JP2005502874A - インターカレート性酸化還元活性部分を用いる電気化学センサー - Google Patents

インターカレート性酸化還元活性部分を用いる電気化学センサー Download PDF

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Publication number
JP2005502874A
JP2005502874A JP2003527391A JP2003527391A JP2005502874A JP 2005502874 A JP2005502874 A JP 2005502874A JP 2003527391 A JP2003527391 A JP 2003527391A JP 2003527391 A JP2003527391 A JP 2003527391A JP 2005502874 A JP2005502874 A JP 2005502874A
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nucleic acid
sequence
stranded nucleic
stranded
double
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JP2005502874A5 (https=
Inventor
ジャッケリン ケイ． バートン
エリザベス エム． ブーン
シャナ オー． ケリー
マイケル ジー． ヒル
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California Institute of Technology
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California Institute of Technology
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Publication of JP2005502874A publication Critical patent/JP2005502874A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2003527391A 2001-09-13 2002-09-13 インターカレート性酸化還元活性部分を用いる電気化学センサー Pending JP2005502874A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/953,242 US6649350B2 (en) 1997-04-09 2001-09-13 Electrochemical sensor using intercalative, redox-active moieties
PCT/US2002/029047 WO2003023365A2 (en) 2001-09-13 2002-09-13 Electrochemical sensor using intercalative, redox-active moieties

Publications (2)

Publication Number Publication Date
JP2005502874A true JP2005502874A (ja) 2005-01-27
JP2005502874A5 JP2005502874A5 (https=) 2006-01-05

Family

ID=25493739

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JP2003527391A Pending JP2005502874A (ja) 2001-09-13 2002-09-13 インターカレート性酸化還元活性部分を用いる電気化学センサー

Country Status (5)

Country Link
US (2) US6649350B2 (https=)
EP (1) EP1425419A4 (https=)
JP (1) JP2005502874A (https=)
AU (1) AU2002336499A1 (https=)
WO (1) WO2003023365A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1187596C (zh) * 2000-09-21 2005-02-02 松下电器产业株式会社 扫描探针显微镜,及其探针和制造方法,及使用其的分子加工法
US7291457B2 (en) * 2001-06-21 2007-11-06 The Regents Of The University Of California Electrochemical detection of mismatch nucleic acids
KR100459394B1 (ko) * 2001-10-30 2004-12-03 엘지전자 주식회사 인터컬레이터를 이용한 핵산의 전기화학발광 검출방법
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
JPWO2005103695A1 (ja) * 2004-04-23 2008-03-13 松下電器産業株式会社 遺伝子検出方法及び遺伝子検出装置
US7511142B2 (en) * 2004-07-28 2009-03-31 Agency For Science, Technology And Research Mediator-modified redox biomolecules for use in electrochemical determination of analyte
US7462720B2 (en) * 2004-09-02 2008-12-09 Agency Science Tech & Res Determination of nucleic acid using electrocatalytic intercalators
KR100745750B1 (ko) * 2005-01-25 2007-08-02 삼성전자주식회사 인터컬레이터를 이용한 핵산의 분리 방법
US8906609B1 (en) 2005-09-26 2014-12-09 Arrowhead Center, Inc. Label-free biomolecule sensor based on surface charge modulated ionic conductance
US20090036315A1 (en) * 2006-02-07 2009-02-05 Antara Biosciences Inc. Device and methods for detecting and quantifying one or more target agents
US20080026394A1 (en) * 2006-07-11 2008-01-31 Antara Biosciences Inc. Methods of detecting one or more cancer markers
US8197650B2 (en) * 2007-06-07 2012-06-12 Sensor Innovations, Inc. Silicon electrochemical sensors
CA2717879A1 (en) * 2008-03-07 2009-09-11 The Curators Of The University Of Missouri Sensor electrode and method for the electrochemical detection of nucleotides
US9005425B2 (en) 2010-03-05 2015-04-14 University Of Utah Research Foundation Detection of nucleic acid lesions and adducts using nanopores
US8758584B2 (en) 2010-12-16 2014-06-24 Sensor Innovations, Inc. Electrochemical sensors
US10024817B2 (en) * 2014-10-17 2018-07-17 Pelogenix, Llc Method for detecting proteases and active infection in biological fluids and tissues
US11131646B2 (en) * 2017-11-03 2021-09-28 Robert Bosch Gmbh Electrochemical sequencing of DNA using an edge electrode
EP3947716A4 (en) * 2019-03-27 2022-12-07 California Institute of Technology SURFACE-IMMOBILIZED BISTABLE POLYNUCLEOTIDE DEVICES FOR DETECTING AND QUANTIFICATION OF MOLECULAR EVENTS
CN112986213B (zh) * 2021-03-12 2022-03-22 福州大学 一种检测口腔癌dna的拉曼光谱传感器
CN113061649B (zh) * 2021-04-02 2022-07-08 福州大学 检测microRNA的表面增强拉曼光谱传感器及其制备方法
CN113960142B (zh) * 2021-10-25 2023-11-10 福州大学 一种回文核酸纳米片超灵敏电化学生物传感器的制备方法
CN116953055A (zh) * 2022-04-19 2023-10-27 中国科学院大连化学物理研究所 一种dna电化学传感器及其制备方法和应用
CN117949508A (zh) * 2024-02-01 2024-04-30 上海市计量测试技术研究院(中国上海测试中心、华东国家计量测试中心、上海市计量器具强制检定中心) 一种检测PDGF-BB的poly A-DNA四面体探针电化学传感器及其应用
CN117907491B (zh) * 2024-03-12 2024-06-04 中国人民解放军军事科学院军事医学研究院 基于双衍生化技术的脱碱基位点lc-ms/ms分析方法
CN118624694B (zh) * 2024-08-09 2024-10-18 云南民族大学 一种基于杂交链式反应和金属纳米簇检测镉离子的电化学方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001051A (en) 1986-12-12 1991-03-19 Regents Of The University Of California Dose critical in-vivo detection of anti-cancer drug levels in blood
US5922857A (en) 1992-09-28 1999-07-13 Chiron Corporation Methods and compositions for controlling translation of HCV proteins
US5312527A (en) 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5543326A (en) 1994-03-04 1996-08-06 Heller; Adam Biosensor including chemically modified enzymes
US5874565A (en) 1995-08-29 1999-02-23 Washington University Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US6221586B1 (en) * 1997-04-09 2001-04-24 California Institute Of Technology Electrochemical sensor using intercalative, redox-active moieties
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
DE19964220C2 (de) * 1998-11-23 2003-07-03 Friz Biochem Gmbh Verfahren zur Herstellung einer modifizierten leitfähigen Oberfläche
DE19945398A1 (de) * 1999-09-22 2001-04-05 Friz Biochem Gmbh Elektrochemische Detektion von sequenzspezifischen Nukleinsäure-Oligomer-Hybridisierungsereignissen
US20010021504A1 (en) * 2000-03-08 2001-09-13 Yoshihiko Makino Method for testing complementation of nucleic acid

Also Published As

Publication number Publication date
US20020146716A1 (en) 2002-10-10
US6649350B2 (en) 2003-11-18
EP1425419A4 (en) 2006-11-22
AU2002336499A1 (en) 2003-03-24
US7202037B2 (en) 2007-04-10
US20040063126A1 (en) 2004-04-01
WO2003023365A3 (en) 2003-08-14
WO2003023365A2 (en) 2003-03-20
EP1425419A2 (en) 2004-06-09

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