JP2004533462A - 血管症の治療のための有機ナイトレートをベースとする化合物 - Google Patents
血管症の治療のための有機ナイトレートをベースとする化合物 Download PDFInfo
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- JP2004533462A JP2004533462A JP2003503221A JP2003503221A JP2004533462A JP 2004533462 A JP2004533462 A JP 2004533462A JP 2003503221 A JP2003503221 A JP 2003503221A JP 2003503221 A JP2003503221 A JP 2003503221A JP 2004533462 A JP2004533462 A JP 2004533462A
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- acid
- nitrooxymethyl
- acetyloxy
- ester
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Classifications
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- A61K31/603—Salicylic acid; Derivatives thereof having further aromatic rings, e.g. diflunisal
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
- A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
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- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/625—Salicylic acid; Derivatives thereof having heterocyclic substituents, e.g. 4-salicycloylmorpholine
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI001240A ITMI20011240A1 (it) | 2001-06-13 | 2001-06-13 | Farmaci per le vasculopatie |
| PCT/EP2002/005846 WO2002100400A1 (en) | 2001-06-13 | 2002-05-28 | Organic nitrate-based compounds for the treatment of vasculopathies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004533462A true JP2004533462A (ja) | 2004-11-04 |
| JP2004533462A5 JP2004533462A5 (https=) | 2005-12-22 |
Family
ID=11447858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003503221A Pending JP2004533462A (ja) | 2001-06-13 | 2002-05-28 | 血管症の治療のための有機ナイトレートをベースとする化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040171592A1 (https=) |
| EP (1) | EP1406613B1 (https=) |
| JP (1) | JP2004533462A (https=) |
| DE (1) | DE60223810T2 (https=) |
| ES (1) | ES2296964T3 (https=) |
| IT (1) | ITMI20011240A1 (https=) |
| WO (1) | WO2002100400A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP2002002582A0 (en) | 1999-12-23 | 2002-09-30 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| CA2487414A1 (en) | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| ITMI20021399A1 (it) * | 2002-06-25 | 2003-12-29 | Nicox Sa | Inibitori della cicloossigenasi 2 |
| JP2005535642A (ja) * | 2002-06-28 | 2005-11-24 | ニトロメッド インコーポレーティッド | オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法 |
| AU2003247792B2 (en) | 2002-07-03 | 2009-09-24 | Nicox S.A. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| US7244753B2 (en) | 2002-07-29 | 2007-07-17 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| US7169805B2 (en) * | 2003-05-28 | 2007-01-30 | Nicox S.A. | Captopril derivatives |
| ATE485261T1 (de) | 2005-11-23 | 2010-11-15 | Nicox Sa | Salicylsäurederivate |
| EP2167070A1 (en) | 2007-07-09 | 2010-03-31 | Nicox S.A. | Use of nitric oxide releasing compounds in the treatment of chronic pain |
| KR101356082B1 (ko) * | 2011-11-18 | 2014-01-29 | 한국식품연구원 | 코니페릴 알코올을 포함하는 ｈＴＲＰＡ1 활성화 조성물 및 그의 용도 |
| CN104341358B (zh) * | 2013-07-25 | 2016-05-18 | 昆药集团股份有限公司 | 一种化合物及其制备方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995030641A1 (en) * | 1994-05-10 | 1995-11-16 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
| IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
| IT1308633B1 (it) * | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| EP1274319B1 (en) * | 2000-04-14 | 2009-08-12 | Mars, Incorporated | Compositions and methods for improving vascular health |
| IT1319202B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
| IT1319201B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per il diabete. |
-
2001
- 2001-06-13 IT IT2001MI001240A patent/ITMI20011240A1/it unknown
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2002
- 2002-05-28 JP JP2003503221A patent/JP2004533462A/ja active Pending
- 2002-05-28 ES ES02747327T patent/ES2296964T3/es not_active Expired - Lifetime
- 2002-05-28 US US10/479,978 patent/US20040171592A1/en not_active Abandoned
- 2002-05-28 EP EP02747327A patent/EP1406613B1/en not_active Expired - Lifetime
- 2002-05-28 WO PCT/EP2002/005846 patent/WO2002100400A1/en not_active Ceased
- 2002-05-28 DE DE60223810T patent/DE60223810T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20040171592A1 (en) | 2004-09-02 |
| DE60223810T2 (de) | 2008-10-30 |
| ITMI20011240A1 (it) | 2002-12-13 |
| ES2296964T3 (es) | 2008-05-01 |
| EP1406613A1 (en) | 2004-04-14 |
| EP1406613B1 (en) | 2007-11-28 |
| ITMI20011240A0 (it) | 2001-06-13 |
| WO2002100400A1 (en) | 2002-12-19 |
| DE60223810D1 (de) | 2008-01-10 |
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