JP2005306755A - 2−ベンゾイルオキシアセトアルデヒド誘導体の製造法 - Google Patents
2−ベンゾイルオキシアセトアルデヒド誘導体の製造法 Download PDFInfo
- Publication number
- JP2005306755A JP2005306755A JP2004123469A JP2004123469A JP2005306755A JP 2005306755 A JP2005306755 A JP 2005306755A JP 2004123469 A JP2004123469 A JP 2004123469A JP 2004123469 A JP2004123469 A JP 2004123469A JP 2005306755 A JP2005306755 A JP 2005306755A
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- Prior art keywords
- formula
- group
- represented
- carbon
- benzoyloxyacetaldehyde
- Prior art date
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- OQEDEGGYERFFGP-UHFFFAOYSA-N 2-oxoethyl benzoate Chemical class O=CCOC(=O)C1=CC=CC=C1 OQEDEGGYERFFGP-UHFFFAOYSA-N 0.000 title claims abstract description 17
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 14
- 150000001875 compounds Chemical class 0.000 claims abstract description 30
- 125000001424 substituent group Chemical group 0.000 claims abstract description 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 12
- 229910001508 alkali metal halide Inorganic materials 0.000 claims abstract description 10
- 150000008045 alkali metal halides Chemical class 0.000 claims abstract description 10
- WDLUEZJSSHTKAP-UHFFFAOYSA-N acetaldehyde;1,1-diethoxyethane Chemical class CC=O.CCOC(C)OCC WDLUEZJSSHTKAP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 5
- 150000001340 alkali metals Chemical group 0.000 claims abstract description 5
- 125000005843 halogen group Chemical group 0.000 claims abstract description 5
- 125000001183 hydrocarbyl group Chemical group 0.000 claims abstract 4
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical group [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 21
- -1 hydroxy mercaptan compound Chemical class 0.000 claims description 16
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 9
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 9
- 235000010235 potassium benzoate Nutrition 0.000 claims description 9
- 239000004300 potassium benzoate Substances 0.000 claims description 9
- 229940103091 potassium benzoate Drugs 0.000 claims description 9
- 239000003377 acid catalyst Substances 0.000 claims description 7
- 229940050390 benzoate Drugs 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 229910052801 chlorine Inorganic materials 0.000 claims description 7
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 7
- OVXJWSYBABKZMD-UHFFFAOYSA-N 2-chloro-1,1-diethoxyethane Chemical compound CCOC(CCl)OCC OVXJWSYBABKZMD-UHFFFAOYSA-N 0.000 claims description 6
- CRZJPEIBPQWDGJ-UHFFFAOYSA-N 2-chloro-1,1-dimethoxyethane Chemical compound COC(CCl)OC CRZJPEIBPQWDGJ-UHFFFAOYSA-N 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 150000001721 carbon Chemical group 0.000 claims description 3
- 239000011203 carbon fibre reinforced carbon Chemical group 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 125000004429 atom Chemical group 0.000 claims description 2
- 150000001558 benzoic acid derivatives Chemical class 0.000 abstract description 7
- 239000002994 raw material Substances 0.000 abstract description 5
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 description 34
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 18
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 13
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- 150000002430 hydrocarbons Chemical group 0.000 description 8
- 238000001914 filtration Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 5
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 5
- 125000002723 alicyclic group Chemical group 0.000 description 5
- 125000001931 aliphatic group Chemical group 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 5
- 238000006482 condensation reaction Methods 0.000 description 5
- 239000012044 organic layer Substances 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 150000001241 acetals Chemical group 0.000 description 4
- 125000000753 cycloalkyl group Chemical group 0.000 description 4
- 238000004821 distillation Methods 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 3
- XFKJXKXIKVQFTM-UHFFFAOYSA-N C(C)OC(CCl)OCC.C(C)OC(COC(C1=CC=CC=C1)=O)OCC Chemical compound C(C)OC(CCl)OCC.C(C)OC(COC(C1=CC=CC=C1)=O)OCC XFKJXKXIKVQFTM-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 3
- 125000000623 heterocyclic group Chemical group 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 2
- SPEUIVXLLWOEMJ-UHFFFAOYSA-N 1,1-dimethoxyethane Chemical compound COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- IKKUKDZKIIIKJK-UHFFFAOYSA-N 2,2-diethoxyethanol Chemical compound CCOC(CO)OCC IKKUKDZKIIIKJK-UHFFFAOYSA-N 0.000 description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- SHLSSLVZXJBVHE-UHFFFAOYSA-N 3-sulfanylpropan-1-ol Chemical compound OCCCS SHLSSLVZXJBVHE-UHFFFAOYSA-N 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 2
- 150000008041 alkali metal carbonates Chemical class 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- WJTCGQSWYFHTAC-UHFFFAOYSA-N cyclooctane Chemical compound C1CCCCCCC1 WJTCGQSWYFHTAC-UHFFFAOYSA-N 0.000 description 2
- 239000004914 cyclooctane Substances 0.000 description 2
- BBGKDYHZQOSNMU-UHFFFAOYSA-N dicyclohexano-18-crown-6 Chemical compound O1CCOCCOC2CCCCC2OCCOCCOC2CCCCC21 BBGKDYHZQOSNMU-UHFFFAOYSA-N 0.000 description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 239000012847 fine chemical Substances 0.000 description 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 125000001624 naphthyl group Chemical group 0.000 description 2
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 2
- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 2
- 239000002798 polar solvent Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 229930195734 saturated hydrocarbon Natural products 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 description 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 description 1
- VDFVNEFVBPFDSB-UHFFFAOYSA-N 1,3-dioxane Chemical group C1COCOC1 VDFVNEFVBPFDSB-UHFFFAOYSA-N 0.000 description 1
- CZLMRJZAHXYRIX-UHFFFAOYSA-N 1,3-dioxepane Chemical group C1CCOCOC1 CZLMRJZAHXYRIX-UHFFFAOYSA-N 0.000 description 1
- GFAJOMHUNNCCJQ-UHFFFAOYSA-N 1,3-dioxetane Chemical group C1OCO1 GFAJOMHUNNCCJQ-UHFFFAOYSA-N 0.000 description 1
- CJSITSBWCLTCAP-UHFFFAOYSA-N 1,3-dioxocane Chemical group C1CCOCOCC1 CJSITSBWCLTCAP-UHFFFAOYSA-N 0.000 description 1
- 125000006091 1,3-dioxolane group Chemical group 0.000 description 1
- WJJSZTJGFCFNKI-UHFFFAOYSA-N 1,3-oxathiolane Chemical compound C1CSCO1 WJJSZTJGFCFNKI-UHFFFAOYSA-N 0.000 description 1
- RPBLJRRVGJPMEZ-UHFFFAOYSA-N 1-(2-chloro-1-propoxyethoxy)propane Chemical compound CCCOC(CCl)OCCC RPBLJRRVGJPMEZ-UHFFFAOYSA-N 0.000 description 1
- HLVFKOKELQSXIQ-UHFFFAOYSA-N 1-bromo-2-methylpropane Chemical compound CC(C)CBr HLVFKOKELQSXIQ-UHFFFAOYSA-N 0.000 description 1
- VFNOSXNBZJRVET-UHFFFAOYSA-N 1-chloro-1,1-diethoxyethane Chemical compound CCOC(C)(Cl)OCC VFNOSXNBZJRVET-UHFFFAOYSA-N 0.000 description 1
- FETFXNFGOYOOSP-UHFFFAOYSA-N 1-sulfanylpropan-2-ol Chemical compound CC(O)CS FETFXNFGOYOOSP-UHFFFAOYSA-N 0.000 description 1
- QFKKHAZEIWDXRZ-UHFFFAOYSA-N 2,2-diethoxyethyl benzoate Chemical compound CCOC(OCC)COC(=O)C1=CC=CC=C1 QFKKHAZEIWDXRZ-UHFFFAOYSA-N 0.000 description 1
- WHSAZJZPFFJHKA-UHFFFAOYSA-N 2,2-dimethoxyethyl benzoate Chemical compound COC(OC)COC(=O)C1=CC=CC=C1 WHSAZJZPFFJHKA-UHFFFAOYSA-N 0.000 description 1
- DYZANRMDXUPKLR-UHFFFAOYSA-N 2-(2-chloro-1-propan-2-yloxyethoxy)propane Chemical compound CC(C)OC(CCl)OC(C)C DYZANRMDXUPKLR-UHFFFAOYSA-N 0.000 description 1
- LILXDMFJXYAKMK-UHFFFAOYSA-N 2-bromo-1,1-diethoxyethane Chemical compound CCOC(CBr)OCC LILXDMFJXYAKMK-UHFFFAOYSA-N 0.000 description 1
- SNSIPRZLEMCODT-UHFFFAOYSA-N 2-iodo-1,1-dimethoxyethane Chemical compound COC(CI)OC SNSIPRZLEMCODT-UHFFFAOYSA-N 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- VMKYTRPNOVFCGZ-UHFFFAOYSA-N 2-sulfanylphenol Chemical compound OC1=CC=CC=C1S VMKYTRPNOVFCGZ-UHFFFAOYSA-N 0.000 description 1
- QNNVICQPXUUBSN-UHFFFAOYSA-N 2-sulfanylpropan-1-ol Chemical compound CC(S)CO QNNVICQPXUUBSN-UHFFFAOYSA-N 0.000 description 1
- 150000000565 5-membered heterocyclic compounds Chemical class 0.000 description 1
- 150000000644 6-membered heterocyclic compounds Chemical class 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 238000000023 Kugelrohr distillation Methods 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- NMPVEAUIHMEAQP-UHFFFAOYSA-N alpha-bromo-acetaldehyde Natural products BrCC=O NMPVEAUIHMEAQP-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 229940092714 benzenesulfonic acid Drugs 0.000 description 1
- 150000001559 benzoic acids Chemical class 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 150000001649 bromium compounds Chemical class 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229910052792 caesium Inorganic materials 0.000 description 1
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 1
- LYQFWZFBNBDLEO-UHFFFAOYSA-M caesium bromide Chemical compound [Br-].[Cs+] LYQFWZFBNBDLEO-UHFFFAOYSA-M 0.000 description 1
- XQPRBTXUXXVTKB-UHFFFAOYSA-M caesium iodide Chemical compound [I-].[Cs+] XQPRBTXUXXVTKB-UHFFFAOYSA-M 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 229940023913 cation exchange resins Drugs 0.000 description 1
- BLUMOBPWAAOPOY-UHFFFAOYSA-M cesium;benzoate Chemical compound [Cs+].[O-]C(=O)C1=CC=CC=C1 BLUMOBPWAAOPOY-UHFFFAOYSA-M 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 1
- 125000004663 dialkyl amino group Chemical group 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 125000001188 haloalkyl group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 150000002440 hydroxy compounds Chemical class 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 229940031993 lithium benzoate Drugs 0.000 description 1
- LDJNSLOKTFFLSL-UHFFFAOYSA-M lithium;benzoate Chemical compound [Li+].[O-]C(=O)C1=CC=CC=C1 LDJNSLOKTFFLSL-UHFFFAOYSA-M 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 239000011973 solid acid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 238000007039 two-step reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
- C07C67/11—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond being mineral ester groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/78—Benzoic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
【解決手段】 本発明の2−ベンゾイルオキシアセトアルデヒド誘導体の製造法は、アルカリ金属ハロゲン化物の存在下、下記式(1)
【化1】
(式中、R1、R2は同一又は異なって炭化水素基を示す。R1とR2は互いに結合して隣接する酸素−炭素−酸素結合とともに環を形成していてもよい。Xはハロゲン原子を示す)で表されるハロゲン化アセトアルデヒドアセタール誘導体と、下記式(2)
【化2】
(式中、Mはアルカリ金属原子を示す。式中のベンゼン環は置換基を有していてもよい)で表される安息香酸塩類を反応させて、下記式(3)
【化3】
(式中、R1、R2は前記に同じ。式中のベンゼン環は置換基を有していてもよい)で表される化合物を得ることを特徴とする。
【選択図】 なし
Description
で表されるハロゲン化アセトアルデヒドアセタール誘導体と、下記式(2)
で表される安息香酸塩類を反応させて、下記式(3)
で表される化合物を得ることを特徴とする2−ベンゾイルオキシアセトアルデヒド誘導体の製造法を提供する。
で表される化合物を得た後、該化合物を、酸触媒の存在下で、下記式(4)
で表されるヒドロキシメルカプタン化合物と反応させて、下記式(5)
で表される化合物を得ることを特徴とする2−ベンゾイルオキシアセトアルデヒド誘導体の製造法を提供する。
2−ベンゾイルオキシアセトアルデヒドジメチルアセタールの製造
三ツ口フラスコにクロロアセトアルデヒドジメチルアセタール(50.0g)、安息香酸カリウム(70.7g)、ヨウ化カリウム(6.66g)およびDMF(N,N−ジメチルホルムアミド)(250mL)を加え還流させた。20時間後、反応液を室温まで冷却し、水(250mL)、酢酸エチル(250mL)を加えて撹拌した。ろ過後、濾液に酢酸エチル(500mL)を加えて抽出した。有機層を減圧濃縮し、続いて減圧蒸留(132−135℃/5mmHg)を行うことにより目的物(61.0g、収率72%)を得た。
1H-NMR(CDCl3) δ: 8.06(m, 2H), 7.56(m, 1H), 7.44(m, 2H), 4.72(t, 1H), 4.36(d, 2H), 3.44(s, 6H)
2−ベンゾイルオキシアセトアルデヒドジエチルアセタールの製造
三ツ口フラスコにクロロアセトアルデヒドジエチルアセタール(2.00g)、安息香酸カリウム(1.91g)、ヨウ化カリウム(0.41g)およびDMF(20mL)を加え還流させた。20時間後、反応液を室温まで冷却し、水(30mL)、酢酸エチル(80mL)を加えて撹拌した。ろ過後、有機層を分離し、減圧濃縮、続いてクーゲルロール蒸留(110−120℃/1mmHg)を行うことにより目的物(2.41g、収率77%)を得た。
2−ベンゾイルオキシアセトアルデヒドジエチルアセタールの製造
三ツ口フラスコにクロロアセトアルデヒドジエチルアセタール(2.00g)、安息香酸カリウム(1.91g)および臭化カリウム(0.30g)およびDMF(20mL)を加え還流させた。20時間後、反応液を室温まで冷却し、水(30mL)、酢酸エチル(80mL)を加えて撹拌した。ろ過後、有機層を水(30mL)で洗浄し、無水硫酸ナトリウムで乾燥した。ろ過、減圧濃縮することにより目的物(0.97g、収率31%)を得た。
2−ベンゾイルオキシアセトアルデヒドジエチルアセタールの製造
三ツ口フラスコにクロロアセトアルデヒドジエチルアセタール(2.00g)、安息香酸(2.16g)、ヨウ化カリウム(0.27g)、炭酸カリウム(1.11g)およびDMF(20mL)を加え還流させた。20時間後、反応液を室温まで冷却し、水(30mL)、酢酸エチル(80mL)を加えて撹拌した。ろ過後、有機層を分離し、減圧濃縮することにより目的物(1.74g、収率56%)を得た。
2−ベンゾイルオキシメチル−1,3−オキサチオランの製造
三ツ口フラスコに実施例1で得た2−ベンゾイルオキシアセトアルデヒドジメチルアセタール(50.0g)、2−メルカプトエタノール(20.4g)、p−トルエンスルホン酸・一水和物(0.90g)、およびトルエン(250mL)を加え加熱した。副生するメタノールは溶媒とともに留去した。150mL程度留出した後、反応液を室温まで冷却し、飽和炭酸水素ナトリウム水溶液および水で洗浄した後、無水炭酸ナトリウムを加えて乾燥した。ろ過後、減圧蒸留(144−147℃/0.60mmHg)によって目的物(54.9g、収率100%)を得た。
1H-NMR(CDCl3) δ: 8.07(m, 2H), 7.55(m, 1H), 7.44(m, 2H), 5.47(dd, 1H), 4.43(m, 2H), 4.29(m, 1H), 4.01(m, 1H), 3.06(m, 2H)
三ツ口フラスコにクロロアセトアルデヒドジエチルアセタール(1.9g)、安息香酸カリウム(2.0g)およびDMF(20mL)を加え還流させた。20時間後、反応液を室温まで冷却し、水(60mL)、酢酸エチル(80mL)を加えて撹拌した。ろ過後、分液し、有機層を濃縮することにより目的物(0.69g、収率30%)を得た。
Claims (5)
- 式(1)におけるXが塩素原子であり、アルカリ金属ハロゲン化物がヨウ化カリウムである請求項1記載の2−ベンゾイルオキシアセトアルデヒド誘導体の製造法。
- 式(1)で表されるハロゲン化アセトアルデヒドアセタール誘導体が、クロロアセトアルデヒドジメチルアセタール又はクロロアセトアルデヒドジエチルアセタールである請求項1又は2記載の2−ベンゾイルオキシアセトアルデヒド誘導体の製造法。
- 式(2)で表される安息香酸塩類が安息香酸カリウムである請求項1〜3の何れかの項に記載の2−ベンゾイルオキシアセトアルデヒド誘導体の製造法。
- 請求項1〜4の何れかの項に記載の方法により下記式(3)
で表される化合物を得た後、該化合物を、酸触媒の存在下で、下記式(4)
で表されるヒドロキシメルカプタン化合物と反応させて、下記式(5)
で表される化合物を得ることを特徴とする2−ベンゾイルオキシアセトアルデヒド誘導体の製造法。
Priority Applications (5)
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JP2004123469A JP4653966B2 (ja) | 2004-04-19 | 2004-04-19 | 2−ベンゾイルオキシアセトアルデヒド誘導体の製造法 |
GB0504337A GB2413325B (en) | 2004-04-19 | 2005-03-02 | Process for producing 2-benzoyloxyacetaldehyde derivative |
US11/076,900 US7692033B2 (en) | 2004-04-19 | 2005-03-11 | Process for producing 2-benzoyloxyacetaldehyde derivative |
CNB2005100659306A CN100556886C (zh) | 2004-04-19 | 2005-04-15 | 生产2-苯甲酰氧基乙醛衍生物的方法 |
US12/397,756 US7728152B2 (en) | 2004-04-19 | 2009-03-04 | Process for producing 2-benzoyloxyacetaldehyde derivative |
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JP2004123469A JP4653966B2 (ja) | 2004-04-19 | 2004-04-19 | 2−ベンゾイルオキシアセトアルデヒド誘導体の製造法 |
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JP4653966B2 JP4653966B2 (ja) | 2011-03-16 |
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GB (1) | GB2413325B (ja) |
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CN106883122B (zh) * | 2017-01-11 | 2020-01-14 | 南京林业大学 | 乙烯基间苯二甲酸二烷基酯单体及其液晶聚合物和制备方法 |
CN114853604B (zh) * | 2022-04-06 | 2023-05-30 | 万华化学集团股份有限公司 | 一种五碳醛的制备方法 |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6110548A (ja) * | 1984-06-27 | 1986-01-18 | Mitsui Petrochem Ind Ltd | スルホンアミド類 |
JPS6210058A (ja) * | 1985-07-09 | 1987-01-19 | Marubishi Yuka Kogyo Kk | ビス(4−ヒドロキシ−3,5−ジブロモフエニル)スルホン誘導体の製法 |
JPS62135466A (ja) * | 1985-11-22 | 1987-06-18 | チバ−ガイギ− アクチエンゲゼルシヤフト | ハロアルコキシ−置換2−(1h−1,2,4−トリアゾリル)−1−フエニルエタン−1−オンケタ−ル、その製法及び該化合物を含有する殺微生物剤 |
JPS6490149A (en) * | 1987-08-14 | 1989-04-06 | Boehringer Biochemia Srl | Pharmacological ethers and thioethers, manufacture and drug composition |
JPH02149554A (ja) * | 1988-02-19 | 1990-06-08 | Hokuriku Seiyaku Co Ltd | フェノキシエチルアミン誘導体 |
JPH03159782A (ja) * | 1989-11-17 | 1991-07-09 | Mitsubishi Paper Mills Ltd | 感熱記録材料 |
JPH0429987A (ja) * | 1990-05-23 | 1992-01-31 | Mitsubishi Paper Mills Ltd | 1,3―オキサチオラン化合物の製造方法 |
JPH0495058A (ja) * | 1990-08-07 | 1992-03-27 | Xingnong Co Ltd | ビス(4―アリルオキシ―3,5―ジブロモフェニル)スルホンの製造方法 |
JP2001139510A (ja) * | 1999-11-17 | 2001-05-22 | Nippon Synthetic Chem Ind Co Ltd:The | 2−ベンジロキシアセトアルデヒドジアルキルアセタールの製造方法 |
JP2002030021A (ja) * | 2000-07-05 | 2002-01-29 | Dsm Fine Chemicals Austria Nachfolger Gmbh & Co Kg | アルキル−またはアリールオキシアセトアルデヒドを製造する方法 |
WO2003051298A2 (en) * | 2001-12-14 | 2003-06-26 | Pharmasset Ltd. | Preparation of intermediates useful in the synthesis of antiviral nucleosides |
US20030135048A1 (en) * | 2001-06-15 | 2003-07-17 | Shire Biochem Inc. | Stereoselective methods for the preparation of nucleosides |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60190464A (ja) * | 1984-03-12 | 1985-09-27 | Ricoh Co Ltd | 2−ピリジルヒドラゾン誘導体 |
AT410791B (de) * | 2000-05-31 | 2003-07-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von acyloxyacetaldehyden |
-
2004
- 2004-04-19 JP JP2004123469A patent/JP4653966B2/ja not_active Expired - Fee Related
-
2005
- 2005-03-02 GB GB0504337A patent/GB2413325B/en not_active Expired - Fee Related
- 2005-03-11 US US11/076,900 patent/US7692033B2/en not_active Expired - Fee Related
- 2005-04-15 CN CNB2005100659306A patent/CN100556886C/zh not_active Expired - Fee Related
-
2009
- 2009-03-04 US US12/397,756 patent/US7728152B2/en not_active Expired - Fee Related
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6110548A (ja) * | 1984-06-27 | 1986-01-18 | Mitsui Petrochem Ind Ltd | スルホンアミド類 |
JPS6210058A (ja) * | 1985-07-09 | 1987-01-19 | Marubishi Yuka Kogyo Kk | ビス(4−ヒドロキシ−3,5−ジブロモフエニル)スルホン誘導体の製法 |
JPS62135466A (ja) * | 1985-11-22 | 1987-06-18 | チバ−ガイギ− アクチエンゲゼルシヤフト | ハロアルコキシ−置換2−(1h−1,2,4−トリアゾリル)−1−フエニルエタン−1−オンケタ−ル、その製法及び該化合物を含有する殺微生物剤 |
JPS6490149A (en) * | 1987-08-14 | 1989-04-06 | Boehringer Biochemia Srl | Pharmacological ethers and thioethers, manufacture and drug composition |
JPH02149554A (ja) * | 1988-02-19 | 1990-06-08 | Hokuriku Seiyaku Co Ltd | フェノキシエチルアミン誘導体 |
JPH03159782A (ja) * | 1989-11-17 | 1991-07-09 | Mitsubishi Paper Mills Ltd | 感熱記録材料 |
JPH0429987A (ja) * | 1990-05-23 | 1992-01-31 | Mitsubishi Paper Mills Ltd | 1,3―オキサチオラン化合物の製造方法 |
JPH0495058A (ja) * | 1990-08-07 | 1992-03-27 | Xingnong Co Ltd | ビス(4―アリルオキシ―3,5―ジブロモフェニル)スルホンの製造方法 |
JP2001139510A (ja) * | 1999-11-17 | 2001-05-22 | Nippon Synthetic Chem Ind Co Ltd:The | 2−ベンジロキシアセトアルデヒドジアルキルアセタールの製造方法 |
JP2002030021A (ja) * | 2000-07-05 | 2002-01-29 | Dsm Fine Chemicals Austria Nachfolger Gmbh & Co Kg | アルキル−またはアリールオキシアセトアルデヒドを製造する方法 |
US20030135048A1 (en) * | 2001-06-15 | 2003-07-17 | Shire Biochem Inc. | Stereoselective methods for the preparation of nucleosides |
WO2003051298A2 (en) * | 2001-12-14 | 2003-06-26 | Pharmasset Ltd. | Preparation of intermediates useful in the synthesis of antiviral nucleosides |
Also Published As
Publication number | Publication date |
---|---|
JP4653966B2 (ja) | 2011-03-16 |
CN100556886C (zh) | 2009-11-04 |
US7692033B2 (en) | 2010-04-06 |
US20090192321A1 (en) | 2009-07-30 |
GB0504337D0 (en) | 2005-04-06 |
CN1690038A (zh) | 2005-11-02 |
US7728152B2 (en) | 2010-06-01 |
GB2413325A (en) | 2005-10-26 |
US20050234246A1 (en) | 2005-10-20 |
GB2413325B (en) | 2007-01-31 |
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