JP2005500298A5 - - Google Patents
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- JP2005500298A5 JP2005500298A5 JP2003504974A JP2003504974A JP2005500298A5 JP 2005500298 A5 JP2005500298 A5 JP 2005500298A5 JP 2003504974 A JP2003504974 A JP 2003504974A JP 2003504974 A JP2003504974 A JP 2003504974A JP 2005500298 A5 JP2005500298 A5 JP 2005500298A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical
- dosage forms
- hikei
- modulator
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000000203 mixture Substances 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000006186 oral dosage form Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 description 5
- 230000001713 cholinergic Effects 0.000 description 4
- 230000000051 modifying Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000035639 Blood Levels Effects 0.000 description 1
- 210000003491 Skin Anatomy 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Description
コリン作動系のモジュレーターと、抗興奮活性を有する物質との組み合わせは、経口的に、または非経口的に投与することができる。既知の投薬形態、例えば経口投与用の錠剤、被覆錠剤または香錠を用いることが可能である。また好適なのは、液体または半液体投薬形態であり、この場合において、剤は、溶液または懸濁液の形態である。用いることができる溶媒または懸濁剤は、水、水性媒体または薬理学的に許容し得る油（植物油または鉱油）である。コリン作動系のモジュレーターと、抗興奮活性を有する物質との組み合わせを含む医薬は、好ましくは、この剤を体に、長期間にわたり制御された方式で送達することができるデポ薬として処方される。
また、本発明において、コリン作動系のモジュレーターと、抗興奮活性を有する物質との組み合わせが、非経口経路により投与されることも可能である。この目的のために、本発明における、コリン作動系のモジュレーターと、抗興奮活性を有する物質との組み合わせの投与のための、経皮的または経粘膜的投薬形態、特に接着性経皮治療システム（活性成分硬膏剤）を用いるのが、特に有利である。これらにより、剤を、制御された方式において、長期間にわたり、皮膚を介して処置するべき患者に送達することが可能になる。
他の利点は、非経口投薬形態を用いると、経口投薬形態を用いるよりも、誤用が、比較的容易に可能ではないことである。所定の活性成分放出領域および所定の放出速度は、患者による過剰投薬を、実質的に不可能にすることができることを意味する。さらに、経皮投薬形態は、他の特性、例えば初回通過効果の回避または血中濃度の一層良好な、一層均一な制御のために、極めて有利である。
Claims (2)
- 経口的に投与される医薬の形態または非経口的に投与される医薬の形態であることを特徴とする、請求項１〜８のいずれかに記載の活性成分の組み合わせ。
- 医薬剤型が、経口投与剤型の形態または非経口投与剤型の形態に製造されることを特徴とする、請求項１１または１２に記載の使用。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10129265A DE10129265A1 (de) | 2001-06-18 | 2001-06-18 | Wirkstoff-Kombination zur medikamentösen Sucht- oder Rauschmitteltherapie |
| PCT/EP2002/006630 WO2002102388A2 (de) | 2001-06-18 | 2002-06-15 | Wirkstoffkombination von z.b. galanthamin oder desoxypeganin mit z.b. acamprosat oder memantin gegen sucht wie z.b. alkoholismus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005500298A JP2005500298A (ja) | 2005-01-06 |
| JP2005500298A5 true JP2005500298A5 (ja) | 2008-02-14 |
Family
ID=7688529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003504974A Pending JP2005500298A (ja) | 2001-06-18 | 2002-06-15 | 嗜癖物質または麻薬に対する依存症を医薬を用いて処置するための活性成分の組み合わせ |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20040192683A1 (ja) |
| EP (1) | EP1397138B1 (ja) |
| JP (1) | JP2005500298A (ja) |
| KR (1) | KR20040010744A (ja) |
| CN (1) | CN1527711A (ja) |
| AR (1) | AR034493A1 (ja) |
| AT (1) | ATE286397T1 (ja) |
| AU (1) | AU2002323873B2 (ja) |
| BR (1) | BR0211008A (ja) |
| CA (1) | CA2450787C (ja) |
| CZ (1) | CZ299951B6 (ja) |
| DE (2) | DE10129265A1 (ja) |
| EA (1) | EA006647B1 (ja) |
| ES (1) | ES2236551T3 (ja) |
| HK (1) | HK1063292A1 (ja) |
| HU (1) | HUP0400865A3 (ja) |
| IL (2) | IL159345A0 (ja) |
| MX (1) | MXPA03011825A (ja) |
| MY (1) | MY129726A (ja) |
| NO (1) | NO20035458D0 (ja) |
| NZ (1) | NZ529944A (ja) |
| PL (1) | PL367207A1 (ja) |
| PT (1) | PT1397138E (ja) |
| SK (1) | SK287180B6 (ja) |
| TW (1) | TWI325320B (ja) |
| UA (1) | UA76753C2 (ja) |
| WO (1) | WO2002102388A2 (ja) |
| ZA (1) | ZA200309232B (ja) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10134038A1 (de) * | 2001-07-12 | 2003-02-06 | Hf Arzneimittelforsch Gmbh | Wirkstoff-Kombination zur medikamentösen Therapie der Nikotinabhängigkeit |
| DE10318714B4 (de) * | 2003-04-25 | 2006-03-23 | Hf Arzneimittelforschung Gmbh | Wirkstoff-Kombinationen und Therapien zur Bekämpfung des Alkoholmissbrauches |
| DE10354894A1 (de) * | 2003-11-24 | 2005-07-07 | Hf Arzneimittelforschung Gmbh | Orale Formulierungen des Desoxypeganins und deren Anwendungen |
| DE102004048927A1 (de) * | 2004-10-06 | 2006-04-20 | Lts Lohmann Therapie-Systeme Ag | Pharmazeutische Kombination enthaltend Desoxypeganin und Cyp2D6 Inhibitoren |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| DK1874282T3 (da) | 2005-04-06 | 2010-10-25 | Adamas Pharmaceuticals Inc | Fremgangsmåder og præparater til behandling af CNS lidelser |
| PT1895994E (pt) * | 2005-05-13 | 2010-12-03 | Alza Corp | Sistema de administração de medicamentos de camada múltipla com barreira contra o fluxo de material do reservatório |
| EP1939238B1 (en) | 2005-09-01 | 2010-10-20 | Mitsubishi Chemical Corporation | Apparatus for heat treatment of polyester particle and method of multistage solid-phase polycondensation of polyester particle |
| US20070104771A1 (en) * | 2005-09-23 | 2007-05-10 | Jay Audett | Transdermal galantamine delivery system |
| US9463172B2 (en) | 2009-02-12 | 2016-10-11 | Indiana University Research & Technology Corporation | Material and methods for treating developmental disorders including comorbid and idiopathic autism |
| JP5885668B2 (ja) | 2009-12-02 | 2016-03-15 | アダマス ファーマシューティカルズ， インコーポレイテッド | アマンタジン組成物および使用方法 |
| EP2621487B1 (en) | 2010-09-28 | 2017-05-03 | Depomed, Inc. | Gastric retentive dosage forms for extended release of acamprosate into the upper gastrointestinal tract |
| PL3884947T3 (pl) * | 2010-12-03 | 2024-05-06 | Nalpropion Pharmaceuticals Llc | Wzrost biodostępności leku w terapii naltreksonem |
| WO2013160728A1 (en) | 2012-04-26 | 2013-10-31 | Alma Mater Studiorum - Universita' Di Bologna | Dual targeting compounds for the treatment of alzheimer's disease |
| US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
| TWI678202B (zh) * | 2016-12-14 | 2019-12-01 | 陸汝斌 | 組合物用於製備治療酒癮或酒精濫用之藥物的用途 |
| CN117860718A (zh) | 2017-08-24 | 2024-04-12 | 阿达玛斯药物有限责任公司 | 金刚烷胺组合物、其制备和使用方法 |
| BG67408B1 (bg) * | 2019-04-12 | 2022-01-17 | Софарма Ад | Перорален лекарствен състав с растителен алкалоид, за лечение на зависимости |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3996934A (en) * | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| US3742951A (en) * | 1971-08-09 | 1973-07-03 | Alza Corp | Bandage for controlled release of vasodilators |
| US4031894A (en) * | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
| DE3315272C2 (de) * | 1983-04-27 | 1986-03-27 | Lohmann Gmbh & Co Kg, 5450 Neuwied | Pharmazeutisches Produkt und Verfahren zu seiner Herstellung |
| DE3843239C1 (ja) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
| EP0424179A3 (en) * | 1989-10-20 | 1991-12-27 | John William Olney | Use of combined excitatory amino acid and cholinergic antagonists to prevent neurological deterioration |
| US5519017A (en) * | 1990-03-29 | 1996-05-21 | Lts Lohmann Therapie-Systeme Gmbh + Co. Kg | Pharmaceutic formulation for the treatment of alcoholism |
| DE4010079A1 (de) * | 1990-03-29 | 1991-10-02 | Lohmann Therapie Syst Lts | Pharmazeutische formulierung zur behandlung des alkoholismus |
| US5668117A (en) * | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
| HU217207B (hu) * | 1994-10-21 | 1999-12-28 | SANOCHEMIA PHARMAZEUTIKA Ag. | Eljárás 4a,5,9,10,11,12-hexahidro-6H-benzofuro[3a,3,2ef][2]-benzazepin-származékok előállítására, és egyes ilyen vegyületek |
| DE19509663A1 (de) * | 1995-03-17 | 1996-09-19 | Lohmann Therapie Syst Lts | Verfahren zur Isolierung von Galanthamin |
| GB9514821D0 (en) * | 1995-07-19 | 1995-09-20 | Sod Conseils Rech Applic | Galanthamine derivatives |
| AT403803B (de) * | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| EP0945133A1 (en) * | 1998-03-26 | 1999-09-29 | Lipha | Combination for the treatment of alcohol and drug dependence containing an opioid antagonist and a NMDA receptor complex modulator |
| JP2002512214A (ja) * | 1998-04-17 | 2002-04-23 | ケネス カリー， | 代謝生成物産生グルタミン酸レセプターアンタゴニストとしてのキュバン誘導体およびそれらの調製プロセス |
| DE19906978B4 (de) * | 1999-02-19 | 2004-07-08 | Lts Lohmann Therapie-Systeme Ag | Pharmazeutische Zusammensetzung enthaltend Desoxypeganin zur Behandlung der Drogenabhängigkeit |
| DE19906979B4 (de) * | 1999-02-19 | 2004-07-08 | Lts Lohmann Therapie-Systeme Ag | Verwendung von Desoxypeganin zur Behandlung der Nikotinabhängigkeit |
| DE19906974C2 (de) * | 1999-02-19 | 2003-10-09 | Lohmann Therapie Syst Lts | Verwendung von Desoxypeganin zur Behandlung des Alkoholismus |
-
2001
- 2001-06-18 DE DE10129265A patent/DE10129265A1/de not_active Withdrawn
-
2002
- 2002-06-14 AR ARP020102244A patent/AR034493A1/es unknown
- 2002-06-15 SK SK1565-2003A patent/SK287180B6/sk not_active IP Right Cessation
- 2002-06-15 KR KR10-2003-7016570A patent/KR20040010744A/ko active Search and Examination
- 2002-06-15 AT AT02754688T patent/ATE286397T1/de not_active IP Right Cessation
- 2002-06-15 EP EP02754688A patent/EP1397138B1/de not_active Expired - Lifetime
- 2002-06-15 PT PT02754688T patent/PT1397138E/pt unknown
- 2002-06-15 BR BR0211008-3A patent/BR0211008A/pt not_active Application Discontinuation
- 2002-06-15 IL IL15934502A patent/IL159345A0/xx active IP Right Grant
- 2002-06-15 CZ CZ20033390A patent/CZ299951B6/cs not_active IP Right Cessation
- 2002-06-15 US US10/480,287 patent/US20040192683A1/en not_active Abandoned
- 2002-06-15 NZ NZ529944A patent/NZ529944A/en unknown
- 2002-06-15 CA CA002450787A patent/CA2450787C/en not_active Expired - Fee Related
- 2002-06-15 PL PL02367207A patent/PL367207A1/xx unknown
- 2002-06-15 EA EA200400041A patent/EA006647B1/ru not_active IP Right Cessation
- 2002-06-15 JP JP2003504974A patent/JP2005500298A/ja active Pending
- 2002-06-15 AU AU2002323873A patent/AU2002323873B2/en not_active Ceased
- 2002-06-15 MX MXPA03011825A patent/MXPA03011825A/es active IP Right Grant
- 2002-06-15 DE DE50201958T patent/DE50201958D1/de not_active Expired - Lifetime
- 2002-06-15 ES ES02754688T patent/ES2236551T3/es not_active Expired - Lifetime
- 2002-06-15 CN CNA028110196A patent/CN1527711A/zh active Pending
- 2002-06-15 UA UA20031211802A patent/UA76753C2/uk unknown
- 2002-06-15 HU HU0400865A patent/HUP0400865A3/hu unknown
- 2002-06-15 WO PCT/EP2002/006630 patent/WO2002102388A2/de active IP Right Grant
- 2002-06-17 TW TW091113176A patent/TWI325320B/zh not_active IP Right Cessation
- 2002-06-17 MY MYPI20022245A patent/MY129726A/en unknown
-
2003
- 2003-11-27 ZA ZA200309232A patent/ZA200309232B/xx unknown
- 2003-12-08 NO NO20035458A patent/NO20035458D0/no not_active Application Discontinuation
- 2003-12-11 IL IL159345A patent/IL159345A/en not_active IP Right Cessation
-
2004
- 2004-08-12 HK HK04106071A patent/HK1063292A1/xx not_active IP Right Cessation
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