JP2004527479A5 - - Google Patents
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- Publication number
- JP2004527479A5 JP2004527479A5 JP2002562358A JP2002562358A JP2004527479A5 JP 2004527479 A5 JP2004527479 A5 JP 2004527479A5 JP 2002562358 A JP2002562358 A JP 2002562358A JP 2002562358 A JP2002562358 A JP 2002562358A JP 2004527479 A5 JP2004527479 A5 JP 2004527479A5
- Authority
- JP
- Japan
- Prior art keywords
- bisphosphonate
- medicament
- medicament according
- hydrate
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 claims 31
- 229940122361 Bisphosphonate Drugs 0.000 claims 20
- 150000004663 bisphosphonates Chemical class 0.000 claims 20
- 150000002148 esters Chemical class 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 206010031264 Osteonecrosis Diseases 0.000 claims 8
- 208000002804 Osteochondritis Diseases 0.000 claims 6
- 201000009859 Osteochondrosis Diseases 0.000 claims 6
- 210000000988 bone and bone Anatomy 0.000 claims 3
- 210000002758 humerus Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims 2
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims 2
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 2
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 2
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims 2
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 claims 2
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims 2
- DKJJVAGXPKPDRL-UHFFFAOYSA-N Tiludronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1 DKJJVAGXPKPDRL-UHFFFAOYSA-N 0.000 claims 2
- UGEPSJNLORCRBO-UHFFFAOYSA-N [3-(dimethylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid Chemical compound CN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O UGEPSJNLORCRBO-UHFFFAOYSA-N 0.000 claims 2
- 229940062527 alendronate Drugs 0.000 claims 2
- 229940112869 bone morphogenetic protein Drugs 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 2
- 229960002286 clodronic acid Drugs 0.000 claims 2
- ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 2
- 229940009626 etidronate Drugs 0.000 claims 2
- 229940015872 ibandronate Drugs 0.000 claims 2
- LWRDQHOZTAOILO-UHFFFAOYSA-N incadronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)NC1CCCCCC1 LWRDQHOZTAOILO-UHFFFAOYSA-N 0.000 claims 2
- 229950006971 incadronic acid Drugs 0.000 claims 2
- VMMKGHQPQIEGSQ-UHFFFAOYSA-N minodronic acid Chemical compound C1=CC=CN2C(CC(O)(P(O)(O)=O)P(O)(O)=O)=CN=C21 VMMKGHQPQIEGSQ-UHFFFAOYSA-N 0.000 claims 2
- 229950011129 minodronic acid Drugs 0.000 claims 2
- PUUSSSIBPPTKTP-UHFFFAOYSA-N neridronic acid Chemical compound NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O PUUSSSIBPPTKTP-UHFFFAOYSA-N 0.000 claims 2
- 229950010733 neridronic acid Drugs 0.000 claims 2
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical group NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims 2
- 229940046231 pamidronate Drugs 0.000 claims 2
- 229940089617 risedronate Drugs 0.000 claims 2
- 229940019375 tiludronate Drugs 0.000 claims 2
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical group OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 2
- 229960004276 zoledronic acid Drugs 0.000 claims 2
- 101150061927 BMP2 gene Proteins 0.000 claims 1
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 claims 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 239000004606 Fillers/Extenders Substances 0.000 claims 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 1
- 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 claims 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 1
- 102100025947 Insulin-like growth factor II Human genes 0.000 claims 1
- 208000027414 Legg-Calve-Perthes disease Diseases 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 101150067309 bmp4 gene Proteins 0.000 claims 1
- 210000003010 carpal bone Anatomy 0.000 claims 1
- 230000009089 cytolysis Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- IWLDTXOHXPDPQG-UHFFFAOYSA-L disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]-3-pyrrolidin-1-ylpropyl]phosphinate Chemical compound [Na+].[Na+].OP(=O)(O)C(P([O-])([O-])=O)(O)CCN1CCCC1 IWLDTXOHXPDPQG-UHFFFAOYSA-L 0.000 claims 1
- 229940029303 fibroblast growth factor-1 Drugs 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 210000004095 humeral head Anatomy 0.000 claims 1
- 210000001872 metatarsal bone Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000000010 osteolytic effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000004233 talus Anatomy 0.000 claims 1
- 210000001137 tarsal bone Anatomy 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 210000002303 tibia Anatomy 0.000 claims 1
- 210000000689 upper leg Anatomy 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR2907A AUPR290701A0 (en) | 2001-02-06 | 2001-02-06 | A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis |
| AUPR4187A AUPR418701A0 (en) | 2001-04-03 | 2001-04-03 | A drug for use in bone grafting |
| AUPR6654A AUPR665401A0 (en) | 2001-07-27 | 2001-07-27 | A drug and method for the treatment of osteonecrosis |
| PCT/AU2001/001616 WO2002062351A1 (en) | 2001-02-06 | 2001-12-13 | A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527479A JP2004527479A (ja) | 2004-09-09 |
| JP2004527479A5 true JP2004527479A5 (https=) | 2005-12-22 |
Family
ID=27158265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002562358A Pending JP2004527479A (ja) | 2001-02-06 | 2001-12-13 | 骨壊死の治療用および骨壊死の発症のリスクのある患者のマネージメント用医薬 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7425549B2 (https=) |
| EP (1) | EP1365769B1 (https=) |
| JP (1) | JP2004527479A (https=) |
| KR (1) | KR20030072399A (https=) |
| CN (1) | CN1233325C (https=) |
| AT (1) | ATE496624T1 (https=) |
| AU (1) | AU2002221339B2 (https=) |
| BR (1) | BR0116862A (https=) |
| CA (1) | CA2435552C (https=) |
| CY (1) | CY1111402T1 (https=) |
| CZ (1) | CZ301361B6 (https=) |
| DE (1) | DE60143964D1 (https=) |
| DK (1) | DK1365769T3 (https=) |
| HU (1) | HUP0303013A3 (https=) |
| IL (1) | IL157201A (https=) |
| MX (1) | MXPA03007029A (https=) |
| NO (1) | NO20033446L (https=) |
| NZ (1) | NZ527351A (https=) |
| PL (1) | PL361909A1 (https=) |
| SI (1) | SI1365769T1 (https=) |
| SK (1) | SK9862003A3 (https=) |
| WO (1) | WO2002062351A1 (https=) |
| ZA (1) | ZA200305890B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE496624T1 (de) * | 2001-02-06 | 2011-02-15 | Sydney Children S Hospitals Network Randwick And Westmead Incorporating The Royal Alexandra Hospital | Arzneimittel zur behandlung von osteonekrose und zur versorgung von patienten mit risiko für die entstehung von osteonekrose |
| EP1383509A4 (en) * | 2001-04-03 | 2005-10-26 | Royal Alexandra Hosp Children | MEDICAMENT FOR USE IN BONE TRAINING |
| SK2532004A3 (en) * | 2001-12-21 | 2004-11-03 | Procter & Gamble | Method for the treatment of bone disorders |
| KR20060058151A (ko) * | 2002-05-10 | 2006-05-29 | 에프. 호프만-라 로슈 아게 | 골다공증 치료 및 예방용 비스포스폰산 |
| ES2291749T5 (es) * | 2002-12-20 | 2011-07-21 | F. Hoffmann-La Roche Ag | Formulación de altas dosis de ibandronato. |
| EP1745791B1 (en) | 2003-05-07 | 2013-06-26 | Osteologix A/S | Treating cartilage/bone conditions with water-soluble strontium salts |
| JPWO2005072747A1 (ja) * | 2004-02-02 | 2007-09-13 | 小野薬品工業株式会社 | 骨吸収抑制剤 |
| ITMI20040218A1 (it) * | 2004-02-10 | 2004-05-10 | Abiogen Pharma Spa | Uso di neridronato sodico per promuovere la neoformazione ossea |
| CA2557324C (en) | 2004-02-26 | 2012-10-16 | Osteologix A/S | Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions |
| US8012949B2 (en) * | 2004-10-08 | 2011-09-06 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS |
| US7687482B2 (en) * | 2006-03-17 | 2010-03-30 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods |
| EP1802641B8 (en) * | 2004-10-08 | 2012-03-07 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
| WO2006050493A2 (en) * | 2004-11-03 | 2006-05-11 | The Regents Of The University Of Michigan | Biodegradable implant for intertransverse process fusion |
| US8071574B2 (en) * | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| US7833270B2 (en) * | 2006-05-05 | 2010-11-16 | Warsaw Orthopedic, Inc | Implant depots to deliver growth factors to treat osteoporotic bone |
| US8062364B1 (en) | 2007-04-27 | 2011-11-22 | Knee Creations, Llc | Osteoarthritis treatment and device |
| DK2459176T3 (en) | 2009-07-31 | 2017-12-04 | Gruenenthal Gmbh | Crystallization process and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US9340565B2 (en) | 2010-11-24 | 2016-05-17 | Thar Pharmaceuticals, Inc. | Crystalline forms |
| GB201200868D0 (en) | 2012-01-19 | 2012-02-29 | Depuy Int Ltd | Bone filler composition |
| SG10201609548UA (en) * | 2013-10-25 | 2016-12-29 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating disease |
| US10022172B2 (en) | 2014-06-25 | 2018-07-17 | Spine Wave, Inc. | Minimally invasive posterolateral fusion |
| CN105012995B (zh) * | 2015-06-04 | 2018-03-09 | 武汉维斯第医用科技股份有限公司 | 一种含促骨愈合药物的胶原蛋白海绵及其制备方法 |
| US9775723B2 (en) | 2015-06-16 | 2017-10-03 | Spine Wave, Inc. | Instrument and system for placing graft, implant and graft material for minimally invasive posterolateral fusion |
| CN108601949A (zh) * | 2016-01-14 | 2018-09-28 | 加利福尼亚大学董事会 | 用llp2a-二膦酸盐化合物治疗骨坏死的方法 |
| US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
| AU2017204355B2 (en) | 2016-07-08 | 2021-09-09 | Mako Surgical Corp. | Scaffold for alloprosthetic composite implant |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5953894A (en) * | 1992-12-23 | 1994-07-19 | Merck & Co., Inc. | Bisphosphonate/estrogen therapy for treating and preventing bone loss |
| US5403829A (en) * | 1993-03-24 | 1995-04-04 | Leiras Oy | Use of bisphosphonates in endo-osteal bone surgery |
| US5646134A (en) * | 1994-04-21 | 1997-07-08 | Merck & Co., Inc. | Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices |
| US5476865A (en) * | 1994-07-06 | 1995-12-19 | Eli Lilly And Company | Methods of inhibiting bone loss |
| CN1113440A (zh) * | 1994-07-29 | 1995-12-20 | 孟照强 | 一种治疗骨伤的中药制剂及其制备方法 |
| WO1996039974A1 (en) * | 1995-06-07 | 1996-12-19 | Implex Corporation | Femoral head core channel filling prosthesis |
| US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
| US5843678A (en) * | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
| US6316408B1 (en) * | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
| AU750803B2 (en) * | 1997-10-29 | 2002-07-25 | University Of Pittsburgh | Use of vectors such as adenoviruses and/or adeno associated viruses and/or retroviruses and/or herpes simplex viruses and/or liposomes and/or plasmids as a vehicle for genetic information enabling mammal cells to produce agents for the treatment of bone pathologies |
| US6268367B1 (en) * | 1998-02-23 | 2001-07-31 | Zymogenetics, Inc. | Piperazine derivatives for treating bone deficit conditions |
| EP1121133A1 (en) | 1998-10-15 | 2001-08-08 | Merck & Co., Inc. | Methods for stimulating bone formation |
| PL351674A1 (en) * | 1999-05-21 | 2003-05-19 | Novartis Ag | Use of bisphosphonic acids for treating angiogenesis |
| AUPQ232599A0 (en) * | 1999-08-19 | 1999-09-09 | Royal Alexandra Hospital For Children, The | Drug for treating fractures |
| AU781068B2 (en) * | 1999-08-19 | 2005-05-05 | Sydney Children's Hospitals Network (Randwick and Westmead) (incorporating The Royal Alexandra Hospital for Children), The | Drug for treating fractures |
| US6482411B1 (en) * | 1999-08-27 | 2002-11-19 | Board Of Regents, The University Of Texas System | Methods of reducing bone loss with CD40 ligand |
| GB0029111D0 (en) | 2000-11-29 | 2001-01-10 | Novartis Ag | Organic compounds |
| ATE496624T1 (de) * | 2001-02-06 | 2011-02-15 | Sydney Children S Hospitals Network Randwick And Westmead Incorporating The Royal Alexandra Hospital | Arzneimittel zur behandlung von osteonekrose und zur versorgung von patienten mit risiko für die entstehung von osteonekrose |
| AUPR553701A0 (en) | 2001-06-07 | 2001-07-12 | Royal Alexandra Hospital For Children, The | A device for the delivery of a drug to a fractured bone |
-
2001
- 2001-12-13 AT AT01273650T patent/ATE496624T1/de active
- 2001-12-13 CZ CZ20032408A patent/CZ301361B6/cs not_active IP Right Cessation
- 2001-12-13 JP JP2002562358A patent/JP2004527479A/ja active Pending
- 2001-12-13 CA CA2435552A patent/CA2435552C/en not_active Expired - Fee Related
- 2001-12-13 PL PL36190901A patent/PL361909A1/xx not_active IP Right Cessation
- 2001-12-13 KR KR10-2003-7010328A patent/KR20030072399A/ko not_active Ceased
- 2001-12-13 WO PCT/AU2001/001616 patent/WO2002062351A1/en not_active Ceased
- 2001-12-13 MX MXPA03007029A patent/MXPA03007029A/es active IP Right Grant
- 2001-12-13 US US10/470,924 patent/US7425549B2/en not_active Expired - Fee Related
- 2001-12-13 DK DK01273650.0T patent/DK1365769T3/da active
- 2001-12-13 AU AU2002221339A patent/AU2002221339B2/en not_active Ceased
- 2001-12-13 NZ NZ527351A patent/NZ527351A/en not_active IP Right Cessation
- 2001-12-13 EP EP01273650A patent/EP1365769B1/en not_active Expired - Lifetime
- 2001-12-13 SI SI200130991T patent/SI1365769T1/sl unknown
- 2001-12-13 DE DE60143964T patent/DE60143964D1/de not_active Expired - Lifetime
- 2001-12-13 BR BR0116862-2A patent/BR0116862A/pt not_active Application Discontinuation
- 2001-12-13 HU HU0303013A patent/HUP0303013A3/hu unknown
- 2001-12-13 SK SK986-2003A patent/SK9862003A3/sk unknown
- 2001-12-13 CN CNB018225365A patent/CN1233325C/zh not_active Expired - Fee Related
-
2003
- 2003-07-30 ZA ZA2003/05890A patent/ZA200305890B/en unknown
- 2003-07-31 IL IL157201A patent/IL157201A/en not_active IP Right Cessation
- 2003-08-04 NO NO20033446A patent/NO20033446L/no not_active Application Discontinuation
-
2008
- 2008-08-13 US US12/191,264 patent/US7612050B2/en not_active Expired - Fee Related
-
2011
- 2011-04-20 CY CY20111100406T patent/CY1111402T1/el unknown
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