JP2004532604A5 - - Google Patents
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- Publication number
- JP2004532604A5 JP2004532604A5 JP2002521507A JP2002521507A JP2004532604A5 JP 2004532604 A5 JP2004532604 A5 JP 2004532604A5 JP 2002521507 A JP2002521507 A JP 2002521507A JP 2002521507 A JP2002521507 A JP 2002521507A JP 2004532604 A5 JP2004532604 A5 JP 2004532604A5
- Authority
- JP
- Japan
- Prior art keywords
- arg
- leu
- phe
- tyr
- trp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 description 22
- 102000004196 processed proteins & peptides Human genes 0.000 description 22
- 108090000765 processed proteins & peptides Proteins 0.000 description 22
- 125000003275 alpha amino acid group Chemical group 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000013060 biological fluid Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- -1 cell line Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000012504 chromatography matrix Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22648900P | 2000-08-18 | 2000-08-18 | |
| PCT/US2001/025891 WO2002016412A2 (en) | 2000-08-18 | 2001-08-17 | Binding polypeptides for b lymphocyte stimulator protein (blys) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012045428A Division JP2012131816A (ja) | 2000-08-18 | 2012-03-01 | Ｂリンパ球刺激因子タンパク質（ＢＬｙＳ）のための結合性ポリペプチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004532604A JP2004532604A (ja) | 2004-10-28 |
| JP2004532604A5 true JP2004532604A5 (enExample) | 2010-10-21 |
Family
ID=22849104
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002521507A Pending JP2004532604A (ja) | 2000-08-18 | 2001-08-17 | Ｂリンパ球刺激因子タンパク質（ＢＬｙＳ）のための結合性ポリペプチド |
| JP2012045428A Pending JP2012131816A (ja) | 2000-08-18 | 2012-03-01 | Ｂリンパ球刺激因子タンパク質（ＢＬｙＳ）のための結合性ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012045428A Pending JP2012131816A (ja) | 2000-08-18 | 2012-03-01 | Ｂリンパ球刺激因子タンパク質（ＢＬｙＳ）のための結合性ポリペプチド |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7118872B2 (enExample) |
| EP (11) | EP2267015A3 (enExample) |
| JP (2) | JP2004532604A (enExample) |
| AT (1) | ATE451390T1 (enExample) |
| AU (2) | AU8506601A (enExample) |
| CA (1) | CA2418006A1 (enExample) |
| DE (1) | DE60140773D1 (enExample) |
| WO (1) | WO2002016412A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8212004B2 (en) * | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
| US6812327B1 (en) * | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| US20050100548A1 (en) * | 2001-07-24 | 2005-05-12 | Biogen Idec Ma Inc. | BAFF, inhibitors thereof and their use in the modulation of B-cell response |
| US20030095967A1 (en) * | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
| PT1255558E (pt) * | 2000-02-16 | 2006-11-30 | Genentech Inc | Anticorpos anti-april e células hibridoma |
| US7879328B2 (en) * | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| EP2275449B1 (en) * | 2000-06-16 | 2016-09-28 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to BLyS |
| US20030091565A1 (en) | 2000-08-18 | 2003-05-15 | Beltzer James P. | Binding polypeptides and methods based thereon |
| UA83458C2 (uk) * | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| ES2387546T3 (es) | 2001-05-11 | 2012-09-25 | Amgen Inc. | Péptidos y moléculas relacionadas que se unen a TALL-1 |
| KR20040019105A (ko) * | 2001-08-03 | 2004-03-04 | 제넨테크, 인크. | ＴＡＣＩｓ 및 ＢＲ3 폴리펩티드 및 이의 용도 |
| US7825089B2 (en) | 2001-10-24 | 2010-11-02 | National Jewish Health | Three-dimensional structures of TALL-1 and its cognate receptors and modified proteins and methods related thereto |
| US20080267965A1 (en) * | 2002-02-21 | 2008-10-30 | Kalled Susan L | Use of Bcma as an Immunoregulatory Agent |
| EP1587944A4 (en) | 2002-03-01 | 2007-03-21 | Dyax Corp | KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| EP2014310B8 (en) * | 2002-03-01 | 2012-12-26 | Dyax Corp. | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| AU2003256836A1 (en) * | 2002-07-25 | 2004-02-16 | Genentech, Inc. | Taci antibodies and uses thereof |
| AU2004233164B2 (en) | 2003-03-28 | 2009-10-08 | Biogen Ma Inc. | Truncated BAFF receptors |
| EP2272868B1 (en) * | 2003-06-05 | 2015-03-04 | Genentech, Inc. | Combination therapy for B cell disorders |
| US20050163775A1 (en) * | 2003-06-05 | 2005-07-28 | Genentech, Inc. | Combination therapy for B cell disorders |
| CN100378122C (zh) * | 2004-12-03 | 2008-04-02 | 中国人民解放军第三军医大学 | B淋巴细胞刺激因子抑制肽及其制备方法 |
| EA015860B1 (ru) * | 2005-10-13 | 2011-12-30 | Хьюман Дженом Сайенсиз, Инк. | Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа |
| US9168286B2 (en) * | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| CA2629306A1 (en) | 2005-11-23 | 2007-05-31 | Genentech, Inc. | Methods and compositions related to b cell assays |
| US8211649B2 (en) | 2006-03-31 | 2012-07-03 | Human Genome Sciences, Inc. | Methods of diagnosing and prognosing hodgkin's lymphoma |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| WO2010093993A2 (en) * | 2009-02-12 | 2010-08-19 | Human Genome Sciences, Inc. | Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance |
| MX353186B (es) | 2009-09-03 | 2018-01-05 | Genentech Inc | Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide. |
| CN103502472B (zh) | 2011-02-28 | 2017-06-06 | 弗·哈夫曼-拉罗切有限公司 | 生物标记物和用于预测对b‑细胞拮抗剂的响应的方法 |
| JP2013040148A (ja) * | 2011-08-19 | 2013-02-28 | Asahi Kasei Corp | シアリルオリゴ糖ペプチド固定化ビーズ |
| US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
| PH12022550138A1 (en) | 2013-03-13 | 2023-03-06 | Amgen Inc | Proteins specific for baff and b7rp1 and uses thereof |
| WO2018026742A1 (en) * | 2016-08-01 | 2018-02-08 | Askgene Pharma Inc. | Novel antibody-albumin-drug conjugates (aadc) and methods for using them |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1195987B (de) | 1962-02-05 | 1965-07-01 | Siemens Ag | Foerdereinrichtung fuer kartenfoermige Aufzeichnungstraeger |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| US5576195A (en) | 1985-11-01 | 1996-11-19 | Xoma Corporation | Vectors with pectate lyase signal sequence |
| CN1033030C (zh) | 1988-06-24 | 1996-10-16 | 唐化学原料公司 | 大环双官能螯合剂及其配合物和抗体共轭物的制备方法 |
| US5756065A (en) | 1988-06-24 | 1998-05-26 | The Dow Chemical Company | Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5349052A (en) | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
| EP0401384B1 (en) | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| CA2067194C (en) | 1989-10-05 | 2003-03-18 | Glenn Kawasaki | Cell-free synthesis and isolation of novel genes and polypeptides |
| US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
| US5747334A (en) | 1990-02-15 | 1998-05-05 | The University Of North Carolina At Chapel Hill | Random peptide library |
| GB9119270D0 (en) * | 1991-10-09 | 1991-10-23 | Seetru Ltd | A novel design for a reflex flat glass type liquid level gauge |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| EP0749475A4 (en) | 1992-08-26 | 1997-05-07 | Harvard College | USE OF CYTOKINE IP-10 AS ANTI-TUMOR AGENT |
| US5869331A (en) | 1992-11-20 | 1999-02-09 | University Of Medicine & Dentistry Of New Jersey | Cell type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins and wild-type envelope fusion proteins |
| GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| WO1998029747A1 (en) * | 1994-11-23 | 1998-07-09 | Abbott Laboratories | Reagents and methods for detecting hepatitis gb virus antigen |
| US5874409A (en) * | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
| JP2000512981A (ja) | 1996-06-06 | 2000-10-03 | ラ ホヤ ファーマシューティカル カンパニー | ａＰＬ免疫応答性ペプチド、その結合体およびａＰＬ抗体媒介病理のための処置方法 |
| EP0921817B1 (en) | 1997-01-29 | 2001-03-28 | PolyMASC Pharmaceuticals plc | Pegylation process |
| EP1798288B1 (en) * | 1997-05-07 | 2009-09-16 | Schering Corporation | Human Toll-like receptor proteins, related reagents and methods |
| US5795724A (en) * | 1997-09-12 | 1998-08-18 | Incyte Pharmaceuticals, Inc. | Human N-acetyl transferase |
| WO1999058558A2 (en) * | 1998-05-13 | 1999-11-18 | Incyte Pharmaceuticals, Inc. | Cell signaling proteins |
| DE19829785A1 (de) | 1998-07-03 | 2000-01-05 | Henkel Kgaa | Verwendung |
| DE60005135T3 (de) * | 1999-01-07 | 2015-04-09 | Zymogenetics, Inc. | Lösliche rezeptoren br43x2 und verfahren zu deren therapeutischen verwendung |
| CA2360062A1 (en) | 1999-01-25 | 2000-07-27 | Biogen, Inc. | Baff, inhibitors thereof and their use in the modulation of b-cell response |
| US6475986B1 (en) * | 1999-02-02 | 2002-11-05 | Research Development Foundation | Uses of THANK, a TNF homologue that activates apoptosis |
| AU3395900A (en) * | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| CA2404945C (en) | 2000-04-27 | 2010-02-09 | Biogen, Inc. | Taci as an anti-tumor agent |
| CA2408617A1 (en) | 2000-05-12 | 2001-11-22 | Amgen Inc. | Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci |
| EP2275449B1 (en) * | 2000-06-16 | 2016-09-28 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to BLyS |
| UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| ES2387546T3 (es) | 2001-05-11 | 2012-09-25 | Amgen Inc. | Péptidos y moléculas relacionadas que se unen a TALL-1 |
| DK1436003T3 (da) | 2001-05-24 | 2010-03-15 | Zymogenetics Inc | TACI-immunoglobulin-fusionsproteiner |
| US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
-
2001
- 2001-08-17 AT AT06005641T patent/ATE451390T1/de not_active IP Right Cessation
- 2001-08-17 EP EP10011186A patent/EP2267015A3/en not_active Withdrawn
- 2001-08-17 EP EP01964181A patent/EP1339746A2/en not_active Withdrawn
- 2001-08-17 AU AU8506601A patent/AU8506601A/xx active Pending
- 2001-08-17 CA CA002418006A patent/CA2418006A1/en not_active Abandoned
- 2001-08-17 EP EP10011204A patent/EP2267019A3/en not_active Withdrawn
- 2001-08-17 EP EP10011242A patent/EP2267020A3/en not_active Withdrawn
- 2001-08-17 EP EP10011313A patent/EP2261246A3/en not_active Withdrawn
- 2001-08-17 EP EP09178022A patent/EP2184291A1/en not_active Withdrawn
- 2001-08-17 AU AU2001285066A patent/AU2001285066B2/en not_active Ceased
- 2001-08-17 EP EP10011187A patent/EP2267016A3/en not_active Withdrawn
- 2001-08-17 EP EP10011189A patent/EP2267017A3/en not_active Withdrawn
- 2001-08-17 EP EP10011315A patent/EP2270040A3/en not_active Withdrawn
- 2001-08-17 EP EP10011203A patent/EP2267018A3/en not_active Withdrawn
- 2001-08-17 DE DE60140773T patent/DE60140773D1/de not_active Expired - Lifetime
- 2001-08-17 US US09/932,322 patent/US7118872B2/en not_active Expired - Lifetime
- 2001-08-17 JP JP2002521507A patent/JP2004532604A/ja active Pending
- 2001-08-17 EP EP06005641A patent/EP1674477B1/en not_active Expired - Lifetime
- 2001-08-17 WO PCT/US2001/025891 patent/WO2002016412A2/en not_active Ceased
-
2012
- 2012-03-01 JP JP2012045428A patent/JP2012131816A/ja active Pending
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