JP2004529163A5 - - Google Patents
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- Publication number
- JP2004529163A5 JP2004529163A5 JP2002586908A JP2002586908A JP2004529163A5 JP 2004529163 A5 JP2004529163 A5 JP 2004529163A5 JP 2002586908 A JP2002586908 A JP 2002586908A JP 2002586908 A JP2002586908 A JP 2002586908A JP 2004529163 A5 JP2004529163 A5 JP 2004529163A5
- Authority
- JP
- Japan
- Prior art keywords
- liposome
- compound
- internalizable
- phospholipid
- liposome according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002502 liposome Substances 0.000 claims 25
- 239000000463 material Substances 0.000 claims 11
- 150000003904 phospholipids Chemical class 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000002184 metal Substances 0.000 claims 5
- 150000002632 lipids Chemical class 0.000 claims 4
- 239000003607 modifier Substances 0.000 claims 4
- 230000007935 neutral effect Effects 0.000 claims 4
- -1 phosphatidylcholine compound Chemical class 0.000 claims 4
- 229930182558 Sterol Natural products 0.000 claims 3
- 150000003432 sterols Chemical class 0.000 claims 3
- 235000003702 sterols Nutrition 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 230000005298 paramagnetic effect Effects 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 239000002616 MRI contrast agent Substances 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 238000012879 PET imaging Methods 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 229960002433 cysteine Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002190 fatty acyls Chemical group 0.000 claims 1
- 229960003180 glutathione Drugs 0.000 claims 1
- 235000003969 glutathione Nutrition 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0111279.6A GB0111279D0 (en) | 2001-05-10 | 2001-05-10 | Radiolabelled liposomes |
| PCT/GB2002/002100 WO2002089771A1 (en) | 2001-05-10 | 2002-05-10 | Liposomes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004529163A JP2004529163A (ja) | 2004-09-24 |
| JP2004529163A5 true JP2004529163A5 (https=) | 2005-12-22 |
| JP4629308B2 JP4629308B2 (ja) | 2011-02-09 |
Family
ID=9914262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002586908A Expired - Fee Related JP4629308B2 (ja) | 2001-05-10 | 2002-05-10 | リポソーム |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040170560A1 (https=) |
| EP (1) | EP1385480B1 (https=) |
| JP (1) | JP4629308B2 (https=) |
| AT (1) | ATE430557T1 (https=) |
| DE (1) | DE60232237D1 (https=) |
| ES (1) | ES2323493T3 (https=) |
| GB (1) | GB0111279D0 (https=) |
| WO (1) | WO2002089771A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101133084B1 (ko) * | 2002-12-31 | 2012-04-04 | 자이더스 비에스브이 파마 프라이빗 리미티드 | 장기간 순환성 비-페길레이티드 리포좀 |
| DE602004027655D1 (de) * | 2003-11-03 | 2010-07-22 | Yissum Res Dev Co | Verfahren zur auswahl von kationischen oder anionischen liposomen zur behandlung einer schleimhautmembran und diese enthaltendes set |
| US8349359B2 (en) * | 2004-11-07 | 2013-01-08 | Your Energy Systems, LLC | Liposomal formulation for oral administration of glutathione (reduced) |
| EP3415151A1 (en) * | 2008-05-23 | 2018-12-19 | The University of British Columbia | Modified drugs for use in liposomal nanoparticles |
| CA2746527A1 (en) * | 2008-09-22 | 2010-03-25 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| AR076634A1 (es) * | 2008-11-21 | 2011-06-29 | Medgenesis Therapeutix Inc | Composiciones y metodo para tratar desordenes del sistema nervioso central |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| AU2010247800A1 (en) | 2009-05-11 | 2011-12-15 | Berg Llc | Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
| AU2010270722B2 (en) * | 2009-07-06 | 2015-06-04 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| CN105168135A (zh) * | 2010-03-12 | 2015-12-23 | 博格有限责任公司 | 辅酶Q10(CoQ10)的静脉内制剂及其使用方法 |
| CA2832324C (en) | 2011-04-04 | 2022-03-15 | Berg Llc | Methods of treating central nervous system tumors |
| BR112013027413A2 (pt) * | 2011-04-26 | 2019-09-24 | Cedars Sinai Medical Center | vancomicina lipossomal para o tratamento de infecções de sarm. |
| US10973763B2 (en) | 2011-06-17 | 2021-04-13 | Berg Llc | Inhalable pharmaceutical compositions |
| FR2979239A1 (fr) * | 2011-08-25 | 2013-03-01 | Trophos | Liposome comprenant au moins un derive de cholesterol |
| US20140023696A1 (en) * | 2012-07-20 | 2014-01-23 | Frederick Timothy Guilford | Treatment for idiopathic pulmonary fibrosis |
| SG10201903112WA (en) | 2013-04-08 | 2019-05-30 | Berg Llc | Treatment of cancer using coenzyme q10 combination therapies |
| CN105579582A (zh) | 2013-07-25 | 2016-05-11 | 埃克西奎雷股份有限公司 | 用于预防和治疗用途的作为免疫刺激剂的基于球形核酸的构建体 |
| WO2015023797A1 (en) * | 2013-08-13 | 2015-02-19 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| KR102370843B1 (ko) | 2013-09-04 | 2022-03-04 | 버그 엘엘씨 | 코엔자임 q10의 연속주입에 의한 암치료 방법 |
| JP6527516B2 (ja) | 2013-12-03 | 2019-06-05 | ノースウェスタン ユニバーシティ | リポソーム粒子、前述のものを作製する方法及びその使用 |
| AU2015269412B2 (en) | 2014-06-04 | 2020-03-12 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| KR102506169B1 (ko) | 2014-09-05 | 2023-03-08 | 피오 파마슈티칼스 코프. | Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법 |
| CA2963931A1 (en) | 2014-10-06 | 2016-04-14 | Exicure, Inc. | Anti-tnf compounds |
| WO2016085986A1 (en) | 2014-11-24 | 2016-06-02 | Northwestern University | High density lipoprptein nanoparticles for inflammation |
| CN105434368A (zh) * | 2014-11-27 | 2016-03-30 | 广州白云山明兴制药有限公司 | 一种注射用还原型谷胱甘肽及其预冻方法 |
| US10078092B2 (en) | 2015-03-18 | 2018-09-18 | Northwestern University | Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules |
| WO2017087576A1 (en) | 2015-11-16 | 2017-05-26 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| EP3452598A4 (en) | 2016-05-06 | 2020-04-29 | Exicure, Inc. | LIPOSOMAL SPHERICAL NUCLEIC ACID (ANS) CONSTRUCTS HAVING ANTISENSE OLIGONUCLEOTIDES (ASO) FOR THE SPECIFIC INACTIVATION OF INTERLEUKIN 17 RECEPTOR RNA |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| JP2020526558A (ja) | 2017-07-13 | 2020-08-31 | ノースウェスタン ユニバーシティ | オリゴヌクレオチド官能化金属有機構造体ナノ粒子を調製するための一般的かつ直接的な方法 |
| US10722465B1 (en) | 2017-12-08 | 2020-07-28 | Quicksilber Scientific, Inc. | Transparent colloidal vitamin supplement |
| US11344497B1 (en) | 2017-12-08 | 2022-05-31 | Quicksilver Scientific, Inc. | Mitochondrial performance enhancement nanoemulsion |
| US11291702B1 (en) | 2019-04-15 | 2022-04-05 | Quicksilver Scientific, Inc. | Liver activation nanoemulsion, solid binding composition, and toxin excretion enhancement method |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6137735A (ja) * | 1984-07-31 | 1986-02-22 | Terumo Corp | ヘモグロビン含有リポソ−ムおよびその製造方法 |
| DE69018460T2 (de) * | 1989-04-18 | 1995-11-09 | Vestar Inc | Markierung mit liposomen von ischämischen geweben. |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5143713A (en) * | 1990-05-30 | 1992-09-01 | Board Of Regents, The University Of Texas System | 99m Tc labeled liposomes |
| AU3244393A (en) * | 1992-12-02 | 1994-06-22 | Vestar, Inc. | Antibiotic formulation and process |
| US6764693B1 (en) * | 1992-12-11 | 2004-07-20 | Amaox, Ltd. | Free radical quenching composition and a method to increase intracellular and/or extracellular antioxidants |
| GB9420390D0 (en) * | 1994-10-10 | 1994-11-23 | Nycomed Salutar Inc | Liposomal agents |
| EP0825852B1 (en) * | 1995-04-18 | 2004-07-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
| US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US6120800A (en) * | 1997-09-25 | 2000-09-19 | Nexstar Pharmaceuticals, Inc. | Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties |
| JPH11171772A (ja) * | 1997-12-11 | 1999-06-29 | Sankyo Co Ltd | 抗腫瘍薬のリポソーム化製剤 |
| MXPA01010977A (es) * | 1999-04-29 | 2002-07-22 | Alza Corp | Composiciones de liposoma para la retencion mejorada del medicamento. |
| CA2340757A1 (en) * | 1999-07-07 | 2001-01-18 | Her Majesty The Queen As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government | Delivery of liposomal-encapsulated antioxidants and applications thereof |
-
2001
- 2001-05-10 GB GBGB0111279.6A patent/GB0111279D0/en not_active Ceased
-
2002
- 2002-05-10 US US10/477,157 patent/US20040170560A1/en not_active Abandoned
- 2002-05-10 WO PCT/GB2002/002100 patent/WO2002089771A1/en not_active Ceased
- 2002-05-10 ES ES02769160T patent/ES2323493T3/es not_active Expired - Lifetime
- 2002-05-10 EP EP02769160A patent/EP1385480B1/en not_active Expired - Lifetime
- 2002-05-10 DE DE60232237T patent/DE60232237D1/de not_active Expired - Lifetime
- 2002-05-10 JP JP2002586908A patent/JP4629308B2/ja not_active Expired - Fee Related
- 2002-05-10 AT AT02769160T patent/ATE430557T1/de not_active IP Right Cessation
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