JP2004529163A5 - - Google Patents
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- Publication number
- JP2004529163A5 JP2004529163A5 JP2002586908A JP2002586908A JP2004529163A5 JP 2004529163 A5 JP2004529163 A5 JP 2004529163A5 JP 2002586908 A JP2002586908 A JP 2002586908A JP 2002586908 A JP2002586908 A JP 2002586908A JP 2004529163 A5 JP2004529163 A5 JP 2004529163A5
- Authority
- JP
- Japan
- Prior art keywords
- liposome
- compound
- internalizable
- phospholipid
- liposome according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002502 liposome Substances 0.000 claims 25
- 239000000463 material Substances 0.000 claims 11
- 150000003904 phospholipids Chemical class 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000002184 metal Substances 0.000 claims 5
- 150000002632 lipids Chemical class 0.000 claims 4
- 239000003607 modifier Substances 0.000 claims 4
- 230000007935 neutral effect Effects 0.000 claims 4
- -1 phosphatidylcholine compound Chemical class 0.000 claims 4
- 229930182558 Sterol Natural products 0.000 claims 3
- 150000003432 sterols Chemical class 0.000 claims 3
- 235000003702 sterols Nutrition 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 230000005298 paramagnetic effect Effects 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 239000002616 MRI contrast agent Substances 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 238000012879 PET imaging Methods 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 229960002433 cysteine Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002190 fatty acyls Chemical group 0.000 claims 1
- 229960003180 glutathione Drugs 0.000 claims 1
- 235000003969 glutathione Nutrition 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0111279.6A GB0111279D0 (en) | 2001-05-10 | 2001-05-10 | Radiolabelled liposomes |
| PCT/GB2002/002100 WO2002089771A1 (en) | 2001-05-10 | 2002-05-10 | Liposomes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004529163A JP2004529163A (ja) | 2004-09-24 |
| JP2004529163A5 true JP2004529163A5 (https=) | 2005-12-22 |
| JP4629308B2 JP4629308B2 (ja) | 2011-02-09 |
Family
ID=9914262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002586908A Expired - Fee Related JP4629308B2 (ja) | 2001-05-10 | 2002-05-10 | リポソーム |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040170560A1 (https=) |
| EP (1) | EP1385480B1 (https=) |
| JP (1) | JP4629308B2 (https=) |
| AT (1) | ATE430557T1 (https=) |
| DE (1) | DE60232237D1 (https=) |
| ES (1) | ES2323493T3 (https=) |
| GB (1) | GB0111279D0 (https=) |
| WO (1) | WO2002089771A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0317882A (pt) * | 2002-12-31 | 2005-12-13 | Bharat Serums & Vaccines Ltd | Processo para fabricação de lipossomas de longa circulação não tratados com peg; lipossoma; composição de doxorrubicina lipossomal de longa duração não tratada com peg; e método |
| ATE470435T1 (de) * | 2003-11-03 | 2010-06-15 | Yissum Res Dev Co | Verfahren zur auswahl von kationischen oder anionischen liposomen zur behandlung einer schleimhautmembran und diese enthaltendes set |
| US8349359B2 (en) * | 2004-11-07 | 2013-01-08 | Your Energy Systems, LLC | Liposomal formulation for oral administration of glutathione (reduced) |
| KR101975843B1 (ko) * | 2008-05-23 | 2019-05-09 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 리포좀 나노입자에 사용하기 위한 변형된 약물 |
| EP2342340A1 (en) * | 2008-09-22 | 2011-07-13 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| AR076634A1 (es) * | 2008-11-21 | 2011-06-29 | Medgenesis Therapeutix Inc | Composiciones y metodo para tratar desordenes del sistema nervioso central |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| CN102481271A (zh) | 2009-05-11 | 2012-05-30 | 博格生物系统有限责任公司 | 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法 |
| JP5854559B2 (ja) * | 2009-07-06 | 2016-02-09 | ヴァリエーション バイオテクノロジーズ インコーポレイテッド | 小胞を調製する方法及びこれから製造される製剤 |
| SG10202010355PA (en) * | 2010-03-12 | 2020-11-27 | Berg Llc | Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof |
| CA2832324C (en) | 2011-04-04 | 2022-03-15 | Berg Llc | Methods of treating central nervous system tumors |
| BR112013027413A2 (pt) * | 2011-04-26 | 2019-09-24 | Cedars Sinai Medical Center | vancomicina lipossomal para o tratamento de infecções de sarm. |
| EP2720680B1 (en) | 2011-06-17 | 2020-02-12 | Berg LLC | Inhalable pharmaceutical compositions |
| FR2979239A1 (fr) * | 2011-08-25 | 2013-03-01 | Trophos | Liposome comprenant au moins un derive de cholesterol |
| US20140023696A1 (en) * | 2012-07-20 | 2014-01-23 | Frederick Timothy Guilford | Treatment for idiopathic pulmonary fibrosis |
| NZ713868A (en) | 2013-04-08 | 2021-12-24 | Berg Llc | Treatment of cancer using coenzyme q10 combination therapies |
| EP3024936B1 (en) | 2013-07-25 | 2019-09-04 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| US10568898B2 (en) * | 2013-08-13 | 2020-02-25 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| KR102370843B1 (ko) | 2013-09-04 | 2022-03-04 | 버그 엘엘씨 | 코엔자임 q10의 연속주입에 의한 암치료 방법 |
| US10182988B2 (en) | 2013-12-03 | 2019-01-22 | Northwestern University | Liposomal particles, methods of making same and uses thereof |
| TR201908550T4 (tr) | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
| US10900039B2 (en) | 2014-09-05 | 2021-01-26 | Phio Pharmaceuticals Corp. | Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1 |
| CR20170181A (es) | 2014-10-06 | 2017-05-31 | Exicure Inc | Compuestos anti-tnf |
| US10517924B2 (en) | 2014-11-24 | 2019-12-31 | Northwestern University | High density lipoprotein nanoparticles for inflammation |
| CN105434368A (zh) * | 2014-11-27 | 2016-03-30 | 广州白云山明兴制药有限公司 | 一种注射用还原型谷胱甘肽及其预冻方法 |
| US10078092B2 (en) | 2015-03-18 | 2018-09-18 | Northwestern University | Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules |
| WO2017087576A1 (en) | 2015-11-16 | 2017-05-26 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| EP3452598A4 (en) | 2016-05-06 | 2020-04-29 | Exicure, Inc. | LIPOSOMAL SPHERICAL NUCLEIC ACID (ANS) CONSTRUCTS HAVING ANTISENSE OLIGONUCLEOTIDES (ASO) FOR THE SPECIFIC INACTIVATION OF INTERLEUKIN 17 RECEPTOR RNA |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| MX2020000387A (es) | 2017-07-13 | 2020-08-17 | Univ Northwestern | Método general y directo para preparar nanopartículas de estructura organometálica funcionalizadas con oligonucleotidos. |
| US11344497B1 (en) | 2017-12-08 | 2022-05-31 | Quicksilver Scientific, Inc. | Mitochondrial performance enhancement nanoemulsion |
| US10722465B1 (en) | 2017-12-08 | 2020-07-28 | Quicksilber Scientific, Inc. | Transparent colloidal vitamin supplement |
| US11291702B1 (en) | 2019-04-15 | 2022-04-05 | Quicksilver Scientific, Inc. | Liver activation nanoemulsion, solid binding composition, and toxin excretion enhancement method |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6137735A (ja) * | 1984-07-31 | 1986-02-22 | Terumo Corp | ヘモグロビン含有リポソ−ムおよびその製造方法 |
| EP0469082B1 (en) * | 1989-04-18 | 1995-04-05 | Vestar, Inc. | Liposomal targeting of ischemic tissue |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5143713A (en) * | 1990-05-30 | 1992-09-01 | Board Of Regents, The University Of Texas System | 99m Tc labeled liposomes |
| WO1994012155A1 (en) * | 1992-12-02 | 1994-06-09 | Vestar, Inc. | Antibiotic formulation and process |
| US6764693B1 (en) * | 1992-12-11 | 2004-07-20 | Amaox, Ltd. | Free radical quenching composition and a method to increase intracellular and/or extracellular antioxidants |
| GB9420390D0 (en) * | 1994-10-10 | 1994-11-23 | Nycomed Salutar Inc | Liposomal agents |
| WO1996032930A1 (en) * | 1995-04-18 | 1996-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
| US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US6120800A (en) * | 1997-09-25 | 2000-09-19 | Nexstar Pharmaceuticals, Inc. | Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties |
| JPH11171772A (ja) * | 1997-12-11 | 1999-06-29 | Sankyo Co Ltd | 抗腫瘍薬のリポソーム化製剤 |
| DE60008234T2 (de) * | 1999-04-29 | 2004-12-30 | Alza Corp., Mountain View | Liposomenzusammensetzungen zur verbesserten wirkstoffzurückhaltung |
| AU6142700A (en) * | 1999-07-07 | 2001-01-30 | Her Majesty The Queen As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government | Delivery of liposomal-encapsulated antioxidants and applications thereof |
-
2001
- 2001-05-10 GB GBGB0111279.6A patent/GB0111279D0/en not_active Ceased
-
2002
- 2002-05-10 JP JP2002586908A patent/JP4629308B2/ja not_active Expired - Fee Related
- 2002-05-10 DE DE60232237T patent/DE60232237D1/de not_active Expired - Lifetime
- 2002-05-10 US US10/477,157 patent/US20040170560A1/en not_active Abandoned
- 2002-05-10 EP EP02769160A patent/EP1385480B1/en not_active Expired - Lifetime
- 2002-05-10 ES ES02769160T patent/ES2323493T3/es not_active Expired - Lifetime
- 2002-05-10 AT AT02769160T patent/ATE430557T1/de not_active IP Right Cessation
- 2002-05-10 WO PCT/GB2002/002100 patent/WO2002089771A1/en not_active Ceased
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