JP2005097237A5 - - Google Patents

Info

Publication number

JP2005097237A5

JP2005097237A5 JP2004068255A JP2004068255A JP2005097237A5 JP 2005097237 A5 JP2005097237 A5 JP 2005097237A5 JP 2004068255 A JP2004068255 A JP 2004068255A JP 2004068255 A JP2004068255 A JP 2004068255A JP 2005097237 A5 JP2005097237 A5 JP 2005097237A5

Authority

JP

Japan

Prior art keywords

acid sequence

amino acid

seq

sequence represented

polypeptide

Prior art date

2004-03-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 153
• 108090000765 processed proteins & peptides Proteins 0.000 claims 108
• 229920001184 polypeptide Polymers 0.000 claims 86
• 102000004196 processed proteins & peptides Human genes 0.000 claims 86
• 230000001737 promoting effect Effects 0.000 claims 66
• 150000003839 salts Chemical class 0.000 claims 63
• 230000028327 secretion Effects 0.000 claims 45
• 230000027455 binding Effects 0.000 claims 40
• 102000006771 Gonadotropins Human genes 0.000 claims 39
• 108010086677 Gonadotropins Proteins 0.000 claims 39
• 239000002622 gonadotropin Substances 0.000 claims 39
• 102000040430 polynucleotide Human genes 0.000 claims 39
• 108091033319 polynucleotide Proteins 0.000 claims 39
• 239000002157 polynucleotide Substances 0.000 claims 39
• 230000016087 ovulation Effects 0.000 claims 34
• 239000003795 chemical substances by application Substances 0.000 claims 33
• 230000004936 stimulating effect Effects 0.000 claims 32
• 150000001413 amino acids Chemical class 0.000 claims 20
• 102000004169 proteins and genes Human genes 0.000 claims 19
• 108090000623 proteins and genes Proteins 0.000 claims 19
• 210000002149 gonad Anatomy 0.000 claims 13
• 230000002710 gonadal effect Effects 0.000 claims 12
• 239000003112 inhibitor Substances 0.000 claims 10
• 239000003163 gonadal steroid hormone Substances 0.000 claims 8
• 238000012216 screening Methods 0.000 claims 8
• 230000036512 infertility Effects 0.000 claims 5
• 208000000509 infertility Diseases 0.000 claims 5
• 231100000535 infertility Toxicity 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 239000000032 diagnostic agent Substances 0.000 claims 4
• 229940039227 diagnostic agent Drugs 0.000 claims 4
• 239000005556 hormone Substances 0.000 claims 4
• 229940088597 hormone Drugs 0.000 claims 4
• 201000009273 Endometriosis Diseases 0.000 claims 3
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 150000001875 compounds Chemical class 0.000 claims 3
• 238000011321 prophylaxis Methods 0.000 claims 3
• 238000011282 treatment Methods 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 230000001939 inductive effect Effects 0.000 claims 2
• 230000035800 maturation Effects 0.000 claims 2
• 230000000580 secretagogue effect Effects 0.000 claims 2
• 230000001568 sexual effect Effects 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 230000004913 activation Effects 0.000 claims 1
• 230000035558 fertility Effects 0.000 claims 1
• 230000003325 follicular Effects 0.000 claims 1
• 230000001456 gonadotroph Effects 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 230000003248 secreting effect Effects 0.000 claims 1