JP2005506295A5 - - Google Patents
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- JP2005506295A5 JP2005506295A5 JP2002576275A JP2002576275A JP2005506295A5 JP 2005506295 A5 JP2005506295 A5 JP 2005506295A5 JP 2002576275 A JP2002576275 A JP 2002576275A JP 2002576275 A JP2002576275 A JP 2002576275A JP 2005506295 A5 JP2005506295 A5 JP 2005506295A5
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- Prior art keywords
- formulas
- treatment
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- compound
- viii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 130
- 238000000034 method Methods 0.000 claims 75
- 238000011282 treatment Methods 0.000 claims 72
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- 238000002360 preparation method Methods 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 16
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- 230000006793 arrhythmia Effects 0.000 claims 11
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- 229910052760 oxygen Inorganic materials 0.000 claims 8
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 6
- 239000008103 glucose Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- -1 various isomers Chemical compound 0.000 claims 6
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
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- ATCGGEJZONJOCL-UHFFFAOYSA-N 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC(N)=NC(C=2C(=CC=C(Cl)C=2)Cl)=N1 ATCGGEJZONJOCL-UHFFFAOYSA-N 0.000 claims 2
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- 208000002177 Cataract Diseases 0.000 claims 2
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 2
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 claims 2
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- 208000010228 Erectile Dysfunction Diseases 0.000 claims 2
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- 208000004547 Hallucinations Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
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- 208000035901 Ischaemic ulcer Diseases 0.000 claims 2
- 208000012659 Joint disease Diseases 0.000 claims 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 2
- 208000007466 Male Infertility Diseases 0.000 claims 2
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- 206010033557 Palpitations Diseases 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 206010061921 Psychotic disorder due to a general medical condition Diseases 0.000 claims 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 2
- 208000007107 Stomach Ulcer Diseases 0.000 claims 2
- 206010042600 Supraventricular arrhythmias Diseases 0.000 claims 2
- 208000001871 Tachycardia Diseases 0.000 claims 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 2
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims 2
- 229930013930 alkaloid Natural products 0.000 claims 2
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- 230000002785 anti-thrombosis Effects 0.000 claims 2
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- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 claims 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 2
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical group [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 claims 2
- 206010061592 cardiac fibrillation Diseases 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 2
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- 208000037976 chronic inflammation Diseases 0.000 claims 2
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- 201000000159 corneal neovascularization Diseases 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 claims 2
- 208000000718 duodenal ulcer Diseases 0.000 claims 2
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- 230000002600 fibrillogenic effect Effects 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 230000010370 hearing loss Effects 0.000 claims 2
- 231100000888 hearing loss Toxicity 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 201000001881 impotence Diseases 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
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- 239000000203 mixture Substances 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 208000019899 phobic disease Diseases 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 229940016667 resveratrol Drugs 0.000 claims 2
- 235000021283 resveratrol Nutrition 0.000 claims 2
- 230000009759 skin aging Effects 0.000 claims 2
- 230000006794 tachycardia Effects 0.000 claims 2
- RKEBJJCZAOFMLH-UHFFFAOYSA-N taspine Natural products COc1ccc2OC(=O)c3c(OC)cc(CN(C)C)c4OC(=O)c1c2c34 RKEBJJCZAOFMLH-UHFFFAOYSA-N 0.000 claims 2
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- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 230000002861 ventricular Effects 0.000 claims 2
- YQAXFVHNHSPUPO-RNJOBUHISA-N 2-[[(2s)-2-[[2-[[(2s,4r)-1-[(2s)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]propanoyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H]1N(C(=O)CN)CCC1 YQAXFVHNHSPUPO-RNJOBUHISA-N 0.000 claims 1
- SIMYWHHAEQQGEH-MAZDBSFSSA-N 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1.C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 SIMYWHHAEQQGEH-MAZDBSFSSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 235000021357 Behenic acid Nutrition 0.000 claims 1
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 1
- 208000035484 Cellulite Diseases 0.000 claims 1
- 208000026845 Cochlear disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000028006 Corneal injury Diseases 0.000 claims 1
- DCXYFEDJOCDNAF-UWTATZPHSA-N D-Asparagine Chemical compound OC(=O)[C@H](N)CC(N)=O DCXYFEDJOCDNAF-UWTATZPHSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 claims 1
- 208000012239 Developmental disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010018341 Gliosis Diseases 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- 206010061309 Neoplasm progression Diseases 0.000 claims 1
- 241000208125 Nicotiana Species 0.000 claims 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 1
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims 1
- 101800000989 Oxytocin Proteins 0.000 claims 1
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010049752 Peau d'orange Diseases 0.000 claims 1
- 208000024777 Prion disease Diseases 0.000 claims 1
- 208000028990 Skin injury Diseases 0.000 claims 1
- 206010072170 Skin wound Diseases 0.000 claims 1
- 208000026062 Tissue disease Diseases 0.000 claims 1
- 206010060872 Transplant failure Diseases 0.000 claims 1
- 208000000921 Urge Urinary Incontinence Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 210000004198 anterior pituitary gland Anatomy 0.000 claims 1
- 108010082685 antiarrhythmic peptide Proteins 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 229940116226 behenic acid Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 239000001110 calcium chloride Substances 0.000 claims 1
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- 230000000747 cardiac effect Effects 0.000 claims 1
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- 230000010261 cell growth Effects 0.000 claims 1
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- 210000004087 cornea Anatomy 0.000 claims 1
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- 230000008878 coupling Effects 0.000 claims 1
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- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
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- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 210000003981 ectoderm Anatomy 0.000 claims 1
- 210000001900 endoderm Anatomy 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
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- 230000007387 gliosis Effects 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
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- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 230000028709 inflammatory response Effects 0.000 claims 1
- 239000007972 injectable composition Substances 0.000 claims 1
- 235000001705 insufficient nutrition Nutrition 0.000 claims 1
- 229950010984 irsogladine Drugs 0.000 claims 1
- 208000037906 ischaemic injury Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 210000003716 mesoderm Anatomy 0.000 claims 1
- 230000006609 metabolic stress Effects 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 230000003387 muscular Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 235000003715 nutritional status Nutrition 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims 1
- 229960001723 oxytocin Drugs 0.000 claims 1
- 102000014187 peptide receptors Human genes 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 239000000018 receptor agonist Substances 0.000 claims 1
- 229940044601 receptor agonist Drugs 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 230000002000 scavenging effect Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 230000005751 tumor progression Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 230000006496 vascular abnormality Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
- 0 *C(*)NC(*)C(*)*N* Chemical compound *C(*)NC(*)C(*)*N* 0.000 description 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/DK2001/000127 WO2001062775A2 (en) | 2000-02-23 | 2001-02-22 | Novel antiarrhythmic peptides |
| US09/792,286 US7250397B2 (en) | 2000-02-23 | 2001-02-22 | Antiarrhythmic peptides |
| US31447001P | 2001-08-23 | 2001-08-23 | |
| PCT/US2002/005773 WO2002077017A2 (en) | 2001-02-22 | 2002-02-22 | Medical uses of intercellular communication facilitating compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005506295A JP2005506295A (ja) | 2005-03-03 |
| JP2005506295A5 true JP2005506295A5 (enrdf_load_stackoverflow) | 2006-01-05 |
Family
ID=27222186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576275A Pending JP2005506295A (ja) | 2001-02-22 | 2002-02-22 | 細胞間連絡促進化合物の新規医薬使用 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1370276B1 (enrdf_load_stackoverflow) |
| JP (1) | JP2005506295A (enrdf_load_stackoverflow) |
| AT (1) | ATE497967T1 (enrdf_load_stackoverflow) |
| IL (1) | IL157447A0 (enrdf_load_stackoverflow) |
| MX (1) | MXPA03007537A (enrdf_load_stackoverflow) |
| WO (1) | WO2002077017A2 (enrdf_load_stackoverflow) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7250397B2 (en) | 2000-02-23 | 2007-07-31 | Zealand Pharma A/S | Antiarrhythmic peptides |
| EP1469875A1 (en) * | 2002-01-29 | 2004-10-27 | Wyeth | Compositions and methods for modulating connexin hemichannels |
| JP4603364B2 (ja) * | 2002-11-25 | 2010-12-22 | ジーランド ファーマ アクティーゼルスカブ | ペプチドギャップ結合モジュレーター |
| CA2550632A1 (en) * | 2003-12-23 | 2005-07-07 | Bjarne Due Larsen | Isopeptide gap junction modulators |
| DE102005005270A1 (de) * | 2005-02-04 | 2006-08-10 | Peter Heger | Verwendung von Hydroxystilben-haltigen Wirkstoffen zur Behandlung leichter bis mittelschwerer Depressionen und Angstzustände |
| GB0514071D0 (en) | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
| WO2007078990A2 (en) | 2005-12-23 | 2007-07-12 | Zealand Pharma A/S | Modified lysine-mimetic compounds |
| EP2468724B1 (en) | 2006-12-21 | 2015-11-18 | Zealand Pharma A/S | Synthesis of pyrrolidine compounds |
| EP2212343A2 (en) * | 2007-07-15 | 2010-08-04 | Zealand Pharma A/S | Peptide gap junction modulators |
| WO2010026487A1 (en) * | 2008-09-08 | 2010-03-11 | University Of Concepcion | Therapeutic methods and compositions |
| GB201512139D0 (en) * | 2015-07-10 | 2015-08-19 | Zealand Pharma As | Methods of treatment |
| JP6989864B2 (ja) | 2017-05-05 | 2022-02-03 | ジーランド ファーマ，アー／エス | ギャップ結合細胞間コミュニケーションモジュレータ及び糖尿病性眼疾患の治療のためのそれらの使用 |
| WO2021159011A1 (en) * | 2020-02-07 | 2021-08-12 | United States Government As Represented By The Department Of Veterans Affairs | Method for treating nervous system injuries using boldine and analogs thereof |
| CA3240515A1 (en) | 2021-12-22 | 2023-06-29 | Breye Therapeutics Aps | Gap junction modulators and their use for the treatment of age-related macular degeneration |
| GB202310195D0 (en) * | 2023-07-03 | 2023-08-16 | Hastings Nataly | Method for mitigating symptoms of neurological condition and a system therefor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19500990A1 (de) * | 1995-01-14 | 1996-07-18 | Stefan Dr Med Dhein | Neues Peptid, seine Herstellung und Verwendung |
| DE19707854A1 (de) * | 1997-02-27 | 1998-09-03 | Dhein Stefan Priv Doz Dr Med | Neue Cyclopeptide, deren Herstellung und Verwendung |
| AU781674B2 (en) * | 2000-02-23 | 2005-06-02 | Zealand Pharma A/S | Novel antiarrhythmic peptides |
-
2002
- 2002-02-22 IL IL15744702A patent/IL157447A0/xx unknown
- 2002-02-22 AT AT02723240T patent/ATE497967T1/de not_active IP Right Cessation
- 2002-02-22 MX MXPA03007537A patent/MXPA03007537A/es active IP Right Grant
- 2002-02-22 WO PCT/US2002/005773 patent/WO2002077017A2/en active Application Filing
- 2002-02-22 EP EP02723240A patent/EP1370276B1/en not_active Expired - Lifetime
- 2002-02-22 JP JP2002576275A patent/JP2005506295A/ja active Pending
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