CA2448722A1 - Use of nk-1 receptor antagonists to modify unwanted behavior in dogs, cats and horses - Google Patents
Use of nk-1 receptor antagonists to modify unwanted behavior in dogs, cats and horses Download PDFInfo
- Publication number
- CA2448722A1 CA2448722A1 CA002448722A CA2448722A CA2448722A1 CA 2448722 A1 CA2448722 A1 CA 2448722A1 CA 002448722 A CA002448722 A CA 002448722A CA 2448722 A CA2448722 A CA 2448722A CA 2448722 A1 CA2448722 A1 CA 2448722A1
- Authority
- CA
- Canada
- Prior art keywords
- methoxybenzylamino
- azabicyclo
- amino
- phenyl
- diphenylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 title claims abstract description 47
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 title claims abstract description 47
- 239000002464 receptor antagonist Substances 0.000 title claims abstract description 40
- 229940044551 receptor antagonist Drugs 0.000 title claims abstract description 40
- 241000282472 Canis lupus familiaris Species 0.000 title claims description 66
- 241000283086 Equidae Species 0.000 title claims description 5
- 241000282326 Felis catus Species 0.000 title claims description 4
- 230000002159 abnormal effect Effects 0.000 claims abstract description 58
- 241001465754 Metazoa Species 0.000 claims abstract description 57
- 230000006400 anxiety behaviour Effects 0.000 claims abstract description 38
- 238000000034 method Methods 0.000 claims abstract description 33
- 150000001875 compounds Chemical class 0.000 claims description 48
- 238000012360 testing method Methods 0.000 claims description 33
- 238000011282 treatment Methods 0.000 claims description 32
- 238000000926 separation method Methods 0.000 claims description 27
- 208000013403 hyperactivity Diseases 0.000 claims description 21
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 230000000949 anxiolytic effect Effects 0.000 claims description 9
- 230000006378 damage Effects 0.000 claims description 9
- 230000008030 elimination Effects 0.000 claims description 7
- 238000003379 elimination reaction Methods 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- XPNMCDYOYIKVGB-CONSDPRKSA-N (2s,3s)-2-benzhydryl-n-[(2-methoxy-5-propan-2-ylphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine Chemical compound COC1=CC=C(C(C)C)C=C1CN[C@@H]1[C@H](C(C=2C=CC=CC=2)C=2C=CC=CC=2)N2CCC1CC2 XPNMCDYOYIKVGB-CONSDPRKSA-N 0.000 claims description 6
- JMPFLCLLMDQYKW-FPOVZHCZSA-N (2s,3s)-2-phenyl-n-[[2-propan-2-yloxy-5-(trifluoromethoxy)phenyl]methyl]piperidin-3-amine Chemical compound CC(C)OC1=CC=C(OC(F)(F)F)C=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)NCCC1 JMPFLCLLMDQYKW-FPOVZHCZSA-N 0.000 claims description 6
- DTQNEFOKTXXQKV-HKUYNNGSSA-N (2s,3s)-n-[(2-methoxyphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound COC1=CC=CC=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)NCCC1 DTQNEFOKTXXQKV-HKUYNNGSSA-N 0.000 claims description 6
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- DLFQYLFMHDOVDP-FPOVZHCZSA-N (2s,3s)-n-[[5-tert-butyl-2-(trifluoromethoxy)phenyl]methyl]-2-phenylpiperidin-3-amine Chemical compound CC(C)(C)C1=CC=C(OC(F)(F)F)C(CN[C@@H]2[C@@H](NCCC2)C=2C=CC=CC=2)=C1 DLFQYLFMHDOVDP-FPOVZHCZSA-N 0.000 claims description 4
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- SFTQTBLXIWAZMI-UPVQGACJSA-N (2s,3s)-1-(5-aminopentyl)-n-[(2-methoxyphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound COC1=CC=CC=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)N(CCCCCN)CCC1 SFTQTBLXIWAZMI-UPVQGACJSA-N 0.000 claims description 3
- PKOQGZGCLCOZTR-CONSDPRKSA-N (2s,3s)-2-benzhydryl-n-[(2-methoxy-5-propylphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine Chemical compound CCCC1=CC=C(OC)C(CN[C@@H]2[C@@H](N3CCC2CC3)C(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 PKOQGZGCLCOZTR-CONSDPRKSA-N 0.000 claims description 3
- NNNAFENHFFKFSL-KBXCAEBGSA-N (2s,3s)-3-[[2-(difluoromethoxy)-5-(trifluoromethoxy)phenyl]methyl]-2-phenylpiperidin-1-amine Chemical compound C([C@@H]1CCCN([C@@H]1C=1C=CC=CC=1)N)C1=CC(OC(F)(F)F)=CC=C1OC(F)F NNNAFENHFFKFSL-KBXCAEBGSA-N 0.000 claims description 3
- UGIPKCIBIXXIEF-HNAYVOBHSA-N (2s,3s)-3-[[2-methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenylpiperidin-1-amine Chemical compound COC1=CC=C(OC(F)(F)F)C=C1C[C@H]1[C@@H](C=2C=CC=CC=2)N(N)CCC1 UGIPKCIBIXXIEF-HNAYVOBHSA-N 0.000 claims description 3
- JWFRVJYQGQVKBH-ICSRJNTNSA-N (2s,3s)-n-[(2,5-dimethoxyphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound COC1=CC=C(OC)C(CN[C@@H]2[C@@H](NCCC2)C=2C=CC=CC=2)=C1 JWFRVJYQGQVKBH-ICSRJNTNSA-N 0.000 claims description 3
- CVJILTLPVIPLLN-ZCYQVOJMSA-N (2s,3s)-n-[(2-methoxy-5-phenylphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound C1([C@@H]2NCCC[C@@H]2NCC2=CC(=CC=C2OC)C=2C=CC=CC=2)=CC=CC=C1 CVJILTLPVIPLLN-ZCYQVOJMSA-N 0.000 claims description 3
- ZXKCJYJNJMQSIK-UNMCSNQZSA-N (2s,3s)-n-[(2-methoxy-5-propan-2-ylphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound COC1=CC=C(C(C)C)C=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)NCCC1 ZXKCJYJNJMQSIK-UNMCSNQZSA-N 0.000 claims description 3
- NVAJOEWMHMGWCN-UNMCSNQZSA-N (2s,3s)-n-[(2-methoxy-5-propylphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound CCCC1=CC=C(OC)C(CN[C@@H]2[C@@H](NCCC2)C=2C=CC=CC=2)=C1 NVAJOEWMHMGWCN-UNMCSNQZSA-N 0.000 claims description 3
- LVCKPTATRKHDFP-ZONZVIQZSA-N (2s,3s)-n-[(5-butan-2-yl-2-methoxyphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound CCC(C)C1=CC=C(OC)C(CN[C@@H]2[C@@H](NCCC2)C=2C=CC=CC=2)=C1 LVCKPTATRKHDFP-ZONZVIQZSA-N 0.000 claims description 3
- OSCSWOVOKGVJPX-GMAHTHKFSA-N (2s,3s)-n-[(5-butyl-2-methoxyphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound CCCCC1=CC=C(OC)C(CN[C@@H]2[C@@H](NCCC2)C=2C=CC=CC=2)=C1 OSCSWOVOKGVJPX-GMAHTHKFSA-N 0.000 claims description 3
- HVWRVAHBKREIOR-HKUYNNGSSA-N (2s,3s)-n-[(5-chloro-2-methoxyphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound COC1=CC=C(Cl)C=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)NCCC1 HVWRVAHBKREIOR-HKUYNNGSSA-N 0.000 claims description 3
- LCYNCOABKRBMTH-FPOVZHCZSA-N (2s,3s)-n-[(5-ethyl-2-methoxyphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound CCC1=CC=C(OC)C(CN[C@@H]2[C@@H](NCCC2)C=2C=CC=CC=2)=C1 LCYNCOABKRBMTH-FPOVZHCZSA-N 0.000 claims description 3
- SGKKYWRWZXXOKO-UNMCSNQZSA-N (2s,3s)-n-[(5-tert-butyl-2-methoxyphenyl)methyl]-2-[3-(trifluoromethoxy)phenyl]piperidin-3-amine Chemical compound COC1=CC=C(C(C)(C)C)C=C1CN[C@@H]1[C@H](C=2C=C(OC(F)(F)F)C=CC=2)NCCC1 SGKKYWRWZXXOKO-UNMCSNQZSA-N 0.000 claims description 3
- JPQLYXMJKNOOIS-UNMCSNQZSA-N (2s,3s)-n-[(5-tert-butyl-2-methoxyphenyl)methyl]-2-phenylpiperidin-3-amine Chemical compound COC1=CC=C(C(C)(C)C)C=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)NCCC1 JPQLYXMJKNOOIS-UNMCSNQZSA-N 0.000 claims description 3
- ZPQUTMAPZMKLCT-ICSRJNTNSA-N (2s,3s)-n-[[2-ethoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenylpiperidin-3-amine Chemical compound CCOC1=CC=C(OC(F)(F)F)C=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)NCCC1 ZPQUTMAPZMKLCT-ICSRJNTNSA-N 0.000 claims description 3
- VWDNLKIXTQMOLA-DHLKQENFSA-N (2s,3s)-n-[[5-[(4,5-dimethyl-1,3-thiazol-2-yl)methylamino]-2-methoxyphenyl]methyl]-2-phenylpiperidin-3-amine Chemical compound C1=C(CN[C@@H]2[C@@H](NCCC2)C=2C=CC=CC=2)C(OC)=CC=C1NCC1=NC(C)=C(C)S1 VWDNLKIXTQMOLA-DHLKQENFSA-N 0.000 claims description 3
- WSGDMCZUYDGFBX-HKUYNNGSSA-N (2s,3s)-n-[[5-chloro-2-(2,2,2-trifluoroethoxy)phenyl]methyl]-2-phenylpiperidin-3-amine Chemical compound FC(F)(F)COC1=CC=C(Cl)C=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)NCCC1 WSGDMCZUYDGFBX-HKUYNNGSSA-N 0.000 claims description 3
- BXCXPWYLAUEXBY-IKFSTVPESA-N (2s,3s,4s,5r)-2-benzhydryl-3-[(2,5-dimethoxyphenyl)methylamino]-n,n-diethyl-1-azabicyclo[2.2.2]octane-5-carboxamide Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(=O)N(CC)CC)([C@@H]1NCC=1C(=CC=C(OC)C=1)OC)[H])C1=CC=CC=C1 BXCXPWYLAUEXBY-IKFSTVPESA-N 0.000 claims description 3
- GKJVNRHHOMPGSG-NSIYGSDQSA-N (2s,3s,4s,5r)-2-benzhydryl-3-[(2-methoxy-5-methylphenyl)methylamino]-1-azabicyclo[2.2.2]octane-5-carboxylic acid Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(O)=O)([C@@H]1NCC=1C(=CC=C(C)C=1)OC)[H])C1=CC=CC=C1 GKJVNRHHOMPGSG-NSIYGSDQSA-N 0.000 claims description 3
- ZBFJTKASKIUJNF-PHXFNYRRSA-N (2s,3s,4s,5r)-2-benzhydryl-3-[(2-methoxy-5-methylsulfinylphenyl)methylamino]-1-azabicyclo[2.2.2]octane-5-carboxylic acid Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(O)=O)([C@@H]1NCC=1C(=CC=C(C=1)S(C)=O)OC)[H])C1=CC=CC=C1 ZBFJTKASKIUJNF-PHXFNYRRSA-N 0.000 claims description 3
- NNQJDQUAJJRYRV-NSIYGSDQSA-N (2s,3s,4s,5r)-2-benzhydryl-3-[(2-methoxy-5-methylsulfonylphenyl)methylamino]-1-azabicyclo[2.2.2]octane-5-carboxylic acid Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(O)=O)([C@@H]1NCC=1C(=CC=C(C=1)S(C)(=O)=O)OC)[H])C1=CC=CC=C1 NNQJDQUAJJRYRV-NSIYGSDQSA-N 0.000 claims description 3
- UGYNIDYASJFWTR-FXZOGHEHSA-N (2s,3s,4s,5r)-2-benzhydryl-3-[(2-methoxy-5-propan-2-ylphenyl)methylamino]-1-azabicyclo[2.2.2]octane-5-carboxylic acid Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(O)=O)([C@@H]1NCC=1C(=CC=C(C=1)C(C)C)OC)[H])C1=CC=CC=C1 UGYNIDYASJFWTR-FXZOGHEHSA-N 0.000 claims description 3
- UCSKUOLGIXJPLU-FXZOGHEHSA-N (2s,3s,4s,5r)-2-benzhydryl-3-[(2-methoxy-5-propylphenyl)methylamino]-1-azabicyclo[2.2.2]octane-5-carboxylic acid Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(O)=O)([C@@H]1NCC=1C(=CC=C(CCC)C=1)OC)[H])C1=CC=CC=C1 UCSKUOLGIXJPLU-FXZOGHEHSA-N 0.000 claims description 3
- FQMDWRVWAZOFJF-QUNNAWRHSA-N (2s,3s,4s,5r)-2-benzhydryl-3-[(5-butan-2-yl-2-methoxyphenyl)methylamino]-1-azabicyclo[2.2.2]octane-5-carboxylic acid Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(O)=O)([C@@H]1NCC=1C(=CC=C(C=1)C(C)CC)OC)[H])C1=CC=CC=C1 FQMDWRVWAZOFJF-QUNNAWRHSA-N 0.000 claims description 3
- HANWCAQDYMDUKN-ATACATFBSA-N (2s,3s,4s,5r)-2-benzhydryl-3-[(5-ethyl-2-methoxyphenyl)methylamino]-1-azabicyclo[2.2.2]octane-5-carboxylic acid Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(O)=O)([C@@H]1NCC=1C(=CC=C(CC)C=1)OC)[H])C1=CC=CC=C1 HANWCAQDYMDUKN-ATACATFBSA-N 0.000 claims description 3
- NOTNLZQKHMFVKX-MTDVLGRSSA-N (2s,3s,4s,5r)-2-benzhydryl-3-[(6-methoxy-6-methylsulfanylcyclohexa-2,4-dien-1-yl)methylamino]-1-azabicyclo[2.2.2]octane-5-carboxylic acid Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(O)=O)([C@@H]1NCC1C(C=CC=C1)(OC)SC)[H])C1=CC=CC=C1 NOTNLZQKHMFVKX-MTDVLGRSSA-N 0.000 claims description 3
- LVCKDBYHCLGPDR-LSGCGUROSA-N (2s,3s,4s,5r)-2-benzhydryl-3-[[2-methoxy-5-(trifluoromethoxy)phenyl]methylamino]-1-azabicyclo[2.2.2]octane-5-carboxylic acid Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(O)=O)([C@@H]1NCC=1C(=CC=C(OC(F)(F)F)C=1)OC)[H])C1=CC=CC=C1 LVCKDBYHCLGPDR-LSGCGUROSA-N 0.000 claims description 3
- BNUOLJBGGUPSKO-YVYLOCOQSA-N (2s,3s,4s,5r)-2-benzhydryl-n,n-diethyl-3-[(2-methoxy-5-propan-2-ylphenyl)methylamino]-1-azabicyclo[2.2.2]octane-5-carboxamide Chemical compound C=1C=CC=CC=1C([C@@H]1N2CC[C@@]([C@H](C2)C(=O)N(CC)CC)([C@@H]1NCC=1C(=CC=C(C=1)C(C)C)OC)[H])C1=CC=CC=C1 BNUOLJBGGUPSKO-YVYLOCOQSA-N 0.000 claims description 3
- GRBSRKIQJCLYFU-WNJJXGMVSA-N 1-(4-fluorophenyl)-4-[(2s,3s)-3-[(2-methoxyphenyl)methylamino]-2-phenylpiperidin-1-yl]butan-1-one Chemical compound COC1=CC=CC=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)N(CCCC(=O)C=2C=CC(F)=CC=2)CCC1 GRBSRKIQJCLYFU-WNJJXGMVSA-N 0.000 claims description 3
- NPKIOBYABGRQLF-YTMVLYRLSA-N 2,4-dimethyl-n-(2-methylpropyl)-n-[3-[[[(2s,3s)-2-phenylpiperidin-3-yl]amino]methyl]-4-propan-2-yloxyphenyl]-1,3-thiazole-5-sulfonamide Chemical compound C1([C@@H]2NCCC[C@@H]2NCC=2C(OC(C)C)=CC=C(C=2)N(CC(C)C)S(=O)(=O)C2=C(N=C(C)S2)C)=CC=CC=C1 NPKIOBYABGRQLF-YTMVLYRLSA-N 0.000 claims description 3
- AUHFOPNHPZPZEI-UHFFFAOYSA-N 2-benzhydryl-n-[[2-methoxy-5-(trifluoromethoxy)phenyl]methyl]-1-azabicyclo[2.2.2]octan-3-amine Chemical compound COC1=CC=C(OC(F)(F)F)C=C1CNC1C(C(C=2C=CC=CC=2)C=2C=CC=CC=2)N2CCC1CC2 AUHFOPNHPZPZEI-UHFFFAOYSA-N 0.000 claims description 3
- HQZONHWUUKPDRH-QGWOSTIUSA-N 4-[(2s,3s)-3-[(2-methoxyphenyl)methylamino]-2-phenylpiperidin-1-yl]-1-phenylbutan-1-ol Chemical compound COC1=CC=CC=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)N(CCCC(O)C=2C=CC=CC=2)CCC1 HQZONHWUUKPDRH-QGWOSTIUSA-N 0.000 claims description 3
- LAOMAAZAXGILTO-WNJJXGMVSA-N 4-[(2s,3s)-3-[(2-methoxyphenyl)methylamino]-2-phenylpiperidin-1-yl]-1-phenylbutan-1-one Chemical compound COC1=CC=CC=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)N(CCCC(=O)C=2C=CC=CC=2)CCC1 LAOMAAZAXGILTO-WNJJXGMVSA-N 0.000 claims description 3
- MBEKBYMBAOKXLY-UPVQGACJSA-N 5-[(2s,3s)-3-[(2-methoxyphenyl)methylamino]-2-phenylpiperidin-1-yl]pentanenitrile Chemical compound COC1=CC=CC=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)N(CCCCC#N)CCC1 MBEKBYMBAOKXLY-UPVQGACJSA-N 0.000 claims description 3
- HIORMPAWFMQDOW-ZCYQVOJMSA-N 6-[(2s,3s)-3-[(2-methoxyphenyl)methylamino]-2-phenylpiperidin-1-yl]hexan-1-ol Chemical compound COC1=CC=CC=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)N(CCCCCCO)CCC1 HIORMPAWFMQDOW-ZCYQVOJMSA-N 0.000 claims description 3
- WUSKHOUAANEBFY-HPZMQGABSA-N 6-[(2s,3s)-3-[(2-methoxyphenyl)methylamino]-2-phenylpiperidin-1-yl]hexane-1,2-diol Chemical compound COC1=CC=CC=C1CN[C@@H]1[C@H](C=2C=CC=CC=2)N(CCCCC(O)CO)CCC1 WUSKHOUAANEBFY-HPZMQGABSA-N 0.000 claims description 3
- ZPRDFJADOFPMGD-WDZYCZAWSA-N C1([C@H]2NCCC[C@H]2C(N)C2=CC(=CC=C2OC(C)C)N(C(C)C)S(=O)(=O)C2=C(N=C(C)S2)C)=CC=CC=C1 Chemical compound C1([C@H]2NCCC[C@H]2C(N)C2=CC(=CC=C2OC(C)C)N(C(C)C)S(=O)(=O)C2=C(N=C(C)S2)C)=CC=CC=C1 ZPRDFJADOFPMGD-WDZYCZAWSA-N 0.000 claims description 3
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
- JGCMPBRNZDBPGS-IGKIAQTJSA-N ethyl 6-[(2s,3s)-3-[(2-methoxyphenyl)methylamino]-2-phenylpiperidin-1-yl]hexanoate Chemical compound N([C@H]1CCCN([C@H]1C=1C=CC=CC=1)CCCCCC(=O)OCC)CC1=CC=CC=C1OC JGCMPBRNZDBPGS-IGKIAQTJSA-N 0.000 claims description 3
- KXCUGLQCBUEEQE-AHWVRZQESA-N n,2,4-trimethyl-n-[3-[[[(2s,3s)-2-phenylpiperidin-3-yl]amino]methyl]-4-propan-2-yloxyphenyl]-1,3-thiazole-5-sulfonamide Chemical compound C1([C@@H]2NCCC[C@@H]2NCC2=CC(=CC=C2OC(C)C)N(C)S(=O)(=O)C2=C(N=C(C)S2)C)=CC=CC=C1 KXCUGLQCBUEEQE-AHWVRZQESA-N 0.000 claims description 3
- FNYBJRDPAREZDB-GMAHTHKFSA-N n,4,5-trimethyl-n-[3-[[[(2s,3s)-2-phenylpiperidin-3-yl]amino]methyl]-4-(trifluoromethoxy)phenyl]-1,3-thiazole-2-sulfonamide Chemical compound C1([C@@H]2NCCC[C@@H]2NCC=2C(OC(F)(F)F)=CC=C(C=2)N(C)S(=O)(=O)C=2SC(C)=C(C)N=2)=CC=CC=C1 FNYBJRDPAREZDB-GMAHTHKFSA-N 0.000 claims description 3
- SZFRAFLMDAIGLU-UHFFFAOYSA-N n-[(2-methoxyphenyl)methyl]-4-methyl-2-phenylpiperidin-3-amine Chemical compound COC1=CC=CC=C1CNC1C(C=2C=CC=CC=2)NCCC1C SZFRAFLMDAIGLU-UHFFFAOYSA-N 0.000 claims description 3
- MYORKKSQSYUQSH-UHFFFAOYSA-N n-[(2-methoxyphenyl)methyl]-5-methyl-2-phenylpiperidin-3-amine Chemical compound COC1=CC=CC=C1CNC1C(C=2C=CC=CC=2)NCC(C)C1 MYORKKSQSYUQSH-UHFFFAOYSA-N 0.000 claims description 3
- DBKJGIXLYZJDMI-UHFFFAOYSA-N n-[(2-methoxyphenyl)methyl]-6-methyl-2-phenylpiperidin-3-amine Chemical compound COC1=CC=CC=C1CNC1C(C=2C=CC=CC=2)NC(C)CC1 DBKJGIXLYZJDMI-UHFFFAOYSA-N 0.000 claims description 3
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- 239000008108 microcrystalline cellulose Substances 0.000 description 1
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- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229940100691 oral capsule Drugs 0.000 description 1
- 239000008203 oral pharmaceutical composition Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000002990 phenothiazines Chemical class 0.000 description 1
- 150000004885 piperazines Chemical class 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
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- 208000022530 polyphagia Diseases 0.000 description 1
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- 239000004089 psychotropic agent Substances 0.000 description 1
- SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 description 1
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- 235000011803 sesame oil Nutrition 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 description 1
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- 235000020357 syrup Nutrition 0.000 description 1
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- 239000002462 tachykinin receptor antagonist Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
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- 230000000699 topical effect Effects 0.000 description 1
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- DYWSVUBJGFTOQC-UHFFFAOYSA-N xi-2-Ethylheptanoic acid Chemical compound CCCCCC(CC)C(O)=O DYWSVUBJGFTOQC-UHFFFAOYSA-N 0.000 description 1
- 229940020965 zoloft Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30669201P | 2001-07-20 | 2001-07-20 | |
| US60/306,692 | 2001-07-20 | ||
| PCT/IB2002/002847 WO2003009848A1 (en) | 2001-07-20 | 2002-07-15 | Use of nk-1 receptor antagonists to modify unwanted behavior in dogs, cats and horses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2448722A1 true CA2448722A1 (en) | 2003-02-06 |
Family
ID=23186426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002448722A Abandoned CA2448722A1 (en) | 2001-07-20 | 2002-07-15 | Use of nk-1 receptor antagonists to modify unwanted behavior in dogs, cats and horses |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20030139443A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1411946A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2005504029A (cg-RX-API-DMAC10.html) |
| KR (1) | KR20040029375A (cg-RX-API-DMAC10.html) |
| CN (1) | CN1529600A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2448722A1 (cg-RX-API-DMAC10.html) |
| CZ (1) | CZ200434A3 (cg-RX-API-DMAC10.html) |
| HU (1) | HUP0401154A2 (cg-RX-API-DMAC10.html) |
| IL (1) | IL158990A0 (cg-RX-API-DMAC10.html) |
| PL (1) | PL367944A1 (cg-RX-API-DMAC10.html) |
| SK (1) | SK252004A3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2003009848A1 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA200308991B (cg-RX-API-DMAC10.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0507325A (pt) * | 2004-01-30 | 2007-07-03 | Pfizer Prod Inc | antagonistas dos receptores nk-1 para melhorar a recuperação da anestesia |
| HUE034099T2 (en) | 2004-01-30 | 2018-01-29 | Zoetis Services Llc | Antimicrobial preservatives for the delivery of multidose formulations using beta-cyclodextrins for liquid dosage forms |
| CN1972937A (zh) * | 2004-04-30 | 2007-05-30 | 先灵公司 | 神经肽受体调节剂 |
| CN114403042A (zh) * | 2021-12-13 | 2022-04-29 | 深圳先进技术研究院 | 一种大动物焦虑症动物模型 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
| US5232929A (en) * | 1990-11-28 | 1993-08-03 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use |
| FR2677361A1 (fr) * | 1991-06-04 | 1992-12-11 | Adir | Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| BR9206073A (pt) * | 1991-05-31 | 1994-12-06 | Pfizer | Derivados de quinuclidina |
| SK282203B6 (sk) * | 1991-06-20 | 2001-12-03 | Pfizer Inc. | Fluoroalkoxybenzylamínové deriváty heterocyklov obsahujúcich dusík, spôsob ich prípravy, medziprodukty, spôsob prípravy medziproduktov, použitie a farmaceutický prostriedok |
| EP0687268B1 (en) * | 1993-03-04 | 1998-05-27 | Pfizer Inc. | Spiroazacyclic derivatives as substance p antagonists |
| EP0623344B1 (fr) * | 1993-05-04 | 2000-07-26 | Ceva Sante Animale | Utilisation de la Sélégiline en médecine vetérinaire |
| IL109646A0 (en) * | 1993-05-19 | 1994-08-26 | Pfizer | Heteroatom substituted alkyl benzylamino-quinuclidines |
| US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
| US5703065A (en) * | 1993-09-17 | 1997-12-30 | Pfizer Inc. | Heteroarylamino and heteroarylsulfonamido substituted 3-benyzlaminomethyl piperidines and related compounds |
| US6083943A (en) * | 1993-09-17 | 2000-07-04 | Pfizer Inc | Substituted azaheterocyclecarboxylic acid |
| US5854262A (en) * | 1993-10-07 | 1998-12-29 | Pfizer Inc. | Aminomethylene substituted non-aromatic heterocycles and use as substance P antagonists |
| PE45195A1 (es) * | 1994-03-03 | 1996-01-17 | Boehringer Ingelheim Kg | Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene |
| US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
| ES2229259T3 (es) * | 1995-01-12 | 2005-04-16 | Glaxo Group Limited | Derivados de piperidina con actividad antagonista de taquiquinina. |
| US5990125A (en) * | 1996-01-19 | 1999-11-23 | Pfizer Inc. | NK-1 receptor antagonists for the treatment of cancer |
| US6117855A (en) * | 1996-10-07 | 2000-09-12 | Merck Sharp & Dohme Ltd. | Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent |
| AU726745B2 (en) * | 1996-10-07 | 2000-11-16 | Merck Sharp & Dohme Limited | CNS-penetrant NK-1 receptor antagonists as antidepressant and/or an anti-anxiety agent |
| CA2275527C (en) * | 1996-12-19 | 2003-09-23 | Hoechst Marion Roussel, Inc. | Novel heterocyclic substituted pyrrolidine amide derivatives |
| US6156749A (en) * | 1997-12-01 | 2000-12-05 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating movement disorders |
| JP4669095B2 (ja) * | 1999-07-19 | 2011-04-13 | 太陽化学株式会社 | ペットの問題行動抑制組成物 |
| CA2280309C (en) * | 1999-08-13 | 2007-05-08 | William Norton Milgram | Use of adrafinil to treat behavioral problems in aged canines |
| CA2324813A1 (en) * | 1999-11-10 | 2001-05-10 | Susan Beth Sobolov-Jaynes | Combination treatment for depression and anxiety |
| US20020049211A1 (en) * | 2000-09-06 | 2002-04-25 | Sobolov-Jaynes Susan Beth | Combination treatment for depression and anxiety |
-
2002
- 2002-07-15 EP EP02745741A patent/EP1411946A1/en not_active Withdrawn
- 2002-07-15 SK SK25-2004A patent/SK252004A3/sk not_active Application Discontinuation
- 2002-07-15 PL PL02367944A patent/PL367944A1/xx not_active Application Discontinuation
- 2002-07-15 JP JP2003515240A patent/JP2005504029A/ja not_active Withdrawn
- 2002-07-15 WO PCT/IB2002/002847 patent/WO2003009848A1/en not_active Ceased
- 2002-07-15 HU HU0401154A patent/HUP0401154A2/hu unknown
- 2002-07-15 CA CA002448722A patent/CA2448722A1/en not_active Abandoned
- 2002-07-15 CN CNA028141873A patent/CN1529600A/zh active Pending
- 2002-07-15 IL IL15899002A patent/IL158990A0/xx unknown
- 2002-07-15 KR KR10-2004-7000901A patent/KR20040029375A/ko not_active Ceased
- 2002-07-15 CZ CZ200434A patent/CZ200434A3/cs unknown
- 2002-07-19 US US10/199,284 patent/US20030139443A1/en not_active Abandoned
-
2003
- 2003-11-19 ZA ZA200308991A patent/ZA200308991B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0401154A2 (hu) | 2004-10-28 |
| JP2005504029A (ja) | 2005-02-10 |
| US20030139443A1 (en) | 2003-07-24 |
| ZA200308991B (en) | 2004-11-19 |
| IL158990A0 (en) | 2004-05-12 |
| KR20040029375A (ko) | 2004-04-06 |
| CZ200434A3 (cs) | 2005-02-16 |
| WO2003009848A1 (en) | 2003-02-06 |
| SK252004A3 (sk) | 2005-03-04 |
| PL367944A1 (en) | 2005-03-07 |
| CN1529600A (zh) | 2004-09-15 |
| EP1411946A1 (en) | 2004-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |