KR100923888B1 - 아데노신 ａ３ 수용체 아고니스트 - Google Patents

아데노신 ａ３ 수용체 아고니스트 Download PDF

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Publication number
KR100923888B1
KR100923888B1 KR1020047001949A KR20047001949A KR100923888B1 KR 100923888 B1 KR100923888 B1 KR 100923888B1 KR 1020047001949 A KR1020047001949 A KR 1020047001949A KR 20047001949 A KR20047001949 A KR 20047001949A KR 100923888 B1 KR100923888 B1 KR 100923888B1
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KR
South Korea
Prior art keywords
alkyl
formula
compound
substituted
hydroxymethyl
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Expired - Fee Related
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KR1020047001949A
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English (en)
Korean (ko)
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KR20040023733A (ko
Inventor
엘제인엘파티
팔레벤카타
바케드카르바이바브
자블록키제프
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씨브이 쎄러퓨틱스, 인코포레이티드
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Publication of KR20040023733A publication Critical patent/KR20040023733A/ko
Application granted granted Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020047001949A 2001-08-08 2002-08-06 아데노신 ａ３ 수용체 아고니스트 Expired - Fee Related KR100923888B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31106901P 2001-08-08 2001-08-08
US60/311,069 2001-08-08
PCT/US2002/024696 WO2003014137A1 (en) 2001-08-08 2002-08-06 Adenosine a3 receptor agonists

Publications (2)

Publication Number Publication Date
KR20040023733A KR20040023733A (ko) 2004-03-18
KR100923888B1 true KR100923888B1 (ko) 2009-10-28

Family

ID=23205248

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047001949A Expired - Fee Related KR100923888B1 (ko) 2001-08-08 2002-08-06 아데노신 ａ３ 수용체 아고니스트

Country Status (20)

Country Link
US (1) US20030078232A1 (https=)
EP (1) EP1414837B1 (https=)
JP (1) JP4357960B2 (https=)
KR (1) KR100923888B1 (https=)
CN (1) CN1244589C (https=)
AT (1) ATE307136T1 (https=)
AU (1) AU2002327426C1 (https=)
CA (1) CA2456744A1 (https=)
DE (1) DE60206775T2 (https=)
DK (1) DK1414837T3 (https=)
ES (1) ES2247371T3 (https=)
HU (1) HUP0401437A3 (https=)
IL (2) IL160231A0 (https=)
MX (1) MXPA04001185A (https=)
NO (1) NO327997B1 (https=)
NZ (1) NZ530976A (https=)
PL (1) PL368205A1 (https=)
RU (1) RU2298557C2 (https=)
WO (1) WO2003014137A1 (https=)
ZA (1) ZA200401000B (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7427606B2 (en) 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US7074801B1 (en) * 2001-04-26 2006-07-11 Eisai Co., Ltd. Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
EP1434782A2 (en) 2001-10-01 2004-07-07 University of Virginia Patent Foundation 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
US6914053B2 (en) * 2002-09-09 2005-07-05 Cv Therapeutics, Inc. Adenosine A3 receptor agonists
WO2004086034A2 (en) * 2003-03-28 2004-10-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor adenosine a3(adora3)
PL2256106T3 (pl) 2003-07-22 2015-08-31 Astex Therapeutics Ltd Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3)
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
US7442687B2 (en) 2004-08-02 2008-10-28 The University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
US7576069B2 (en) 2004-08-02 2009-08-18 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
AU2005267706B2 (en) 2004-08-02 2011-12-08 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity
AU2005306325A1 (en) * 2004-11-22 2006-05-26 King Pharmaceuticals Research & Development Inc. Enhancing treatment of HIF-1 mediated disorders with adenosine A3 receptor agonists
MX2007008781A (es) 2005-01-21 2007-09-11 Astex Therapeutics Ltd Compuestos farmaceuticos.
GB0505219D0 (en) * 2005-03-14 2005-04-20 Novartis Ag Organic compounds
EP1881991A1 (en) 2005-05-19 2008-01-30 Cv Therapeutics, Inc. A1 adenosine receptor agonists
US7381714B2 (en) * 2005-05-19 2008-06-03 Cv Therapeutics, Inc. A1 adenosine receptor agonists
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
WO2007047401A2 (en) * 2005-10-13 2007-04-26 Cv Therapeutics, Inc. A1 adenosine receptor agonists
WO2007120972A2 (en) 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
US7589076B2 (en) * 2006-05-18 2009-09-15 Pgx Health, Llc Substituted aryl piperidinylalkynyladenosines as A2AR agonists
US8188063B2 (en) 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
DE102007012645A1 (de) * 2007-03-16 2008-09-18 Bayer Healthcare Ag Substituierte Imidazo- und Triazolopyrimidine
JP2010522719A (ja) * 2007-03-28 2010-07-08 ノイロサーチ アクティーゼルスカブ プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用
EP2132208A1 (en) 2007-03-28 2009-12-16 NeuroSearch AS Purinyl derivatives and their use as potassium channel modulators
US20090088403A1 (en) * 2007-05-07 2009-04-02 Randy Blakely A3 adenosine receptors as targets for the modulation of central serotonergic signaling
JP2011500716A (ja) * 2007-10-16 2011-01-06 ギリアード・パロ・アルト・インコーポレイテッド Ａ３アデノシン受容体アンタゴニスト
US8058259B2 (en) 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
RU2451010C1 (ru) * 2011-01-11 2012-05-20 Закрытое Акционерное Общество "Ива Фарм" Палладиево-медные катализаторы гомогенного селективного окисления тиольных групп, комбинация и композиция на их основе и способ терапевтического воздействия
CA2876780A1 (en) 2012-06-26 2014-01-03 Saniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014138485A1 (en) * 2013-03-08 2014-09-12 Irm Llc Ex vivo production of platelets from hematopoietic stem cells and the product thereof
AU2018269403B2 (en) * 2017-05-19 2025-03-27 Alltech, Inc. Pharmaceutical agents, compositions, and methods relating thereto
WO2020185859A1 (en) 2019-03-12 2020-09-17 Arcus Biosciences, Inc. Treatment of oncogene-driven cancers
US12310965B2 (en) 2019-03-29 2025-05-27 Arcus Biosciences, Inc. Treatment of cancer utilizing an identified adenosine fingerprint
EP3988100A4 (en) * 2019-06-21 2023-07-26 Academy of Military Medical Sciences ADENOSINE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT OR STEREOISOMERIDE THEREOF AND USE
WO2022143740A1 (zh) * 2020-12-29 2022-07-07 浙江春禾医药科技有限公司 A3腺苷受体激动剂及其制备方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078778A2 (en) * 1999-06-22 2000-12-28 Cv Therapeutics, Inc. C-pyrazole a2a receptor agonists
WO2000078779A2 (en) * 1999-06-22 2000-12-28 Cv Therapeutics, Inc. N-pyrazole a2a receptor agonists
WO2000078777A1 (en) * 1999-06-22 2000-12-28 Cv Therapeutics, Inc. Propargyl phenyl ether a2a receptor agonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078778A2 (en) * 1999-06-22 2000-12-28 Cv Therapeutics, Inc. C-pyrazole a2a receptor agonists
WO2000078779A2 (en) * 1999-06-22 2000-12-28 Cv Therapeutics, Inc. N-pyrazole a2a receptor agonists
WO2000078777A1 (en) * 1999-06-22 2000-12-28 Cv Therapeutics, Inc. Propargyl phenyl ether a2a receptor agonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of medicinal Chemistry, vol.39(3),802-806

Also Published As

Publication number Publication date
NO20040969L (no) 2004-04-19
DE60206775D1 (de) 2006-03-02
HUP0401437A3 (en) 2007-05-29
AU2002327426A2 (en) 2003-02-24
JP4357960B2 (ja) 2009-11-04
JP2005501842A (ja) 2005-01-20
ES2247371T3 (es) 2006-03-01
IL160231A0 (en) 2004-07-25
DE60206775T2 (de) 2006-07-20
NZ530976A (en) 2005-07-29
DK1414837T3 (da) 2005-11-07
AU2002327426B2 (en) 2007-06-14
IL160231A (en) 2010-11-30
AU2002327426C1 (en) 2008-03-06
RU2004106635A (ru) 2005-07-27
ATE307136T1 (de) 2005-11-15
MXPA04001185A (es) 2005-06-17
US20030078232A1 (en) 2003-04-24
CN1244589C (zh) 2006-03-08
CA2456744A1 (en) 2003-02-20
HUP0401437A2 (hu) 2004-11-29
RU2298557C2 (ru) 2007-05-10
EP1414837A1 (en) 2004-05-06
EP1414837B1 (en) 2005-10-19
CN1538972A (zh) 2004-10-20
WO2003014137A1 (en) 2003-02-20
PL368205A1 (en) 2005-03-21
NO327997B1 (no) 2009-11-09
KR20040023733A (ko) 2004-03-18
ZA200401000B (en) 2004-10-18

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