JP2004527524A - 非経口初回抗原刺激後の粘膜追加免疫 - Google Patents

非経口初回抗原刺激後の粘膜追加免疫 Download PDF

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JP2004527524A
JP2004527524A JP2002578702A JP2002578702A JP2004527524A JP 2004527524 A JP2004527524 A JP 2004527524A JP 2002578702 A JP2002578702 A JP 2002578702A JP 2002578702 A JP2002578702 A JP 2002578702A JP 2004527524 A JP2004527524 A JP 2004527524A
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virus
antigens
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JP2004527524A5 (enExample
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デレック オーヘイガン,
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カイロン コーポレイション
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    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
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    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
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    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
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    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002578702A 2001-04-05 2002-04-05 非経口初回抗原刺激後の粘膜追加免疫 Withdrawn JP2004527524A (ja)

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Application Number Priority Date Filing Date Title
US28238901P 2001-04-05 2001-04-05
PCT/US2002/010869 WO2002080648A2 (en) 2001-04-05 2002-04-05 Mucosal boosting following parenteral priming

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JP2009057158A Division JP2009120620A (ja) 2001-04-05 2009-03-10 非経口初回抗原刺激後の粘膜追加免疫

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JP2004527524A true JP2004527524A (ja) 2004-09-09
JP2004527524A5 JP2004527524A5 (enExample) 2005-12-22

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JP2002578702A Withdrawn JP2004527524A (ja) 2001-04-05 2002-04-05 非経口初回抗原刺激後の粘膜追加免疫
JP2009057158A Withdrawn JP2009120620A (ja) 2001-04-05 2009-03-10 非経口初回抗原刺激後の粘膜追加免疫
JP2012274421A Withdrawn JP2013053162A (ja) 2001-04-05 2012-12-17 非経口初回抗原刺激後の粘膜追加免疫

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JP2012274421A Withdrawn JP2013053162A (ja) 2001-04-05 2012-12-17 非経口初回抗原刺激後の粘膜追加免疫

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US (3) US20030072764A1 (enExample)
EP (1) EP1372528B1 (enExample)
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CA (1) CA2439111A1 (enExample)
ES (1) ES2399386T3 (enExample)
WO (1) WO2002080648A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011525902A (ja) * 2008-06-25 2011-09-29 ノバルティス アーゲー 遅延型追加刺激免疫処置に対する迅速な応答
JP2016502995A (ja) * 2012-12-17 2016-02-01 ユーロシネ ヴァクシンズ アクチエボラーグ 鼻腔内予防接種投薬レジメン
WO2019235466A1 (ja) * 2018-06-05 2019-12-12 東興薬品工業株式会社 B型肝炎ワクチン経鼻投与システム

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9326174D0 (en) * 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
MXPA04011249A (es) * 2002-05-14 2005-06-06 Chiron Srl Vacunas mucosales con adyuvante de quitosano y antigenos meningococicos.
GB0302218D0 (en) * 2003-01-30 2003-03-05 Chiron Sri Vaccine formulation & Mucosal delivery
AU2003239744B2 (en) * 2002-05-14 2008-07-03 Novartis Vaccines And Diagnostics S.R.L. Mucosal combination vaccines for bacterial meningitis
GB0300881D0 (en) * 2003-01-15 2003-02-12 Secr Defence Therapeutic treatment
CA2523266A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Compositions comprising cationic microparticles and hcv e1e2 dna and methods of use thereof
ES2350043T3 (es) * 2003-06-17 2011-01-17 Mannkind Corporation Composiciones para producir, incrementar y mantener las respuestas inmunes contra epítopos restringidos de mhc de clase i, con fines profilácticos o terapéuticos.
CU23470A1 (es) * 2004-08-11 2009-12-17 Ct Ingenieria Genetica Biotech Vectores vivos recombinantes y su uso en composiciones farmacéuticas contra el virus de la hepatitis c
SG173336A1 (en) * 2006-03-31 2011-08-29 Novartis Ag Combined mucosal and parenteral immunization against hiv
US20090105668A1 (en) * 2007-10-19 2009-04-23 Devon Monroe Feminine vaginal douche for tightening a vaginal orifice
GB0810305D0 (en) 2008-06-05 2008-07-09 Novartis Ag Influenza vaccination
US9387239B2 (en) * 2008-05-30 2016-07-12 U.S. Army Medical Research And Materiel Command Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof
EP3725328A3 (en) 2008-06-27 2020-12-23 Zoetis Services LLC Novel adjuvant compositions
CU20080215A7 (es) * 2008-11-19 2012-06-21 Inst Finlay Vacunas unitemporales
EP2742952A1 (en) 2012-12-17 2014-06-18 Eurocine Vaccines AB Influenza vaccine composition
WO2015042369A2 (en) 2013-09-19 2015-03-26 Zoetis Llc Oil-based adjuvants
CN114699518B (zh) 2015-01-16 2024-07-02 硕腾服务有限责任公司 口蹄疫疫苗
CA3104833A1 (en) 2018-07-16 2020-01-23 Dcprime B.V. A combination product for use in tumor vaccination.
AU2020264083A1 (en) 2019-04-25 2021-12-02 Mendus B.V. Methods of tumor vaccination

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6024983A (en) * 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
US5462734A (en) * 1990-11-02 1995-10-31 Wisconsin Alumni Research Foundation Bovine herpesvirus vaccine and method of using same
US6004534A (en) * 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
US5679647A (en) * 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
CA2205130A1 (en) * 1994-11-17 1996-05-30 Jan Roland Holmgren Immunogens for stimulating mucosal immunity
AU4369596A (en) * 1994-11-21 1996-06-17 Virginia L. Scofield Sperm as vaccine vectors
AU3210997A (en) * 1996-05-24 1997-12-09 University Of Maryland At Baltimore Dna vaccines for eliciting a mucosal immune response
SE9602280D0 (sv) * 1996-06-10 1996-06-10 Pharmatrix Ab Immunstimulerande lipidformulering
ATE208629T1 (de) * 1996-08-27 2001-11-15 Chiron Corp Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung
CA2314934C (en) * 1997-12-16 2006-08-29 Chiron Corporation Use of microparticles combined with submicron oil-in-water emulsions
EP1069910A1 (en) * 1998-04-09 2001-01-24 GlaxoSmithKline Biologicals S.A. Adjuvant compositions
AU5677399A (en) * 1998-08-20 2000-03-14 Wistar Institute Of Anatomy And Biology, The Methods of augmenting mucosal immunity through systemic priming and mucosal boosting
ATE499948T1 (de) * 2001-01-12 2011-03-15 Novartis Vaccines & Diagnostic Nukleinsäure mukosale immunisierung
CA2441626A1 (en) * 2001-03-28 2002-10-17 Children's Medical Center Corporation Fusion protein construct and method for inducing hiv-specific serum igg and secretory iga antibodies in-vivo

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011525902A (ja) * 2008-06-25 2011-09-29 ノバルティス アーゲー 遅延型追加刺激免疫処置に対する迅速な応答
JP2016502995A (ja) * 2012-12-17 2016-02-01 ユーロシネ ヴァクシンズ アクチエボラーグ 鼻腔内予防接種投薬レジメン
WO2019235466A1 (ja) * 2018-06-05 2019-12-12 東興薬品工業株式会社 B型肝炎ワクチン経鼻投与システム
JPWO2019235466A1 (ja) * 2018-06-05 2021-06-24 東興薬品工業株式会社 B型肝炎ワクチン経鼻投与システム
US12070497B2 (en) 2018-06-05 2024-08-27 Toko Yakuhin Kogyo Co., Ltd. Hepatitis B vaccine transnasal administration system
JP7685834B2 (ja) 2018-06-05 2025-05-30 東興薬品工業株式会社 B型肝炎ワクチン経鼻投与システム

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US20030072764A1 (en) 2003-04-17
WO2002080648A3 (en) 2002-11-28
US20120171244A1 (en) 2012-07-05
CA2439111A1 (en) 2002-10-17
JP2009120620A (ja) 2009-06-04
WO2002080648A2 (en) 2002-10-17
EP1372528B1 (en) 2013-01-02
EP1372528A4 (en) 2005-03-16
EP1372528A2 (en) 2004-01-02
ES2399386T3 (es) 2013-04-01
US20070196391A1 (en) 2007-08-23
JP2013053162A (ja) 2013-03-21

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