JP2005508332A5 - - Google Patents
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- JP2005508332A5 JP2005508332A5 JP2003530309A JP2003530309A JP2005508332A5 JP 2005508332 A5 JP2005508332 A5 JP 2005508332A5 JP 2003530309 A JP2003530309 A JP 2003530309A JP 2003530309 A JP2003530309 A JP 2003530309A JP 2005508332 A5 JP2005508332 A5 JP 2005508332A5
- Authority
- JP
- Japan
- Prior art keywords
- administration
- cobalamin
- composition
- therapeutic agent
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- ASARMUCNOOHMLO-WLORSUFZSA-L cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2s)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O ASARMUCNOOHMLO-WLORSUFZSA-L 0.000 claims 44
- 239000003814 drug Substances 0.000 claims 25
- 239000000203 mixture Substances 0.000 claims 25
- 108010078791 Carrier Proteins Proteins 0.000 claims 23
- 229940124597 therapeutic agent Drugs 0.000 claims 23
- 102000014914 Carrier Proteins Human genes 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 21
- 150000002431 hydrogen Chemical class 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 125000000304 alkynyl group Chemical group 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 229910052751 metal Inorganic materials 0.000 claims 12
- 239000002184 metal Substances 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 229910052717 sulfur Inorganic materials 0.000 claims 12
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 102000011409 Transcobalamins Human genes 0.000 claims 9
- 108010023603 Transcobalamins Proteins 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 125000004429 atom Chemical group 0.000 claims 8
- 239000000032 diagnostic agent Substances 0.000 claims 8
- 229940039227 diagnostic agent Drugs 0.000 claims 8
- -1 morpholino nucleic acids Chemical class 0.000 claims 8
- 230000005298 paramagnetic effect Effects 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 229910020676 Co—N Inorganic materials 0.000 claims 6
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000002124 5'-adenosyl group Chemical group N1=CN=C2N(C=NC2=C1N)[C@H]1[C@H](O)[C@H](O)[C@H](O1)C* 0.000 claims 3
- 241000239290 Araneae Species 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 229910019142 PO4 Inorganic materials 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims 3
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- UCOHKZKRNWNULS-UHFFFAOYSA-N aminocyanamide Chemical group NNC#N UCOHKZKRNWNULS-UHFFFAOYSA-N 0.000 claims 3
- 230000000692 anti-sense effect Effects 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical compound [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 239000010941 cobalt Substances 0.000 claims 3
- 229910017052 cobalt Inorganic materials 0.000 claims 3
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 238000001361 intraarterial administration Methods 0.000 claims 3
- 238000007918 intramuscular administration Methods 0.000 claims 3
- 238000007916 intrasternal administration Methods 0.000 claims 3
- 238000007919 intrasynovial administration Methods 0.000 claims 3
- 238000007913 intrathecal administration Methods 0.000 claims 3
- 238000007915 intraurethral administration Methods 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 3
- 150000002923 oximes Chemical class 0.000 claims 3
- 238000007911 parenteral administration Methods 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 3
- 239000010452 phosphate Substances 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000007921 spray Substances 0.000 claims 3
- 238000007920 subcutaneous administration Methods 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 239000000829 suppository Substances 0.000 claims 3
- 125000004001 thioalkyl group Chemical group 0.000 claims 3
- 150000003573 thiols Chemical class 0.000 claims 3
- 238000011200 topical administration Methods 0.000 claims 3
- 238000002054 transplantation Methods 0.000 claims 3
- WYMDDFRYORANCC-UHFFFAOYSA-N 2-[[3-[bis(carboxymethyl)amino]-2-hydroxypropyl]-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)CN(CC(O)=O)CC(O)=O WYMDDFRYORANCC-UHFFFAOYSA-N 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 229910052688 Gadolinium Inorganic materials 0.000 claims 2
- ZCYVEMRRCGMTRW-AHCXROLUSA-N Iodine-123 Chemical compound [123I] ZCYVEMRRCGMTRW-AHCXROLUSA-N 0.000 claims 2
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical group [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- KRHYYFGTRYWZRS-BJUDXGSMSA-N ac1l2y5h Chemical compound [18FH] KRHYYFGTRYWZRS-BJUDXGSMSA-N 0.000 claims 2
- CPELXLSAUQHCOX-AHCXROLUSA-N ac1l4zwb Chemical compound [76BrH] CPELXLSAUQHCOX-AHCXROLUSA-N 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- OKTJSMMVPCPJKN-BJUDXGSMSA-N carbon-11 Chemical group [11C] OKTJSMMVPCPJKN-BJUDXGSMSA-N 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 125000003346 cobalamin group Chemical group 0.000 claims 2
- 230000002950 deficient Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 229940059947 gadolinium Drugs 0.000 claims 2
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 claims 2
- 229940055742 indium-111 Drugs 0.000 claims 2
- 229940029329 intrinsic factor Drugs 0.000 claims 2
- XMBWDFGMSWQBCA-OIOBTWANSA-N iodane Chemical compound [124IH] XMBWDFGMSWQBCA-OIOBTWANSA-N 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 229940056501 technetium 99m Drugs 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 0 CC(C(C[C@@]1(C)NC(C(*)C2NC(C(*)C(*3)C(*)(CCC(*)=*)C(*)(CC(I)=I)C33I)C(*)(CC(*)=*)C2(*)CCC(*)=*)C(*)(*)C1(*)CCC(S)=S)N1*)C(*)(CCC(C)=*)[C@@](C)(CC(I)=*)C31I Chemical compound CC(C(C[C@@]1(C)NC(C(*)C2NC(C(*)C(*3)C(*)(CCC(*)=*)C(*)(CC(I)=I)C33I)C(*)(CC(*)=*)C2(*)CCC(*)=*)C(*)(*)C1(*)CCC(S)=S)N1*)C(*)(CCC(C)=*)[C@@](C)(CC(I)=*)C31I 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32618301P | 2001-09-28 | 2001-09-28 | |
| PCT/US2002/031038 WO2003026674A1 (en) | 2001-09-28 | 2002-09-30 | Coadministration of transport protein with conjugated cobalamin to deliver agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508332A JP2005508332A (ja) | 2005-03-31 |
| JP2005508332A5 true JP2005508332A5 (enExample) | 2006-01-05 |
Family
ID=23271139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530309A Pending JP2005508332A (ja) | 2001-09-28 | 2002-09-30 | 薬剤を送達するための、輸送タンパク質とコンジュゲートコバラミンとの同時投与 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20030144198A1 (enExample) |
| EP (1) | EP1435973A4 (enExample) |
| JP (1) | JP2005508332A (enExample) |
| CA (1) | CA2461705A1 (enExample) |
| WO (1) | WO2003026674A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5739313A (en) * | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
| US6806363B1 (en) * | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
| JP2003531105A (ja) | 1999-10-15 | 2003-10-21 | メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ | 造影剤および治療薬として有用なコバラミン結合体 |
| US7591995B2 (en) * | 1999-10-15 | 2009-09-22 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
| WO2002055530A2 (en) * | 2000-10-25 | 2002-07-18 | Mayo Foundation | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
| CA2447395A1 (en) * | 2001-05-16 | 2002-11-21 | Faulk Pharmaceuticals, Inc. | Targeted delivery of drugs for the treatment of parasitic infections |
| US20030018009A1 (en) * | 2001-06-20 | 2003-01-23 | Collins Douglas A. | Adenosyl-cobalamin fortified compositions |
| JP2005508332A (ja) * | 2001-09-28 | 2005-03-31 | メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ | 薬剤を送達するための、輸送タンパク質とコンジュゲートコバラミンとの同時投与 |
| US7232805B2 (en) * | 2003-09-10 | 2007-06-19 | Inflabloc Pharmaceuticals, Inc. | Cobalamin conjugates for anti-tumor therapy |
| WO2005034877A2 (en) * | 2003-10-10 | 2005-04-21 | University Of Southern California | G-csf transferrin fusion proteins |
| CN1902214A (zh) * | 2003-12-22 | 2007-01-24 | 索里达哥股份有限公司 | 用于诊断和治疗异常细胞增殖的钴胺素衍生物 |
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| US20100178245A1 (en) * | 2009-01-13 | 2010-07-15 | Arnsdorf Morton F | Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites |
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| US8877221B2 (en) | 2010-10-27 | 2014-11-04 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same |
| US9107983B2 (en) | 2010-10-27 | 2015-08-18 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising statins |
| US9308190B2 (en) | 2011-06-06 | 2016-04-12 | Warsaw Orthopedic, Inc. | Methods and compositions to enhance bone growth comprising a statin |
| DE102012014581A1 (de) * | 2012-07-24 | 2014-01-30 | Azoba Health Care Ag | Vitaminzubereitung |
| CA2921507A1 (en) * | 2013-08-22 | 2015-02-26 | Robert Doyle | Compositions comprising vitamin b12 and intrinsic factor and methods of use thereof |
| US20160008342A1 (en) | 2014-06-16 | 2016-01-14 | The Regents Of The University Of California | Methods of improving cell-based therapy |
| US20180154007A1 (en) * | 2015-05-20 | 2018-06-07 | Syracuse University | Glycemic Control Using Intrinsic Factor Bound to A Vitamin B12 Conjugate of a Glucagon-Like Peptide-1 Receptor Agonist |
| US11207415B2 (en) | 2016-04-15 | 2021-12-28 | Syracuse University | Peptide drug improvement using vitamin B12 and haptocorrin binding substrate conjugates |
| US20190231925A1 (en) * | 2018-01-31 | 2019-08-01 | Changchun Ja Biotech. Co., Ltd. | Heparin sodium supported hydrogel sustained-release paster |
| US20220062418A1 (en) * | 2018-11-29 | 2022-03-03 | The Trustees Of Dartmouth College | Tumor targeting vitamin b12 derivatives for x-ray activated chemotherapy |
| WO2022006436A2 (en) * | 2020-07-01 | 2022-01-06 | Bioaffinity Technologies, Inc. | Compositions and methods for cellular delivery of rna |
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| US6806363B1 (en) * | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
| EP1231942A1 (en) * | 1999-10-15 | 2002-08-21 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging agents and as antitumor agents |
| JP2003531105A (ja) * | 1999-10-15 | 2003-10-21 | メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ | 造影剤および治療薬として有用なコバラミン結合体 |
| US6165789A (en) * | 1999-10-27 | 2000-12-26 | Isis Pharmaceuticals, Inc. | Antisense modulation of hnRNP A1 expression |
| US6159734A (en) * | 2000-01-18 | 2000-12-12 | Isis Pharmaceuticals, Inc. | Antisense modulation of peroxisome proliferator-activated receptor gamma expression |
| US20020002146A1 (en) * | 2000-02-11 | 2002-01-03 | Halevie-Goldman Brian D. | Compositions and methods for the production of S-adenosylmethionine within the body |
| US6962906B2 (en) * | 2000-03-14 | 2005-11-08 | Active Motif | Oligonucleotide analogues, methods of synthesis and methods of use |
| US20020042394A1 (en) * | 2000-05-31 | 2002-04-11 | Hogenkamp Henricus P.C. | Cobalamin compounds useful as antibiotic agents and as imaging agents |
| US20020049155A1 (en) * | 2000-05-31 | 2002-04-25 | Hogenkamp Henricus P.C. | Cobalamin compounds useful as cardiovascular agents and as imaging agents |
| WO2002042318A2 (en) * | 2000-10-25 | 2002-05-30 | Mayo Foundation For Medical Education And Research | Transcobalamin receptor binding conjugates for neutron capture therapy |
| WO2002055530A2 (en) * | 2000-10-25 | 2002-07-18 | Mayo Foundation | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
| US20030018009A1 (en) * | 2001-06-20 | 2003-01-23 | Collins Douglas A. | Adenosyl-cobalamin fortified compositions |
| JP2005508332A (ja) * | 2001-09-28 | 2005-03-31 | メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ | 薬剤を送達するための、輸送タンパク質とコンジュゲートコバラミンとの同時投与 |
-
2002
- 2002-09-30 JP JP2003530309A patent/JP2005508332A/ja active Pending
- 2002-09-30 WO PCT/US2002/031038 patent/WO2003026674A1/en not_active Ceased
- 2002-09-30 EP EP02766416A patent/EP1435973A4/en not_active Withdrawn
- 2002-09-30 US US10/262,318 patent/US20030144198A1/en not_active Abandoned
- 2002-09-30 CA CA002461705A patent/CA2461705A1/en not_active Abandoned
-
2004
- 2004-08-12 US US10/918,638 patent/US20050249663A1/en not_active Abandoned
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