JP2005501842A5 - - Google Patents

Download PDF

Info

Publication number
JP2005501842A5
JP2005501842A5 JP2003519086A JP2003519086A JP2005501842A5 JP 2005501842 A5 JP2005501842 A5 JP 2005501842A5 JP 2003519086 A JP2003519086 A JP 2003519086A JP 2003519086 A JP2003519086 A JP 2003519086A JP 2005501842 A5 JP2005501842 A5 JP 2005501842A5
Authority
JP
Japan
Prior art keywords
optionally substituted
compound
hydroxymethyl
pyrazol
purin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003519086A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005501842A (ja
JP4357960B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/024696 external-priority patent/WO2003014137A1/en
Publication of JP2005501842A publication Critical patent/JP2005501842A/ja
Publication of JP2005501842A5 publication Critical patent/JP2005501842A5/ja
Application granted granted Critical
Publication of JP4357960B2 publication Critical patent/JP4357960B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2003519086A 2001-08-08 2002-08-06 アデノシンa3レセプターアゴニスト Expired - Fee Related JP4357960B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31106901P 2001-08-08 2001-08-08
PCT/US2002/024696 WO2003014137A1 (en) 2001-08-08 2002-08-06 Adenosine a3 receptor agonists

Publications (3)

Publication Number Publication Date
JP2005501842A JP2005501842A (ja) 2005-01-20
JP2005501842A5 true JP2005501842A5 (https=) 2005-11-17
JP4357960B2 JP4357960B2 (ja) 2009-11-04

Family

ID=23205248

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003519086A Expired - Fee Related JP4357960B2 (ja) 2001-08-08 2002-08-06 アデノシンa3レセプターアゴニスト

Country Status (20)

Country Link
US (1) US20030078232A1 (https=)
EP (1) EP1414837B1 (https=)
JP (1) JP4357960B2 (https=)
KR (1) KR100923888B1 (https=)
CN (1) CN1244589C (https=)
AT (1) ATE307136T1 (https=)
AU (1) AU2002327426C1 (https=)
CA (1) CA2456744A1 (https=)
DE (1) DE60206775T2 (https=)
DK (1) DK1414837T3 (https=)
ES (1) ES2247371T3 (https=)
HU (1) HUP0401437A3 (https=)
IL (2) IL160231A0 (https=)
MX (1) MXPA04001185A (https=)
NO (1) NO327997B1 (https=)
NZ (1) NZ530976A (https=)
PL (1) PL368205A1 (https=)
RU (1) RU2298557C2 (https=)
WO (1) WO2003014137A1 (https=)
ZA (1) ZA200401000B (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7427606B2 (en) 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7074801B1 (en) * 2001-04-26 2006-07-11 Eisai Co., Ltd. Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
NZ556354A (en) 2001-10-01 2008-10-31 Univ Virginia 2-Propynyl adenosine analogs having A2A agonist activity and compositions thereof
US6914053B2 (en) * 2002-09-09 2005-07-05 Cv Therapeutics, Inc. Adenosine A3 receptor agonists
WO2004086034A2 (en) * 2003-03-28 2004-10-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor adenosine a3(adora3)
CA2532965C (en) 2003-07-22 2013-05-14 Astex Therapeutics Limited 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
AU2005267706B2 (en) 2004-08-02 2011-12-08 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
US7576069B2 (en) 2004-08-02 2009-08-18 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
WO2006023272A1 (en) 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
CA2585581A1 (en) * 2004-11-22 2006-05-26 King Pharmaceuticals Research & Development Inc. Enhancing treatment of hif-1 mediated disorders with adenosine a3 receptor agonists
MX2007008781A (es) 2005-01-21 2007-09-11 Astex Therapeutics Ltd Compuestos farmaceuticos.
GB0505219D0 (en) * 2005-03-14 2005-04-20 Novartis Ag Organic compounds
JP5042996B2 (ja) * 2005-05-19 2012-10-03 ギリアード・パロ・アルト・インコーポレイテッド A1アデノシンレセプターアゴニスト
US7514417B2 (en) 2005-05-19 2009-04-07 Cv Therapeutics, Inc. A1 adenosine receptor agonists
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
ATE497960T1 (de) * 2005-10-13 2011-02-15 Cv Therapeutics Inc A1-adenosinrezeptoragonisten
US8178509B2 (en) 2006-02-10 2012-05-15 University Of Virginia Patent Foundation Method to treat sickle cell disease
US7589076B2 (en) * 2006-05-18 2009-09-15 Pgx Health, Llc Substituted aryl piperidinylalkynyladenosines as A2AR agonists
US8188063B2 (en) 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
DE102007012645A1 (de) * 2007-03-16 2008-09-18 Bayer Healthcare Ag Substituierte Imidazo- und Triazolopyrimidine
EP2144911A2 (en) 2007-03-28 2010-01-20 NeuroSearch AS Purinyl derivatives and their use as potassium channel modulators
KR101564233B1 (ko) * 2007-03-28 2015-10-29 뉴로서치 에이/에스 푸리닐 유도체 및 칼륨 채널 조절제로서의 이의 용도
US20090088403A1 (en) * 2007-05-07 2009-04-02 Randy Blakely A3 adenosine receptors as targets for the modulation of central serotonergic signaling
WO2009052310A1 (en) * 2007-10-16 2009-04-23 Cv Therapeutics, Inc A3 adenosine receptor antagonists
US8058259B2 (en) 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
RU2451010C1 (ru) * 2011-01-11 2012-05-20 Закрытое Акционерное Общество "Ива Фарм" Палладиево-медные катализаторы гомогенного селективного окисления тиольных групп, комбинация и композиция на их основе и способ терапевтического воздействия
US9475797B2 (en) 2012-06-26 2016-10-25 Saniona A/S Phenyl triazole derivative and its use for modulating the GABAA receptor complex
WO2014138485A1 (en) * 2013-03-08 2014-09-12 Irm Llc Ex vivo production of platelets from hematopoietic stem cells and the product thereof
CN110545822A (zh) 2017-05-19 2019-12-06 全技术公司 药剂、组合物及其相关方法
CN113795267A (zh) 2019-03-12 2021-12-14 艾库斯生物科学有限公司 致癌基因驱动的癌症的治疗
WO2020205527A1 (en) 2019-03-29 2020-10-08 Arcus Biosciences, Inc. Treatment of cancer utilizing an identified adenosine fingerprint
JP2022538409A (ja) * 2019-06-21 2022-09-02 アカデミー オブ ミリタリー メディカル サイエンシズ アデノシン化合物、その医薬的に許容可能な塩又はその立体異性体及びその使用
AU2021413448A1 (en) * 2020-12-29 2023-07-20 Zhejiang Vimgreen Pharmaceuticals, Ltd Adenosine a3 receptor agonists, preparation methods and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists

Similar Documents

Publication Publication Date Title
JP2005501842A5 (https=)
RU2004106635A (ru) Агонисты а3 рецепторов аденозина
CN1152041C (zh) C-吡唑a2a受体激动剂
JP4727880B2 (ja) N−ピラゾールa2a受容体アゴニスト
CN1155608C (zh) 炔丙基苯基醚a2a受体激动剂
JP2003535871A (ja) 2−アミノカルボニル−9h−プリン誘導体類
JP2003506460A5 (https=)
AU2002327426A1 (en) Adenosine A3 receptor agonists
JP2004501929A (ja) プリン誘導体
US20090156544A1 (en) A1 adenosine receptor agonists
JP5042996B2 (ja) A1アデノシンレセプターアゴニスト
Jacobson Adenosine receptor agonists
ES2333651T3 (es) Agonistas del receptor de adenosina a3.
HK1048821B (zh) 噻吩a2a受体激动剂
Joshi et al. Purine derivatives as ligands for A3 adenosine receptors
EP1943251B1 (en) A1 adenosine receptor agonists