JP2004532817A5 - - Google Patents
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- Publication number
- JP2004532817A5 JP2004532817A5 JP2002563203A JP2002563203A JP2004532817A5 JP 2004532817 A5 JP2004532817 A5 JP 2004532817A5 JP 2002563203 A JP2002563203 A JP 2002563203A JP 2002563203 A JP2002563203 A JP 2002563203A JP 2004532817 A5 JP2004532817 A5 JP 2004532817A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- human tau
- tau protein
- truncated form
- truncated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims 14
- 102000057063 human MAPT Human genes 0.000 claims 14
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 210000001124 body fluid Anatomy 0.000 claims 3
- 239000010839 body fluid Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000005013 brain tissue Anatomy 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000013498 tau Proteins Human genes 0.000 claims 1
- 108010026424 tau Proteins Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0017501A AT500379B8 (de) | 2001-02-02 | 2001-02-02 | Tau-proteine |
| PCT/EP2002/000897 WO2002062851A1 (en) | 2001-02-02 | 2002-01-29 | Conformationally abnormal forms of tau proteins and specific antibodies thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004532817A JP2004532817A (ja) | 2004-10-28 |
| JP2004532817A5 true JP2004532817A5 (cg-RX-API-DMAC7.html) | 2005-12-22 |
| JP4163955B2 JP4163955B2 (ja) | 2008-10-08 |
Family
ID=3658236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002563203A Expired - Lifetime JP4163955B2 (ja) | 2001-02-02 | 2002-01-29 | 構造的に異常な形のタウタンパク質およびそれに対する特異抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7446180B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1355949B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4163955B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN101307107A (cg-RX-API-DMAC7.html) |
| AT (2) | AT500379B8 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2002237296A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2437453C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60235746D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1355949T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2339427T3 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2299889C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002062851A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT500379B8 (de) | 2001-02-02 | 2009-08-15 | Axon Neuroscience | Tau-proteine |
| US20060167227A1 (en) * | 2002-07-12 | 2006-07-27 | Axon Neuroscience Forschungs-Und Entwicklungs Gmbh | Truncated tau proteins |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| HRP20140240T4 (hr) | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| ES2321996B1 (es) * | 2006-01-26 | 2010-03-05 | Consejo Superior Investig. Cientificas | Uso de compuestos que se unen al dominio de union a microtubulos de tau en la elaboracion de composiciones farmaceuticas, dichas composiciones farmaceuticas y su aplicacion en el tratamiento de tauopatias. |
| US8012936B2 (en) * | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| WO2009143556A1 (en) * | 2008-05-30 | 2009-12-03 | The University Of Sydney | TREATMENTS FOR EXCITOTOXICITY AND Aß-MEDIATED TOXICITY AND AGE-ASSOCIATED NEURONAL DYSFUNCTION |
| US8609097B2 (en) * | 2009-06-10 | 2013-12-17 | Hoffmann-La Roche Inc. | Use of an anti-Tau pS422 antibody for the treatment of brain diseases |
| CN106390107B (zh) * | 2009-06-10 | 2019-12-31 | 纽约大学 | 病理tau蛋白的免疫靶向 |
| AU2010286501B2 (en) * | 2009-08-28 | 2015-06-11 | The Board Of Regents Of The University Of Texas System | Antibodies that bind Tau oligomers |
| US10266585B2 (en) | 2009-08-28 | 2019-04-23 | The Board Of Regents Of The Univerity Of Texas System | Methods of treating brain injury |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| ITRM20100320A1 (it) * | 2010-06-11 | 2011-12-11 | Consiglio Nazionale Ricerche | Metodo per la diagnostica e il trattamento delle taupatie |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| CA2813493C (en) | 2010-10-11 | 2019-07-09 | University Of Zurich | Human anti-tau antibodies |
| AU2011315920B2 (en) | 2010-10-15 | 2016-04-28 | The Board Of Regents Of The University Of Texas System | Antibodies that bind amyloid oligomers |
| US20120244174A1 (en) | 2011-01-31 | 2012-09-27 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| JP6457263B2 (ja) * | 2011-05-20 | 2019-01-23 | オリゴメリックス インコーポレイテッド | タウプロテアーゼ組成物および使用方法 |
| ME03008B (me) * | 2011-09-19 | 2018-10-20 | Axon Neuroscience Se | Terapija na osnovu proteina i dijagnoza patologije u којој posreduje tau u alcнajмerovoj bolesti |
| KR101981351B1 (ko) * | 2011-10-07 | 2019-09-02 | 에이씨 이뮨 에스.에이. | 타우를 인식하는 포스포특이적 항체 |
| SG10201708959WA (en) | 2012-07-03 | 2017-11-29 | Univ Washington | Antibodies to tau |
| NZ630542A (en) * | 2012-08-16 | 2017-06-30 | Ipierian Inc | Methods of treating a tauopathy |
| US9200068B2 (en) * | 2012-12-18 | 2015-12-01 | Regents Of The University Of Minnesota | Compositions and methods related to tauopathy |
| CA2896066C (en) | 2012-12-21 | 2022-07-12 | Biogen Ma Inc. | Human anti-tau antibodies |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| US10501531B2 (en) | 2013-03-13 | 2019-12-10 | Prothena Biosciences Limited | Tau immunotherapy |
| WO2014150877A2 (en) * | 2013-03-15 | 2014-09-25 | Ac Immune S.A. | Anti-tau antibodies and methods of use |
| AU2014368696A1 (en) | 2013-12-20 | 2016-06-02 | F. Hoffmann-La Roche Ag | Humanized anti-Tau(pS422) antibodies and methods of use |
| JP2017512751A (ja) | 2014-02-14 | 2017-05-25 | アイピエリアン，インコーポレイティド | タウペプチド、抗タウ抗体、およびそれらの使用方法 |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
| TWI734975B (zh) * | 2014-06-27 | 2021-08-01 | 美商Ｃ２Ｎ醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| CN107073297B (zh) | 2014-07-08 | 2021-09-14 | 纽约大学 | Tau显像配体和其在Tau蛋白病的诊断和治疗中的用途 |
| TWI669314B (zh) | 2015-02-26 | 2019-08-21 | 美國禮來大藥廠 | 針對ｔａｕ之抗體及其用途 |
| NZ775762A (en) * | 2015-06-05 | 2025-02-28 | Genentech Inc | Anti-tau antibodies and methods of use |
| WO2016207245A1 (en) | 2015-06-24 | 2016-12-29 | F. Hoffmann-La Roche Ag | Humanized anti-tau(ps422) antibodies and methods of use |
| WO2017005734A1 (en) | 2015-07-06 | 2017-01-12 | Ucb Biopharma Sprl | Tau-binding antibodies |
| WO2017027685A2 (en) | 2015-08-13 | 2017-02-16 | New York University | Antibody-based molecules specific for the truncated asp421 epitope of tau and their uses in the diagnosis and treatment of tauopathy |
| PT3452507T (pt) | 2016-05-02 | 2022-12-20 | Prothena Biosciences Ltd | Imunoterapia anti-tau |
| MY198194A (en) | 2016-05-02 | 2023-08-09 | Prothena Biosciences Ltd | Antibodies Recognizing Tau |
| PH12018502613B1 (en) * | 2016-07-12 | 2023-02-01 | H Lundbeck As | Antibodies specific for hyperphosphorylated tau and methods of use thereof |
| CA3032692A1 (en) | 2016-08-09 | 2018-02-15 | Eli Lilly And Company | Combination antibody therapy for the treatment of neurodegenerative diseases |
| UA128383C2 (uk) | 2016-12-07 | 2024-07-03 | Дженентек, Інк. | Антитіло до тау-білка та спосіб його застосування |
| MX2019006330A (es) | 2016-12-07 | 2019-09-26 | Genentech Inc | Anticuerpos anti-tau y metodos de uso. |
| KR102784294B1 (ko) | 2017-05-02 | 2025-03-19 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| CN107686839B (zh) * | 2017-09-25 | 2020-12-04 | 安徽朵能生物科技有限公司 | 微管结合蛋白cript、其治疗性突变体及其应用 |
| CA3107788A1 (en) | 2018-07-31 | 2020-02-06 | Eli Lilly And Company | Combination of anti-tau antibody and oga inhibitor for treatment of diseases characterized by aberrant tau aggregation |
| WO2020160156A2 (en) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anti-gal3 antibodies and uses thereof |
| JP7630834B2 (ja) | 2019-03-03 | 2025-02-18 | プロセナ バイオサイエンシーズ リミテッド | タウ認識抗体 |
| CN120648640A (zh) | 2019-03-18 | 2025-09-16 | 瑞泽恩制药公司 | 用于鉴定tau接种或聚集的基因修饰因子的CRISPR/Cas筛选平台 |
| WO2020201828A1 (en) | 2019-04-05 | 2020-10-08 | Tauc3 Biologics Limited | Anti-tauc3 antibodies and uses thereof |
| GB2585252A (en) | 2019-07-05 | 2021-01-06 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| WO2022144406A1 (en) | 2020-12-29 | 2022-07-07 | Neurimmune Ag | Human anti-tau antibodies |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5733734A (en) * | 1991-08-14 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments |
| JPH06239899A (ja) | 1993-02-12 | 1994-08-30 | Teijin Ltd | ヒトタウ蛋白に対する抗体、並びに該抗体を利用する体液中のヒトタウ蛋白の測定方法 |
| AT500379B8 (de) | 2001-02-02 | 2009-08-15 | Axon Neuroscience | Tau-proteine |
| US20020164657A1 (en) * | 2001-02-23 | 2002-11-07 | Sharma Satish K. | Assays for assessing A beta-Tau aggregation |
-
2001
- 2001-02-02 AT AT0017501A patent/AT500379B8/de not_active IP Right Cessation
-
2002
- 2002-01-29 AT AT02703586T patent/ATE461941T1/de active
- 2002-01-29 RU RU2003126594/13A patent/RU2299889C2/ru active
- 2002-01-29 DK DK02703586.4T patent/DK1355949T3/da active
- 2002-01-29 ES ES02703586T patent/ES2339427T3/es not_active Expired - Lifetime
- 2002-01-29 CN CNA2008101081547A patent/CN101307107A/zh active Pending
- 2002-01-29 US US10/470,928 patent/US7446180B2/en not_active Expired - Lifetime
- 2002-01-29 JP JP2002563203A patent/JP4163955B2/ja not_active Expired - Lifetime
- 2002-01-29 AU AU2002237296A patent/AU2002237296A1/en not_active Abandoned
- 2002-01-29 CA CA2437453A patent/CA2437453C/en not_active Expired - Lifetime
- 2002-01-29 CN CNB028053133A patent/CN100503638C/zh not_active Expired - Lifetime
- 2002-01-29 WO PCT/EP2002/000897 patent/WO2002062851A1/en not_active Ceased
- 2002-01-29 EP EP02703586A patent/EP1355949B1/en not_active Expired - Lifetime
- 2002-01-29 DE DE60235746T patent/DE60235746D1/de not_active Expired - Lifetime
-
2008
- 2008-11-04 US US12/264,694 patent/US20090123936A1/en not_active Abandoned
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