JP2004528321A - ステロールおよびサポニンを含むポリヌクレオチド結合複合体 - Google Patents

ステロールおよびサポニンを含むポリヌクレオチド結合複合体 Download PDF

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JP2004528321A
JP2004528321A JP2002579019A JP2002579019A JP2004528321A JP 2004528321 A JP2004528321 A JP 2004528321A JP 2002579019 A JP2002579019 A JP 2002579019A JP 2002579019 A JP2002579019 A JP 2002579019A JP 2004528321 A JP2004528321 A JP 2004528321A
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conjugate
saponin
sterol
primary
group
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JP2004528321A5 (https=
Inventor
セーレン キルビュ，ニコライ
ダルスガールト，クリスティアン
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ノルディック ワクチン テクノロジー アクティーゼルスカブ
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Publication of JP2004528321A publication Critical patent/JP2004528321A/ja
Publication of JP2004528321A5 publication Critical patent/JP2004528321A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Cosmetics (AREA)
JP2002579019A 2001-04-04 2002-04-04 ステロールおよびサポニンを含むポリヌクレオチド結合複合体 Withdrawn JP2004528321A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200100560 2001-04-04
US30860901P 2001-07-31 2001-07-31
PCT/DK2002/000229 WO2002080981A2 (en) 2001-04-04 2002-04-04 Polynucleotide binding complexes comprising sterols and saponins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010120290A Division JP2010180249A (ja) 2001-04-04 2010-05-26 ステロールおよびサポニンを含むポリヌクレオチド結合複合体

Publications (2)

Publication Number Publication Date
JP2004528321A true JP2004528321A (ja) 2004-09-16
JP2004528321A5 JP2004528321A5 (https=) 2005-12-22

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002579019A Withdrawn JP2004528321A (ja) 2001-04-04 2002-04-04 ステロールおよびサポニンを含むポリヌクレオチド結合複合体
JP2010120290A Pending JP2010180249A (ja) 2001-04-04 2010-05-26 ステロールおよびサポニンを含むポリヌクレオチド結合複合体

Family Applications After (1)

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JP2010120290A Pending JP2010180249A (ja) 2001-04-04 2010-05-26 ステロールおよびサポニンを含むポリヌクレオチド結合複合体

Country Status (7)

Country Link
EP (2) EP1377320B1 (https=)
JP (2) JP2004528321A (https=)
AT (1) ATE409495T1 (https=)
DE (1) DE60229118D1 (https=)
DK (1) DK1377320T3 (https=)
NZ (1) NZ529347A (https=)
WO (1) WO2002080981A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020526536A (ja) * 2017-07-11 2020-08-31 フライエ ウニヴェルジテート ベルリン サポニンの新規な使用およびその分離のための方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE449612T1 (de) * 2002-10-02 2009-12-15 Nordic Vaccine Technology As Zusammensetzung zur impfung
WO2009106085A1 (en) * 2008-02-28 2009-09-03 Nordic Vaccine A/S Vaccine compositions comprising saccharide antigens
DK2750683T4 (da) * 2011-10-03 2021-04-12 Croda Int Plc Nanopartikler, fremgangsmåde til fremstilling og anvendelse deraf som bærer for amfipatiske eller hydrofobe molekyler inden for medicin, herunder cancerbehandling, og i fødevarerelaterede forbindelser
AR095962A1 (es) 2013-04-01 2015-11-25 Moreinx Ab Nanopartículas, compuestas de esterol y saponina de quillaja saponaria molina, proceso para preparación y uso de las mismas como portadores para moléculas anfipáticas o hidrófobas en el campo de la medicina incluyendo tratamiento de cáncer y compuestos relacionados con alimentos
CN108498376B (zh) * 2018-04-02 2020-11-13 榛硕（武汉）智能科技有限公司 一种甲基硅油乳液及其制备方法
CN109295080B (zh) * 2018-09-19 2021-08-20 昆明理工大学 珠子参β-香树脂醇合成酶基因Pjβ-AS的用途

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162282A (en) 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
GB2064320B (en) 1979-10-13 1983-10-12 Welsh Nat School Med Intra-ocular irrigation fluid
US4310505A (en) 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4533254A (en) 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
US4443432A (en) 1981-10-05 1984-04-17 Alcon Laboratories, Inc. Ophthmalic irrigating solution
US4550022A (en) 1981-10-05 1985-10-29 Alcon Laboratories, Inc. Tissue irrigating solution
US4526714A (en) 1982-12-13 1985-07-02 Cordis Europa N.V. Conjugates of anticoagulant and protein
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
SE450674B (sv) 1982-11-17 1987-07-13 Volvo Ab Kabelholje
US4728575A (en) 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
CA1264668A (en) 1984-06-20 1990-01-23 Pieter R. Cullis Extrusion techniques for producing liposomes
US4921706A (en) 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
NZ217844A (en) 1985-10-11 1989-10-27 Sumitomo Pharma A sustained release pharmaceutical composition containing silicone elastomer and an albumin
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
IL79559A0 (en) 1986-07-29 1986-10-31 Univ Ramot Contrast agents for nmr medical imaging
US4728578A (en) 1986-08-13 1988-03-01 The Lubrizol Corporation Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers
US5554372A (en) 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US4938970A (en) 1987-02-06 1990-07-03 Hustead Robert E Painless electrolyte solutions
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US5583112A (en) 1987-05-29 1996-12-10 Cambridge Biotech Corporation Saponin-antigen conjugates and the use thereof
NZ230747A (en) 1988-09-30 1992-05-26 Bror Morein Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
DE68912139T2 (de) 1988-11-09 1994-04-28 Colin Tilcock Liposomale radiologische kontrastmittel.
FR2645866B1 (fr) 1989-04-17 1991-07-05 Centre Nat Rech Scient Nouvelles lipopolyamines, leur preparation et leur emploi
JPH04507244A (ja) 1989-07-27 1992-12-17 ユニバックス・バイオロジクス・インコーポレイテッド リピドａ類似体／免疫原性担体コンジュゲートおよびそのワクチンとしての使用
NL9002314A (nl) * 1990-10-23 1992-05-18 Nederlanden Staat Immunogene complexen, in het bijzonder iscoms.
GB9106673D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
CA2102605A1 (en) 1991-05-23 1992-11-24 Evan C. Unger Liposoluble compounds for magnetic resonance imaging
SE502569C2 (sv) * 1991-05-31 1995-11-13 British Tech Group Användning av en immunologiskt inert matris av en sterol och saponiner som kan bilda sfäriska nanopartiklar med snäv storleksfördelning som läkemedelsbärare, partiklar, komposition samt kit
US5273965A (en) 1992-07-02 1993-12-28 Cambridge Biotech Corporation Methods for enhancing drug delivery with modified saponins
US5650398A (en) 1992-07-02 1997-07-22 Cambridge Biotech Corporation Drug delivery enhancement via modified saponins
AU1077795A (en) 1993-09-30 1995-04-18 Seed Capital Investments (Sci) B.V. Compounds with adjuvant activity
AU2112697A (en) * 1996-02-09 1997-08-28 Pi-Wan Cheng Receptor ligand-facilitated delivery of biologically active molecules
NZ333562A (en) 1996-06-25 2001-04-27 Stichting Inst Voor Dierhouder Vaccine comprising antigens bound by thioester or disulphide bonds to fatty acid carriers such palmitic acid, antigens bound in reversible and labile way
JP3963506B2 (ja) * 1996-08-26 2007-08-22 俊彦 松尾 リポソーム点眼剤
AUPO517897A0 (en) * 1997-02-19 1997-04-11 Csl Limited Chelating immunostimulating complexes
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
CA2287976A1 (fr) * 1997-04-30 1998-11-05 Bruno Guy Composition vaccinale anti-helicobacter comprenant un adjuvant de type th1
US6080725A (en) 1997-05-20 2000-06-27 Galenica Pharmaceuticals, Inc. Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof
AUPO732997A0 (en) * 1997-06-12 1997-07-03 Csl Limited Ganglioside immunostimulating complexes and uses thereof
DE19740092A1 (de) * 1997-09-12 1999-03-18 Ulrich Dr Med Hengge Liposomen und Verfahren zur Transfektion von Zellen
US6013258A (en) * 1997-10-09 2000-01-11 Zycos Inc. Immunogenic peptides from the HPV E7 protein
EP1156783B1 (en) * 1999-03-02 2007-10-24 Transave, Inc. Encapsulation of bioactive complexes in liposomes
AU2001246393A1 (en) 2000-03-31 2001-10-08 Vaccine Chip Technology Aps Immunostimulating properties of a fragment of tgf-beta

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020526536A (ja) * 2017-07-11 2020-08-31 フライエ ウニヴェルジテート ベルリン サポニンの新規な使用およびその分離のための方法
US11708388B2 (en) 2017-07-11 2023-07-25 Freie Universität Berlin Uses of a saponin and method for its isolation
JP2023115283A (ja) * 2017-07-11 2023-08-18 フライエ ウニヴェルジテート ベルリン サポニンの新規な使用およびその分離のための方法

Also Published As

Publication number Publication date
NZ529347A (en) 2008-01-31
EP2011517A1 (en) 2009-01-07
DK1377320T3 (da) 2009-02-09
WO2002080981A3 (en) 2002-12-19
EP1377320B1 (en) 2008-10-01
EP1377320A2 (en) 2004-01-07
WO2002080981A2 (en) 2002-10-17
JP2010180249A (ja) 2010-08-19
DE60229118D1 (de) 2008-11-13
ATE409495T1 (de) 2008-10-15

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