JP2005247873A5 - - Google Patents

Info

Publication number

JP2005247873A5

JP2005247873A5 JP2005159852A JP2005159852A JP2005247873A5 JP 2005247873 A5 JP2005247873 A5 JP 2005247873A5 JP 2005159852 A JP2005159852 A JP 2005159852A JP 2005159852 A JP2005159852 A JP 2005159852A JP 2005247873 A5 JP2005247873 A5 JP 2005247873A5

Authority

JP

Japan

Prior art keywords

acid

hydroxy

diphosphonic acid

bisphosphonate

amino

Prior art date

2005-05-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 229940122361 Bisphosphonate Drugs 0.000 claims 12
• 150000004663 bisphosphonates Chemical class 0.000 claims 11
• OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims 3
• MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 claims 3
• IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims 3
• ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 3
• WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical group OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 3
• PMXAPNNYCFBALB-UHFFFAOYSA-N (1-hydroxy-1-phosphono-3-pyrrolidin-1-ylpropyl)phosphonic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CCN1CCCC1 PMXAPNNYCFBALB-UHFFFAOYSA-N 0.000 claims 2
• DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims 2
• 208000001132 Osteoporosis Diseases 0.000 claims 2
• DKJJVAGXPKPDRL-UHFFFAOYSA-N Tiludronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1 DKJJVAGXPKPDRL-UHFFFAOYSA-N 0.000 claims 2
• NPLHDPAQRZJWHX-UHFFFAOYSA-N [5,5-bis(diethoxyphosphoryl)-1,4-dihydropyrazol-3-yl]-phenylmethanone Chemical class N1C(P(=O)(OCC)OCC)(P(=O)(OCC)OCC)CC(C(=O)C=2C=CC=CC=2)=N1 NPLHDPAQRZJWHX-UHFFFAOYSA-N 0.000 claims 2
• 239000002253 acid Substances 0.000 claims 2
• 229940062527 alendronate Drugs 0.000 claims 2
• 229960002286 clodronic acid Drugs 0.000 claims 2
• VMMKGHQPQIEGSQ-UHFFFAOYSA-N minodronic acid Chemical compound C1=CC=CN2C(CC(O)(P(O)(O)=O)P(O)(O)=O)=CN=C21 VMMKGHQPQIEGSQ-UHFFFAOYSA-N 0.000 claims 2
• 238000011321 prophylaxis Methods 0.000 claims 2
• RDFHOSXBGDLRQF-UHFFFAOYSA-N (2-anilino-1-phosphono-2-sulfanylideneethyl)phosphonic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)C(=S)NC1=CC=CC=C1 RDFHOSXBGDLRQF-UHFFFAOYSA-N 0.000 claims 1
• HLNJFEXZDGURGZ-UHFFFAOYSA-M 1-methylpyridin-1-ium;iodide Chemical compound [I-].C[N+]1=CC=CC=C1 HLNJFEXZDGURGZ-UHFFFAOYSA-M 0.000 claims 1
• FQYJIIQYLCWPDD-UHFFFAOYSA-N 3-[methyl(2-phenylsulfanylethyl)amino]propan-1-ol Chemical compound OCCCN(C)CCSC1=CC=CC=C1 FQYJIIQYLCWPDD-UHFFFAOYSA-N 0.000 claims 1
• -1 N, N-di-methyl-amino Chemical group 0.000 claims 1
• PQBAWAQIRZIWIV-UHFFFAOYSA-N N-methylpyridinium Chemical class C[N+]1=CC=CC=C1 PQBAWAQIRZIWIV-UHFFFAOYSA-N 0.000 claims 1
• VADUXZPJGJBSLQ-UHFFFAOYSA-N [1-hydroxy-3-(1-methylpyridin-1-ium-3-yl)-1-phosphonopropyl]phosphonic acid;hydroxide Chemical compound [OH-].C[N+]1=CC=CC(CCC(O)(P(O)(O)=O)P(O)(O)=O)=C1 VADUXZPJGJBSLQ-UHFFFAOYSA-N 0.000 claims 1
• 150000007513 acids Chemical class 0.000 claims 1
• 230000008416 bone turnover Effects 0.000 claims 1
• JFGHPLSPUGOSLV-UHFFFAOYSA-L disodium;[3-(dimethylamino)-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate Chemical compound [Na+].[Na+].CN(C)CCC(O)(P(O)(O)=O)P([O-])([O-])=O JFGHPLSPUGOSLV-UHFFFAOYSA-L 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940009626 etidronate Drugs 0.000 claims 1
• 229940015872 ibandronate Drugs 0.000 claims 1
• 229960005236 ibandronic acid Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• PUUSSSIBPPTKTP-UHFFFAOYSA-N neridronic acid Chemical compound NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O PUUSSSIBPPTKTP-UHFFFAOYSA-N 0.000 claims 1
• 229940046231 pamidronate Drugs 0.000 claims 1
• 229960003978 pamidronic acid Drugs 0.000 claims 1
• 229940089617 risedronate Drugs 0.000 claims 1
• 229960000759 risedronic acid Drugs 0.000 claims 1
• 229940019375 tiludronate Drugs 0.000 claims 1
• 238000011282 treatment Methods 0.000 claims 1
• 229960004276 zoledronic acid Drugs 0.000 claims 1