JP2005505293A5 - - Google Patents
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- Publication number
- JP2005505293A5 JP2005505293A5 JP2003535704A JP2003535704A JP2005505293A5 JP 2005505293 A5 JP2005505293 A5 JP 2005505293A5 JP 2003535704 A JP2003535704 A JP 2003535704A JP 2003535704 A JP2003535704 A JP 2003535704A JP 2005505293 A5 JP2005505293 A5 JP 2005505293A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- nucleic acid
- acid molecule
- polypeptide
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000004169 proteins and genes Human genes 0.000 claims 18
- 108090000623 proteins and genes Proteins 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 229920001184 polypeptide Polymers 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 102000004961 Furin Human genes 0.000 claims 6
- 108090001126 Furin Proteins 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 238000003776 cleavage reaction Methods 0.000 claims 5
- 230000007017 scission Effects 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000001712 STAT5 Transcription Factor Human genes 0.000 claims 3
- 108010029477 STAT5 Transcription Factor Proteins 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 230000008685 targeting Effects 0.000 claims 3
- 230000002103 transcriptional effect Effects 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000026731 phosphorylation Effects 0.000 claims 2
- 238000006366 phosphorylation reaction Methods 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 101000845170 Homo sapiens Thymic stromal lymphopoietin Proteins 0.000 claims 1
- 101710160107 Outer membrane protein A Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 102000045535 human TSLP Human genes 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000006240 membrane receptors Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 230000002992 thymic effect Effects 0.000 claims 1
- 239000012646 vaccine adjuvant Substances 0.000 claims 1
- 229940124931 vaccine adjuvant Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30734501P | 2001-07-23 | 2001-07-23 | |
| US60/307,345 | 2001-07-23 | ||
| PCT/US2002/023475 WO2003032898A2 (en) | 2001-07-23 | 2002-07-23 | Modified human thymic stromal lymphopoietin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010153133A Division JP2010279365A (ja) | 2001-07-23 | 2010-07-05 | 修飾したヒト胸腺ストローマ細胞リンホポエチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005505293A JP2005505293A (ja) | 2005-02-24 |
| JP2005505293A5 true JP2005505293A5 (enExample) | 2006-01-05 |
| JP5329016B2 JP5329016B2 (ja) | 2013-10-30 |
Family
ID=23189325
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003535704A Expired - Lifetime JP5329016B2 (ja) | 2001-07-23 | 2002-07-23 | 修飾したヒト胸腺ストローマ細胞リンホポエチン |
| JP2010153133A Pending JP2010279365A (ja) | 2001-07-23 | 2010-07-05 | 修飾したヒト胸腺ストローマ細胞リンホポエチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010153133A Pending JP2010279365A (ja) | 2001-07-23 | 2010-07-05 | 修飾したヒト胸腺ストローマ細胞リンホポエチン |
Country Status (11)
| Country | Link |
|---|---|
| US (9) | US7288633B2 (enExample) |
| EP (1) | EP1417231B1 (enExample) |
| JP (2) | JP5329016B2 (enExample) |
| AU (1) | AU2002359238B2 (enExample) |
| CA (1) | CA2454578C (enExample) |
| DK (1) | DK1417231T3 (enExample) |
| ES (1) | ES2422879T3 (enExample) |
| MX (1) | MXPA04000631A (enExample) |
| PL (1) | PL371773A1 (enExample) |
| PT (1) | PT1417231E (enExample) |
| WO (1) | WO2003032898A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL371773A1 (en) * | 2001-07-23 | 2005-06-27 | Immunex Corporation | Modified human thymic stromal lymphopoietin |
| ATE555194T1 (de) * | 2001-12-18 | 2012-05-15 | Cancer Rec Tech Ltd | Methode zur herstellung von proliferierenden und differenzierenden zelllinien |
| SI1651247T1 (sl) * | 2003-07-18 | 2009-02-28 | Schering Corp | Zdravljenje in diagnoza neoplazem z uporabo timusnega stromalnega limfopoietina |
| US20050249712A1 (en) | 2004-03-23 | 2005-11-10 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods for use of TSLP and agonists and antagonists thereof |
| SE532251C2 (sv) * | 2006-11-28 | 2009-11-24 | Theravac Pharmaceuticals Ab | Nya formuleringar av TSLP för behandling av TH2-medierade inflammatoriska sjukdomar genom vaccinering |
| JP5059119B2 (ja) | 2006-12-14 | 2012-10-24 | シェーリング コーポレイション | 操作された抗ｔｓｌｐ抗体 |
| WO2009032954A1 (en) * | 2007-09-04 | 2009-03-12 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Deletions in domain ii of pseudomonas exotoxin a that reduce non-specific toxicity |
| US7982016B2 (en) * | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
| EP2213682A1 (en) | 2009-01-30 | 2010-08-04 | Institut Curie | TSLP promotes immune evasion and persistence of viruses |
| GB0918782D0 (en) * | 2009-10-26 | 2009-12-09 | St Georges Hosp Medical School | A protein as an adjuvant for a vaccine |
| ES2784123T3 (es) | 2009-11-04 | 2020-09-22 | Merck Sharp & Dohme | Anticuerpo anti TSLP genomodificado |
| EA038332B1 (ru) | 2015-09-09 | 2021-08-10 | Новартис Аг | Молекулы, связывающиеся с тимусным стромальным лимфопоэтином (tslp), и способы применения таких молекул |
| HRP20210650T1 (hr) | 2015-09-09 | 2021-05-28 | Novartis Ag | Protutijela koja vežu timusni stromalni limfopoetin (tslp) i postupci uporabe protutijela |
| US11001624B2 (en) | 2016-04-05 | 2021-05-11 | Vib Vzw | TSLP inhibitors |
| US12110324B2 (en) | 2022-07-22 | 2024-10-08 | Flagship Pioneering Innovations Vi, Llc | Antigen binding molecules targeting thymic stromal lymphopoietin (TSLP) |
| AU2024334289A1 (en) | 2023-08-25 | 2026-04-09 | Proteologix Us Inc. | Anti-il-13 multispecific antibody constructs and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011912A (en) * | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
| ATE188610T1 (de) | 1992-04-30 | 2000-01-15 | Amgen Inc | Methoden zur behandlung von interleukin- 1 und - tumor - nekrose - faktor - verursachten krankheiten |
| GB9209874D0 (en) | 1992-05-07 | 1992-06-24 | Ml Lab Plc | Pharmaceutical compositions |
| WO1995000103A2 (en) | 1993-06-15 | 1995-01-05 | Il-Yang Pharm. Co., Ltd. | Anti-sense oligodeoxynucleotide to fibrogenic cytokines and use thereof |
| GB9702944D0 (en) | 1997-02-13 | 1997-04-02 | Univ Manchester | Reducing fibrosis |
| US6844170B1 (en) * | 1998-03-19 | 2005-01-18 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
| US6982320B2 (en) | 1998-03-19 | 2006-01-03 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
| AU3072799A (en) | 1998-03-19 | 1999-10-11 | Human Genome Sciences, Inc. | Cytokine receptor common gamma chain like |
| JP2002526079A (ja) | 1998-09-21 | 2002-08-20 | シェーリング コーポレイション | ヒトインターロイキン−ｂ５０、治療的使用 |
| US20030099947A1 (en) * | 1998-09-21 | 2003-05-29 | Bazan J. Fernando | Mammalian cytokines; related reagents and methods |
| DE69936105T3 (de) | 1998-11-13 | 2017-07-27 | Immunex Corporation | Menschliche tslp nukleinsäuren und polypeptide |
| EP1140976A4 (en) | 1998-12-30 | 2003-05-21 | Millennium Pharm Inc | SECRETED PROTEINS AND THEIR USES |
| US20010021380A1 (en) | 1999-04-19 | 2001-09-13 | Pluenneke John D. | Soluble tumor necrosis factor receptor treatment of medical disorders |
| EP1712239A3 (en) | 2000-05-12 | 2007-08-22 | Immunex Corporation | Interleukin-1 inhibitors in the treatment of diseases |
| ES2391124T3 (es) | 2000-06-28 | 2012-11-21 | Amgen Inc. | Moléculas de receptor de linfopoyetina estromal tímica y usos de las mismas |
| US6955895B2 (en) | 2000-06-28 | 2005-10-18 | Whitehead Institute For Biomedical Research | Thymic stromal lymphopoietin receptor molecules and uses thereof |
| PL371773A1 (en) | 2001-07-23 | 2005-06-27 | Immunex Corporation | Modified human thymic stromal lymphopoietin |
| GB2381685A (en) | 2001-10-30 | 2003-05-07 | Amino Holdings Ltd | Gateway device for converting digital signals to analogue signals |
| AU2003208888B2 (en) * | 2002-02-01 | 2006-10-19 | Merck Sharp & Dohme Llc | Uses of mammalian cytokine; related reagents |
| HRP20020453A2 (en) | 2002-05-23 | 2003-12-31 | Pliva D D | 1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
| KR101317045B1 (ko) | 2002-09-06 | 2013-10-16 | 암젠 인코포레이티드 | 치료학적 인체 항-ｉｌ-1ｒ1 모노클로날 항체 |
| SI1651247T1 (sl) | 2003-07-18 | 2009-02-28 | Schering Corp | Zdravljenje in diagnoza neoplazem z uporabo timusnega stromalnega limfopoietina |
| US20050249712A1 (en) * | 2004-03-23 | 2005-11-10 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods for use of TSLP and agonists and antagonists thereof |
| EP1793856A2 (en) | 2004-08-20 | 2007-06-13 | Amgen Inc. | Methods and compositions for treating allergic inflammation |
| CA2635599C (en) | 2006-01-13 | 2014-06-17 | Irm Llc | Antibodies against thymic stromal lymphopoietin receptor for treating allergic diseases |
| GB0603683D0 (en) | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
| JP5059119B2 (ja) | 2006-12-14 | 2012-10-24 | シェーリング コーポレイション | 操作された抗ｔｓｌｐ抗体 |
| CN102027012A (zh) | 2007-06-20 | 2011-04-20 | Irm责任有限公司 | 用于治疗变应性疾病的方法和组合物 |
-
2002
- 2002-07-23 PL PL02371773A patent/PL371773A1/xx not_active Application Discontinuation
- 2002-07-23 AU AU2002359238A patent/AU2002359238B2/en not_active Expired
- 2002-07-23 EP EP02793761.4A patent/EP1417231B1/en not_active Expired - Lifetime
- 2002-07-23 PT PT2793761T patent/PT1417231E/pt unknown
- 2002-07-23 US US10/202,699 patent/US7288633B2/en not_active Expired - Lifetime
- 2002-07-23 WO PCT/US2002/023475 patent/WO2003032898A2/en not_active Ceased
- 2002-07-23 DK DK02793761.4T patent/DK1417231T3/da active
- 2002-07-23 CA CA2454578A patent/CA2454578C/en not_active Expired - Lifetime
- 2002-07-23 MX MXPA04000631A patent/MXPA04000631A/es active IP Right Grant
- 2002-07-23 JP JP2003535704A patent/JP5329016B2/ja not_active Expired - Lifetime
- 2002-07-23 ES ES02793761T patent/ES2422879T3/es not_active Expired - Lifetime
-
2007
- 2007-10-30 US US11/981,423 patent/US7709217B2/en not_active Expired - Lifetime
-
2010
- 2010-03-12 US US12/723,499 patent/US7973151B2/en not_active Expired - Fee Related
- 2010-07-05 JP JP2010153133A patent/JP2010279365A/ja active Pending
-
2011
- 2011-06-01 US US13/151,126 patent/US20110230637A1/en not_active Abandoned
-
2012
- 2012-09-10 US US13/608,808 patent/US8598318B2/en not_active Expired - Fee Related
-
2013
- 2013-12-03 US US14/095,524 patent/US9045558B2/en not_active Expired - Fee Related
-
2015
- 2015-05-20 US US14/717,334 patent/US20150252089A1/en not_active Abandoned
-
2016
- 2016-09-08 US US15/259,931 patent/US20160377630A1/en not_active Abandoned
-
2020
- 2020-09-14 US US17/020,325 patent/US20210102955A1/en not_active Abandoned
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