JP2005513140A - 穀類βグルカン組成物、その調製方法及び使用 - Google Patents
穀類βグルカン組成物、その調製方法及び使用 Download PDFInfo
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- JP2005513140A JP2005513140A JP2003554788A JP2003554788A JP2005513140A JP 2005513140 A JP2005513140 A JP 2005513140A JP 2003554788 A JP2003554788 A JP 2003554788A JP 2003554788 A JP2003554788 A JP 2003554788A JP 2005513140 A JP2005513140 A JP 2005513140A
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- membrane
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Abstract
Description
β(1→3)β(1→4)グルカン、及び
有効量の1種又は複数種の対象化合物
を含む膜を提供する。
i)β(1→3)β(1→4)グルカンの水溶液を1種若しくは複数種の対象化合物と混合して組成物を形成すること;
ii)組成物を乾燥させて膜を形成すること、又は
iii)組成物を物品に塗布し、塗布した組成物を乾燥させて膜でコーティングした物品を生成すること
を含む、膜或いは膜でコーティングした物品を生成する方法を提供する。
β(1→3)β(1→4)グルカン、及び
有効量の1種又は複数種の対象化合物
を含む、1層又は複数の層の膜でコーティングされた物品を提供する。
本発明を説明するにあたって、以下の用語を使用し、これらは以下に示すように定義されることを意図する。
i)約0.01重量%〜約4.0重量%のβ(1→3)β(1→4)グルカンを含む水溶液を1種又は複数種の対象化合物と混合して組成物を形成すること;
ii)組成物を乾燥させて膜を形成すること、又は
iii)組成物を物品に塗布し、塗布した組成物を乾燥させて膜でコーティングした物品を生成すること
を含む方法を提供する。
β(1→3)β(1→4)グルカン、及び
有効量の甘味剤
を含む甘味剤組成物が提供される。
アスピリン、ジフルニサル、フェノプロフェンカルシウム、ナプロキセン、アセトアミノフェン、イブプロフェン、ケトプロフェン、トルメチンナトリウム、インドメタシンなどの非ステロイド性非炎症性、
ベンゾナテート、1,2−エタンジスルホン酸カラミフェン(caramiphen edisylate)、メントール、臭化水素酸デキストロメトルファン、塩酸クロフェジアノールなどの鎮咳剤、
塩酸プソイドエフェドリン、フェニレフェリン、フェニルプロパノールアミン、硫酸プソイドエフェドリンなどの鬱血除去剤、
マレイン酸ブロムフェニルアミン、マレイン酸クロルフェニラミン、マレイン酸カルビノキサミン、フマル酸クレマスチン、d−マレイン酸クロルフェニラミン、塩酸ジフェンヒドラミン、塩酸ジフェニルピラリン、マレイン酸アザタジン、クエン酸ジフェンヒドラミン、コハク酸ドキシラミン、塩酸プロメタジン、マレイン酸ピリラミン、クエン酸トリペレンナミン、塩酸トリプロリジン、アクリバスチン(acrivastine)、ロラタジン、ブロムフェニルアミン、d−ブロムフェニラミンなどの抗ヒスタミン剤
グアイフェネシン、トコン、ヨウ化カリウム、抱水テルピンなどの去痰剤、
ロペラミドなどの止瀉剤、
ファモチジン、ラニチジン、アベナントラミド、トラニラストなどのH2アンタゴニスト剤;及びオメプラゾール、ランソプラゾールなどのプロトンポンプ阻害剤、
脂肪族アルコール、バルビツール酸塩などの、一般の非選択的CNS抑制剤、
カフェイン、ニコチン、ストリキニーネ、ピクロトキシン、ペンチレンテトラゾールなどの、一般の非選択的CNS興奮剤、
フェニヒダントイン(phenyhydantoin)、フェノバルビタール、プリミドン、カルバマゼピン、エトスクシミド、メトスクシミド、フェンスクシミド、トリメタジオン、ジアゼパム、ベンゾジアゼピン、フェナセミド、フェネツリド(pheneturide)、アセタゾールアミド、スルチアム、ブロミドなどの、CNS機能を選択的に改変する薬剤
レボドパ、アマンタジンなどの抗パーキンソン病薬、
モルフィン、ヘロイン、ヒドロモルフォン、メトポン、オキシモルフォン、レボルファノール、コデイン、ヒドロコドン、キシコドン、ナロルフィン、ナロキソン、ナルトレキソンなどの麻薬性鎮痛剤、
サリチル酸塩、フェニルブタゾン、インドメタシン、フェナセチンなどの解熱鎮痛剤、並びに
クロルプロマジン、メトトリメプラジン、ハロペリドール、クロザピン、レセルピン、イミプラミン、トラニルシプロミ、フェネルジン、リチウムなどの精神薬理学的薬
が含まれる。
純度>85%を有するカラスムギβグルカンの1重量%水溶液を以下の実施例で使用した。この溶液は、Ceapro Inc.(カナダ、アルバータ州エドモントン)から直接購入したか、又はCeapro Inc.から入手したカラスムギβグルカン粉末(>85%純度)から調製した。溶液は、米国特許第6,284,886号に記載されている方法で、それだけには限定されないがソルビン酸カリウム、ソルビン酸、塩化ベンザルコニウム、及びパラベンを含めた人による消費及び製薬での使用に認可された保存料のみを使用して、βグルカン粉末から調製した。
相Aを以下のように調製した。
相Aを以下のように調製した。
以前の実施例に記載されているように膜組成物を混合した。
天然の抗ヒスタミン及び抗酸化活性を有するカラスムギ抽出物から薄膜を調製した。
相Aを以下のように調製した。
相Aを以下のように調製した。
リボン、フィラメント、又は編みフィラメントの形態のワックスを塗っていないデンタルフロス(Oral−B Ultrafloss(商標))に、実施例5に従って調製した抗菌組成物をスプレーした、或いはそれに浸漬した。過剰の溶液を、例えばコーティングしたフロスをローラーの間で搾ることによって除去し、フロスを60℃の温気中で10〜15分間乾燥させた。
以前の実施例に記載されているように膜組成物を混合した。
Claims (35)
- β(1→3)β(1→4)グルカン、及び
有効量の1種又は複数種の対象化合物
を含む膜。 - 前記膜が約5〜約50重量%の前記β(1→3)β(1→4)グルカンを含む、請求項1に記載の膜。
- 前記膜が約10〜約35重量%の前記β(1→3)β(1→4)グルカンを含む、請求項1に記載の膜。
- 前記膜が約15〜約25重量%の前記β(1→3)β(1→4)グルカンを含む、請求項1に記載の膜。
- 前記膜が約0.001〜約50重量%の前記1種又は複数種の対象化合物を含む、請求項1に記載の膜。
- 前記膜が約5〜約35重量%の前記1種又は複数種の対象化合物を含む、請求項1に記載の膜。
- 前記膜が約10〜約25重量%の前記1種又は複数種の対象化合物を含む、請求項1に記載の膜。
- 前記グルカンが穀類種子又は穀類種子の一部由来である、請求項1に記載の膜。
- 前記穀類が、オオムギの栽培品種、カラスムギの栽培品種、コムギの栽培品種、ライムギの栽培品種、ソルガムの栽培品種、キビの栽培品種、トウモロコシの栽培品種、及びそれらの混合物からなる群から選択される、請求項8に記載の膜。
- 前記1種又は複数種の対象化合物が、薬剤活性物質、抗微生物剤、香味剤、及びそれらの混合物からなる群から選択される、請求項1に記載の膜。
- 前記1種又は複数種の対象化合物が薬剤活性物質である、請求項1に記載の膜。
- 前記薬剤活性物質が、非ステロイド性抗炎症薬、鎮咳剤、鬱血除去剤、抗ヒスタミン剤、去痰剤、止瀉剤、H2アンタゴニスト、非選択的中枢神経系抑制剤、非選択的中枢神経系興奮剤、中枢神経系の機能を選択的に改変する薬剤、パーキンソン病を処置するための薬物、麻薬性鎮痛剤、解熱鎮痛剤、精神薬理学的薬剤、及びそれらの混合物からなる群から選択される、請求項11に記載の膜。
- 前記1種又は複数種の対象化合物が抗微生物剤である、請求項1に記載の膜。
- 前記抗微生物剤が、トリクロサン、塩化セチルピリジニウム、サンギナリン、臭化ドミフェン、第四級アンモニウム塩、亜鉛化合物、フッ化物、アレキシジン、オクトニダイン、EDTA、硝酸銀、チモール、サリチル酸メチル、ユーカリプトール、メントール、及びそれらの混合物からなる群から選択される、請求項13に記載の膜。
- 前記1種又は複数種の対象化合物が香味剤である、請求項1に記載の膜。
- i)β(1→3)β(1→4)グルカンの水溶液を1種若しくは複数種の対象化合物と混合して組成物を形成すること、
ii)前記組成物を乾燥させて膜を形成すること、又は
iii)前記組成物を物品に塗布し、塗布した組成物を乾燥させて膜でコーティングした物品を生成すること
を含む、膜或いは膜でコーティングした物品を生成する方法。 - 前記グルカン及び前記1種又は複数種の対象化合物を混合した後、均一な組成物を形成するのに十分な時間これらを静置する、請求項16に記載の方法。
- 前記組成物が乳濁液である、請求項17に記載の方法。
- 前記乳濁液が乳化剤なしで形成される、請求項18に記載の方法。
- 約65%〜約100%の範囲の純度を有するグルカンを使用して前記水溶液を形成する、請求項16に記載の方法。
- 約75%〜約100%の範囲の純度を有するグルカンを使用して前記水溶液を形成する、請求項16に記載の方法。
- 約85%〜約100%の範囲の純度を有するグルカンを使用して前記水溶液を形成する、請求項16に記載の方法。
- 請求項1に記載の膜の1層又は複数の層でコーティングした物品。
- 前記1種又は複数種の対象化合物が、薬剤、抗微生物剤、香味剤、及びそれらの混合物からなる群から選択される請求項23に記載の物品。
- 前記物品が錠剤又はカプセルの形態の薬剤配合物である、請求項23に記載の物品。
- 前記1種又は複数種の対象化合物が香味剤である、請求項23に記載の物品。
- 前記1層又は複数の層のそれぞれが個別の香味剤を含む、請求項23に記載の物品。
- 物品がステントである、請求項23に記載の物品。
- 物品がティッシュペーパーである、請求項23に記載の物品。
- 物品がデンタルフロスである、請求項23に記載の物品。
- 請求項1に記載の膜を含む薬剤配合物。
- 前記配合物が1種又は複数種の対象化合物の送達に適したパッチの形態である、請求項31に記載の配合物。
- β(1→3)β(1→4)グルカン、及び
有効量の甘味剤
を含む甘味剤組成物。 - 前記甘味剤が、他の甘味剤なしで好ましい刺激応答を生じさせるのに有効である、請求項33に記載の組成物。
- 前記甘味剤がアセスルファム−Kである、請求項34に記載の組成物。
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PCT/CA2002/001896 WO2003054077A1 (en) | 2001-12-11 | 2002-12-11 | Cereal beta glucan compositions, methods of preparation and uses thereof |
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Also Published As
Publication number | Publication date |
---|---|
DE60222802D1 (de) | 2007-11-15 |
EP1453909A1 (en) | 2004-09-08 |
US20100158988A1 (en) | 2010-06-24 |
CA2467378A1 (en) | 2003-07-03 |
CA2467378C (en) | 2009-09-01 |
US20050031674A1 (en) | 2005-02-10 |
US8632798B2 (en) | 2014-01-21 |
ES2294180T3 (es) | 2008-04-01 |
DE60222802T2 (de) | 2008-07-10 |
EP1453909B1 (en) | 2007-10-03 |
AU2002347165B2 (en) | 2008-05-29 |
AU2008207405A1 (en) | 2008-09-11 |
AU2008207405B2 (en) | 2011-05-26 |
AU2002347165A1 (en) | 2003-07-09 |
ATE374796T1 (de) | 2007-10-15 |
WO2003054077A1 (en) | 2003-07-03 |
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