JP2005504029A - 犬の好ましくない行動を改善するためのｎｋ−１受容体アンタゴニストの使用 - Google Patents
犬の好ましくない行動を改善するためのｎｋ−１受容体アンタゴニストの使用 Download PDFInfo
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- JP2005504029A JP2005504029A JP2003515240A JP2003515240A JP2005504029A JP 2005504029 A JP2005504029 A JP 2005504029A JP 2003515240 A JP2003515240 A JP 2003515240A JP 2003515240 A JP2003515240 A JP 2003515240A JP 2005504029 A JP2005504029 A JP 2005504029A
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- Prior art keywords
- methoxybenzylamino
- diphenylmethyl
- azabicyclo
- octane
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 description 1
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- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
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- 230000007310 pathophysiology Effects 0.000 description 1
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- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000002990 phenothiazines Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
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- 102000005962 receptors Human genes 0.000 description 1
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- 208000023504 respiratory system disease Diseases 0.000 description 1
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- 239000000932 sedative agent Substances 0.000 description 1
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 1
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- 229940076279 serotonin Drugs 0.000 description 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 description 1
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 1
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- 208000019116 sleep disease Diseases 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 239000008247 solid mixture Substances 0.000 description 1
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- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30669201P | 2001-07-20 | 2001-07-20 | |
| PCT/IB2002/002847 WO2003009848A1 (en) | 2001-07-20 | 2002-07-15 | Use of nk-1 receptor antagonists to modify unwanted behavior in dogs, cats and horses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005504029A true JP2005504029A (ja) | 2005-02-10 |
| JP2005504029A5 JP2005504029A5 (cg-RX-API-DMAC10.html) | 2005-09-22 |
Family
ID=23186426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003515240A Withdrawn JP2005504029A (ja) | 2001-07-20 | 2002-07-15 | 犬の好ましくない行動を改善するためのｎｋ−１受容体アンタゴニストの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20030139443A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1411946A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2005504029A (cg-RX-API-DMAC10.html) |
| KR (1) | KR20040029375A (cg-RX-API-DMAC10.html) |
| CN (1) | CN1529600A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2448722A1 (cg-RX-API-DMAC10.html) |
| CZ (1) | CZ200434A3 (cg-RX-API-DMAC10.html) |
| HU (1) | HUP0401154A2 (cg-RX-API-DMAC10.html) |
| IL (1) | IL158990A0 (cg-RX-API-DMAC10.html) |
| PL (1) | PL367944A1 (cg-RX-API-DMAC10.html) |
| SK (1) | SK252004A3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2003009848A1 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA200308991B (cg-RX-API-DMAC10.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0507325A (pt) * | 2004-01-30 | 2007-07-03 | Pfizer Prod Inc | antagonistas dos receptores nk-1 para melhorar a recuperação da anestesia |
| HUE034099T2 (en) | 2004-01-30 | 2018-01-29 | Zoetis Services Llc | Antimicrobial preservatives for the delivery of multidose formulations using beta-cyclodextrins for liquid dosage forms |
| CN1972937A (zh) * | 2004-04-30 | 2007-05-30 | 先灵公司 | 神经肽受体调节剂 |
| CN114403042A (zh) * | 2021-12-13 | 2022-04-29 | 深圳先进技术研究院 | 一种大动物焦虑症动物模型 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
| US5232929A (en) * | 1990-11-28 | 1993-08-03 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use |
| FR2677361A1 (fr) * | 1991-06-04 | 1992-12-11 | Adir | Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| BR9206073A (pt) * | 1991-05-31 | 1994-12-06 | Pfizer | Derivados de quinuclidina |
| SK282203B6 (sk) * | 1991-06-20 | 2001-12-03 | Pfizer Inc. | Fluoroalkoxybenzylamínové deriváty heterocyklov obsahujúcich dusík, spôsob ich prípravy, medziprodukty, spôsob prípravy medziproduktov, použitie a farmaceutický prostriedok |
| EP0687268B1 (en) * | 1993-03-04 | 1998-05-27 | Pfizer Inc. | Spiroazacyclic derivatives as substance p antagonists |
| EP0623344B1 (fr) * | 1993-05-04 | 2000-07-26 | Ceva Sante Animale | Utilisation de la Sélégiline en médecine vetérinaire |
| IL109646A0 (en) * | 1993-05-19 | 1994-08-26 | Pfizer | Heteroatom substituted alkyl benzylamino-quinuclidines |
| US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
| US5703065A (en) * | 1993-09-17 | 1997-12-30 | Pfizer Inc. | Heteroarylamino and heteroarylsulfonamido substituted 3-benyzlaminomethyl piperidines and related compounds |
| US6083943A (en) * | 1993-09-17 | 2000-07-04 | Pfizer Inc | Substituted azaheterocyclecarboxylic acid |
| US5854262A (en) * | 1993-10-07 | 1998-12-29 | Pfizer Inc. | Aminomethylene substituted non-aromatic heterocycles and use as substance P antagonists |
| PE45195A1 (es) * | 1994-03-03 | 1996-01-17 | Boehringer Ingelheim Kg | Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene |
| US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
| ES2229259T3 (es) * | 1995-01-12 | 2005-04-16 | Glaxo Group Limited | Derivados de piperidina con actividad antagonista de taquiquinina. |
| US5990125A (en) * | 1996-01-19 | 1999-11-23 | Pfizer Inc. | NK-1 receptor antagonists for the treatment of cancer |
| US6117855A (en) * | 1996-10-07 | 2000-09-12 | Merck Sharp & Dohme Ltd. | Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent |
| AU726745B2 (en) * | 1996-10-07 | 2000-11-16 | Merck Sharp & Dohme Limited | CNS-penetrant NK-1 receptor antagonists as antidepressant and/or an anti-anxiety agent |
| CA2275527C (en) * | 1996-12-19 | 2003-09-23 | Hoechst Marion Roussel, Inc. | Novel heterocyclic substituted pyrrolidine amide derivatives |
| US6156749A (en) * | 1997-12-01 | 2000-12-05 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating movement disorders |
| JP4669095B2 (ja) * | 1999-07-19 | 2011-04-13 | 太陽化学株式会社 | ペットの問題行動抑制組成物 |
| CA2280309C (en) * | 1999-08-13 | 2007-05-08 | William Norton Milgram | Use of adrafinil to treat behavioral problems in aged canines |
| CA2324813A1 (en) * | 1999-11-10 | 2001-05-10 | Susan Beth Sobolov-Jaynes | Combination treatment for depression and anxiety |
| US20020049211A1 (en) * | 2000-09-06 | 2002-04-25 | Sobolov-Jaynes Susan Beth | Combination treatment for depression and anxiety |
-
2002
- 2002-07-15 EP EP02745741A patent/EP1411946A1/en not_active Withdrawn
- 2002-07-15 SK SK25-2004A patent/SK252004A3/sk not_active Application Discontinuation
- 2002-07-15 PL PL02367944A patent/PL367944A1/xx not_active Application Discontinuation
- 2002-07-15 JP JP2003515240A patent/JP2005504029A/ja not_active Withdrawn
- 2002-07-15 WO PCT/IB2002/002847 patent/WO2003009848A1/en not_active Ceased
- 2002-07-15 HU HU0401154A patent/HUP0401154A2/hu unknown
- 2002-07-15 CA CA002448722A patent/CA2448722A1/en not_active Abandoned
- 2002-07-15 CN CNA028141873A patent/CN1529600A/zh active Pending
- 2002-07-15 IL IL15899002A patent/IL158990A0/xx unknown
- 2002-07-15 KR KR10-2004-7000901A patent/KR20040029375A/ko not_active Ceased
- 2002-07-15 CZ CZ200434A patent/CZ200434A3/cs unknown
- 2002-07-19 US US10/199,284 patent/US20030139443A1/en not_active Abandoned
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2003
- 2003-11-19 ZA ZA200308991A patent/ZA200308991B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0401154A2 (hu) | 2004-10-28 |
| US20030139443A1 (en) | 2003-07-24 |
| ZA200308991B (en) | 2004-11-19 |
| IL158990A0 (en) | 2004-05-12 |
| KR20040029375A (ko) | 2004-04-06 |
| CA2448722A1 (en) | 2003-02-06 |
| CZ200434A3 (cs) | 2005-02-16 |
| WO2003009848A1 (en) | 2003-02-06 |
| SK252004A3 (sk) | 2005-03-04 |
| PL367944A1 (en) | 2005-03-07 |
| CN1529600A (zh) | 2004-09-15 |
| EP1411946A1 (en) | 2004-04-28 |
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