JP2005504715A - 持続放出特性を有する吸入用粒子 - Google Patents

持続放出特性を有する吸入用粒子 Download PDF

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Publication number
JP2005504715A
JP2005504715A JP2002554139A JP2002554139A JP2005504715A JP 2005504715 A JP2005504715 A JP 2005504715A JP 2002554139 A JP2002554139 A JP 2002554139A JP 2002554139 A JP2002554139 A JP 2002554139A JP 2005504715 A JP2005504715 A JP 2005504715A
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JP
Japan
Prior art keywords
glycero
particles
lipid
delivery
drug
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JP2002554139A
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English (en)
Japanese (ja)
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JP2005504715A5 (https=
Inventor
バス,スジト,ケイ.
フルカック,ジェフリー,エス.
リップ,マイケル
エルバート,カタリーナ
エドワーズ,デービッド,エイ.
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アドバンスト インハレーション リサーチ,インコーポレイテッド
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Publication of JP2005504715A publication Critical patent/JP2005504715A/ja
Publication of JP2005504715A5 publication Critical patent/JP2005504715A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544Phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002554139A 2000-12-29 2001-12-18 持続放出特性を有する吸入用粒子 Withdrawn JP2005504715A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75210900A 2000-12-29 2000-12-29
PCT/US2001/048956 WO2002053190A2 (en) 2000-12-29 2001-12-18 Particles for inhalation having sustained release properties

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006162862A Division JP2006249099A (ja) 2000-12-29 2006-06-12 持続放出特性を有する吸入用粒子

Publications (2)

Publication Number Publication Date
JP2005504715A true JP2005504715A (ja) 2005-02-17
JP2005504715A5 JP2005504715A5 (https=) 2009-02-12

Family

ID=25024911

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002554139A Withdrawn JP2005504715A (ja) 2000-12-29 2001-12-18 持続放出特性を有する吸入用粒子
JP2006162862A Withdrawn JP2006249099A (ja) 2000-12-29 2006-06-12 持続放出特性を有する吸入用粒子

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006162862A Withdrawn JP2006249099A (ja) 2000-12-29 2006-06-12 持続放出特性を有する吸入用粒子

Country Status (6)

Country Link
US (2) US7048908B2 (https=)
EP (1) EP1345629A2 (https=)
JP (2) JP2005504715A (https=)
AU (1) AU2002230993B2 (https=)
CA (1) CA2433335C (https=)
WO (1) WO2002053190A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016516062A (ja) * 2013-03-15 2016-06-02 リズム・ファーマシューティカルズ・インコーポレイテッド 医薬組成物

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