JP2004526747A5 - - Google Patents
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- Publication number
- JP2004526747A5 JP2004526747A5 JP2002578972A JP2002578972A JP2004526747A5 JP 2004526747 A5 JP2004526747 A5 JP 2004526747A5 JP 2002578972 A JP2002578972 A JP 2002578972A JP 2002578972 A JP2002578972 A JP 2002578972A JP 2004526747 A5 JP2004526747 A5 JP 2004526747A5
- Authority
- JP
- Japan
- Prior art keywords
- bone
- medicament
- bone graft
- bisphosphonate
- supplement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000988 bone and bone Anatomy 0.000 claims 41
- 239000003814 drug Substances 0.000 claims 38
- 229940122361 Bisphosphonate Drugs 0.000 claims 19
- 150000004663 bisphosphonates Chemical class 0.000 claims 19
- 239000013589 supplement Substances 0.000 claims 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 5
- 239000004568 cement Substances 0.000 claims 4
- 230000007547 defect Effects 0.000 claims 4
- 239000000499 gel Substances 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 230000004819 osteoinduction Effects 0.000 claims 4
- 210000001185 bone marrow Anatomy 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 238000001356 surgical procedure Methods 0.000 claims 3
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical group OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 3
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims 2
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 206010017076 Fracture Diseases 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 229920000954 Polyglycolide Polymers 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 239000004633 polyglycolic acid Substances 0.000 claims 2
- 239000004626 polylactic acid Substances 0.000 claims 2
- 229920005989 resin Polymers 0.000 claims 2
- 239000011347 resin Substances 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims 1
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- 206010061573 Congenital pseudarthrosis Diseases 0.000 claims 1
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 claims 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000002565 Open Fractures Diseases 0.000 claims 1
- 108090000573 Osteocalcin Proteins 0.000 claims 1
- 102000004067 Osteocalcin Human genes 0.000 claims 1
- 208000003076 Osteolysis Diseases 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims 1
- 102000013275 Somatomedins Human genes 0.000 claims 1
- DKJJVAGXPKPDRL-UHFFFAOYSA-N Tiludronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1 DKJJVAGXPKPDRL-UHFFFAOYSA-N 0.000 claims 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- UGEPSJNLORCRBO-UHFFFAOYSA-N [3-(dimethylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid Chemical compound CN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O UGEPSJNLORCRBO-UHFFFAOYSA-N 0.000 claims 1
- 230000002745 absorbent Effects 0.000 claims 1
- 239000002250 absorbent Substances 0.000 claims 1
- 229940062527 alendronate Drugs 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 229910045601 alloy Inorganic materials 0.000 claims 1
- 239000000956 alloy Substances 0.000 claims 1
- 208000037873 arthrodesis Diseases 0.000 claims 1
- 238000011882 arthroplasty Methods 0.000 claims 1
- 229920000249 biocompatible polymer Polymers 0.000 claims 1
- 229960002286 clodronic acid Drugs 0.000 claims 1
- ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims 1
- 230000037416 cystogenesis Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- IWLDTXOHXPDPQG-UHFFFAOYSA-L disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]-3-pyrrolidin-1-ylpropyl]phosphinate Chemical compound [Na+].[Na+].OP(=O)(O)C(P([O-])([O-])=O)(O)CCN1CCCC1 IWLDTXOHXPDPQG-UHFFFAOYSA-L 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229940009626 etidronate Drugs 0.000 claims 1
- 229940126864 fibroblast growth factor Drugs 0.000 claims 1
- 210000002082 fibula Anatomy 0.000 claims 1
- 229940015872 ibandronate Drugs 0.000 claims 1
- LWRDQHOZTAOILO-UHFFFAOYSA-N incadronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)NC1CCCCCC1 LWRDQHOZTAOILO-UHFFFAOYSA-N 0.000 claims 1
- 229950006971 incadronic acid Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 208000029791 lytic metastatic bone lesion Diseases 0.000 claims 1
- 210000004373 mandible Anatomy 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 210000002050 maxilla Anatomy 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- VMMKGHQPQIEGSQ-UHFFFAOYSA-N minodronic acid Chemical compound C1=CC=CN2C(CC(O)(P(O)(O)=O)P(O)(O)=O)=CN=C21 VMMKGHQPQIEGSQ-UHFFFAOYSA-N 0.000 claims 1
- 229950011129 minodronic acid Drugs 0.000 claims 1
- PUUSSSIBPPTKTP-UHFFFAOYSA-N neridronic acid Chemical compound NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O PUUSSSIBPPTKTP-UHFFFAOYSA-N 0.000 claims 1
- 229950010733 neridronic acid Drugs 0.000 claims 1
- 230000002138 osteoinductive effect Effects 0.000 claims 1
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical group NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims 1
- 229940046231 pamidronate Drugs 0.000 claims 1
- 230000000849 parathyroid Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229940089617 risedronate Drugs 0.000 claims 1
- 210000003625 skull Anatomy 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 210000002303 tibia Anatomy 0.000 claims 1
- 229940019375 tiludronate Drugs 0.000 claims 1
- 239000010936 titanium Substances 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000005740 tumor formation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR4187A AUPR418701A0 (en) | 2001-04-03 | 2001-04-03 | A drug for use in bone grafting |
| AUPR9613A AUPR961301A0 (en) | 2001-12-17 | 2001-12-17 | A drug for use in bone grafting |
| PCT/AU2002/000412 WO2002080933A1 (en) | 2001-04-03 | 2002-03-28 | A drug for use in bone grafting |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004526747A JP2004526747A (ja) | 2004-09-02 |
| JP2004526747A5 true JP2004526747A5 (https=) | 2005-12-22 |
Family
ID=25646639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002578972A Pending JP2004526747A (ja) | 2001-04-03 | 2002-03-28 | 骨移植で使用される医薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040157798A1 (https=) |
| EP (1) | EP1383509A4 (https=) |
| JP (1) | JP2004526747A (https=) |
| AU (1) | AU2002244520B2 (https=) |
| NZ (1) | NZ528659A (https=) |
| WO (1) | WO2002080933A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0300620D0 (sv) * | 2003-03-05 | 2003-03-05 | Bone Support Ab | A new bone substitute composition |
| CA2539359A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate |
| SE0302983D0 (sv) | 2003-11-11 | 2003-11-11 | Bone Support Ab | Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed |
| ITMI20040218A1 (it) * | 2004-02-10 | 2004-05-10 | Abiogen Pharma Spa | Uso di neridronato sodico per promuovere la neoformazione ossea |
| SE527528C2 (sv) | 2004-06-22 | 2006-04-04 | Bone Support Ab | Anordning för framställning av härdbar massa samt användning av anordningen |
| US8852240B2 (en) | 2004-10-25 | 2014-10-07 | Kieran Murphy, Llc | Methods and compositions for fostering and preserving bone growth |
| US8071574B2 (en) * | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| US20070077267A1 (en) * | 2005-10-03 | 2007-04-05 | Sdgi Holdings, Inc. | Bioactive composite implants |
| US8287596B1 (en) * | 2006-10-11 | 2012-10-16 | Nuvasive, Inc. | Intraoperative surgical barrier and related methods |
| US8106008B2 (en) * | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| WO2008108395A1 (ja) * | 2007-03-06 | 2008-09-12 | Takara Bio Inc. | オステオカルシン含有抽出物の製造方法 |
| AU2007352435B2 (en) * | 2007-04-27 | 2012-01-19 | Unigene Laboratories, Inc. | Methods and compositions for fostering and preserving bone growth |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| DK2459176T3 (en) | 2009-07-31 | 2017-12-04 | Gruenenthal Gmbh | Crystallization process and bioavailability |
| US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
| US9180137B2 (en) | 2010-02-09 | 2015-11-10 | Bone Support Ab | Preparation of bone cement compositions |
| US20110307074A1 (en) * | 2010-05-24 | 2011-12-15 | University Of The Witwatersrand, Johannesburg | Biomaterials for use in methods of bone replacement therapy |
| US9340565B2 (en) | 2010-11-24 | 2016-05-17 | Thar Pharmaceuticals, Inc. | Crystalline forms |
| CA2830505A1 (en) * | 2011-03-21 | 2012-09-27 | Ronald Childs | Sleeve for bone fixation device |
| GB201200868D0 (en) * | 2012-01-19 | 2012-02-29 | Depuy Int Ltd | Bone filler composition |
| DK2958603T3 (en) | 2013-02-20 | 2018-07-16 | Bone Support Ab | IMPROVED CURE FOR HARDWARE BONE COMPENSATION |
| US10238507B2 (en) | 2015-01-12 | 2019-03-26 | Surgentec, Llc | Bone graft delivery system and method for using same |
| JP2018514248A (ja) * | 2015-03-23 | 2018-06-07 | ボーナ スーポート アーベー | 二相性セラミック骨代用材 |
| US20180289859A1 (en) * | 2015-10-05 | 2018-10-11 | Hettwer Holding Aps | Compositions and methods for treatment of bone defects |
| US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
| US10687828B2 (en) | 2018-04-13 | 2020-06-23 | Surgentec, Llc | Bone graft delivery system and method for using same |
| US11116647B2 (en) | 2018-04-13 | 2021-09-14 | Surgentec, Llc | Bone graft delivery system and method for using same |
| ES2975487T3 (es) | 2018-04-23 | 2024-07-08 | Moroxite T Ab | Novedoso enfoque terapéutico mediante administración dirigida de cerámicas moduladas por moléculas bioactivas |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208219A (en) * | 1991-02-14 | 1993-05-04 | Celtrix Pharmaceuticals Inc. | Method for inducing bone growth |
| EP0523926A3 (en) * | 1991-07-15 | 1993-12-01 | Smith & Nephew Richards Inc | Prosthetic implants with bioabsorbable coating |
| AU5953894A (en) * | 1992-12-23 | 1994-07-19 | Merck & Co., Inc. | Bisphosphonate/estrogen therapy for treating and preventing bone loss |
| US5403829A (en) * | 1993-03-24 | 1995-04-04 | Leiras Oy | Use of bisphosphonates in endo-osteal bone surgery |
| US5646134A (en) * | 1994-04-21 | 1997-07-08 | Merck & Co., Inc. | Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices |
| JPH11511041A (ja) * | 1995-06-06 | 1999-09-28 | メルク エンド カンパニー インコーポレーテッド | 整形外科的埋め込み装置の無菌性動揺を防止するビスホスホネートセメント組成物 |
| EP0950417A3 (en) * | 1998-02-23 | 2000-02-23 | Pfizer Products Inc. | Treatment of skeletal disorders |
| AU776555B2 (en) * | 1999-02-09 | 2004-09-16 | Sloan-Kettering Institute For Cancer Research | Anti-resorptive bone cements and allogeneic, autografic, and xenografic bone grafts |
| AUPQ232599A0 (en) * | 1999-08-19 | 1999-09-09 | Royal Alexandra Hospital For Children, The | Drug for treating fractures |
| ES2394211T3 (es) * | 2000-06-20 | 2013-01-23 | Novartis Ag | Procedimiento de administración de bifosfonatos |
| ATE496624T1 (de) * | 2001-02-06 | 2011-02-15 | Sydney Children S Hospitals Network Randwick And Westmead Incorporating The Royal Alexandra Hospital | Arzneimittel zur behandlung von osteonekrose und zur versorgung von patienten mit risiko für die entstehung von osteonekrose |
-
2002
- 2002-03-28 EP EP02712634A patent/EP1383509A4/en not_active Withdrawn
- 2002-03-28 AU AU2002244520A patent/AU2002244520B2/en not_active Ceased
- 2002-03-28 JP JP2002578972A patent/JP2004526747A/ja active Pending
- 2002-03-28 NZ NZ528659A patent/NZ528659A/en unknown
- 2002-03-28 US US10/474,072 patent/US20040157798A1/en not_active Abandoned
- 2002-03-28 WO PCT/AU2002/000412 patent/WO2002080933A1/en not_active Ceased
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