JP2005506298A5 - - Google Patents
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- Publication number
- JP2005506298A5 JP2005506298A5 JP2002576907A JP2002576907A JP2005506298A5 JP 2005506298 A5 JP2005506298 A5 JP 2005506298A5 JP 2002576907 A JP2002576907 A JP 2002576907A JP 2002576907 A JP2002576907 A JP 2002576907A JP 2005506298 A5 JP2005506298 A5 JP 2005506298A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- composition
- group
- arylalkyl
- heteroarylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 3
- 150000003384 small molecules Chemical class 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- -1 small molecule compound Chemical class 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 230000036456 mitotic arrest Effects 0.000 claims 1
- 229940127084 other anti-cancer agent Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 230000004952 protein activity Effects 0.000 claims 1
- 229940121649 protein inhibitor Drugs 0.000 claims 1
- 239000012268 protein inhibitor Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27995601P | 2001-03-29 | 2001-03-29 | |
| US28036601P | 2001-03-30 | 2001-03-30 | |
| PCT/US2002/009817 WO2002078639A2 (en) | 2001-03-29 | 2002-03-28 | A method of treating proliferative diseases using eg5 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005506298A JP2005506298A (ja) | 2005-03-03 |
| JP2005506298A5 true JP2005506298A5 (OSRAM) | 2005-12-22 |
Family
ID=26959985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576907A Withdrawn JP2005506298A (ja) | 2001-03-29 | 2002-03-28 | Ｅｇ５阻害剤を用いる増殖性疾患の治療方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20020165240A1 (OSRAM) |
| EP (1) | EP1372657A4 (OSRAM) |
| JP (1) | JP2005506298A (OSRAM) |
| CA (1) | CA2442455A1 (OSRAM) |
| IL (1) | IL158083A0 (OSRAM) |
| MX (1) | MXPA03008691A (OSRAM) |
| WO (1) | WO2002078639A2 (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040009156A1 (en) * | 2001-10-12 | 2004-01-15 | Christoph Reinhard | Antisense therapy using oligonucleotides that target human kinesin genes for treatment of cancer |
| ATE480527T1 (de) * | 2001-12-11 | 2010-09-15 | Kyowa Hakko Kirin Co Ltd | Thiadiazolinderivate zur krebsbehandlung |
| US7199107B2 (en) | 2002-05-23 | 2007-04-03 | Isis Pharmaceuticals, Inc. | Antisense modulation of kinesin-like 1 expression |
| ES2394850T3 (es) | 2003-04-18 | 2013-02-06 | Kyowa Hakko Kirin Co., Ltd. | Inhibidor de cinesina mitótica |
| KR20060014071A (ko) * | 2003-06-10 | 2006-02-14 | 교와 핫꼬 고교 가부시끼가이샤 | 티아디아졸린 유도체 |
| WO2005007124A2 (en) | 2003-07-23 | 2005-01-27 | Bristol-Myers Squibb Company | Substituted dihydropyrimidine inhibitors of calcium channel function |
| US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
| US20050158320A1 (en) * | 2003-11-12 | 2005-07-21 | Nichols M. J. | Combinations for the treatment of proliferative diseases |
| US20050100508A1 (en) * | 2003-11-12 | 2005-05-12 | Nichols M. J. | Methods for identifying drug combinations for the treatment of proliferative diseases |
| US7662581B1 (en) | 2003-12-18 | 2010-02-16 | Novartis Vaccines And Diagnostics, Inc. | Eg5 co-crystals |
| EP2033959B1 (de) * | 2003-12-20 | 2011-04-27 | Merck Patent GmbH | Tetrahydropyranochinolinderivate |
| ES2360073T3 (es) * | 2004-03-23 | 2011-05-31 | Oncotherapy Science, Inc. | Método para diagnosticar cáncer de pulmón de células no pequeñas. |
| DE102004021637A1 (de) * | 2004-05-03 | 2005-12-01 | Merck Patent Gmbh | Dihydrobenzothiophene |
| MY141233A (en) | 2004-08-18 | 2010-03-31 | Astrazeneca Ab | Enantiomers of selected fused heterocyclics and uses thereof |
| WO2006074293A2 (en) * | 2005-01-07 | 2006-07-13 | President And Fellows Of Harvard College | Bicyclic dihydropyrimidines as eg5 inhibitors |
| JPWO2006101103A1 (ja) * | 2005-03-22 | 2008-09-04 | 協和醗酵工業株式会社 | 造血器腫瘍治療剤 |
| TW200714593A (en) * | 2005-03-22 | 2007-04-16 | Kyowa Hakko Kogyo Kk | Agent for treatment of solid tumor |
| JPWO2006137490A1 (ja) * | 2005-06-24 | 2009-01-22 | 協和発酵キリン株式会社 | 再狭窄治療剤 |
| DE102006002065B4 (de) * | 2006-01-16 | 2007-11-29 | Infineon Technologies Austria Ag | Kompensationsbauelement mit reduziertem und einstellbarem Einschaltwiderstand |
| CA2644643C (en) | 2006-03-22 | 2015-05-19 | Janssen Pharmaceutica N.V. | Inhibitors of the interaction between mdm2 and p53 |
| KR20110022000A (ko) * | 2008-05-30 | 2011-03-04 | 다나-파버 캔서 인스티튜트 인크. | 감수분열 키네신-연관된 질환의 치료 방법 |
| BR112012029326A2 (pt) | 2010-05-20 | 2017-08-08 | Astrazeneca Ab | processo para a preparação de animais olefínicas substituídas por arila |
| RU2427373C1 (ru) * | 2010-11-08 | 2011-08-27 | Виктор Вениаминович Тец | Средство для индукции эндогенного интерферона |
| CN113135859B (zh) * | 2021-04-26 | 2022-08-26 | 安徽省庆云医药股份有限公司 | 一种绿色合成瑞舒伐他汀钙中间体的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2658804A1 (de) * | 1976-12-24 | 1978-07-06 | Bayer Ag | Kreislaufbeeinflussende mittel |
| EP0330470A3 (en) * | 1988-02-24 | 1992-01-02 | Ajinomoto Co., Inc. | 1,4-dihydropyridine derivatives useful against tumour cells |
| US5536724A (en) * | 1992-03-03 | 1996-07-16 | Sri International | Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins |
| US5767131A (en) * | 1993-04-05 | 1998-06-16 | Synaptic Pharmaceutical Corporation | Dihydropyridines and new uses thereof |
-
2002
- 2002-03-28 US US10/108,403 patent/US20020165240A1/en not_active Abandoned
- 2002-03-28 CA CA002442455A patent/CA2442455A1/en not_active Abandoned
- 2002-03-28 EP EP02717741A patent/EP1372657A4/en not_active Withdrawn
- 2002-03-28 JP JP2002576907A patent/JP2005506298A/ja not_active Withdrawn
- 2002-03-28 MX MXPA03008691A patent/MXPA03008691A/es unknown
- 2002-03-28 IL IL15808302A patent/IL158083A0/xx unknown
- 2002-03-28 WO PCT/US2002/009817 patent/WO2002078639A2/en not_active Ceased
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