JP2005508983A - Ｐｄｅ４又はｐｄｅ３／４阻害剤及び抗リウマチ薬の複合薬 - Google Patents
Ｐｄｅ４又はｐｄｅ３／４阻害剤及び抗リウマチ薬の複合薬 Download PDFInfo
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- JP2005508983A JP2005508983A JP2003541843A JP2003541843A JP2005508983A JP 2005508983 A JP2005508983 A JP 2005508983A JP 2003541843 A JP2003541843 A JP 2003541843A JP 2003541843 A JP2003541843 A JP 2003541843A JP 2005508983 A JP2005508983 A JP 2005508983A
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- methyl
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- dione
- rheumatic
- dmard
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- DDYUBCCTNHWSQM-UHFFFAOYSA-N 3-(3-cyclopentyloxy-4-methoxyphenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide Chemical compound COC1=CC=C(C(CC(N)=O)N2C(C3=CC=CC=C3C2=O)=O)C=C1OC1CCCC1 DDYUBCCTNHWSQM-UHFFFAOYSA-N 0.000 claims description 7
- JEXXKWQSTOIMJW-UHFFFAOYSA-N 5-methyl-n-[4-(trifluoromethyl)phenyl]-1,2-oxazole-3-carboxamide Chemical compound O1C(C)=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=N1 JEXXKWQSTOIMJW-UHFFFAOYSA-N 0.000 claims description 7
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- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims description 7
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01000607 | 2001-11-09 | ||
| PCT/EP2002/012415 WO2003039552A1 (en) | 2001-11-09 | 2002-11-07 | Combination of pde4 or pde3/4 inhibitor and an anti-rheumatic drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508983A true JP2005508983A (ja) | 2005-04-07 |
| JP2005508983A5 JP2005508983A5 (https=) | 2006-01-05 |
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| JP2003541843A Pending JP2005508983A (ja) | 2001-11-09 | 2002-11-07 | Ｐｄｅ４又はｐｄｅ３／４阻害剤及び抗リウマチ薬の複合薬 |
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| Country | Link |
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| US (2) | US20030092706A1 (https=) |
| EP (1) | EP1448202A1 (https=) |
| JP (1) | JP2005508983A (https=) |
| AU (1) | AU2002300754B2 (https=) |
| CA (1) | CA2399840C (https=) |
| WO (1) | WO2003039552A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005533104A (ja) * | 2002-07-15 | 2005-11-04 | ユニテック ファーマシューティカルズ， インコーポレイテッド | 慢性関節リウマチを処置するためのレフルノミド類似体 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7718644B2 (en) * | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| PT1511516E (pt) * | 2002-05-28 | 2009-02-20 | Nycomed Gmbh | Preparação farmacêutica para aplicação tópica |
| UA82323C2 (uk) * | 2002-08-09 | 2008-04-10 | Меда Фарма Гмбх & Ко. Кг | Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань |
| ES2335498T3 (es) | 2003-03-10 | 2010-03-29 | Nycomed Gmbh | Nuevo proceso para la preparacion de reflumilast. |
| JP2007536350A (ja) * | 2004-05-10 | 2007-12-13 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肺気腫の予防又は治療のためのロフルミラストの使用 |
| CA2589808A1 (en) * | 2004-11-02 | 2006-05-11 | Dainippon Sumitomo Pharma Co., Ltd. | Combination drug for treating autoimmune disease |
| EP2363128B1 (en) * | 2005-03-11 | 2016-02-17 | Vertex Pharmaceuticals Incorporated | Indole modulators of ATP-binding cassette transporters |
| US8663694B2 (en) * | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
| KR100838702B1 (ko) * | 2007-02-08 | 2008-06-16 | 한국화학연구원 | 1-[1-(3,4-디알콕시아릴)-피리딜메틸]-1ｈ-피라졸 화합물의제조방법 |
| WO2010091381A2 (en) * | 2009-02-09 | 2010-08-12 | Callisto Pharmaceuticals, Inc. | An intermittent dosing strategy for treating rheumatoid arthrtis |
| WO2013016718A1 (en) * | 2011-07-28 | 2013-01-31 | Cellworks Research India Private Limited | Compositions, process of preparation of said compositions and method of treating inflammatory diseases |
| BR112015019276A2 (pt) | 2013-02-19 | 2017-07-18 | Pfizer | compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios |
| WO2016012896A1 (en) | 2014-07-24 | 2016-01-28 | Pfizer Inc. | Pyrazolopyrimidine compounds |
| MD20170011A2 (ro) | 2014-08-06 | 2017-08-31 | Pfizer Inc. | Compuşi imidazopiridazinici |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000053182A2 (en) * | 1999-03-10 | 2000-09-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh | 3-cyclopropylmethoxy-4-difluoromethoxy-n-(3,5-dichloropyrid-4-yl)benzamide in the treatment of multiple sclerosis |
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2002
- 2002-06-28 US US10/184,068 patent/US20030092706A1/en not_active Abandoned
- 2002-08-27 AU AU2002300754A patent/AU2002300754B2/en not_active Ceased
- 2002-08-27 CA CA2399840A patent/CA2399840C/en not_active Expired - Fee Related
- 2002-11-07 WO PCT/EP2002/012415 patent/WO2003039552A1/en not_active Ceased
- 2002-11-07 JP JP2003541843A patent/JP2005508983A/ja active Pending
- 2002-11-07 EP EP02792742A patent/EP1448202A1/en not_active Withdrawn
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2007
- 2007-07-19 US US11/826,876 patent/US20070270441A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005533104A (ja) * | 2002-07-15 | 2005-11-04 | ユニテック ファーマシューティカルズ， インコーポレイテッド | 慢性関節リウマチを処置するためのレフルノミド類似体 |
| JP2010168402A (ja) * | 2002-07-15 | 2010-08-05 | Unitech Pharmaceuticals Inc | 慢性関節リウマチを処置するためのレフルノミド類似体 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1448202A1 (en) | 2004-08-25 |
| US20030092706A1 (en) | 2003-05-15 |
| CA2399840A1 (en) | 2003-05-09 |
| CA2399840C (en) | 2010-10-19 |
| US20070270441A1 (en) | 2007-11-22 |
| WO2003039552A1 (en) | 2003-05-15 |
| AU2002300754B2 (en) | 2008-05-15 |
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