JP2005502874A5 - - Google Patents
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- Publication number
- JP2005502874A5 JP2005502874A5 JP2003527391A JP2003527391A JP2005502874A5 JP 2005502874 A5 JP2005502874 A5 JP 2005502874A5 JP 2003527391 A JP2003527391 A JP 2003527391A JP 2003527391 A JP2003527391 A JP 2003527391A JP 2005502874 A5 JP2005502874 A5 JP 2005502874A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- sequence
- stranded nucleic
- stranded
- double
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical group 0.000 claims 113
- 108020004707 nucleic acids Proteins 0.000 claims 71
- 102000039446 nucleic acids Human genes 0.000 claims 71
- 238000000034 method Methods 0.000 claims 56
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 55
- 239000002853 nucleic acid probe Substances 0.000 claims 55
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 49
- 238000009830 intercalation Methods 0.000 claims 45
- 239000011248 coating agent Substances 0.000 claims 30
- 238000000576 coating method Methods 0.000 claims 30
- 108090000623 proteins and genes Proteins 0.000 claims 25
- 239000002356 single layer Substances 0.000 claims 25
- 230000006378 damage Effects 0.000 claims 24
- 102000004169 proteins and genes Human genes 0.000 claims 19
- 239000000523 sample Substances 0.000 claims 18
- 239000002773 nucleotide Substances 0.000 claims 11
- 125000003729 nucleotide group Chemical group 0.000 claims 11
- 238000010531 catalytic reduction reaction Methods 0.000 claims 10
- 108020004414 DNA Proteins 0.000 claims 9
- 230000005778 DNA damage Effects 0.000 claims 9
- 231100000277 DNA damage Toxicity 0.000 claims 9
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 5
- 108091034117 Oligonucleotide Proteins 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 4
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 3
- 102000053602 DNA Human genes 0.000 claims 3
- WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 claims 3
- 229940104302 cytosine Drugs 0.000 claims 3
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical group O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 3
- 238000000151 deposition Methods 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical group [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 3
- 229910052737 gold Inorganic materials 0.000 claims 3
- 239000010931 gold Substances 0.000 claims 3
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 3
- 238000006722 reduction reaction Methods 0.000 claims 3
- AKIZPWSPNKVOMT-UHFFFAOYSA-N 1-sulfanylhexan-1-ol Chemical compound CCCCCC(O)S AKIZPWSPNKVOMT-UHFFFAOYSA-N 0.000 claims 2
- RGKBRPAAQSHTED-UHFFFAOYSA-N 8-oxoadenine Chemical compound NC1=NC=NC2=C1NC(=O)N2 RGKBRPAAQSHTED-UHFFFAOYSA-N 0.000 claims 2
- 102000006467 TATA-Box Binding Protein Human genes 0.000 claims 2
- 108010044281 TATA-Box Binding Protein Proteins 0.000 claims 2
- 229960000643 adenine Drugs 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 238000006911 enzymatic reaction Methods 0.000 claims 2
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical group [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 claims 2
- 230000003902 lesion Effects 0.000 claims 2
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical group [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 claims 2
- 229960000907 methylthioninium chloride Drugs 0.000 claims 2
- 108091008146 restriction endonucleases Proteins 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- JTBBWRKSUYCPFY-UHFFFAOYSA-N 2,3-dihydro-1h-pyrimidin-4-one Chemical group O=C1NCNC=C1 JTBBWRKSUYCPFY-UHFFFAOYSA-N 0.000 claims 1
- LDHYTBAFXANWKM-UHFFFAOYSA-N 2-amino-3,7-dihydropurin-6-one Chemical compound O=C1NC(N)=NC2=C1NC=N2.O=C1NC(N)=NC2=C1N=CN2 LDHYTBAFXANWKM-UHFFFAOYSA-N 0.000 claims 1
- MKKDSIYTXTZFAU-UHFFFAOYSA-N 2-amino-3,7-dihydropurin-6-one;5-methyl-1h-pyrimidine-2,4-dione Chemical compound CC1=CNC(=O)NC1=O.O=C1NC(N)=NC2=C1NC=N2 MKKDSIYTXTZFAU-UHFFFAOYSA-N 0.000 claims 1
- KQLXBKWUVBMXEM-UHFFFAOYSA-N 2-amino-3,7-dihydropurin-6-one;7h-purin-6-amine Chemical compound NC1=NC=NC2=C1NC=N2.O=C1NC(N)=NC2=C1NC=N2 KQLXBKWUVBMXEM-UHFFFAOYSA-N 0.000 claims 1
- NBAKTGXDIBVZOO-UHFFFAOYSA-N 5,6-dihydrothymine Chemical compound CC1CNC(=O)NC1=O NBAKTGXDIBVZOO-UHFFFAOYSA-N 0.000 claims 1
- 208000035657 Abasia Diseases 0.000 claims 1
- 229930024421 Adenine Natural products 0.000 claims 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 101000969370 Haemophilus parahaemolyticus Type II methyltransferase M.HhaI Proteins 0.000 claims 1
- 102000016397 Methyltransferase Human genes 0.000 claims 1
- 108060004795 Methyltransferase Proteins 0.000 claims 1
- 102000006943 Uracil-DNA Glycosidase Human genes 0.000 claims 1
- 108010072685 Uracil-DNA Glycosidase Proteins 0.000 claims 1
- ASJWEHCPLGMOJE-LJMGSBPFSA-N ac1l3rvh Chemical compound N1C(=O)NC(=O)[C@@]2(C)[C@@]3(C)C(=O)NC(=O)N[C@H]3[C@H]21 ASJWEHCPLGMOJE-LJMGSBPFSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 230000009615 deamination Effects 0.000 claims 1
- 238000006481 deamination reaction Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 108700025694 p53 Genes Proteins 0.000 claims 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/953,242 US6649350B2 (en) | 1997-04-09 | 2001-09-13 | Electrochemical sensor using intercalative, redox-active moieties |
| PCT/US2002/029047 WO2003023365A2 (en) | 2001-09-13 | 2002-09-13 | Electrochemical sensor using intercalative, redox-active moieties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005502874A JP2005502874A (ja) | 2005-01-27 |
| JP2005502874A5 true JP2005502874A5 (https=) | 2006-01-05 |
Family
ID=25493739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003527391A Pending JP2005502874A (ja) | 2001-09-13 | 2002-09-13 | インターカレート性酸化還元活性部分を用いる電気化学センサー |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6649350B2 (https=) |
| EP (1) | EP1425419A4 (https=) |
| JP (1) | JP2005502874A (https=) |
| AU (1) | AU2002336499A1 (https=) |
| WO (1) | WO2003023365A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1187596C (zh) * | 2000-09-21 | 2005-02-02 | 松下电器产业株式会社 | 扫描探针显微镜,及其探针和制造方法,及使用其的分子加工法 |
| US7291457B2 (en) * | 2001-06-21 | 2007-11-06 | The Regents Of The University Of California | Electrochemical detection of mismatch nucleic acids |
| KR100459394B1 (ko) * | 2001-10-30 | 2004-12-03 | 엘지전자 주식회사 | 인터컬레이터를 이용한 핵산의 전기화학발광 검출방법 |
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| JPWO2005103695A1 (ja) * | 2004-04-23 | 2008-03-13 | 松下電器産業株式会社 | 遺伝子検出方法及び遺伝子検出装置 |
| US7511142B2 (en) * | 2004-07-28 | 2009-03-31 | Agency For Science, Technology And Research | Mediator-modified redox biomolecules for use in electrochemical determination of analyte |
| US7462720B2 (en) * | 2004-09-02 | 2008-12-09 | Agency Science Tech & Res | Determination of nucleic acid using electrocatalytic intercalators |
| KR100745750B1 (ko) * | 2005-01-25 | 2007-08-02 | 삼성전자주식회사 | 인터컬레이터를 이용한 핵산의 분리 방법 |
| US8906609B1 (en) | 2005-09-26 | 2014-12-09 | Arrowhead Center, Inc. | Label-free biomolecule sensor based on surface charge modulated ionic conductance |
| US20090036315A1 (en) * | 2006-02-07 | 2009-02-05 | Antara Biosciences Inc. | Device and methods for detecting and quantifying one or more target agents |
| US20080026394A1 (en) * | 2006-07-11 | 2008-01-31 | Antara Biosciences Inc. | Methods of detecting one or more cancer markers |
| US8197650B2 (en) * | 2007-06-07 | 2012-06-12 | Sensor Innovations, Inc. | Silicon electrochemical sensors |
| CA2717879A1 (en) * | 2008-03-07 | 2009-09-11 | The Curators Of The University Of Missouri | Sensor electrode and method for the electrochemical detection of nucleotides |
| US9005425B2 (en) | 2010-03-05 | 2015-04-14 | University Of Utah Research Foundation | Detection of nucleic acid lesions and adducts using nanopores |
| US8758584B2 (en) | 2010-12-16 | 2014-06-24 | Sensor Innovations, Inc. | Electrochemical sensors |
| US10024817B2 (en) * | 2014-10-17 | 2018-07-17 | Pelogenix, Llc | Method for detecting proteases and active infection in biological fluids and tissues |
| US11131646B2 (en) * | 2017-11-03 | 2021-09-28 | Robert Bosch Gmbh | Electrochemical sequencing of DNA using an edge electrode |
| EP3947716A4 (en) * | 2019-03-27 | 2022-12-07 | California Institute of Technology | SURFACE-IMMOBILIZED BISTABLE POLYNUCLEOTIDE DEVICES FOR DETECTING AND QUANTIFICATION OF MOLECULAR EVENTS |
| CN112986213B (zh) * | 2021-03-12 | 2022-03-22 | 福州大学 | 一种检测口腔癌dna的拉曼光谱传感器 |
| CN113061649B (zh) * | 2021-04-02 | 2022-07-08 | 福州大学 | 检测microRNA的表面增强拉曼光谱传感器及其制备方法 |
| CN113960142B (zh) * | 2021-10-25 | 2023-11-10 | 福州大学 | 一种回文核酸纳米片超灵敏电化学生物传感器的制备方法 |
| CN116953055A (zh) * | 2022-04-19 | 2023-10-27 | 中国科学院大连化学物理研究所 | 一种dna电化学传感器及其制备方法和应用 |
| CN117949508A (zh) * | 2024-02-01 | 2024-04-30 | 上海市计量测试技术研究院(中国上海测试中心、华东国家计量测试中心、上海市计量器具强制检定中心) | 一种检测PDGF-BB的poly A-DNA四面体探针电化学传感器及其应用 |
| CN117907491B (zh) * | 2024-03-12 | 2024-06-04 | 中国人民解放军军事科学院军事医学研究院 | 基于双衍生化技术的脱碱基位点lc-ms/ms分析方法 |
| CN118624694B (zh) * | 2024-08-09 | 2024-10-18 | 云南民族大学 | 一种基于杂交链式反应和金属纳米簇检测镉离子的电化学方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5001051A (en) | 1986-12-12 | 1991-03-19 | Regents Of The University Of California | Dose critical in-vivo detection of anti-cancer drug levels in blood |
| US5922857A (en) | 1992-09-28 | 1999-07-13 | Chiron Corporation | Methods and compositions for controlling translation of HCV proteins |
| US5312527A (en) | 1992-10-06 | 1994-05-17 | Concordia University | Voltammetric sequence-selective sensor for target polynucleotide sequences |
| US5824473A (en) | 1993-12-10 | 1998-10-20 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5591578A (en) | 1993-12-10 | 1997-01-07 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US6071699A (en) | 1996-06-07 | 2000-06-06 | California Institute Of Technology | Nucleic acid mediated electron transfer |
| US5543326A (en) | 1994-03-04 | 1996-08-06 | Heller; Adam | Biosensor including chemically modified enzymes |
| US5874565A (en) | 1995-08-29 | 1999-02-23 | Washington University | Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus |
| US6096273A (en) | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
| US7014992B1 (en) | 1996-11-05 | 2006-03-21 | Clinical Micro Sensors, Inc. | Conductive oligomers attached to electrodes and nucleoside analogs |
| US6221586B1 (en) * | 1997-04-09 | 2001-04-24 | California Institute Of Technology | Electrochemical sensor using intercalative, redox-active moieties |
| US6063573A (en) | 1998-01-27 | 2000-05-16 | Clinical Micro Sensors, Inc. | Cycling probe technology using electron transfer detection |
| DE19964220C2 (de) * | 1998-11-23 | 2003-07-03 | Friz Biochem Gmbh | Verfahren zur Herstellung einer modifizierten leitfähigen Oberfläche |
| DE19945398A1 (de) * | 1999-09-22 | 2001-04-05 | Friz Biochem Gmbh | Elektrochemische Detektion von sequenzspezifischen Nukleinsäure-Oligomer-Hybridisierungsereignissen |
| US20010021504A1 (en) * | 2000-03-08 | 2001-09-13 | Yoshihiko Makino | Method for testing complementation of nucleic acid |
-
2001
- 2001-09-13 US US09/953,242 patent/US6649350B2/en not_active Expired - Lifetime
-
2002
- 2002-09-13 WO PCT/US2002/029047 patent/WO2003023365A2/en not_active Ceased
- 2002-09-13 EP EP02773352A patent/EP1425419A4/en not_active Withdrawn
- 2002-09-13 AU AU2002336499A patent/AU2002336499A1/en not_active Abandoned
- 2002-09-13 JP JP2003527391A patent/JP2005502874A/ja active Pending
-
2003
- 2003-08-14 US US10/641,884 patent/US7202037B2/en not_active Expired - Fee Related
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