JP2004531478A5 - - Google Patents
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- Publication number
- JP2004531478A5 JP2004531478A5 JP2002562732A JP2002562732A JP2004531478A5 JP 2004531478 A5 JP2004531478 A5 JP 2004531478A5 JP 2002562732 A JP2002562732 A JP 2002562732A JP 2002562732 A JP2002562732 A JP 2002562732A JP 2004531478 A5 JP2004531478 A5 JP 2004531478A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salts
- pharmaceutical compositions
- salts including
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- -1 ethylenedioxyphenyl Chemical group 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 3
- 230000005907 cancer growth Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 150000002339 glycosphingolipids Chemical class 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 150000003408 sphingolipids Chemical class 0.000 claims 3
- 150000003512 tertiary amines Chemical class 0.000 claims 3
- 230000005747 tumor angiogenesis Effects 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002723 alicyclic group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 0 C[N+](C1C=C*(*)C=C1)[O-] Chemical compound C[N+](C1C=C*(*)C=C1)[O-] 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26094801P | 2001-01-10 | 2001-01-10 | |
| US26219601P | 2001-01-17 | 2001-01-17 | |
| PCT/US2002/000808 WO2002062777A2 (en) | 2001-01-10 | 2002-01-10 | Amino ceramide-like compounds and therapeutic methods of use |
| CA002454456A CA2454456A1 (en) | 2001-01-10 | 2003-12-24 | Amino ceramide-like compounds and therapeutic methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004531478A JP2004531478A (ja) | 2004-10-14 |
| JP2004531478A5 true JP2004531478A5 (enExample) | 2006-01-05 |
Family
ID=34841311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002562732A Pending JP2004531478A (ja) | 2001-01-10 | 2002-01-10 | アミノセラミド様化合物および治療目的での使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7335681B2 (enExample) |
| EP (1) | EP1358172B1 (enExample) |
| JP (1) | JP2004531478A (enExample) |
| BR (1) | BR0206400A (enExample) |
| CA (2) | CA2434028C (enExample) |
| WO (1) | WO2002062777A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1358172B1 (en) | 2001-01-10 | 2009-11-18 | The Regents of The University of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US6855830B2 (en) | 2001-07-16 | 2005-02-15 | Genzyme Corporation | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
| US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| US20060217560A1 (en) * | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
| BRPI0517701A8 (pt) | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
| PL383715A1 (pl) * | 2005-01-26 | 2008-05-12 | Allergan, Inc. | Amidy kwasu 3-arylo-3-hydroksy-2-amino-propionowego, amidy kwasu 3-heteroarylo-3-hydroksy-2-amino-propionowego i ich związki pokrewne posiadające aktywność przeciwbólową i/lub pobudzającą odporność |
| ES2546181T3 (es) | 2006-05-09 | 2015-09-21 | Genzyme Corporation | Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos |
| US9314466B2 (en) | 2007-03-06 | 2016-04-19 | Allergan, Inc. | Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| EP2594565B1 (en) | 2007-05-31 | 2018-10-24 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| KR101640263B1 (ko) | 2007-10-05 | 2016-07-15 | 젠자임 코포레이션 | 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법 |
| EP2211856A4 (en) | 2007-11-29 | 2011-02-09 | Hospital For Sick Children | COMPOSITIONS AND METHODS FOR TREATING LYSOSOMAL DISORDER |
| US8741967B2 (en) | 2007-12-12 | 2014-06-03 | Children's Hospital & Research Center At Oakland | Use of unsaturated sphingosine compounds as chemotherapeutic agents for the treatment of cancer |
| WO2009132082A2 (en) * | 2008-04-22 | 2009-10-29 | Medical College Of Georgia Research Institute, Inc. | Immunogenic compositions containing ceramide and methods of use thereof |
| JP2011529500A (ja) | 2008-07-28 | 2011-12-08 | ジェンザイム コーポレーション | 虚脱性糸球体症および他の糸球体疾患の処置のためのグルコシルセラミドシンターゼ阻害 |
| CN102271678B (zh) | 2008-10-03 | 2017-06-30 | 简詹姆公司 | 2‑酰胺基丙醇型葡糖神经酰胺合成酶抑制剂 |
| US20100248365A1 (en) * | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | Ganglioside biosynthesis modulators |
| MY192644A (en) | 2009-11-27 | 2022-08-29 | Genzyme Corp | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
| CN103154742B (zh) | 2010-06-20 | 2017-11-21 | 佐拉生物科学公司 | 用于鉴定高风险冠状动脉疾病患者的脂质组学标志 |
| WO2021214771A1 (en) * | 2020-04-23 | 2021-10-28 | The Israel Institute of Biological Research (IIBR) | Glucosylceramide synthase inhibitors for prevention and treatment of viral diseases |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1128951A (zh) * | 1993-08-13 | 1996-08-14 | 生化学工业株式会社 | 治疗神经元疾病的药物 |
| CA2192555C (en) * | 1994-06-10 | 2005-01-11 | Jinichi Inokuchi | 2-acylaminopropanol compound and medicinal composition |
| WO2001004108A1 (en) | 1999-07-09 | 2001-01-18 | Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US6255336B1 (en) * | 1995-09-20 | 2001-07-03 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US20030073680A1 (en) * | 1995-09-20 | 2003-04-17 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US5916911A (en) * | 1995-09-20 | 1999-06-29 | The Regents Of The University Of Michigan | Amino ceramide--like compounds and therapeutic methods of use |
| NO965193L (no) * | 1995-12-08 | 1997-06-09 | Seikagaku Kogyo Kk Seikagaku C | Aminalkoholderivat og fremgangsmåte for fremstilling derav |
| US5972928A (en) | 1997-05-21 | 1999-10-26 | Johns Hopkins University | Methods for treatment of conditions associated with lactosylceramide |
| JP4036500B2 (ja) | 1997-05-23 | 2008-01-23 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
| US6511979B1 (en) | 1998-07-27 | 2003-01-28 | Johns Hopkins University | Methods for treating conditions modulated by lactosylceramide |
| EP1384719A1 (en) * | 1999-07-09 | 2004-01-28 | The Regents of The University of Michigan | Inhibitors of the glucosyl ceramide synthase enzyme useful for the treatment of cancers, sphingolipidosis and microbial infections |
| US20040260099A1 (en) | 2001-01-10 | 2004-12-23 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| EP1358172B1 (en) | 2001-01-10 | 2009-11-18 | The Regents of The University of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US7148251B2 (en) * | 2001-01-10 | 2006-12-12 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US20020198240A1 (en) * | 2001-01-10 | 2002-12-26 | Shayman James A. | Amino ceramide - like compounds and therapeutic methods of use |
| US6855830B2 (en) | 2001-07-16 | 2005-02-15 | Genzyme Corporation | Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
| US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| US20060217560A1 (en) | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
-
2002
- 2002-01-10 EP EP02718827A patent/EP1358172B1/en not_active Expired - Lifetime
- 2002-01-10 JP JP2002562732A patent/JP2004531478A/ja active Pending
- 2002-01-10 BR BR0206400-6A patent/BR0206400A/pt not_active Application Discontinuation
- 2002-01-10 WO PCT/US2002/000808 patent/WO2002062777A2/en not_active Ceased
- 2002-01-10 CA CA2434028A patent/CA2434028C/en not_active Expired - Lifetime
-
2003
- 2003-12-24 CA CA002454456A patent/CA2454456A1/en not_active Abandoned
-
2006
- 2006-09-15 US US11/522,063 patent/US7335681B2/en not_active Expired - Lifetime
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