RU RU2004108209/15A patent/RU2291703C2/ru not_active IP Right Cessation
- 2002-08-20 CN CNA028164210A patent/CN1545549A/zh active Pending
- 2002-08-20 BR BR0212098-4A patent/BR0212098A/pt not_active Application Discontinuation
- 2002-08-23 US US10/226,711 patent/US7294508B2/en not_active Expired - Fee Related
-
2003
- 2003-05-28 ZA ZA200304132A patent/ZA200304132B/en unknown
-
2004
- 2004-02-12 IL IL160351A patent/IL160351A/en not_active IP Right Cessation
-
2007
- 2007-11-13 US US11/939,397 patent/US20080064099A1/en not_active Abandoned
- 2007-11-30 JP JP2007311763A patent/JP2008099706A/ja active Pending
-
2008
- 2008-04-25 JP JP2008115762A patent/JP2008194055A/ja active Pending
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