JP2005508332A

JP2005508332A - 薬剤を送達するための、輸送タンパク質とコンジュゲートコバラミンとの同時投与

薬剤を送達するための、輸送タンパク質とコンジュゲートコバラミンとの同時投与 Download PDF

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Publication number: JP2005508332A
Authority: JP; Japan
Prior art keywords: administration; cobalamin; independently; transport protein; bond
Prior art date: 2001-09-28
Legal status : Pending

Application number

JP2003530309A

Other languages

English (en)

Japanese (ja)

Other versions

JP2005508332A5 (enExample

Inventor

コリンズ，ダグラス・エイ

Original Assignee

メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ

Priority date

2001-09-28

Filing date

2002-09-30

Publication date

2005-03-31

2002-09-30 Application filed by メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ filed Critical メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ

2005-03-31 Publication of JP2005508332A publication Critical patent/JP2005508332A/ja

2006-01-05 Publication of JP2005508332A5 publication Critical patent/JP2005508332A5/ja

Status Pending legal-status Critical Current

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108010078791 Carrier Proteins Proteins 0.000 title claims abstract description 122
102000014914 Carrier Proteins Human genes 0.000 title claims abstract description 110
FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 title abstract description 202
238000012377 drug delivery Methods 0.000 title description 21
238000011260 co-administration Methods 0.000 title description 2
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239000010941 cobalt Substances 0.000 claims description 11
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125000002124 5'-adenosyl group Chemical group N1=CN=C2N(C=NC2=C1N)[C@H]1[C@H](O)[C@H](O)[C@H](O1)C* 0.000 claims description 10
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UCOHKZKRNWNULS-UHFFFAOYSA-N aminocyanamide Chemical group NNC#N UCOHKZKRNWNULS-UHFFFAOYSA-N 0.000 claims description 10
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239000010452 phosphate Substances 0.000 claims description 9
108091028043 Nucleic acid sequence Proteins 0.000 claims description 8
229910019142 PO4 Inorganic materials 0.000 claims description 8
APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 claims description 8
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125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims description 8
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 8
238000007920 subcutaneous administration Methods 0.000 claims description 8
125000001424 substituent group Chemical group 0.000 claims description 8
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238000001361 intraarterial administration Methods 0.000 claims description 7
238000007916 intrasternal administration Methods 0.000 claims description 7
238000007919 intrasynovial administration Methods 0.000 claims description 7
238000007911 parenteral administration Methods 0.000 claims description 7
238000011200 topical administration Methods 0.000 claims description 7
238000002054 transplantation Methods 0.000 claims description 7
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229910052688 Gadolinium Inorganic materials 0.000 claims description 5
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UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims description 5
230000014509 gene expression Effects 0.000 claims description 5
ZCYVEMRRCGMTRW-AHCXROLUSA-N Iodine-123 Chemical compound [123I] ZCYVEMRRCGMTRW-AHCXROLUSA-N 0.000 claims description 4
GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical group [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 claims description 4
CPELXLSAUQHCOX-AHCXROLUSA-N ac1l4zwb Chemical compound [76BrH] CPELXLSAUQHCOX-AHCXROLUSA-N 0.000 claims description 4
125000003346 cobalamin group Chemical group 0.000 claims description 4
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OKTJSMMVPCPJKN-BJUDXGSMSA-N carbon-11 Chemical group [11C] OKTJSMMVPCPJKN-BJUDXGSMSA-N 0.000 claims description 3
XMBWDFGMSWQBCA-OIOBTWANSA-N iodane Chemical compound [124IH] XMBWDFGMSWQBCA-OIOBTWANSA-N 0.000 claims description 3
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ASARMUCNOOHMLO-WLORSUFZSA-L cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2s)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O ASARMUCNOOHMLO-WLORSUFZSA-L 0.000 claims 62
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WYMDDFRYORANCC-UHFFFAOYSA-N 2-[[3-[bis(carboxymethyl)amino]-2-hydroxypropyl]-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)CN(CC(O)=O)CC(O)=O WYMDDFRYORANCC-UHFFFAOYSA-N 0.000 claims 2
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