JP2004536032A - 再石灰化歯科用接着フィルム - Google Patents
再石灰化歯科用接着フィルム Download PDFInfo
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- JP2004536032A JP2004536032A JP2002550922A JP2002550922A JP2004536032A JP 2004536032 A JP2004536032 A JP 2004536032A JP 2002550922 A JP2002550922 A JP 2002550922A JP 2002550922 A JP2002550922 A JP 2002550922A JP 2004536032 A JP2004536032 A JP 2004536032A
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- adhesive film
- water
- dental adhesive
- protein
- soluble
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Dental Preparations (AREA)
- Cosmetics (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10063945A DE10063945A1 (de) | 2000-12-20 | 2000-12-20 | Remineralisierende Dental-Klebefolie |
| PCT/EP2001/014512 WO2002049578A1 (de) | 2000-12-20 | 2001-12-11 | Remineralisierende denatal-klebefolie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004536032A true JP2004536032A (ja) | 2004-12-02 |
| JP2004536032A5 JP2004536032A5 (enExample) | 2005-12-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002550922A Pending JP2004536032A (ja) | 2000-12-20 | 2001-12-11 | 再石灰化歯科用接着フィルム |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20030219388A1 (enExample) |
| EP (1) | EP1343450B1 (enExample) |
| JP (1) | JP2004536032A (enExample) |
| AT (1) | ATE385760T1 (enExample) |
| AU (1) | AU2002219172A1 (enExample) |
| BR (1) | BR0116331A (enExample) |
| CA (1) | CA2432456C (enExample) |
| DE (2) | DE10063945A1 (enExample) |
| MX (1) | MXPA03005482A (enExample) |
| WO (1) | WO2002049578A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007538019A (ja) * | 2004-05-18 | 2007-12-27 | エス ウント ツェー ポリマー ジリコーン ウント コンポジット シュペーツィアリテーテン ゲーエムベーハー | ナノ結晶性アパタイトを含有する組成物 |
| JP2012505192A (ja) * | 2008-10-08 | 2012-03-01 | ノバミン テクノロジー インコーポレイテッド | 歯の再石灰化 |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10241434B4 (de) * | 2002-09-06 | 2007-09-13 | Ivoclar Vivadent Ag | Dentale Polymerfolie |
| DE10249831A1 (de) * | 2002-09-23 | 2004-04-15 | Sustech Gmbh & Co. Kg | Süssigkeit |
| DE20214694U1 (de) * | 2002-09-23 | 2004-02-19 | Sustech Gmbh & Co. Kg | Kaugummi |
| DE10248632A1 (de) * | 2002-09-23 | 2004-04-01 | Sustech Gmbh & Co. Kg | Umhüllter Kaugummi |
| DE10245212B4 (de) * | 2002-09-27 | 2008-01-03 | Ivoclar Vivadent Ag | Verwendung säurehaltiger Mittel zur Desensibilisierung von Zähnen |
| KR101240883B1 (ko) * | 2004-11-16 | 2013-03-07 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 카제이네이트를 포함하는 치과용 충전제, 방법, 조성물 |
| EP1819313B1 (en) | 2004-11-16 | 2010-12-29 | 3M Innovative Properties Company | Dental fillers and compositions including phosphate salts |
| US8710114B2 (en) | 2004-11-16 | 2014-04-29 | 3M Innovative Properties Company | Dental fillers including a phosphorus containing surface treatment, and compositions and methods thereof |
| KR20070086324A (ko) | 2004-11-16 | 2007-08-27 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 칼슘과 인을 방출하는 유리를 함유한 치과용 조성물 |
| DE102006009793A1 (de) * | 2005-10-31 | 2007-09-06 | Sus Tech Gmbh & Co. Kg | Verwendung von schwer wasserlöslichen Calciumsalzen und/oder deren Kompositen |
| WO2007051545A1 (de) * | 2005-10-31 | 2007-05-10 | Henkel Ag & Co. Kgaa | Remineralisierende mund- und zahnpflege- und -reinigungsmittel mit tensid(en) |
| WO2007051544A1 (de) * | 2005-10-31 | 2007-05-10 | Henkel Ag & Co. Kgaa | Remineralisierende mund- und zahnpflege- und -reinigungsmittel mit silikat(en) |
| WO2007051543A1 (de) * | 2005-10-31 | 2007-05-10 | Henkel Ag & Co. Kgaa | Viskose remineralisierende mund- und zahnpflege- und -reinigungsmittel |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| DE102006009799A1 (de) * | 2006-03-01 | 2007-09-06 | Henkel Kgaa | Vorwiegend plättchenförmige schwer wasserlösliche Calciumsalze und/oder deren Kompositmaterialien, umfassend diese |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| DE102006055223A1 (de) * | 2006-11-21 | 2008-05-29 | Heraeus Kulzer Gmbh | Mittel zum Schutz von Zahnflächen im Anschluss an konventionelle Bleichverfahren durch biomimetische Abscheidung von Fluorapatit |
| BRPI0720183B1 (pt) | 2006-12-05 | 2019-03-26 | Unilever N.V. | Produto para tratamento bucal, produto que compreende uma primeira composição e uso de uma primeira composição. |
| US20090317339A1 (en) * | 2008-06-23 | 2009-12-24 | Deepak Sharma | Teeth Bleaching Compositions and Devices |
| US9060947B2 (en) | 2009-08-03 | 2015-06-23 | Mcneil-Ppc, Inc. | Tooth sensitivity treatment compositions |
| US8632754B2 (en) | 2009-08-03 | 2014-01-21 | Mcneil-Ppc, Inc. | Tooth sensitivity treatment compositions |
| US8603442B2 (en) | 2009-08-03 | 2013-12-10 | Mcneil-Ppc, Inc. | Tooth sensitivity treatment compositions |
| US20110097368A1 (en) * | 2009-10-23 | 2011-04-28 | Cao Group, Inc. | Treatment Varnish Compositions for Teeth Surfaces |
| CN101856511B (zh) * | 2010-06-03 | 2013-02-13 | 山东大学 | 一种氟磷灰石涂层及其制备方法 |
| CN104927854B (zh) * | 2015-07-02 | 2019-01-11 | 华北电力大学(保定) | 一种非稀土离子激活的黄色荧光粉及其制备方法 |
| KR102853539B1 (ko) * | 2015-10-26 | 2025-09-01 | 바스프 에스이 | 구강 관리 제품 및 방법 |
| RU2651041C1 (ru) * | 2016-11-03 | 2018-04-18 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) | Состав и способ для получения биоактивной стоматологической лечебно-профилактической пленки |
| CN106619144A (zh) * | 2016-12-31 | 2017-05-10 | 安徽省健源医疗器械设备有限公司 | 一种烤瓷牙用胶粘剂及其制备方法 |
| CN107670114A (zh) * | 2017-10-07 | 2018-02-09 | 北京林业大学 | 一种基于桉木纳米微晶纤维素增强的医用生物复合材料及其制备方法 |
| PL3513777T3 (pl) * | 2018-01-22 | 2024-02-26 | Ivoclar Vivadent Ag | Sposób remineralizacji zębów |
| WO2021001529A1 (de) | 2019-07-04 | 2021-01-07 | Ferton Holding S.A. | Zusammensetzung zur remineralisierung von zähnen |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2835628A (en) * | 1957-04-01 | 1958-05-20 | Jacob A Saffir | Means for treating teeth |
| GB1142325A (en) * | 1965-05-14 | 1969-02-05 | Higham Stanley Russell | Means for administering drugs |
| US4097588A (en) * | 1975-03-11 | 1978-06-27 | National Research Development Corporation | Mineralizing dental mouthrinse |
| DE2648190C3 (de) * | 1976-10-25 | 1980-02-21 | Metallgesellschaft Ag, 6000 Frankfurt | Verfahren zur Herstellung von Schwefel nach dem Claus-Verfahren |
| JPS5835965B2 (ja) * | 1979-07-31 | 1983-08-05 | ライオン株式会社 | 口腔用組成物 |
| US4634589A (en) * | 1984-05-18 | 1987-01-06 | Wurttembergische Parfumerie-Fabrik Gmbh | Dentifrice for hypersensitive teeth |
| JP4040705B2 (ja) * | 1996-01-24 | 2008-01-30 | 株式会社サンギ | 口腔組成物 |
| JPH1017449A (ja) * | 1996-07-05 | 1998-01-20 | Sangi Co Ltd | 知覚過敏症用組成物 |
| DE19652257A1 (de) * | 1996-12-16 | 1998-06-18 | Lohmann Therapie Syst Lts | Einzeln dosierte, bei Kontakt mit Flüssigkeit schnell zerfallende, wirkstoff- und insbesondere aromastoffhaltige, folienförmige Darreichnungsform |
| US6013591A (en) * | 1997-01-16 | 2000-01-11 | Massachusetts Institute Of Technology | Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production |
| US5989569A (en) * | 1997-06-06 | 1999-11-23 | The Procter & Gamble Company | Delivery system for a tooth whitener using a permanently deformable strip of material |
| IT1299563B1 (it) * | 1998-07-17 | 2000-03-16 | Giovanni Dolci | Uso odontostomatologico di materiali a base apatitica nanostrutturati |
| US6596298B2 (en) * | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
| US6270347B1 (en) * | 1999-06-10 | 2001-08-07 | Rensselaer Polytechnic Institute | Nanostructured ceramics and composite materials for orthopaedic-dental implants |
| DE19930335A1 (de) * | 1999-07-02 | 2001-01-18 | Henkel Kgaa | Kompositmaterialien aus Calciumverbindungen und Proteinkomponenten |
| DE10028975B4 (de) * | 2000-06-16 | 2005-06-30 | Henkel Kgaa | Zusammensetzungen zur Behandlung von Zahn- und/oder Knochengewebe |
| DE10032456A1 (de) * | 2000-07-04 | 2002-01-31 | Lohmann Therapie Syst Lts | Schnell zerfallende Darreichungsform zur Freisetzung von Wirkstoffen im Mundraum oder in Körperhöhlen |
-
2000
- 2000-12-20 DE DE10063945A patent/DE10063945A1/de not_active Ceased
-
2001
- 2001-12-11 AU AU2002219172A patent/AU2002219172A1/en not_active Abandoned
- 2001-12-11 AT AT01271194T patent/ATE385760T1/de active
- 2001-12-11 WO PCT/EP2001/014512 patent/WO2002049578A1/de not_active Ceased
- 2001-12-11 BR BR0116331-0A patent/BR0116331A/pt not_active Application Discontinuation
- 2001-12-11 MX MXPA03005482A patent/MXPA03005482A/es unknown
- 2001-12-11 DE DE50113612T patent/DE50113612D1/de not_active Expired - Lifetime
- 2001-12-11 EP EP01271194A patent/EP1343450B1/de not_active Expired - Lifetime
- 2001-12-11 JP JP2002550922A patent/JP2004536032A/ja active Pending
- 2001-12-11 CA CA2432456A patent/CA2432456C/en not_active Expired - Fee Related
-
2003
- 2003-06-19 US US10/465,157 patent/US20030219388A1/en not_active Abandoned
-
2007
- 2007-01-04 US US11/649,637 patent/US20070128130A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007538019A (ja) * | 2004-05-18 | 2007-12-27 | エス ウント ツェー ポリマー ジリコーン ウント コンポジット シュペーツィアリテーテン ゲーエムベーハー | ナノ結晶性アパタイトを含有する組成物 |
| JP2012505192A (ja) * | 2008-10-08 | 2012-03-01 | ノバミン テクノロジー インコーポレイテッド | 歯の再石灰化 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE385760T1 (de) | 2008-03-15 |
| EP1343450B1 (de) | 2008-02-13 |
| BR0116331A (pt) | 2003-10-14 |
| DE10063945A1 (de) | 2002-07-04 |
| AU2002219172A1 (en) | 2002-07-01 |
| WO2002049578A1 (de) | 2002-06-27 |
| DE50113612D1 (de) | 2008-03-27 |
| MXPA03005482A (es) | 2003-10-06 |
| EP1343450A1 (de) | 2003-09-17 |
| CA2432456A1 (en) | 2002-06-27 |
| CA2432456C (en) | 2010-12-07 |
| US20070128130A1 (en) | 2007-06-07 |
| US20030219388A1 (en) | 2003-11-27 |
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