JP2005510574A5 - - Google Patents
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- Publication number
- JP2005510574A5 JP2005510574A5 JP2003547631A JP2003547631A JP2005510574A5 JP 2005510574 A5 JP2005510574 A5 JP 2005510574A5 JP 2003547631 A JP2003547631 A JP 2003547631A JP 2003547631 A JP2003547631 A JP 2003547631A JP 2005510574 A5 JP2005510574 A5 JP 2005510574A5
- Authority
- JP
- Japan
- Prior art keywords
- target
- elongation factor
- aliphatic
- ligand
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003446 ligand Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 14
- 125000001931 aliphatic group Chemical group 0.000 claims 12
- 125000000524 functional group Chemical group 0.000 claims 9
- 102000002508 Peptide Elongation Factors Human genes 0.000 claims 6
- 108010068204 Peptide Elongation Factors Proteins 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 230000000269 nucleophilic effect Effects 0.000 claims 4
- 239000002184 metal Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 150000003573 thiols Chemical group 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/990,421 US6919178B2 (en) | 2000-11-21 | 2001-11-21 | Extended tethering approach for rapid identification of ligands |
| US10/121,216 US6998233B2 (en) | 1998-06-26 | 2002-04-10 | Methods for ligand discovery |
| PCT/US2002/013061 WO2003046200A2 (en) | 2001-11-21 | 2002-04-24 | Methods for ligand discovery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009020721A Division JP2009109515A (ja) | 2001-11-21 | 2009-01-30 | リガンド発見のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005510574A JP2005510574A (ja) | 2005-04-21 |
| JP2005510574A5 true JP2005510574A5 (https=) | 2005-12-22 |
| JP4391237B2 JP4391237B2 (ja) | 2009-12-24 |
Family
ID=26819229
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003547631A Expired - Fee Related JP4391237B2 (ja) | 2001-11-21 | 2002-04-24 | リガンド発見のための方法 |
| JP2009020721A Withdrawn JP2009109515A (ja) | 2001-11-21 | 2009-01-30 | リガンド発見のための方法 |
| JP2011040912A Pending JP2011140497A (ja) | 2001-11-21 | 2011-02-25 | リガンド発見のための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009020721A Withdrawn JP2009109515A (ja) | 2001-11-21 | 2009-01-30 | リガンド発見のための方法 |
| JP2011040912A Pending JP2011140497A (ja) | 2001-11-21 | 2011-02-25 | リガンド発見のための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050142614A1 (https=) |
| EP (2) | EP1939625A3 (https=) |
| JP (3) | JP4391237B2 (https=) |
| AU (2) | AU2002254725A1 (https=) |
| CA (1) | CA2464094C (https=) |
| IL (1) | IL161409A0 (https=) |
| MX (1) | MXPA04004814A (https=) |
| NZ (1) | NZ532579A (https=) |
| RU (1) | RU2295518C2 (https=) |
| WO (1) | WO2003046200A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214487B2 (en) | 1998-06-26 | 2007-05-08 | Sunesis Pharmaceuticals, Inc. | Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates |
| US6919178B2 (en) * | 2000-11-21 | 2005-07-19 | Sunesis Pharmaceuticals, Inc. | Extended tethering approach for rapid identification of ligands |
| US6335155B1 (en) * | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
| WO2003081210A2 (en) | 2002-03-21 | 2003-10-02 | Sunesis Pharmaceuticals, Inc. | Identification of kinase inhibitors |
| KR20070053214A (ko) * | 2004-08-26 | 2007-05-23 | 니콜라스 피라말 인디아 리미티드 | 신규 생분해성 링커를 함유하는 프로드럭 |
| DK2526933T3 (en) | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| SG10202107066WA (en) * | 2007-03-28 | 2021-07-29 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| US20120101114A1 (en) | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| CA2730930C (en) | 2008-07-16 | 2015-01-13 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors |
| JP2012501654A (ja) * | 2008-09-05 | 2012-01-26 | アビラ セラピューティクス， インコーポレイテッド | 不可逆的インヒビターの設計のためのアルゴリズム |
| US9556426B2 (en) | 2009-09-16 | 2017-01-31 | Celgene Avilomics Research, Inc. | Protein kinase conjugates and inhibitors |
| JP2013516422A (ja) | 2009-12-30 | 2013-05-13 | アビラ セラピューティクス， インコーポレイテッド | タンパク質のリガンド−指向性共有的修飾 |
| CN102939110A (zh) | 2010-04-21 | 2013-02-20 | 诺沃—诺迪斯克有限公司 | 蛋白质的选择性修饰 |
| CA3007787C (en) | 2010-06-03 | 2020-03-10 | Pharmacyclics Llc | The use of inhibitors of bruton's tyrosine kinase (btk) |
| JP2014520863A (ja) | 2011-07-13 | 2014-08-25 | ファーマサイクリックス，インク． | Ｂｒｕｔｏｎ型チロシンキナーゼの阻害剤 |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| KR20210033067A (ko) | 2012-06-04 | 2021-03-25 | 파마싸이클릭스 엘엘씨 | 브루톤 타이로신 키나아제 저해제의 결정 형태 |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| EA201590855A1 (ru) | 2012-11-15 | 2015-11-30 | Фармасайкликс, Инк. | Соединения пирролопиримидина как ингибиторы киназ |
| JP6800750B2 (ja) | 2013-08-02 | 2020-12-16 | ファーマサイクリックス エルエルシー | 固形腫瘍の処置方法 |
| US9415050B2 (en) | 2013-08-12 | 2016-08-16 | Pharmacyclics Llc | Methods for the treatment of HER2 amplified cancer |
| BR112016006978A2 (pt) | 2013-09-30 | 2017-08-01 | Pharmacyclics Llc | inibidores de tirosina quinase de bruton |
| US9885086B2 (en) | 2014-03-20 | 2018-02-06 | Pharmacyclics Llc | Phospholipase C gamma 2 and resistance associated mutations |
| AU2015296215A1 (en) | 2014-08-01 | 2017-03-23 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| KR20170033358A (ko) | 2014-08-07 | 2017-03-24 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 키나아제 저해제의 신규한 제제 |
| IL315294A (en) | 2015-03-03 | 2024-10-01 | Pharmacyclics Llc | Pharmaceutical formulations of bruton's tyrosine kinase inhibitor |
| JP7697280B2 (ja) * | 2021-06-15 | 2025-06-24 | 株式会社オートネットワーク技術研究所 | 車載制御装置、イーサネットスイッチおよび機器設定方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5367058A (en) * | 1993-08-25 | 1994-11-22 | Becton, Dickinson And Company | Modified antibodies with increased affinity |
| US5361058A (en) * | 1993-11-02 | 1994-11-01 | Gould Electronics Inc. | Time delay fuse |
| DE19610103A1 (de) * | 1996-03-15 | 1997-09-18 | Basf Ag | Cycloalkylderivate und ihre Synthese an fester Phase |
| WO1999041216A1 (en) * | 1998-02-17 | 1999-08-19 | Chembridge Corporation | Supports for solid state chemical reactions and method of use thereof |
| US6344330B1 (en) * | 1998-03-27 | 2002-02-05 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
| CA2430234C (en) * | 2000-11-21 | 2008-02-12 | Sunesis Pharmaceuticals, Inc. | An extended tethering approach for rapid identification of ligands |
-
2002
- 2002-04-24 MX MXPA04004814A patent/MXPA04004814A/es active IP Right Grant
- 2002-04-24 IL IL16140902A patent/IL161409A0/xx unknown
- 2002-04-24 AU AU2002254725A patent/AU2002254725A1/en not_active Abandoned
- 2002-04-24 EP EP08006555A patent/EP1939625A3/en not_active Withdrawn
- 2002-04-24 JP JP2003547631A patent/JP4391237B2/ja not_active Expired - Fee Related
- 2002-04-24 RU RU2004119036/04A patent/RU2295518C2/ru not_active IP Right Cessation
- 2002-04-24 EP EP02723967A patent/EP1446496A4/en not_active Withdrawn
- 2002-04-24 CA CA2464094A patent/CA2464094C/en not_active Expired - Fee Related
- 2002-04-24 WO PCT/US2002/013061 patent/WO2003046200A2/en not_active Ceased
- 2002-04-24 NZ NZ532579A patent/NZ532579A/en not_active IP Right Cessation
-
2005
- 2005-02-09 US US11/054,754 patent/US20050142614A1/en not_active Abandoned
-
2009
- 2009-01-30 JP JP2009020721A patent/JP2009109515A/ja not_active Withdrawn
- 2009-07-22 AU AU2009202965A patent/AU2009202965A1/en not_active Abandoned
-
2011
- 2011-02-25 JP JP2011040912A patent/JP2011140497A/ja active Pending
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