JP2005503323A5 - - Google Patents

Info

Publication number

JP2005503323A5

JP2005503323A5 JP2002559034A JP2002559034A JP2005503323A5 JP 2005503323 A5 JP2005503323 A5 JP 2005503323A5 JP 2002559034 A JP2002559034 A JP 2002559034A JP 2002559034 A JP2002559034 A JP 2002559034A JP 2005503323 A5 JP2005503323 A5 JP 2005503323A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

alkyl

compound

administered

group

Prior art date

2002-01-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000008194 pharmaceutical composition Substances 0.000 claims 67
• 150000001875 compounds Chemical class 0.000 claims 43
• 125000000217 alkyl group Chemical group 0.000 claims 35
• 229910052739 hydrogen Inorganic materials 0.000 claims 28
• 239000001257 hydrogen Substances 0.000 claims 28
• 150000002431 hydrogen Chemical class 0.000 claims 28
• 125000000547 substituted alkyl group Chemical group 0.000 claims 28
• 125000003118 aryl group Chemical group 0.000 claims 21
• 201000011510 cancer Diseases 0.000 claims 17
• 125000000753 cycloalkyl group Chemical group 0.000 claims 14
• 239000000203 mixture Substances 0.000 claims 14
• 125000003107 substituted aryl group Chemical group 0.000 claims 14
• 150000003883 epothilone derivatives Chemical class 0.000 claims 9
• 238000001990 intravenous administration Methods 0.000 claims 9
• 238000001802 infusion Methods 0.000 claims 8
• 239000000243 solution Substances 0.000 claims 8
• 239000003085 diluting agent Substances 0.000 claims 7
• 229910052736 halogen Inorganic materials 0.000 claims 7
• 150000002367 halogens Chemical class 0.000 claims 7
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
• 229910052760 oxygen Inorganic materials 0.000 claims 7
• MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 7
• 239000001301 oxygen Substances 0.000 claims 7
• 150000003839 salts Chemical class 0.000 claims 7
• 239000011780 sodium chloride Substances 0.000 claims 7
• 239000012453 solvate Substances 0.000 claims 7
• NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 7
• 229910052717 sulfur Inorganic materials 0.000 claims 7
• 239000011593 sulfur Substances 0.000 claims 7
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
• DKGAVHZHDRPRBM-UHFFFAOYSA-N t-BuOH Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 4
• 238000001035 drying Methods 0.000 claims 4
• 239000002736 nonionic surfactant Substances 0.000 claims 4
• 239000008389 polyethoxylated castor oil Substances 0.000 claims 4
• BPKIGYQJPYCAOW-FFJTTWKXSA-I calcium;potassium;disodium;(2S)-2-hydroxypropanoate;dichloride;dihydroxide;hydrate Chemical group O.[OH-].[OH-].[Na+].[Na+].[Cl-].[Cl-].[K+].[Ca+2].C[C@H](O)C([O-])=O BPKIGYQJPYCAOW-FFJTTWKXSA-I 0.000 claims 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
• 238000007911 parenteral administration Methods 0.000 claims 3
• 239000004094 surface-active agent Substances 0.000 claims 3
• 206010070840 Gastrointestinal tract irritation Diseases 0.000 claims 2
• 206010022998 Irritability Diseases 0.000 claims 2
• 206010028813 Nausea Diseases 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 206010029350 Neurotoxicity Diseases 0.000 claims 2
• 239000008156 Ringer's lactate solution Substances 0.000 claims 2
• 206010044221 Toxic encephalopathy Diseases 0.000 claims 2
• 206010047700 Vomiting Diseases 0.000 claims 2
• 230000001093 anti-cancer Effects 0.000 claims 2
• 230000001387 anti-histamine Effects 0.000 claims 2
• 239000000739 antihistaminic agent Substances 0.000 claims 2
• 238000002512 chemotherapy Methods 0.000 claims 2
• 230000002887 neurotoxic Effects 0.000 claims 2
• 231100000228 neurotoxicity Toxicity 0.000 claims 2
• 238000001959 radiotherapy Methods 0.000 claims 2
• 239000002904 solvent Substances 0.000 claims 2
• 230000003442 weekly Effects 0.000 claims 2
• XOZIUKBZLSUILX-GIQCAXHBSA-N (4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione Chemical group O1C(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC\C(C)=C/C[C@H]1C(\C)=C\C1=CSC(C)=N1 XOZIUKBZLSUILX-GIQCAXHBSA-N 0.000 claims 1
• XLMXUUQMSMKFMH-UZRURVBFSA-N 2-hydroxyethyl (Z,12R)-12-hydroxyoctadec-9-enoate Chemical group CCCCCC[C@@H](O)C\C=C/CCCCCCCC(=O)OCCO XLMXUUQMSMKFMH-UZRURVBFSA-N 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 229940093181 Glucose Injection Drugs 0.000 claims 1
• 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims 1
• 238000007865 diluting Methods 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 238000004806 packaging method and process Methods 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 239000008227 sterile water for injection Substances 0.000 claims 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1