JP2004535189A5 - - Google Patents
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- Publication number
- JP2004535189A5 JP2004535189A5 JP2003502199A JP2003502199A JP2004535189A5 JP 2004535189 A5 JP2004535189 A5 JP 2004535189A5 JP 2003502199 A JP2003502199 A JP 2003502199A JP 2003502199 A JP2003502199 A JP 2003502199A JP 2004535189 A5 JP2004535189 A5 JP 2004535189A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant protein
- host cell
- expression
- level
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 13
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 12
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 230000014509 gene expression Effects 0.000 claims 9
- 239000013598 vector Substances 0.000 claims 8
- 230000035897 transcription Effects 0.000 claims 6
- 238000013518 transcription Methods 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 239000012679 serum free medium Substances 0.000 claims 2
- 101000756632 Homo sapiens Actin, cytoplasmic 1 Proteins 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000011031 large-scale manufacturing process Methods 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29596101P | 2001-06-04 | 2001-06-04 | |
| US33362001P | 2001-11-26 | 2001-11-26 | |
| US35240402P | 2002-01-29 | 2002-01-29 | |
| PCT/US2002/017763 WO2002099089A1 (en) | 2001-06-04 | 2002-06-04 | Compositions and methods for high-level, large-scale production of recombinant proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004535189A JP2004535189A (ja) | 2004-11-25 |
| JP2004535189A5 true JP2004535189A5 (enExample) | 2006-01-05 |
Family
ID=27404392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003502199A Pending JP2004535189A (ja) | 2001-06-04 | 2002-06-04 | 組換えタンパク質の高レベルの大規模生成のための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040161817A1 (enExample) |
| EP (1) | EP1402006A4 (enExample) |
| JP (1) | JP2004535189A (enExample) |
| KR (1) | KR20040032105A (enExample) |
| CN (1) | CN1533432A (enExample) |
| AU (1) | AU2002310321A1 (enExample) |
| CA (1) | CA2463310A1 (enExample) |
| WO (2) | WO2002099089A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7812148B2 (en) | 2001-04-05 | 2010-10-12 | Millipore Corporation | Vectors comprising CpG islands without position effect varigation and having increased expression |
| EP1572994B1 (en) | 2002-12-20 | 2007-02-21 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
| JP4709743B2 (ja) | 2003-02-01 | 2011-06-22 | ミリポア・コーポレイション | 改善された発現エレメント |
| BRPI0408246A (pt) * | 2003-03-11 | 2006-03-01 | Applied Research Systems | vetores de expressão que compreendem o promotor ie2 do mcmv |
| KR101271884B1 (ko) | 2004-11-08 | 2013-06-05 | 크로마제닉스 비.브이. | 고수준으로 단백질을 발현하는 숙주세포의 선택 |
| CN101090968B (zh) | 2004-11-08 | 2011-10-26 | 科罗迈吉尼科斯公司 | 高水平表达蛋白质的宿主细胞的选择 |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| GB0504587D0 (en) | 2005-03-05 | 2005-04-13 | Ml Lab Plc | Vectors comprising guinea pig CMV regulatory elements |
| ES2330784T3 (es) * | 2005-03-05 | 2009-12-15 | Millipore Corporation | Vectores que comprenden nuevos elementos reguladores. |
| GB0509965D0 (en) * | 2005-05-17 | 2005-06-22 | Ml Lab Plc | Improved expression elements |
| EP1739179A1 (en) * | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
| WO2007107578A1 (en) | 2006-03-20 | 2007-09-27 | Chromagenics B.V. | Expression augmenting dna fragments, use thereof, and methods for finding thereof |
| EP2389586B2 (en) * | 2009-01-22 | 2018-01-24 | Momenta Pharmaceuticals, Inc. | Galactose-alpha-1,3-galactose-containing n-glycans in glycoprotein products derived from cho cells |
| CN105121715B (zh) | 2012-12-11 | 2018-10-26 | 艾伯特叶史瓦大学爱因斯坦医学院 | 高通量受体:配体鉴定方法 |
| ES2750550T3 (es) | 2013-03-01 | 2020-03-26 | Univ Minnesota | Corrección de gen a base de TALEN |
| CN104341503A (zh) * | 2013-07-29 | 2015-02-11 | 西藏海思科药业集团股份有限公司 | 对蒙古人种和高加索人种低免疫原性的、抗cd20的人抗体 |
| CN104341505A (zh) * | 2013-07-29 | 2015-02-11 | 西藏海思科药业集团股份有限公司 | 对蒙古人种和高加索人种低免疫原性的、抗egfr的人鼠嵌合抗体 |
| SG11201605632SA (en) * | 2014-01-21 | 2016-08-30 | Einstein Coll Med | Cellular platform for rapid and comprehensive t-cell immunomonitoring |
| CN109475628A (zh) | 2016-05-18 | 2019-03-15 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| CA3022331A1 (en) | 2016-05-18 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Variant pd-l1 polypeptides, t-cell modulatory multimeric polypeptides, and methods of use thereof |
| AU2017379900B2 (en) | 2016-12-22 | 2024-12-05 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| WO2018129474A1 (en) | 2017-01-09 | 2018-07-12 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| EP3596118B1 (en) | 2017-03-15 | 2024-08-21 | Cue Biopharma, Inc. | Combination of multimeric fusion polypeptides and immune checkpoint inhibitor for treating hpv-associated cancer |
| WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| EP3805396B1 (en) * | 2018-05-24 | 2024-09-11 | National University Corporation Hokkaido University | Novel vector and use thereof |
| EP4149534A4 (en) | 2020-05-12 | 2024-09-04 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING T CELLS AND METHODS OF USE THEREOF |
| WO2022056014A1 (en) | 2020-09-09 | 2022-03-17 | Cue Biopharma, Inc. | Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO162160C (no) * | 1987-01-09 | 1989-11-15 | Medi Cult As | Serumfritt vekstmedium, samt anvendelse derav. |
| IL87737A (en) * | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
| SE9303601D0 (sv) * | 1993-11-01 | 1993-11-01 | Kabi Pharmacia Ab | Improved cell cultivation method and medium |
| WO2000005393A2 (en) * | 1998-07-21 | 2000-02-03 | Cobra Therapeutics Limited | A polynucleotide comprising a ubiquitous chromatin opening element (ucoe) |
-
2002
- 2002-06-04 CN CNA028143825A patent/CN1533432A/zh active Pending
- 2002-06-04 EP EP02734688A patent/EP1402006A4/en not_active Withdrawn
- 2002-06-04 CA CA002463310A patent/CA2463310A1/en not_active Abandoned
- 2002-06-04 AU AU2002310321A patent/AU2002310321A1/en not_active Abandoned
- 2002-06-04 WO PCT/US2002/017763 patent/WO2002099089A1/en not_active Ceased
- 2002-06-04 US US10/163,863 patent/US20040161817A1/en not_active Abandoned
- 2002-06-04 WO PCT/US2002/017770 patent/WO2002099070A2/en not_active Ceased
- 2002-06-04 KR KR10-2003-7015872A patent/KR20040032105A/ko not_active Withdrawn
- 2002-06-04 JP JP2003502199A patent/JP2004535189A/ja active Pending
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