JP2004532604A - Ｂリンパ球刺激因子タンパク質（ＢＬｙＳ）のための結合性ポリペプチド - Google Patents
Ｂリンパ球刺激因子タンパク質（ＢＬｙＳ）のための結合性ポリペプチド Download PDFInfo
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- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
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- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000008362 succinate buffer Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 238000011191 terminal modification Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 229910052716 thallium Inorganic materials 0.000 description 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 1
- 238000010396 two-hybrid screening Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
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- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22648900P | 2000-08-18 | 2000-08-18 | |
| PCT/US2001/025891 WO2002016412A2 (en) | 2000-08-18 | 2001-08-17 | Binding polypeptides for b lymphocyte stimulator protein (blys) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012045428A Division JP2012131816A (ja) | 2000-08-18 | 2012-03-01 | Ｂリンパ球刺激因子タンパク質（ＢＬｙＳ）のための結合性ポリペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004532604A true JP2004532604A (ja) | 2004-10-28 |
| JP2004532604A5 JP2004532604A5 (enExample) | 2010-10-21 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002521507A Pending JP2004532604A (ja) | 2000-08-18 | 2001-08-17 | Ｂリンパ球刺激因子タンパク質（ＢＬｙＳ）のための結合性ポリペプチド |
| JP2012045428A Pending JP2012131816A (ja) | 2000-08-18 | 2012-03-01 | Ｂリンパ球刺激因子タンパク質（ＢＬｙＳ）のための結合性ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012045428A Pending JP2012131816A (ja) | 2000-08-18 | 2012-03-01 | Ｂリンパ球刺激因子タンパク質（ＢＬｙＳ）のための結合性ポリペプチド |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7118872B2 (enExample) |
| EP (11) | EP2267015A3 (enExample) |
| JP (2) | JP2004532604A (enExample) |
| AT (1) | ATE451390T1 (enExample) |
| AU (2) | AU8506601A (enExample) |
| CA (1) | CA2418006A1 (enExample) |
| DE (1) | DE60140773D1 (enExample) |
| WO (1) | WO2002016412A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013040148A (ja) * | 2011-08-19 | 2013-02-28 | Asahi Kasei Corp | シアリルオリゴ糖ペプチド固定化ビーズ |
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| US20030095967A1 (en) * | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
| PT1255558E (pt) * | 2000-02-16 | 2006-11-30 | Genentech Inc | Anticorpos anti-april e células hibridoma |
| US7879328B2 (en) * | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| EP2275449B1 (en) * | 2000-06-16 | 2016-09-28 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to BLyS |
| US20030091565A1 (en) | 2000-08-18 | 2003-05-15 | Beltzer James P. | Binding polypeptides and methods based thereon |
| UA83458C2 (uk) * | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
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| KR20040019105A (ko) * | 2001-08-03 | 2004-03-04 | 제넨테크, 인크. | ＴＡＣＩｓ 및 ＢＲ3 폴리펩티드 및 이의 용도 |
| US7825089B2 (en) | 2001-10-24 | 2010-11-02 | National Jewish Health | Three-dimensional structures of TALL-1 and its cognate receptors and modified proteins and methods related thereto |
| US20080267965A1 (en) * | 2002-02-21 | 2008-10-30 | Kalled Susan L | Use of Bcma as an Immunoregulatory Agent |
| EP1587944A4 (en) | 2002-03-01 | 2007-03-21 | Dyax Corp | KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| EP2014310B8 (en) * | 2002-03-01 | 2012-12-26 | Dyax Corp. | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| AU2003256836A1 (en) * | 2002-07-25 | 2004-02-16 | Genentech, Inc. | Taci antibodies and uses thereof |
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| US20050163775A1 (en) * | 2003-06-05 | 2005-07-28 | Genentech, Inc. | Combination therapy for B cell disorders |
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| US9168286B2 (en) * | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| CA2629306A1 (en) | 2005-11-23 | 2007-05-31 | Genentech, Inc. | Methods and compositions related to b cell assays |
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| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| WO2010093993A2 (en) * | 2009-02-12 | 2010-08-19 | Human Genome Sciences, Inc. | Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance |
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| CN103502472B (zh) | 2011-02-28 | 2017-06-06 | 弗·哈夫曼-拉罗切有限公司 | 生物标记物和用于预测对b‑细胞拮抗剂的响应的方法 |
| US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
| PH12022550138A1 (en) | 2013-03-13 | 2023-03-06 | Amgen Inc | Proteins specific for baff and b7rp1 and uses thereof |
| WO2018026742A1 (en) * | 2016-08-01 | 2018-02-08 | Askgene Pharma Inc. | Novel antibody-albumin-drug conjugates (aadc) and methods for using them |
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| JP2004509615A (ja) * | 2000-06-16 | 2004-04-02 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | ＢＬｙＳに免疫特異的に結合する抗体 |
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2001
- 2001-08-17 AT AT06005641T patent/ATE451390T1/de not_active IP Right Cessation
- 2001-08-17 EP EP10011186A patent/EP2267015A3/en not_active Withdrawn
- 2001-08-17 EP EP01964181A patent/EP1339746A2/en not_active Withdrawn
- 2001-08-17 AU AU8506601A patent/AU8506601A/xx active Pending
- 2001-08-17 CA CA002418006A patent/CA2418006A1/en not_active Abandoned
- 2001-08-17 EP EP10011204A patent/EP2267019A3/en not_active Withdrawn
- 2001-08-17 EP EP10011242A patent/EP2267020A3/en not_active Withdrawn
- 2001-08-17 EP EP10011313A patent/EP2261246A3/en not_active Withdrawn
- 2001-08-17 EP EP09178022A patent/EP2184291A1/en not_active Withdrawn
- 2001-08-17 AU AU2001285066A patent/AU2001285066B2/en not_active Ceased
- 2001-08-17 EP EP10011187A patent/EP2267016A3/en not_active Withdrawn
- 2001-08-17 EP EP10011189A patent/EP2267017A3/en not_active Withdrawn
- 2001-08-17 EP EP10011315A patent/EP2270040A3/en not_active Withdrawn
- 2001-08-17 EP EP10011203A patent/EP2267018A3/en not_active Withdrawn
- 2001-08-17 DE DE60140773T patent/DE60140773D1/de not_active Expired - Lifetime
- 2001-08-17 US US09/932,322 patent/US7118872B2/en not_active Expired - Lifetime
- 2001-08-17 JP JP2002521507A patent/JP2004532604A/ja active Pending
- 2001-08-17 EP EP06005641A patent/EP1674477B1/en not_active Expired - Lifetime
- 2001-08-17 WO PCT/US2001/025891 patent/WO2002016412A2/en not_active Ceased
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2012
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004509615A (ja) * | 2000-06-16 | 2004-04-02 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | ＢＬｙＳに免疫特異的に結合する抗体 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013040148A (ja) * | 2011-08-19 | 2013-02-28 | Asahi Kasei Corp | シアリルオリゴ糖ペプチド固定化ビーズ |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1674477A3 (en) | 2007-02-28 |
| EP1674477B1 (en) | 2009-12-09 |
| EP2267020A2 (en) | 2010-12-29 |
| ATE451390T1 (de) | 2009-12-15 |
| EP2270040A2 (en) | 2011-01-05 |
| AU8506601A (en) | 2002-03-04 |
| JP2012131816A (ja) | 2012-07-12 |
| EP2267018A3 (en) | 2011-04-20 |
| EP2267018A2 (en) | 2010-12-29 |
| WO2002016412A3 (en) | 2003-06-26 |
| EP2267017A3 (en) | 2011-07-06 |
| EP2261246A3 (en) | 2011-07-13 |
| EP2184291A1 (en) | 2010-05-12 |
| EP2267019A2 (en) | 2010-12-29 |
| EP2267019A3 (en) | 2011-07-06 |
| EP2267016A3 (en) | 2011-04-20 |
| EP1339746A2 (en) | 2003-09-03 |
| EP2267015A2 (en) | 2010-12-29 |
| EP2261246A2 (en) | 2010-12-15 |
| EP2267015A3 (en) | 2011-04-20 |
| US20030194743A1 (en) | 2003-10-16 |
| DE60140773D1 (de) | 2010-01-21 |
| WO2002016412A2 (en) | 2002-02-28 |
| EP2267020A3 (en) | 2011-04-20 |
| EP1674477A2 (en) | 2006-06-28 |
| CA2418006A1 (en) | 2002-02-28 |
| US7118872B2 (en) | 2006-10-10 |
| EP2270040A3 (en) | 2011-07-06 |
| EP2267017A2 (en) | 2010-12-29 |
| EP2267016A2 (en) | 2010-12-29 |
| AU2001285066B2 (en) | 2006-06-29 |
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