JP2005512590A - 乳酸菌の新規株およびそれを含む食用組成物、薬剤および獣医製品 - Google Patents
乳酸菌の新規株およびそれを含む食用組成物、薬剤および獣医製品 Download PDFInfo
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Abstract
Description
アラニントランスアミナーゼ値の上昇を確認する適合性血清試験に基づいて非アルコール依存性肝脂肪変性の症状を有すると診断された24名の患者(女性10名、男性14名、平均年齢49±12歳)を試験に含めた。すべての患者に1日あたり1兆8000億の、顆粒形態で凍結乾燥したストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)細菌を投与した。
5名の患者を試験に含めた:それらはアスパラギン酸トランスアミナーゼ(AST)とアラニントランスアミナーゼ(ALT)レベルが上昇しており、肝細胞診を行ったところ試験の開始前6ヶ月以内に生じた非アルコール依存性肝脂肪変性の症状が確かめられた2名の男性および3名の女性であった。これら患者はその他の慢性肝疾患の症状を示さず、トリグリセリドを低下させるための薬剤を服用していなかった。4ヶ月間、各患者に1日1兆8000億の以下の種の細菌を投与した:
−ストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)
−ラクトバシラス・ブレビス(CD2)
−ビフィドバクテリウム・インファンティス
−ラクトバシラス・プランタルム
−ラクトバシラス・カゼイ
−ラクトバシラス・ブルガリクス
−ラクトバシラス・アシドフィラス
−ストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)−1500億
−ラクトバシラス・ブレビス(CD2)−100億
−ビフィドバクテリウム・インファンティス−1000億
−ラクトバシラス・プランタルム−100億
−ラクトバシラス・カゼイ−100億
−ラクトバシラス・ブルガリクス−300億
−ラクトバシラス・アシドフィラス−300億
Claims (17)
- DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に2001年12月4日に寄託した生物学的に純粋なストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)株、受託番号DSM14667およびその子孫ならびに突然変異体。
- ストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス株またはその子孫および突然変異体を含む組成物。
- さらにDSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に寄託されたラクトバシラス・ブレビスCD2株、受託番号DSM11988またはその子孫あるいは突然変異体を含む請求項2に記載の組成物。
- さらに、ビフィドバクテリウム・インファンティス、ビフィドバクテリウム・ブレビ、ビフィドバクテリウム・ロンガム、ビフィドバクテリウム・ビフィドゥム、ラクトバシラス・プランタルム、ラクトバシラス・カゼイ、ラクトバシラス・ブルガリクス、ラクトバシラス・アシドフィラスからなる群から選択される株またはそれらの混合物を含む請求項3に記載の組成物。
- さらに以下の少なくとも1つの成分:ビタミンE、コリン、ウルソデオキシコール酸、クロフィブラート、チグリタゾン、ゲムフィブロジル、ベタイン、N−アセチルシステイン、ロシグリタゾン、塩基性アミノ酸、L−カルニチンまたは低級アルカニルL−カルニチンあるいはそれらの医薬上許容される塩を含む請求項2〜4のいずれかに記載の組成物。
- DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に2001年12月4日に寄託したストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)株、受託番号DSM14667またはその子孫あるいは突然変異体の、非アルコール依存性肝脂肪変性、脂肪肝、肝性脳症、インスリン抵抗性、高インスリン血症、肥満症、自閉症、注意力欠如および注意力欠如/多動の予防/治療のための食用組成物の調製のための使用。
- DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に2001年12月4日に寄託したストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)株、受託番号DSM14667またはその子孫あるいは突然変異体の、非アルコール依存性肝脂肪変性、脂肪肝、肝性脳症、インスリン抵抗性、高インスリン血症、肥満症、自閉症、注意力欠如および注意力欠如/多動の予防/治療のための経口または経腸経路によって投与できる薬剤の調製のための使用。
- DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に2001年12月4日に寄託したストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)株、受託番号DSM14667またはその子孫あるいは突然変異体の、非アルコール依存性肝脂肪変性、脂肪肝、インスリン抵抗性、高インスリン血症および肥満症の予防/治療のための獣医製品の調製のための使用。
- DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に2001年12月4日に寄託したストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)株、受託番号DSM14667またはその子孫あるいは突然変異体と、DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に寄託されたラクトバシラス・ブレビスCD2株、受託番号DSM11988またはその子孫あるいは突然変異体の混合物の、非アルコール依存性肝脂肪変性、脂肪肝、肝性脳症、インスリン抵抗性、高インスリン血症、肥満症、自閉症、注意力欠如および注意力欠如/多動の予防/治療のための食用組成物の調製のための使用。
- DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に2001年12月4日に寄託したストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)株、受託番号DSM14667またはその子孫あるいは突然変異体と、DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に寄託されたラクトバシラス・ブレビスCD2株、受託番号DSM11988またはその子孫あるいは突然変異体の混合物の、非アルコール依存性肝脂肪変性、脂肪肝、肝性脳症、インスリン抵抗性、高インスリン血症、肥満症、自閉症、注意力欠如および注意力欠如/多動の予防/治療のための経口または経腸経路により投与できる薬剤の調製のための使用。
- DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に2001年12月4日に寄託したストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)株、受託番号DSM14667またはその子孫あるいは突然変異体と、DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に寄託されたラクトバシラス・ブレビスCD2株、受託番号DSM11988またはその子孫あるいは突然変異体の混合物の、非アルコール依存性肝脂肪変性、脂肪肝、インスリン抵抗性、高インスリン血症、肥満症の予防/治療のための獣医製品の調製のための使用。
- 該混合物がさらにビフィドバクテリウム・インファンティス、ビフィドバクテリウム・ブレビ、ビフィドバクテリウム・ロンガム、ビフィドバクテリウム・ビフィドゥム、ラクトバシラス・プランタルム、ラクトバシラス・カゼイ、ラクトバシラス・ブルガリクス、ラクトバシラス・アシドフィラスの株またはそれらの混合物を含む請求項9〜11のいずれかに記載の使用。
- 食用組成物または薬剤が、DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に2001年12月4日に寄託したストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)株、受託番号DSM14667またはその子孫あるいは突然変異体の500億から3兆6000億の細菌を、使用者に投与することができる請求項6、7、9または10に記載の使用。
- DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に2001年12月4日に寄託したストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)株、受託番号DSM14667を含む有効量の食用組成物または薬剤を必要とする個体に投与することによる、非アルコール依存性肝脂肪変性、脂肪肝、肝性脳症、インスリン抵抗性、高インスリン血症、肥満症、自閉症、注意力欠如および注意力欠如/多動の予防/治療方法。
- 食用組成物または薬剤がさらに、DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に寄託されたラクトバシラス・ブレビス(CD2)株、受託番号DSM11988またはその子孫あるいは突然変異体を含む請求項14に記載の方法。
- 食用組成物または薬剤がさらに、ビフィドバクテリウム・インファンティス、ビフィドバクテリウム・ブレビ、ビフィドバクテリウム・ロンガム、ビフィドバクテリウム・ビフィドゥム、ラクトバシラス・プランタルム、ラクトバシラス・カゼイ、ラクトバシラス・ブルガリクス、ラクトバシラス・アシドフィラスを含む群から選択される株またはそれらの混合物を含む請求項15に記載の方法。
- 有効量の食用組成物または薬剤が、DSMZ(ドイッチェ・サムルンク・フォン・ミクロオルガニズメン・ウント・ツェルクルツレン・ゲー・エム・ベー・ハー、ドイツ国、ブラウンシュヴァイク)に2001年12月4日に寄託したストレプトコッカス・サーモフィラス・エス・エス・ピー・サリヴァリウス(CD8)株、受託番号DSM14667を1日あたり500−3兆6000億細菌含む、請求項14から16のいずれかに記載の方法。
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WO2015182155A1 (ja) * | 2014-05-29 | 2015-12-03 | 日東薬品工業株式会社 | 新規乳酸菌及び該乳酸菌を含む組成物 |
WO2018174125A1 (ja) * | 2017-03-22 | 2018-09-27 | 雪印メグミルク株式会社 | 脂質代謝改善用組成物 |
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IT1283225B1 (it) * | 1996-03-11 | 1998-04-16 | Renata Maria Anna Ve Cavaliere | Ceppi di batteri, composizione farmaceutica contenente uno o piu' di tali ceppi e uso dei medesimi per la prevenzione e la terapia delle |
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KR101238836B1 (ko) | 2011-05-17 | 2013-03-04 | 삼육대학교산학협력단 | 혼합 유산균을 포함하는 비만 또는 비만 관련 질환 치료 또는 예방용 약제학적 조성물 또는 식품 조성물 |
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BR112018070518A2 (pt) * | 2016-04-14 | 2019-01-29 | Dupont Nutrition Biosci Aps | bactéria do gênero bifidobacterium, usos de uma bactéria do gênero bifidobacterium e método para reduzir a ingestão de alimentos, energia e/ou gordura |
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CN115181698B (zh) * | 2022-06-28 | 2023-09-08 | 广东粤港澳大湾区国家纳米科技创新研究院 | 一种益生菌组合物及应用 |
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JPS61221124A (ja) * | 1985-03-26 | 1986-10-01 | Advance Res & Dev Co Ltd | 肝機能改善剤 |
US5716615A (en) * | 1992-02-10 | 1998-02-10 | Renata Maria Anna Cavaliere Vesely | Dietary and pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use |
US6297229B1 (en) * | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
US5760010A (en) | 1995-01-01 | 1998-06-02 | Klein; Ira | Method of treating liver disorders with a macrolide antibiotic |
IT1283225B1 (it) * | 1996-03-11 | 1998-04-16 | Renata Maria Anna Ve Cavaliere | Ceppi di batteri, composizione farmaceutica contenente uno o piu' di tali ceppi e uso dei medesimi per la prevenzione e la terapia delle |
WO1999029330A1 (en) * | 1997-12-05 | 1999-06-17 | Viva America Marketing, Inc. | Composition and method for treating nonalcoholic steatohepatitis |
IT1298918B1 (it) * | 1998-02-20 | 2000-02-07 | Mendes Srl | Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche |
IT1309427B1 (it) * | 1999-05-28 | 2002-01-23 | Mendes S U R L | Composizione dietetica o farmaceutica utile per la prevenzione o iltrattamento dell'iperossaluria e suo uso |
ITRM20010763A1 (it) | 2001-12-21 | 2003-06-21 | Simone Claudio De | Nuovo ceppo di batterio lattico e composizioni commestibili, farmaci e prodotti veterinari che lo contengono. |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014024776A (ja) * | 2012-07-25 | 2014-02-06 | Yakult Honsha Co Ltd | Nash予防治療剤 |
WO2015182155A1 (ja) * | 2014-05-29 | 2015-12-03 | 日東薬品工業株式会社 | 新規乳酸菌及び該乳酸菌を含む組成物 |
JPWO2015182155A1 (ja) * | 2014-05-29 | 2017-04-20 | 日東薬品工業株式会社 | 新規乳酸菌及び該乳酸菌を含む組成物 |
WO2018174125A1 (ja) * | 2017-03-22 | 2018-09-27 | 雪印メグミルク株式会社 | 脂質代謝改善用組成物 |
JPWO2018174125A1 (ja) * | 2017-03-22 | 2020-01-23 | 雪印メグミルク株式会社 | 脂質代謝改善用組成物 |
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