JP2004531220A5 - - Google Patents
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- JP2004531220A5 JP2004531220A5 JP2002557978A JP2002557978A JP2004531220A5 JP 2004531220 A5 JP2004531220 A5 JP 2004531220A5 JP 2002557978 A JP2002557978 A JP 2002557978A JP 2002557978 A JP2002557978 A JP 2002557978A JP 2004531220 A5 JP2004531220 A5 JP 2004531220A5
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- Prior art keywords
- protein
- amino acid
- acid sequence
- identity
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 145
- 241000700605 Viruses Species 0.000 claims 60
- 102000004169 proteins and genes Human genes 0.000 claims 58
- 108090000623 proteins and genes Proteins 0.000 claims 58
- 241000351643 Metapneumovirus Species 0.000 claims 45
- 150000007523 nucleic acids Chemical group 0.000 claims 39
- 108020004707 nucleic acids Proteins 0.000 claims 36
- 102000039446 nucleic acids Human genes 0.000 claims 36
- 238000000034 method Methods 0.000 claims 31
- 210000004027 cell Anatomy 0.000 claims 15
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 14
- 108091006027 G proteins Proteins 0.000 claims 14
- 102000030782 GTP binding Human genes 0.000 claims 14
- 108091000058 GTP-Binding Proteins 0.000 claims 14
- 101150039699 M2-1 gene Proteins 0.000 claims 14
- 101150103632 M2-2 gene Proteins 0.000 claims 14
- 101710085938 Matrix protein Proteins 0.000 claims 14
- 101710127721 Membrane protein Proteins 0.000 claims 14
- 101710141454 Nucleoprotein Proteins 0.000 claims 14
- 102100034574 P protein Human genes 0.000 claims 14
- 101710181008 P protein Proteins 0.000 claims 14
- 101710177166 Phosphoprotein Proteins 0.000 claims 14
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 claims 13
- 241000711504 Paramyxoviridae Species 0.000 claims 13
- 241000711902 Pneumovirus Species 0.000 claims 11
- 230000000120 cytopathologic effect Effects 0.000 claims 11
- 241001493065 dsRNA viruses Species 0.000 claims 11
- 238000012360 testing method Methods 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 208000015181 infectious disease Diseases 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 241000342334 Human metapneumovirus Species 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 5
- 241000712461 unidentified influenza virus Species 0.000 claims 5
- 241000271566 Aves Species 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 108700026244 Open Reading Frames Proteins 0.000 claims 4
- 241000711955 Turkey rhinotracheitis virus Species 0.000 claims 4
- 230000002238 attenuated effect Effects 0.000 claims 4
- 238000012544 monitoring process Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 238000002856 computational phylogenetic analysis Methods 0.000 claims 3
- 230000002458 infectious effect Effects 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 241000711404 Avian avulavirus 1 Species 0.000 claims 2
- 229920001917 Ficoll Polymers 0.000 claims 2
- 241000893570 Hendra henipavirus Species 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- 241000713196 Influenza B virus Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241000712079 Measles morbillivirus Species 0.000 claims 2
- 241000711386 Mumps virus Species 0.000 claims 2
- 241000711408 Murine respirovirus Species 0.000 claims 2
- 241000526636 Nipah henipavirus Species 0.000 claims 2
- 241000711904 Pneumoviridae Species 0.000 claims 2
- 241001068295 Replication defective viruses Species 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 231100000676 disease causative agent Toxicity 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 206010066226 Metapneumovirus infection Diseases 0.000 claims 1
- 206010051497 Rhinotracheitis Diseases 0.000 claims 1
- 241000439025 Tupavirus Species 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 108700010900 influenza virus proteins Proteins 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 230000017960 syncytium formation Effects 0.000 claims 1
- 210000003501 vero cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01200213 | 2001-01-19 | ||
| EP01200213.5 | 2001-01-19 | ||
| EP01203985.5 | 2001-10-18 | ||
| EP01203985 | 2001-10-18 | ||
| PCT/NL2002/000040 WO2002057302A2 (en) | 2001-01-19 | 2002-01-18 | A virus causing respiratory tract illness in susceptible mammals |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011050982A Division JP2011177173A (ja) | 2001-01-19 | 2011-03-09 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004531220A JP2004531220A (ja) | 2004-10-14 |
| JP2004531220A5 true JP2004531220A5 (OSRAM) | 2005-12-22 |
| JP5503096B2 JP5503096B2 (ja) | 2014-05-28 |
Family
ID=26076820
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002557978A Expired - Lifetime JP5503096B2 (ja) | 2001-01-19 | 2002-01-18 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
| JP2011050982A Pending JP2011177173A (ja) | 2001-01-19 | 2011-03-09 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
| JP2013142224A Expired - Lifetime JP5813060B2 (ja) | 2001-01-19 | 2013-07-08 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011050982A Pending JP2011177173A (ja) | 2001-01-19 | 2011-03-09 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
| JP2013142224A Expired - Lifetime JP5813060B2 (ja) | 2001-01-19 | 2013-07-08 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
Country Status (21)
| Country | Link |
|---|---|
| US (10) | US8927206B2 (OSRAM) |
| EP (1) | EP1351981B1 (OSRAM) |
| JP (3) | JP5503096B2 (OSRAM) |
| KR (4) | KR101412317B1 (OSRAM) |
| CN (2) | CN101921732A (OSRAM) |
| AU (1) | AU2002228471B2 (OSRAM) |
| BR (1) | BR0206591A (OSRAM) |
| CA (1) | CA2435180C (OSRAM) |
| DK (1) | DK1351981T3 (OSRAM) |
| EA (1) | EA006879B1 (OSRAM) |
| ES (1) | ES2393468T3 (OSRAM) |
| HU (1) | HUP0500244A3 (OSRAM) |
| IL (1) | IL157003A0 (OSRAM) |
| MX (1) | MXPA03006430A (OSRAM) |
| NO (1) | NO335551B1 (OSRAM) |
| NZ (2) | NZ527221A (OSRAM) |
| PL (1) | PL213926B1 (OSRAM) |
| SG (1) | SG149684A1 (OSRAM) |
| UA (1) | UA93981C2 (OSRAM) |
| WO (1) | WO2002057302A2 (OSRAM) |
| ZA (1) | ZA200305655B (OSRAM) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060094105A1 (en) | 1998-04-24 | 2006-05-04 | University Hospitals Of Cleveland | Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses |
| US20030232061A1 (en) * | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| US8715922B2 (en) | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
| SG149684A1 (en) | 2001-01-19 | 2009-02-27 | Vironovative Bv | A virus causing respiratory tract illness in susceptible animals |
| KR101076102B1 (ko) * | 2002-02-21 | 2011-10-21 | 비로노바티브 비.브이. | 메타뉴모바이러스에서 유래한 이종성 항원을 포함하는재조합 파라인플루엔자 바이러스 발현 시스템 및 백신 |
| DE10221836A1 (de) * | 2002-05-16 | 2003-12-04 | Lohmann Animal Health Gmbh | Attenuierung von Metapneumovirus |
| WO2004010935A2 (en) * | 2002-07-25 | 2004-02-05 | Medimmune, Inc. | Methods of treating and preventing rsv, hmpv, and piv using anti-rsv, anti-hmpv, and anti-piv antibodies |
| AU2003297602A1 (en) * | 2002-12-02 | 2004-06-23 | University Of Maryland, College Park | Avian pneumovirus genes, recombinant avian pneumoviruses and methods of making |
| AU2003294533A1 (en) * | 2002-12-19 | 2004-07-14 | Universite Laval | Molecular methods and compositions for detecting and quantifying respiratory viruses |
| EP1603939A2 (en) | 2003-02-28 | 2005-12-14 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Recombinant human metapneumovirus and its use |
| WO2004085650A1 (en) | 2003-03-24 | 2004-10-07 | The University Of Hong Kong | A high-troughput diagnostic assay for the human virus causing severe acute respiratory syndrome (sars) |
| ATE469170T1 (de) | 2003-03-28 | 2010-06-15 | Medimmune Llc | Zusammensetzungen und verfahren mit dem respiratory syncytial virus untergruppe b stamm 9320 |
| KR20110094361A (ko) * | 2003-04-11 | 2011-08-23 | 메디뮨 엘엘씨 | 재조합 ｉｌ９ 항체 및 그의 용도 |
| JP2006524511A (ja) * | 2003-04-25 | 2006-11-02 | メッドイミューン バクシーンズ，インコーポレイティド | メタニューモウイルス由来の異種抗原を含む組換えパラインフルエンザウイルス発現系およびワクチン |
| CA2523319A1 (en) | 2003-04-25 | 2004-11-11 | Medimmune Vaccines, Inc. | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
| EP1473037A1 (en) * | 2003-05-02 | 2004-11-03 | Vironovative B.V. | Treatment of hPMV infections with Ribavirin |
| AU2004274717A1 (en) * | 2003-09-22 | 2005-03-31 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | A method for detecting Nipah virus and method for providing immunoprotection against henipaviruses |
| EP1755673B1 (en) | 2004-04-12 | 2014-07-23 | MedImmune, LLC | Anti-il-9 antibody formulations and uses thereof |
| JP4546212B2 (ja) * | 2004-10-21 | 2010-09-15 | 三菱化学メディエンス株式会社 | 抗原蛋白質を発現した細胞を利用する抗体測定方法 |
| EP1869225A4 (en) * | 2005-03-10 | 2010-02-24 | Medimmune Vaccines Inc | METAPNEUMOVIRENSTÄMME AND THEIR USE IN VACCINATE FORMULATIONS AND AS VECTORS FOR THE EXPRESSION OF ANTIGENOUS SEQUENCES AND METHOD FOR SPREADING THE VIRUS |
| US20080175836A1 (en) * | 2005-12-09 | 2008-07-24 | Karp Nelson M | Immunogenic composition based on conditionally live virion and method for producing the same |
| US8492097B2 (en) | 2006-04-24 | 2013-07-23 | Diagnostic Hybrids, Inc. | Compositions and methods for human metapneumovirus monoclonal antibodies |
| WO2009012155A2 (en) * | 2007-07-13 | 2009-01-22 | Medimmune, Llc | Preparation of negative-stranded rna viruses by electroporation |
| WO2009062532A1 (en) * | 2007-11-16 | 2009-05-22 | Vironovative Bv | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
| US20090186050A1 (en) * | 2007-11-16 | 2009-07-23 | Fouchier Ron A M | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
| CA2741523C (en) | 2008-10-24 | 2022-06-21 | Jonathan S. Towner | Human ebola virus species and compositions and methods thereof |
| KR101073991B1 (ko) * | 2009-10-27 | 2011-10-21 | 대한민국 | 국내사육 닭에서 유행하는 신규한 ｂ형 조류메타뉴모바이러스 ｓｃ1509주 및 이의 용도 |
| CN101880732B (zh) * | 2010-06-29 | 2012-10-10 | 中国药品生物制品检定所 | 猴副流感病毒5型的rt-pcr检测方法及试剂盒 |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| ES3005233T3 (en) | 2010-10-01 | 2025-03-14 | Modernatx Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| JP2015501844A (ja) | 2011-12-16 | 2015-01-19 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物 |
| CA2865856C (en) | 2012-03-20 | 2023-03-14 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| WO2013151663A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| EA039682B1 (ru) * | 2012-06-04 | 2022-02-28 | Хумабс Биомед Са | Антитела, нейтрализующие rsv, mpv и pvm, и их применения |
| CN102676701B (zh) * | 2012-06-11 | 2013-08-14 | 广东温氏食品集团股份有限公司 | 禽肺病毒通用型rt-pcr检测引物及检测方法 |
| ES2921623T3 (es) | 2012-11-26 | 2022-08-30 | Modernatx Inc | ARN modificado terminalmente |
| WO2014115893A1 (ja) | 2013-01-28 | 2014-07-31 | 株式会社イーベック | ヒト・メタニューモウイルスに特異的なヒト抗体もしくはその抗原結合性断片 |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| CN103360472B (zh) * | 2013-07-30 | 2015-02-25 | 北京市农林科学院 | 禽偏肺病毒抗体elisa检测试剂盒 |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| CL2013002829A1 (es) * | 2013-10-01 | 2014-04-04 | Univ Pontificia Catolica Chile | Formulacion inmunogenica que contiene bcg vivas recombinantes que expresan antigenos de metapneumovirus (hmpv) en una suspension que se prepara a partir de un liofilizado sin la necesidad de adjuvante; su uso farmaceutico; vacuna contra hmpv. |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| WO2015135925A1 (en) * | 2014-03-10 | 2015-09-17 | Fondation The Ark | Respiratory syncytial virus (rsv) replication inhibitors |
| MD3718565T2 (ro) | 2015-10-22 | 2022-09-30 | Modernatx Inc | Vaccinuri împotriva virusului respirator |
| DE102016215118A1 (de) | 2016-08-12 | 2018-02-15 | Anicon Labor Gmbh | Infektiöse Bronchitis (IB)-Virus Varianten und diesbezügliche Zusammensetzungen, Verwendungen und Verfahren |
| WO2018076342A1 (en) * | 2016-10-31 | 2018-05-03 | Wuhan Sanli Biotechnology Co., Ltd. | Respiratory syncytial virus vaccine |
| EP3551193A4 (en) | 2016-12-08 | 2020-08-19 | Modernatx, Inc. | NUCLEIC ACID VACCINES AGAINST RESPIRATORY VIRUSES |
| WO2018170347A1 (en) | 2017-03-17 | 2018-09-20 | Modernatx, Inc. | Zoonotic disease rna vaccines |
| CN112262215B (zh) * | 2018-04-23 | 2025-03-18 | 美国卫生和人力服务部 | 嵌合载体 |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| US20240279610A1 (en) | 2021-06-09 | 2024-08-22 | Universität Duisburg-Essen | Method for immortalising vesicle-secreting cells |
| WO2023004307A1 (en) * | 2021-07-19 | 2023-01-26 | Epivax, Inc. | T cell epitopes and related compositions useful in the prevention and treatment of respiratory syncytial virus infection |
| KR102911418B1 (ko) * | 2023-11-20 | 2026-01-14 | 서울대학교산학협력단 | 조류메타뉴모바이러스 변이주 및 이를 포함하는 백신 조성물 |
| US12605349B2 (en) | 2024-09-05 | 2026-04-21 | Orbus Therapeutics, Inc. | Methods of treating grade 3 astrocytoma |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| DE68915165T2 (de) | 1988-04-22 | 1994-09-08 | Upjohn Co | Schimärische glykoproteine enthaltende immunogenische abschnitte von menschlichem parainfluenzavirus typ 3. |
| US5137819A (en) | 1988-07-08 | 1992-08-11 | University Of British Columbia | Cellulose binding fusion proteins for immobilization and purification of polypeptides |
| US5854037A (en) | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
| GB9200117D0 (en) | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
| WO1995028500A1 (en) | 1994-04-19 | 1995-10-26 | Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis | Nucleic acids and methods for the discrimination between syncytium inducing and non syncytium inducing variants of the human immunodeficiency virus |
| SE504386C2 (sv) | 1994-05-30 | 1997-01-27 | Bengt Wilhelm Toernqvist | Bottenkonstruktion på ett deplacementfartygsskrov |
| DK0702085T4 (da) | 1994-07-18 | 2010-04-06 | Conzelmann Karl Klaus Prof Dr | Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus |
| US7153510B1 (en) | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
| ATE181112T1 (de) | 1995-08-09 | 1999-06-15 | Schweiz Serum & Impfinst | Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren |
| CA2230033C (en) | 1995-09-27 | 2010-01-26 | Peter L. Collins | Production of infectious respiratory syncytial virus from cloned nucleotide sequences |
| US5869036A (en) | 1995-12-08 | 1999-02-09 | St. Louis University | Live attenuated vaccines based on CP45 HPIV-3 strain and method to ensure attenuation in such vaccine |
| ES2109189B1 (es) | 1996-03-14 | 1998-05-16 | Iberica Cyanamid | Vectores basados en genomas virales defectivos recombinantes y su empleo en la formulacion de vacunas. |
| US6180398B1 (en) | 1996-07-12 | 2001-01-30 | Virogeneitics Corporation | Two-step immunization procedure against the pyramyxoviridae family of viruses using recombinant virus and subunit protein preparation |
| EP0912724B1 (en) | 1996-07-15 | 2009-12-09 | The Government of The United States of America, as represented by The Department of Health and Human Services | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences |
| BR9712138A (pt) | 1996-09-27 | 2000-01-18 | American Cyanamid Co | Vìrus de rna isolado, vacina, processo para imunizr um indivìduo para induzir proteção contra um vìrus de rna não segmentado, sentido negativo, de filamento único, da ordem mononegavirales e para produzir vìrus de rna, molécula de ácido nucleico isolada e composição. |
| US5817494A (en) | 1997-05-21 | 1998-10-06 | Incyte Pharmaceuticals, Inc. | Ubiquitin conjugation proteins |
| DE69842165D1 (de) | 1997-05-23 | 2011-04-21 | Us Of America As Represented By The Secretary Of The Dept Of Health And Human Services | Herstellung attenuierter parainfluenza-virus impfstoffe aus klonierten nukleotidsequenzen |
| US7192593B2 (en) | 1997-05-23 | 2007-03-20 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens |
| ES2287977T3 (es) | 1997-07-11 | 2007-12-16 | Yale University | Rabdovirus con cubiertas rediseñadas. |
| JP2001517448A (ja) | 1997-09-19 | 2001-10-09 | アメリカン・サイアナミド・カンパニー | 弱毒化呼吸合胞体ウイルス |
| US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| WO2000020600A1 (en) * | 1998-10-05 | 2000-04-13 | Akzo Nobel N.V. | Avian pneumovirus vaccine and diagnostic agent |
| ATE367445T1 (de) | 1999-05-18 | 2007-08-15 | Dnavec Research Inc | Viraler paramyxoviridae vektor mit einem defekten hüllprotein-gen |
| KR100940776B1 (ko) | 1999-07-09 | 2010-02-11 | 더 가버먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 리프리젠티드 바이 더 디파트먼트 오브 헬스 앤 휴먼 서비씨즈 | 약독화된 사람-소 키메라 파라인플루엔자바이러스(ｐｉｖ) 백신 |
| ATE233623T1 (de) | 1999-07-29 | 2003-03-15 | Hatebur Umformmaschinen Ag | Vorrichtung zur erzeugung einer hebe- und senkbewegung |
| FR2801607B1 (fr) | 1999-11-26 | 2001-12-28 | Merial Sas | Pneumovirus du canard et vaccins correspondants |
| EP1103610A1 (en) | 1999-11-26 | 2001-05-30 | Introgene B.V. | Production of vaccines from immortalised mammalian cell lines |
| JP4795597B2 (ja) | 1999-12-10 | 2011-10-19 | アメリカ合衆国 | パラインフルエンザウィルス（ｐｉｖ）及びヒトの病原体により引き起こされる感染及び疾病を保護するためへの組換えｐｉｖのベクターとしての使用 |
| US6764685B1 (en) | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
| US6387586B1 (en) | 2000-11-06 | 2002-05-14 | Eastman Kodak Company | High contrast visually adaptive radiographic film and imaging assembly for thoracic imaging |
| EP1480671B1 (en) | 2000-11-28 | 2007-08-08 | MedImmune Vaccines, Inc. | Recombinant rsv virus expression systems and vaccines |
| US6632459B2 (en) | 2000-12-11 | 2003-10-14 | Nutricia N.V. | Chlorogenic acid and an analog thereof for immune system stimulation |
| US8715922B2 (en) | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
| US20030232061A1 (en) | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| SG149684A1 (en) | 2001-01-19 | 2009-02-27 | Vironovative Bv | A virus causing respiratory tract illness in susceptible animals |
| US7704509B2 (en) | 2001-11-21 | 2010-04-27 | United States Of America | Recovery of recombinant human parainfluenza virus type 1 (HPIV1) from cDNA and use of recombinant HPIV1 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens |
| KR101076102B1 (ko) | 2002-02-21 | 2011-10-21 | 비로노바티브 비.브이. | 메타뉴모바이러스에서 유래한 이종성 항원을 포함하는재조합 파라인플루엔자 바이러스 발현 시스템 및 백신 |
| DE10221836A1 (de) | 2002-05-16 | 2003-12-04 | Lohmann Animal Health Gmbh | Attenuierung von Metapneumovirus |
| WO2004010935A2 (en) | 2002-07-25 | 2004-02-05 | Medimmune, Inc. | Methods of treating and preventing rsv, hmpv, and piv using anti-rsv, anti-hmpv, and anti-piv antibodies |
| US6605283B1 (en) * | 2002-11-01 | 2003-08-12 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleotide sequence for the Avian Metapneumovirus (Colorado) attachment glycoprotein gene |
| AU2003294533A1 (en) | 2002-12-19 | 2004-07-14 | Universite Laval | Molecular methods and compositions for detecting and quantifying respiratory viruses |
| EP1603939A2 (en) | 2003-02-28 | 2005-12-14 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Recombinant human metapneumovirus and its use |
| CN1757063A (zh) | 2003-03-05 | 2006-04-05 | 皇家飞利浦电子股份有限公司 | 确定在光学介质上写入/擦除信息的功率参数的设备和方法 |
| TW200508247A (en) | 2003-04-08 | 2005-03-01 | Vironovative Bv | Sars |
| CA2523319A1 (en) | 2003-04-25 | 2004-11-11 | Medimmune Vaccines, Inc. | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
| JP2006524511A (ja) | 2003-04-25 | 2006-11-02 | メッドイミューン バクシーンズ，インコーポレイティド | メタニューモウイルス由来の異種抗原を含む組換えパラインフルエンザウイルス発現系およびワクチン |
| US20040229219A1 (en) | 2003-04-30 | 2004-11-18 | Gallaher William R. | Method of inhibiting human metapneumovirus and human coronavirus in the prevention and treatment of severe acute respiratory syndrome (SARS) |
| EP1533370A1 (en) | 2003-11-18 | 2005-05-25 | ViroNovative B.V. | Novel atypical pneumonia-causing virus |
| EP1548748A1 (en) | 2003-12-17 | 2005-06-29 | Interuniversitaire Microelectronica Centrum vzw ( IMEC) | A method for making probes for atomic force microscopy |
| WO2005080991A1 (en) | 2004-02-20 | 2005-09-01 | Erasmus Universiteit Rotterdam | Method to detect antigen-specific cytolytic activity |
| US8318423B2 (en) | 2004-07-06 | 2012-11-27 | Focus Diagnostics, Inc. | Methods and compositions for detecting rhinoviruses |
| EP2272950A3 (en) | 2004-11-11 | 2011-07-20 | Abbott Biologicals B.V. | Defective influenza virus particles |
| EP2295542B1 (en) | 2004-12-24 | 2013-01-30 | Abbott Biologicals B.V. | Rescue of influenza virus |
| EP1869225A4 (en) | 2005-03-10 | 2010-02-24 | Medimmune Vaccines Inc | METAPNEUMOVIRENSTÄMME AND THEIR USE IN VACCINATE FORMULATIONS AND AS VECTORS FOR THE EXPRESSION OF ANTIGENOUS SEQUENCES AND METHOD FOR SPREADING THE VIRUS |
| WO2006110214A2 (en) | 2005-04-08 | 2006-10-19 | Medimmune, Inc. | Antibodies against mammalian metapneumovirus |
| EP1748447B1 (en) | 2005-07-28 | 2008-10-22 | Interuniversitair Microelektronica Centrum ( Imec) | Dual tip atomic force microscopy probe and method for producing such a probe |
| EP1925318A1 (en) | 2006-11-20 | 2008-05-28 | Paul-Ehrlich-Institut | Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu |
| US20090186050A1 (en) | 2007-11-16 | 2009-07-23 | Fouchier Ron A M | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
| CA2805741C (en) | 2010-07-23 | 2019-08-13 | Karin Bengtsson Loevgren | Composition including an iscom matrix and ectodomains |
| JP5923723B2 (ja) | 2011-06-02 | 2016-05-25 | パナソニックＩｐマネジメント株式会社 | 人物属性推定システム、人物属性推定装置、及び人物属性推定方法 |
| SG11201502189UA (en) | 2012-09-23 | 2015-04-29 | Univ Erasmus Medical Ct | Human betacoronavirus lineage c and identification of n-terminal dipeptidyl peptidase as its virus receptor |
| CN109402065B (zh) * | 2018-08-08 | 2021-07-30 | 温氏食品集团股份有限公司 | 一种番鸭c亚型禽偏肺病毒弱毒株及其制备和应用 |
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