JP2004536078A - 炎症プロセスおおび／または免疫疾患に対するイミダゾトリアジノン誘導体およびそれらの使用 - Google Patents
炎症プロセスおおび／または免疫疾患に対するイミダゾトリアジノン誘導体およびそれらの使用 Download PDFInfo
- Publication number
- JP2004536078A JP2004536078A JP2003502000A JP2003502000A JP2004536078A JP 2004536078 A JP2004536078 A JP 2004536078A JP 2003502000 A JP2003502000 A JP 2003502000A JP 2003502000 A JP2003502000 A JP 2003502000A JP 2004536078 A JP2004536078 A JP 2004536078A
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- tert
- yield
- embedded image
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCc(nc1*)c2[n]1N=C(*)NC2=O Chemical compound CCc(nc1*)c2[n]1N=C(*)NC2=O 0.000 description 4
- WZVZUKROCHDMDT-UHFFFAOYSA-N CCC(C(O)=O)NC(C)=O Chemical compound CCC(C(O)=O)NC(C)=O WZVZUKROCHDMDT-UHFFFAOYSA-N 0.000 description 1
- SBIGYTCANPNGIF-UHFFFAOYSA-N CCC(C1=NN=C(C(C)(C)C)NC1=O)NC(C(CC1)CCC1C(C)(C)C)=O Chemical compound CCC(C1=NN=C(C(C)(C)C)NC1=O)NC(C(CC1)CCC1C(C)(C)C)=O SBIGYTCANPNGIF-UHFFFAOYSA-N 0.000 description 1
- NIRGQYMNTIFYFI-UHFFFAOYSA-N CCC(C1=NN=C(C2CCCC2)NC1=O)NC(C)=O Chemical compound CCC(C1=NN=C(C2CCCC2)NC1=O)NC(C)=O NIRGQYMNTIFYFI-UHFFFAOYSA-N 0.000 description 1
- ZUZHFKLADFQQKZ-UHFFFAOYSA-N CCC(C1=NN=C(c2cccc([N+]([O-])=O)c2)NC1=O)N Chemical compound CCC(C1=NN=C(c2cccc([N+]([O-])=O)c2)NC1=O)N ZUZHFKLADFQQKZ-UHFFFAOYSA-N 0.000 description 1
- SEMFAIIOMJFFIO-UHFFFAOYSA-N CCOC(C(C1NC(C)=[O](C)C1)=O)=O Chemical compound CCOC(C(C1NC(C)=[O](C)C1)=O)=O SEMFAIIOMJFFIO-UHFFFAOYSA-N 0.000 description 1
- ZFJCIAUNANWWCB-UHFFFAOYSA-N CCc(nc1C(CC2)CCC2C(C)(C)C)c2[n]1N=C(C(C)(C)C)NC2=O Chemical compound CCc(nc1C(CC2)CCC2C(C)(C)C)c2[n]1N=C(C(C)(C)C)NC2=O ZFJCIAUNANWWCB-UHFFFAOYSA-N 0.000 description 1
- ZOLVYQHCUJFLBW-UHFFFAOYSA-N CCc(nc1C(CC2)CCC2C(C)(C)C)c2[n]1N=C(c1cccc(F)c1)NC2=O Chemical compound CCc(nc1C(CC2)CCC2C(C)(C)C)c2[n]1N=C(c1cccc(F)c1)NC2=O ZOLVYQHCUJFLBW-UHFFFAOYSA-N 0.000 description 1
- GWTCZUZCEZDCCN-KDURUIRLSA-N CCc(nc1[C@H](CC2)CC[C@H]2C(C)(C)C)c2[n]1N=C(c1cccc3c1cccc3)NC2=O Chemical compound CCc(nc1[C@H](CC2)CC[C@H]2C(C)(C)C)c2[n]1N=C(c1cccc3c1cccc3)NC2=O GWTCZUZCEZDCCN-KDURUIRLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0113344.6A GB0113344D0 (en) | 2001-06-01 | 2001-06-01 | Novel heterocycles 3 |
| PCT/EP2002/005436 WO2002098879A1 (en) | 2001-06-01 | 2002-05-17 | Imidazotriazinones derivatives and their use against inflammatory processes and/or immune diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004536078A true JP2004536078A (ja) | 2004-12-02 |
| JP2004536078A5 JP2004536078A5 (https=) | 2005-12-22 |
Family
ID=9915717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003502000A Pending JP2004536078A (ja) | 2001-06-01 | 2002-05-17 | 炎症プロセスおおび／または免疫疾患に対するイミダゾトリアジノン誘導体およびそれらの使用 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US7115602B2 (https=) |
| EP (1) | EP1399447A1 (https=) |
| JP (1) | JP2004536078A (https=) |
| KR (1) | KR20040023605A (https=) |
| CN (1) | CN1512993A (https=) |
| BG (1) | BG108381A (https=) |
| BR (1) | BR0210910A (https=) |
| CA (1) | CA2449095A1 (https=) |
| CO (1) | CO5540381A2 (https=) |
| CZ (1) | CZ295609B6 (https=) |
| EC (1) | ECSP034872A (https=) |
| EE (1) | EE200300570A (https=) |
| GB (1) | GB0113344D0 (https=) |
| GT (1) | GT200200099A (https=) |
| HR (1) | HRP20031090A2 (https=) |
| HU (1) | HUP0400773A3 (https=) |
| MX (1) | MXPA03010985A (https=) |
| NO (1) | NO20035324D0 (https=) |
| NZ (1) | NZ529848A (https=) |
| PE (1) | PE20030231A1 (https=) |
| PL (1) | PL366906A1 (https=) |
| RU (1) | RU2003138078A (https=) |
| SK (1) | SK14672003A3 (https=) |
| SV (1) | SV2003001061A (https=) |
| UA (1) | UA75149C2 (https=) |
| UY (1) | UY27312A1 (https=) |
| WO (1) | WO2002098879A1 (https=) |
| ZA (1) | ZA200309111B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2388111A (en) * | 2002-05-01 | 2003-11-05 | Bayer Ag | Novel imidazotriazinone compounds |
| GB2388594A (en) * | 2002-05-16 | 2003-11-19 | Bayer Ag | Imidazo-triazine PDE 4 inhibitors |
| FR2850653A1 (fr) * | 2003-02-04 | 2004-08-06 | Univ Pasteur | Derives de pyrazolotriazine, procede de preparation et utilisations |
| JP2006219374A (ja) | 2003-06-13 | 2006-08-24 | Daiichi Asubio Pharma Co Ltd | Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体 |
| TW200745106A (en) * | 2005-10-03 | 2007-12-16 | Astrazeneca Ab | Chemical compounds |
| EP2685983B1 (en) * | 2011-03-17 | 2016-05-18 | Algiax Pharmaceuticals GmbH | Novel use of imidazotriazinones |
| WO2013156231A1 (en) * | 2012-04-16 | 2013-10-24 | Algiax Pharmaceuticals Gmbh | Use of imidazotriazinones in neuropathic pain |
| EP3125900A1 (en) * | 2014-03-28 | 2017-02-08 | Algiax Pharmaceuticals GmbH | Treatment of cognitive disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791025A (fr) * | 1971-11-19 | 1973-05-07 | Allen & Hanburys Ltd | Composes heterocycliques |
| GB1457873A (en) | 1973-01-04 | 1976-12-08 | Allen & Hanburys Ltd | Imidazotriazines |
| DK109578A (da) * | 1977-03-25 | 1978-09-26 | Allen & Hanburys Ltd | Fremgangsmaade til fremstilling af heterocycliske forbindelser |
| US6362178B1 (en) | 1997-11-12 | 2002-03-26 | Bayer Aktiengesellschaft | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| DE19827640A1 (de) * | 1998-06-20 | 1999-12-23 | Bayer Ag | 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone |
| US6503908B1 (en) * | 1999-10-11 | 2003-01-07 | Pfizer Inc | Pharmaceutically active compounds |
-
2001
- 2001-06-01 GB GBGB0113344.6A patent/GB0113344D0/en not_active Ceased
-
2002
- 2002-05-17 WO PCT/EP2002/005436 patent/WO2002098879A1/en not_active Ceased
- 2002-05-17 MX MXPA03010985A patent/MXPA03010985A/es unknown
- 2002-05-17 HR HR20031090A patent/HRP20031090A2/hr not_active Application Discontinuation
- 2002-05-17 PL PL02366906A patent/PL366906A1/xx not_active Application Discontinuation
- 2002-05-17 KR KR10-2003-7015526A patent/KR20040023605A/ko not_active Withdrawn
- 2002-05-17 SK SK1467-2003A patent/SK14672003A3/sk unknown
- 2002-05-17 HU HU0400773A patent/HUP0400773A3/hu unknown
- 2002-05-17 UA UA20031213199A patent/UA75149C2/uk unknown
- 2002-05-17 BR BR0210910-7A patent/BR0210910A/pt not_active IP Right Cessation
- 2002-05-17 NZ NZ529848A patent/NZ529848A/en unknown
- 2002-05-17 CZ CZ20033275A patent/CZ295609B6/cs not_active IP Right Cessation
- 2002-05-17 CN CNA028110528A patent/CN1512993A/zh active Pending
- 2002-05-17 RU RU2003138078/04A patent/RU2003138078A/ru not_active Application Discontinuation
- 2002-05-17 JP JP2003502000A patent/JP2004536078A/ja active Pending
- 2002-05-17 EP EP02743040A patent/EP1399447A1/en not_active Withdrawn
- 2002-05-17 CA CA002449095A patent/CA2449095A1/en not_active Abandoned
- 2002-05-17 EE EEP200300570A patent/EE200300570A/xx unknown
- 2002-05-28 UY UY27312A patent/UY27312A1/es not_active Application Discontinuation
- 2002-05-29 GT GT200200099A patent/GT200200099A/es unknown
- 2002-05-30 US US10/160,352 patent/US7115602B2/en not_active Expired - Fee Related
- 2002-05-31 SV SV2002001061A patent/SV2003001061A/es not_active Application Discontinuation
- 2002-05-31 PE PE2002000464A patent/PE20030231A1/es not_active Application Discontinuation
-
2003
- 2003-11-24 ZA ZA200309111A patent/ZA200309111B/en unknown
- 2003-11-24 BG BG108381A patent/BG108381A/bg unknown
- 2003-11-28 NO NO20035324A patent/NO20035324D0/no not_active Application Discontinuation
- 2003-12-01 EC EC2003004872A patent/ECSP034872A/es unknown
- 2003-12-10 CO CO03108302A patent/CO5540381A2/es not_active Application Discontinuation
-
2004
- 2004-10-12 US US10/964,380 patent/US20050065153A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PE20030231A1 (es) | 2003-05-16 |
| KR20040023605A (ko) | 2004-03-18 |
| CA2449095A1 (en) | 2002-12-12 |
| UA75149C2 (en) | 2006-03-15 |
| NO20035324L (no) | 2003-11-28 |
| RU2003138078A (ru) | 2005-05-27 |
| CZ20033275A3 (en) | 2004-03-17 |
| HUP0400773A2 (hu) | 2004-07-28 |
| SV2003001061A (es) | 2003-03-18 |
| MXPA03010985A (es) | 2004-10-28 |
| ECSP034872A (es) | 2004-01-28 |
| NO20035324D0 (no) | 2003-11-28 |
| BR0210910A (pt) | 2004-06-08 |
| US20030139415A1 (en) | 2003-07-24 |
| UY27312A1 (es) | 2003-02-28 |
| PL366906A1 (en) | 2005-02-07 |
| HUP0400773A3 (en) | 2007-09-28 |
| NZ529848A (en) | 2006-02-24 |
| EP1399447A1 (en) | 2004-03-24 |
| CZ295609B6 (cs) | 2005-08-17 |
| SK14672003A3 (sk) | 2004-08-03 |
| BG108381A (bg) | 2004-11-30 |
| GB0113344D0 (en) | 2001-07-25 |
| CN1512993A (zh) | 2004-07-14 |
| GT200200099A (es) | 2003-02-13 |
| HRP20031090A2 (en) | 2005-08-31 |
| ZA200309111B (en) | 2004-11-24 |
| EE200300570A (et) | 2004-04-15 |
| US20050065153A1 (en) | 2005-03-24 |
| WO2002098879A1 (en) | 2002-12-12 |
| US7115602B2 (en) | 2006-10-03 |
| CO5540381A2 (es) | 2005-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2546987C (en) | 5,7-diaminopyrazolo [4,3-d] pyrimidines with pde-5 inhibiting activity | |
| US20040152739A1 (en) | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | |
| CN104822670B (zh) | 5‑苯氧基‑3h‑嘧啶‑4‑酮衍生物和它们作为hiv逆转录酶抑制剂的用途 | |
| JP4084836B2 (ja) | ｐ３８ＭＡＰキナーゼインヒビターとしてのトリアゾロピリジニルスルファニル誘導体 | |
| EP0927171A1 (en) | Pyrazinones and triazinones and their derivatives thereof | |
| EP3302484B1 (en) | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors | |
| JP2004536078A (ja) | 炎症プロセスおおび／または免疫疾患に対するイミダゾトリアジノン誘導体およびそれらの使用 | |
| EP1397363B1 (en) | 5-ethyl-imidazotriazinones | |
| JP2005531550A (ja) | ホスホジエステラーゼ阻害剤としての５−エチル−イミダゾ（５，１−ｆ）（１，２，４）トリアジン−４（３ｈ）−オン | |
| EP1399439B1 (en) | 2-heteroaryl-imidazotriazinones and their use in the treatment of inflammatory or immune diseases | |
| US7087605B2 (en) | 5-Ethyl-imidazotriazinones | |
| AU2002344351A1 (en) | Imidazotriazinones derivatives and their use against inflammatory processes and/or immune diseases | |
| KR100871535B1 (ko) | Ｐ38 ｍａｐ 키나아제 억제제로서의트리아졸로피리딘일설판일 유도체 | |
| EP1504008A1 (en) | 7-aminoimidazotriazones | |
| HK1142522A (en) | 5, 7-diaminopyrazolo [4,3-d] pyrimidines with pde -5 inhibiting activity and composition thereof | |
| HK1030211A (en) | 3(5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050510 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050510 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090310 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090811 |