JP2004532642A - 動物細胞の培養方法と動物細胞でのポリペプチド産生 - Google Patents

動物細胞の培養方法と動物細胞でのポリペプチド産生 Download PDF

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JP2004532642A
JP2004532642A JP2003503770A JP2003503770A JP2004532642A JP 2004532642 A JP2004532642 A JP 2004532642A JP 2003503770 A JP2003503770 A JP 2003503770A JP 2003503770 A JP2003503770 A JP 2003503770A JP 2004532642 A JP2004532642 A JP 2004532642A
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medium
glucose
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JP2004532642A5 (https=
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デラクルーズ，ネスリィハン
エチェベリー，ティナ
オストランド，マイケル
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Microbiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2003503770A 2001-06-13 2002-06-11 動物細胞の培養方法と動物細胞でのポリペプチド産生 Pending JP2004532642A (ja)

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US29801301P 2001-06-13 2001-06-13
PCT/US2002/018687 WO2002101019A2 (en) 2001-06-13 2002-06-11 Methods of culturing animal cells and polypeptide production in animal cells

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JP2004532642A true JP2004532642A (ja) 2004-10-28
JP2004532642A5 JP2004532642A5 (https=) 2006-01-05

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US (1) US20030087372A1 (https=)
EP (1) EP1404813A4 (https=)
JP (1) JP2004532642A (https=)
AU (1) AU2002316230A1 (https=)
CA (1) CA2447791A1 (https=)
WO (1) WO2002101019A2 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010519909A (ja) * 2007-03-02 2010-06-10 ワイス エルエルシー ポリペプチドの産生のための細胞培養における銅およびグルタミン酸塩の使用
JP2013524826A (ja) * 2010-04-26 2013-06-20 ノバルティス アーゲー 改良型細胞培養培地
JP2013544763A (ja) * 2010-09-17 2013-12-19 バクスター、インターナショナル、インコーポレイテッド 弱酸性〜中性のｐＨにおける、ヒスチジンを有する水性製剤を介した免疫グロブリンの安定化
JP2017504344A (ja) * 2014-01-29 2017-02-09 エルジー ライフ サイエンシーズ リミテッドＬｇ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． 培養培地の最適化により組換えタンパク質のガラクトシル化を調節する方法
JP2023538881A (ja) * 2020-08-14 2023-09-12 ブリストル－マイヤーズ スクイブ カンパニー タンパク質の製造方法
JP2024516401A (ja) * 2021-04-27 2024-04-15 アムジエン・インコーポレーテツド 温度の使用による非対称抗体の製品品質の調節

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RU2451082C2 (ru) * 2004-08-27 2012-05-20 Вайет Рисёрч Айрлэнд Лимитед Производство полипептидов
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Cited By (10)

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Publication number Priority date Publication date Assignee Title
JP2010519909A (ja) * 2007-03-02 2010-06-10 ワイス エルエルシー ポリペプチドの産生のための細胞培養における銅およびグルタミン酸塩の使用
JP2013524826A (ja) * 2010-04-26 2013-06-20 ノバルティス アーゲー 改良型細胞培養培地
JP2016052310A (ja) * 2010-04-26 2016-04-14 ノバルティス アーゲー 改良型細胞培養培地
JP2013544763A (ja) * 2010-09-17 2013-12-19 バクスター、インターナショナル、インコーポレイテッド 弱酸性〜中性のｐＨにおける、ヒスチジンを有する水性製剤を介した免疫グロブリンの安定化
KR101879885B1 (ko) * 2010-09-17 2018-07-18 박스알타 인코퍼레이티드 약산성 내지 중성 ｐｈ에서 히스티딘을 갖는 수성 제형을 통한 면역글로불린의 안정화
JP2018203784A (ja) * 2010-09-17 2018-12-27 バクスアルタ ゲーエムベーハー 弱酸性〜中性のｐＨにおける、ヒスチジンを有する水性製剤を介した免疫グロブリンの安定化
JP2017504344A (ja) * 2014-01-29 2017-02-09 エルジー ライフ サイエンシーズ リミテッドＬｇ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． 培養培地の最適化により組換えタンパク質のガラクトシル化を調節する方法
JP2019154450A (ja) * 2014-01-29 2019-09-19 エルジー・ケム・リミテッド 培養培地の最適化により組換えタンパク質のガラクトシル化を調節する方法
JP2023538881A (ja) * 2020-08-14 2023-09-12 ブリストル－マイヤーズ スクイブ カンパニー タンパク質の製造方法
JP2024516401A (ja) * 2021-04-27 2024-04-15 アムジエン・インコーポレーテツド 温度の使用による非対称抗体の製品品質の調節

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AU2002316230A1 (en) 2002-12-23
EP1404813A4 (en) 2004-11-24
EP1404813A2 (en) 2004-04-07
WO2002101019A3 (en) 2003-04-10
US20030087372A1 (en) 2003-05-08
WO2002101019A2 (en) 2002-12-19
CA2447791A1 (en) 2002-12-19

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