JP2005510574A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005510574A5 JP2005510574A5 JP2003547631A JP2003547631A JP2005510574A5 JP 2005510574 A5 JP2005510574 A5 JP 2005510574A5 JP 2003547631 A JP2003547631 A JP 2003547631A JP 2003547631 A JP2003547631 A JP 2003547631A JP 2005510574 A5 JP2005510574 A5 JP 2005510574A5
- Authority
- JP
- Japan
- Prior art keywords
- target
- elongation factor
- aliphatic
- ligand
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003446 ligand Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 14
- 125000001931 aliphatic group Chemical group 0.000 claims 12
- 125000000524 functional group Chemical group 0.000 claims 9
- 102000002508 Peptide Elongation Factors Human genes 0.000 claims 6
- 108010068204 Peptide Elongation Factors Proteins 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 230000000269 nucleophilic effect Effects 0.000 claims 4
- 239000002184 metal Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 150000003573 thiols Chemical group 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/990,421 US6919178B2 (en) | 2000-11-21 | 2001-11-21 | Extended tethering approach for rapid identification of ligands |
| US10/121,216 US6998233B2 (en) | 1998-06-26 | 2002-04-10 | Methods for ligand discovery |
| PCT/US2002/013061 WO2003046200A2 (en) | 2001-11-21 | 2002-04-24 | Methods for ligand discovery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009020721A Division JP2009109515A (ja) | 2001-11-21 | 2009-01-30 | リガンド発見のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005510574A JP2005510574A (ja) | 2005-04-21 |
| JP2005510574A5 true JP2005510574A5 (https=) | 2005-12-22 |
| JP4391237B2 JP4391237B2 (ja) | 2009-12-24 |
Family
ID=26819229
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003547631A Expired - Fee Related JP4391237B2 (ja) | 2001-11-21 | 2002-04-24 | リガンド発見のための方法 |
| JP2009020721A Withdrawn JP2009109515A (ja) | 2001-11-21 | 2009-01-30 | リガンド発見のための方法 |
| JP2011040912A Pending JP2011140497A (ja) | 2001-11-21 | 2011-02-25 | リガンド発見のための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009020721A Withdrawn JP2009109515A (ja) | 2001-11-21 | 2009-01-30 | リガンド発見のための方法 |
| JP2011040912A Pending JP2011140497A (ja) | 2001-11-21 | 2011-02-25 | リガンド発見のための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050142614A1 (https=) |
| EP (2) | EP1939625A3 (https=) |
| JP (3) | JP4391237B2 (https=) |
| AU (2) | AU2002254725A1 (https=) |
| CA (1) | CA2464094C (https=) |
| IL (1) | IL161409A0 (https=) |
| MX (1) | MXPA04004814A (https=) |
| NZ (1) | NZ532579A (https=) |
| RU (1) | RU2295518C2 (https=) |
| WO (1) | WO2003046200A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214487B2 (en) | 1998-06-26 | 2007-05-08 | Sunesis Pharmaceuticals, Inc. | Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates |
| US6335155B1 (en) * | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
| US6919178B2 (en) * | 2000-11-21 | 2005-07-19 | Sunesis Pharmaceuticals, Inc. | Extended tethering approach for rapid identification of ligands |
| WO2003081210A2 (en) | 2002-03-21 | 2003-10-02 | Sunesis Pharmaceuticals, Inc. | Identification of kinase inhibitors |
| AR054181A1 (es) * | 2004-08-26 | 2007-06-06 | Nicholas Piramal India Ltd | Prodrogas que contienen enlaces bio-divisibles. composiiciones farmaceuticas |
| BRPI0622054B8 (pt) | 2006-09-22 | 2021-05-25 | Oxford Amherst Llc | composto e composição farmacêutica |
| IL295053A (en) * | 2007-03-28 | 2022-09-01 | Pharmacyclics Llc | Broton tyrosine kinase inhibitors |
| US20120101114A1 (en) | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| ES2660418T3 (es) | 2008-07-16 | 2018-03-22 | Pharmacyclics Llc | Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos |
| JP2012501654A (ja) * | 2008-09-05 | 2012-01-26 | アビラ セラピューティクス， インコーポレイテッド | 不可逆的インヒビターの設計のためのアルゴリズム |
| NZ620174A (en) | 2009-09-16 | 2016-08-26 | Celgene Avilomics Res Inc | Protein kinase conjugates and inhibitors |
| EP2519664A4 (en) | 2009-12-30 | 2014-03-12 | Avila Therapeutics Inc | LIGAND-RELATED COVALENTS MODIFYING A PROTEIN |
| US8859731B2 (en) | 2010-04-21 | 2014-10-14 | Novo Nordisk A/S | Selective modification of proteins |
| CN107898791A (zh) | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| US9138436B2 (en) | 2011-07-13 | 2015-09-22 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| JO3754B1 (ar) | 2012-06-04 | 2021-01-31 | Pharmacyclics Llc | أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| EA201590855A1 (ru) | 2012-11-15 | 2015-11-30 | Фармасайкликс, Инк. | Соединения пирролопиримидина как ингибиторы киназ |
| CA2919996A1 (en) | 2013-08-02 | 2015-02-05 | Pharmacyclics Llc | Methods for the treatment of solid tumors |
| US9415050B2 (en) | 2013-08-12 | 2016-08-16 | Pharmacyclics Llc | Methods for the treatment of HER2 amplified cancer |
| CA2925124A1 (en) | 2013-09-30 | 2015-04-02 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| WO2015143400A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics, Inc. | Phospholipase c gamma 2 and resistance associated mutations |
| AU2015296215A1 (en) | 2014-08-01 | 2017-03-23 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| SG11201700849XA (en) | 2014-08-07 | 2017-03-30 | Pharmacyclics Llc | Novel formulations of a bruton's tyrosine kinase inhibitor |
| IL315294A (en) | 2015-03-03 | 2024-10-01 | Pharmacyclics Llc | Pharmaceutical formulations of bruton's tyrosine kinase inhibitor |
| JP7697280B2 (ja) * | 2021-06-15 | 2025-06-24 | 株式会社オートネットワーク技術研究所 | 車載制御装置、イーサネットスイッチおよび機器設定方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5367058A (en) * | 1993-08-25 | 1994-11-22 | Becton, Dickinson And Company | Modified antibodies with increased affinity |
| US5361058A (en) * | 1993-11-02 | 1994-11-01 | Gould Electronics Inc. | Time delay fuse |
| DE19610103A1 (de) * | 1996-03-15 | 1997-09-18 | Basf Ag | Cycloalkylderivate und ihre Synthese an fester Phase |
| WO1999041216A1 (en) * | 1998-02-17 | 1999-08-19 | Chembridge Corporation | Supports for solid state chemical reactions and method of use thereof |
| US6344330B1 (en) * | 1998-03-27 | 2002-02-05 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
| AU2573102A (en) * | 2000-11-21 | 2002-06-03 | Sunesis Pharmaceuticals Inc | An extended tethering approach for rapid identification of ligands |
-
2002
- 2002-04-24 CA CA2464094A patent/CA2464094C/en not_active Expired - Fee Related
- 2002-04-24 NZ NZ532579A patent/NZ532579A/en not_active IP Right Cessation
- 2002-04-24 EP EP08006555A patent/EP1939625A3/en not_active Withdrawn
- 2002-04-24 JP JP2003547631A patent/JP4391237B2/ja not_active Expired - Fee Related
- 2002-04-24 EP EP02723967A patent/EP1446496A4/en not_active Withdrawn
- 2002-04-24 AU AU2002254725A patent/AU2002254725A1/en not_active Abandoned
- 2002-04-24 RU RU2004119036/04A patent/RU2295518C2/ru not_active IP Right Cessation
- 2002-04-24 IL IL16140902A patent/IL161409A0/xx unknown
- 2002-04-24 WO PCT/US2002/013061 patent/WO2003046200A2/en not_active Ceased
- 2002-04-24 MX MXPA04004814A patent/MXPA04004814A/es active IP Right Grant
-
2005
- 2005-02-09 US US11/054,754 patent/US20050142614A1/en not_active Abandoned
-
2009
- 2009-01-30 JP JP2009020721A patent/JP2009109515A/ja not_active Withdrawn
- 2009-07-22 AU AU2009202965A patent/AU2009202965A1/en not_active Abandoned
-
2011
- 2011-02-25 JP JP2011040912A patent/JP2011140497A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005510574A5 (https=) | ||
| Lin et al. | Fabrication of oriented antibody-conjugated magnetic nanoprobes and their immunoaffinity application | |
| US9029473B2 (en) | Functionalised polymers for binding metal surfaces | |
| Zajac et al. | Protein microarrays and quantum dot probes for early cancer detection | |
| Kennedy et al. | Development of nanoparticle probes for multiplex SERS imaging of cell surface proteins | |
| KR102412431B1 (ko) | 신장 질환을 검출하기 위한 방법 | |
| ATE312200T1 (de) | Einzelschicht und elektrode zur feststellung von markierten molekülen und verfahren zu deren verwendung | |
| RU2004119036A (ru) | Способы нахождения лигандов | |
| EP2290100A8 (en) | Kits for displacement Sandwich Immuno-PCR | |
| WO2005016115A3 (en) | Biosensors utilizing dendrimer-immobilized ligands and their use thereof | |
| TW201936626A (zh) | 基於陣列之環狀肽庫 | |
| JP2009092651A (ja) | 担体およびその製造方法 | |
| JP2008504528A5 (https=) | ||
| CN105823768A (zh) | 一种基于表面增强拉曼散射技术的检测芯片、制备方法以及试剂盒 | |
| Luo et al. | Molecularly imprinted polymer based hybrid structure SiO2@ MPS-CdTe/CdS: a novel fluorescence probe for hepatitis A virus | |
| JPWO2003066644A1 (ja) | フェライト結合有機物質及びその製造方法 | |
| JP2001521625A (ja) | 標的生物学的物質を単離するための方法、捕獲相、検出相、及び試薬 | |
| ATE354091T1 (de) | Verfahren zur quantitativen bestimmung mehrerer analyten | |
| US12037430B2 (en) | Target substance polymer replica substrate, method for producing same, and method for producing substrate sensor | |
| JP4213029B2 (ja) | 特異的標識化方法 | |
| CN106415271A (zh) | 用于执行多重分析方法的对照 | |
| JP2006506947A5 (https=) | ||
| JP2003536056A (ja) | リガンドの固定化のための表面 | |
| US8158343B2 (en) | Method to detect virus related immunological markers for the diagnosis of respiratory tract infections | |
| KR101779611B1 (ko) | 표적 항원 검출용 카트리지 및 이를 이용한 표적 항원의 검출 방법 |