JP2004528328A - 徐放性粒子 - Google Patents
徐放性粒子 Download PDFInfo
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- JP2004528328A JP2004528328A JP2002582705A JP2002582705A JP2004528328A JP 2004528328 A JP2004528328 A JP 2004528328A JP 2002582705 A JP2002582705 A JP 2002582705A JP 2002582705 A JP2002582705 A JP 2002582705A JP 2004528328 A JP2004528328 A JP 2004528328A
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- 150000002009 diols Chemical class 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
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- NWVVVBRKAWDGAB-UHFFFAOYSA-N hydroquinone methyl ether Natural products COC1=CC=C(O)C=C1 NWVVVBRKAWDGAB-UHFFFAOYSA-N 0.000 description 1
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- SSDSCDGVMJFTEQ-UHFFFAOYSA-N octadecyl 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 SSDSCDGVMJFTEQ-UHFFFAOYSA-N 0.000 description 1
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- LQAZPMXASFNKCD-UHFFFAOYSA-M potassium;dodecane-1-sulfonate Chemical compound [K+].CCCCCCCCCCCCS([O-])(=O)=O LQAZPMXASFNKCD-UHFFFAOYSA-M 0.000 description 1
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- FDNAPBUWERUEDA-UHFFFAOYSA-N silicon tetrachloride Chemical compound Cl[Si](Cl)(Cl)Cl FDNAPBUWERUEDA-UHFFFAOYSA-N 0.000 description 1
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- HFQQZARZPUDIFP-UHFFFAOYSA-M sodium;2-dodecylbenzenesulfonate Chemical compound [Na+].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O HFQQZARZPUDIFP-UHFFFAOYSA-M 0.000 description 1
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- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- UQMOLLPKNHFRAC-UHFFFAOYSA-N tetrabutyl silicate Chemical compound CCCCO[Si](OCCCC)(OCCCC)OCCCC UQMOLLPKNHFRAC-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- ZQZCOBSUOFHDEE-UHFFFAOYSA-N tetrapropyl silicate Chemical compound CCCO[Si](OCCC)(OCCC)OCCC ZQZCOBSUOFHDEE-UHFFFAOYSA-N 0.000 description 1
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
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- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
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- 239000010937 tungsten Substances 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- UIYCHXAGWOYNNA-UHFFFAOYSA-N vinyl sulfide Chemical group C=CSC=C UIYCHXAGWOYNNA-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83885401A | 2001-04-20 | 2001-04-20 | |
| US09/920,689 US20030031694A1 (en) | 2001-04-20 | 2001-08-02 | Controlled release particles |
| PCT/US2002/008969 WO2002085113A1 (en) | 2001-04-20 | 2002-03-22 | Controlled release particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004528328A true JP2004528328A (ja) | 2004-09-16 |
| JP2004528328A5 JP2004528328A5 (https=) | 2005-12-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002582705A Pending JP2004528328A (ja) | 2001-04-20 | 2002-03-22 | 徐放性粒子 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20030031694A1 (https=) |
| EP (1) | EP1392115A1 (https=) |
| JP (1) | JP2004528328A (https=) |
| CA (1) | CA2443518A1 (https=) |
| WO (1) | WO2002085113A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010053056A (ja) * | 2008-08-27 | 2010-03-11 | Tokyo Metropolitan Industrial Technology Research Institute | 徐放性製剤とその製造方法 |
| KR101541797B1 (ko) * | 2013-08-29 | 2015-08-04 | 이동하 | 해충 방제용 서방형 루어의 제조방법 |
| KR101773820B1 (ko) * | 2014-11-14 | 2017-09-01 | 이동하 | 솔수염하늘소 유인용 페로몬 조성물 및 서방형 루어의 제조 방법 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7758888B2 (en) | 2000-04-21 | 2010-07-20 | Sol-Gel Technologies Ltd. | Composition exhibiting enhanced formulation stability and delivery of topical active ingredients |
| ATE477042T1 (de) * | 2002-06-12 | 2010-08-15 | Traptek Llc | Verkapselte aktive teilchen und verfahren für ihre herstellung und verwendung |
| WO2004081222A2 (en) | 2003-03-14 | 2004-09-23 | Sol-Gel Technologies Ltd. | Agent-encapsulating micro- and nanoparticles, methods for preparation of same and products containing same |
| EP1645597A1 (en) * | 2003-07-09 | 2006-04-12 | Tokyo University of Science, Educational Foundation | Conjugate of fine porous particles with polymer molecules and utilization thereof |
| JP2007500590A (ja) | 2003-07-31 | 2007-01-18 | ゾル−ゲル テクノロジーズ エルティーディー． | 活性成分が充填されたマイクロカプセル及びその製造方法 |
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| CA3069359C (en) | 2017-07-12 | 2023-01-10 | Sol-Gel Technologies Ltd. | Compositions comprising encapsulated tretinoin |
| EP3672406A4 (en) * | 2017-08-27 | 2021-06-09 | Agrorim, Ltd. | PHEROMONCLATHRATES |
| US20230109010A1 (en) * | 2020-02-18 | 2023-04-06 | Bps Just Energy Technology, Llc | Pesticide compositions with supramolecular structures for agricultural use |
| US12595407B2 (en) | 2022-04-08 | 2026-04-07 | Saudi Arabian Oil Company | Radiation activated well treatment |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63225302A (ja) * | 1987-03-12 | 1988-09-20 | Lion Corp | 湿度感応性製剤の製造方法 |
| JPH04339869A (ja) * | 1991-05-16 | 1992-11-26 | Furukawa Alum Co Ltd | 防かび親水性塗布組成物 |
| EP0680753A2 (de) * | 1994-05-06 | 1995-11-08 | Feinchemie GmbH Sebnitz | Metalloxidkomposit mit steuerbarer Wirkstoffabgabe |
| JPH0899801A (ja) * | 1994-10-03 | 1996-04-16 | Suzuki Yushi Kogyo Kk | 抗菌性無機多孔質微粒子 |
| JPH11131049A (ja) * | 1997-10-28 | 1999-05-18 | Japan Science & Technology Corp | シリカ有機物複合体とその製造方法 |
| WO1999037705A1 (en) * | 1997-12-09 | 1999-07-29 | The Regents Of The University Of California | Block polymer processing for mesostructured inorganic oxide materials |
| JPH11263702A (ja) * | 1997-12-11 | 1999-09-28 | Rohm & Haas Co | 徐放性組成物 |
| WO2000051724A1 (en) * | 1999-02-27 | 2000-09-08 | The Procter & Gamble Company | Method for protecting and/or controlled release of active ingredients |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4579779A (en) * | 1983-09-30 | 1986-04-01 | Freund Industrial Co., Ltd. | Method of encapsulating volatile organic liquids |
| JPS6327502A (ja) * | 1986-07-22 | 1988-02-05 | Agency Of Ind Science & Technol | シクロデキストリン−シリカ複合体及びその製造方法 |
| US4818522A (en) * | 1987-09-14 | 1989-04-04 | Reheis, Inc. | Encapsulation of adjuvants within antiperspirant actives |
| US6005162A (en) * | 1988-04-20 | 1999-12-21 | Norian Corporation | Methods of repairing bone |
| AR244505A1 (es) * | 1988-05-14 | 1993-11-30 | Deutsche Ges Schaedlingsbek | Metodo para impedir o retardar la formacion de niveles indeseables de fosfina en un espacio o ambiente, y producto plaguicida para llevar a cabo dicho metodo. |
| US5057296A (en) * | 1990-12-10 | 1991-10-15 | Mobil Oil Corp. | Method for synthesizing mesoporous crystalline material |
| US5264203A (en) * | 1990-01-25 | 1993-11-23 | Mobil Oil Corporation | Synthetic mesoporous crystalline materials |
| GB9021061D0 (en) * | 1990-09-27 | 1990-11-07 | Unilever Plc | Encapsulating method and products containing encapsulated material |
| DE4100119A1 (de) * | 1991-01-04 | 1992-07-09 | Bayer Ag | Verwendung von polyether-polycarbonat-blockcopolymeren als beschichtungen fuer kunststofformkoerper |
| CA2080424A1 (en) * | 1991-10-25 | 1993-04-26 | Jerry Moy | Microcapsules containing inorganic colloids and method for making the same |
| US5169403A (en) * | 1991-11-01 | 1992-12-08 | Clairol, Inc. | Direct dyes having a quaternary center with a long aliphatic chain |
| US5591453A (en) * | 1994-07-27 | 1997-01-07 | The Trustees Of The University Of Pennsylvania | Incorporation of biologically active molecules into bioactive glasses |
| US6027742A (en) * | 1995-05-19 | 2000-02-22 | Etex Corporation | Bioresorbable ceramic composites |
| US5856271A (en) * | 1995-06-07 | 1999-01-05 | Battelle Memorial Institute | Method of making controlled released devices |
| US5730996A (en) * | 1996-05-23 | 1998-03-24 | Amcol International Corporation | Intercalates and expoliates formed with organic pesticide compounds and compositions containing the same |
| US5730912A (en) * | 1996-05-30 | 1998-03-24 | M-Cap Technologies International | Method of the encapsulation of liquids |
| EP0849221B1 (de) * | 1996-12-19 | 2001-01-03 | Ciba SC Holding AG | Farbmittelbeladenes Molekularsieb |
| US5876690A (en) * | 1997-02-11 | 1999-03-02 | National Science Council | Mesoporous aluminosilicate molecular sieves having "tubules-within-a-tubule" hierarchical order morphology and the preparation thereof |
| ES2156481B1 (es) * | 1998-03-03 | 2002-02-01 | Univ Valencia Politecnica | Procedimiento de obtencion de tamices moleculares inorganicos modificados y su uso como emisores de semioquimicos. |
| US6096469A (en) * | 1999-05-18 | 2000-08-01 | 3M Innovative Properties Company | Ink receptor media suitable for inkjet printing |
| US6011067A (en) * | 1999-06-11 | 2000-01-04 | Thione International, Inc. | Antioxidant composition for the treatment of psoriasis and related diseases |
| AUPQ573300A0 (en) * | 2000-02-21 | 2000-03-16 | Australian Nuclear Science & Technology Organisation | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
| US6387453B1 (en) * | 2000-03-02 | 2002-05-14 | Sandia Corporation | Method for making surfactant-templated thin films |
-
2001
- 2001-08-02 US US09/920,689 patent/US20030031694A1/en not_active Abandoned
-
2002
- 2002-03-22 JP JP2002582705A patent/JP2004528328A/ja active Pending
- 2002-03-22 EP EP02764149A patent/EP1392115A1/en not_active Withdrawn
- 2002-03-22 CA CA002443518A patent/CA2443518A1/en not_active Abandoned
- 2002-03-22 WO PCT/US2002/008969 patent/WO2002085113A1/en not_active Ceased
-
2005
- 2005-01-04 US US11/029,192 patent/US20050196456A1/en not_active Abandoned
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63225302A (ja) * | 1987-03-12 | 1988-09-20 | Lion Corp | 湿度感応性製剤の製造方法 |
| JPH04339869A (ja) * | 1991-05-16 | 1992-11-26 | Furukawa Alum Co Ltd | 防かび親水性塗布組成物 |
| EP0680753A2 (de) * | 1994-05-06 | 1995-11-08 | Feinchemie GmbH Sebnitz | Metalloxidkomposit mit steuerbarer Wirkstoffabgabe |
| JPH0899801A (ja) * | 1994-10-03 | 1996-04-16 | Suzuki Yushi Kogyo Kk | 抗菌性無機多孔質微粒子 |
| JPH11131049A (ja) * | 1997-10-28 | 1999-05-18 | Japan Science & Technology Corp | シリカ有機物複合体とその製造方法 |
| WO1999037705A1 (en) * | 1997-12-09 | 1999-07-29 | The Regents Of The University Of California | Block polymer processing for mesostructured inorganic oxide materials |
| JPH11263702A (ja) * | 1997-12-11 | 1999-09-28 | Rohm & Haas Co | 徐放性組成物 |
| WO2000051724A1 (en) * | 1999-02-27 | 2000-09-08 | The Procter & Gamble Company | Method for protecting and/or controlled release of active ingredients |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010053056A (ja) * | 2008-08-27 | 2010-03-11 | Tokyo Metropolitan Industrial Technology Research Institute | 徐放性製剤とその製造方法 |
| KR101541797B1 (ko) * | 2013-08-29 | 2015-08-04 | 이동하 | 해충 방제용 서방형 루어의 제조방법 |
| KR101773820B1 (ko) * | 2014-11-14 | 2017-09-01 | 이동하 | 솔수염하늘소 유인용 페로몬 조성물 및 서방형 루어의 제조 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1392115A1 (en) | 2004-03-03 |
| US20050196456A1 (en) | 2005-09-08 |
| CA2443518A1 (en) | 2002-10-31 |
| US20030031694A1 (en) | 2003-02-13 |
| WO2002085113A1 (en) | 2002-10-31 |
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