CN1233325C - 治疗骨坏死和处理有发展为骨坏死危险的患者用的药物 - Google Patents
治疗骨坏死和处理有发展为骨坏死危险的患者用的药物 Download PDFInfo
- Publication number
- CN1233325C CN1233325C CNB018225365A CN01822536A CN1233325C CN 1233325 C CN1233325 C CN 1233325C CN B018225365 A CNB018225365 A CN B018225365A CN 01822536 A CN01822536 A CN 01822536A CN 1233325 C CN1233325 C CN 1233325C
- Authority
- CN
- China
- Prior art keywords
- diphosphonate
- purposes
- medicine
- bone
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 71
- 229940079593 drug Drugs 0.000 title claims abstract description 9
- 206010031264 Osteonecrosis Diseases 0.000 title claims description 62
- 238000011282 treatment Methods 0.000 title claims description 30
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 76
- XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical compound [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 claims description 64
- 150000003009 phosphonic acids Chemical class 0.000 claims description 33
- 150000002148 esters Chemical class 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 27
- 201000009859 Osteochondrosis Diseases 0.000 claims description 26
- 208000007656 osteochondritis dissecans Diseases 0.000 claims description 25
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical class NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims description 23
- 229940062527 alendronate Drugs 0.000 claims description 23
- 210000002758 humerus Anatomy 0.000 claims description 12
- VMMKGHQPQIEGSQ-UHFFFAOYSA-N minodronic acid Chemical compound C1=CC=CN2C(CC(O)(P(O)(O)=O)P(O)(O)=O)=CN=C21 VMMKGHQPQIEGSQ-UHFFFAOYSA-N 0.000 claims description 12
- 229950011129 minodronic acid Drugs 0.000 claims description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 11
- 239000011734 sodium Substances 0.000 claims description 11
- 229910052708 sodium Inorganic materials 0.000 claims description 11
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical group NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims description 10
- 229940046231 pamidronate Drugs 0.000 claims description 10
- 210000000845 cartilage Anatomy 0.000 claims description 9
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims description 8
- DCSBSVSZJRSITC-UHFFFAOYSA-M alendronate sodium trihydrate Chemical compound O.O.O.[Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O DCSBSVSZJRSITC-UHFFFAOYSA-M 0.000 claims description 8
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 7
- 230000006378 damage Effects 0.000 claims description 7
- 229960000759 risedronic acid Drugs 0.000 claims description 7
- 210000004233 talus Anatomy 0.000 claims description 7
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims description 6
- ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 claims description 6
- 229940009626 etidronate Drugs 0.000 claims description 6
- 241001061264 Astragalus Species 0.000 claims description 5
- 102000013275 Somatomedins Human genes 0.000 claims description 5
- 235000006533 astragalus Nutrition 0.000 claims description 5
- 210000003010 carpal bone Anatomy 0.000 claims description 5
- 229960000579 clodronate disodium Drugs 0.000 claims description 5
- SKUHWSDHMJMHIW-UHFFFAOYSA-L disodium;[(4-chlorophenyl)sulfanyl-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate Chemical compound [Na+].[Na+].OP([O-])(=O)C(P(O)([O-])=O)SC1=CC=C(Cl)C=C1 SKUHWSDHMJMHIW-UHFFFAOYSA-L 0.000 claims description 5
- 210000001699 lower leg Anatomy 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 238000002054 transplantation Methods 0.000 claims description 5
- 239000013589 supplement Substances 0.000 claims description 4
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims description 3
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims description 3
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims description 3
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims description 3
- 206010058112 Chondrolysis Diseases 0.000 claims description 3
- 229940112869 bone morphogenetic protein Drugs 0.000 claims description 3
- 230000012010 growth Effects 0.000 claims description 3
- 230000009545 invasion Effects 0.000 claims description 3
- 208000004141 microcephaly Diseases 0.000 claims description 3
- 210000002303 tibia Anatomy 0.000 claims description 3
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 2
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims description 2
- 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 claims description 2
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims description 2
- 102100025947 Insulin-like growth factor II Human genes 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 1
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 21
- 229940122361 Bisphosphonate Drugs 0.000 abstract description 4
- 150000004663 bisphosphonates Chemical class 0.000 abstract description 4
- 239000004606 Fillers/Extenders Substances 0.000 abstract description 2
- 230000000278 osteoconductive effect Effects 0.000 abstract 1
- 230000002138 osteoinductive effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 27
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 27
- 208000010392 Bone Fractures Diseases 0.000 description 20
- 206010017076 Fracture Diseases 0.000 description 20
- 230000003203 everyday effect Effects 0.000 description 20
- 230000000694 effects Effects 0.000 description 16
- 230000011164 ossification Effects 0.000 description 16
- 230000002980 postoperative effect Effects 0.000 description 15
- 208000027414 Legg-Calve-Perthes disease Diseases 0.000 description 14
- 210000000689 upper leg Anatomy 0.000 description 13
- 210000002745 epiphysis Anatomy 0.000 description 12
- 230000003442 weekly effect Effects 0.000 description 12
- 241000700159 Rattus Species 0.000 description 9
- 238000011160 research Methods 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 230000001338 necrotic effect Effects 0.000 description 8
- 239000011780 sodium chloride Substances 0.000 description 8
- 210000001624 hip Anatomy 0.000 description 7
- 208000032170 Congenital Abnormalities Diseases 0.000 description 6
- 210000004394 hip joint Anatomy 0.000 description 6
- 238000001356 surgical procedure Methods 0.000 description 6
- 206010023204 Joint dislocation Diseases 0.000 description 5
- 230000009102 absorption Effects 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 210000001188 articular cartilage Anatomy 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 230000003211 malignant effect Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 239000003018 immunosuppressive agent Substances 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- 201000008482 osteoarthritis Diseases 0.000 description 4
- 230000036407 pain Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000033115 angiogenesis Effects 0.000 description 3
- 230000036770 blood supply Effects 0.000 description 3
- 230000009089 cytolysis Effects 0.000 description 3
- 239000002254 cytotoxic agent Substances 0.000 description 3
- 229940127089 cytotoxic agent Drugs 0.000 description 3
- 238000001647 drug administration Methods 0.000 description 3
- 239000003862 glucocorticoid Substances 0.000 description 3
- 208000014951 hematologic disease Diseases 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 3
- 229960004276 zoledronic acid Drugs 0.000 description 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241000131317 Capitulum Species 0.000 description 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
- 229930105110 Cyclosporin A Natural products 0.000 description 2
- 108010036949 Cyclosporine Proteins 0.000 description 2
- 208000007875 Femur Head Necrosis Diseases 0.000 description 2
- 206010017711 Gangrene Diseases 0.000 description 2
- 208000007446 Hip Dislocation Diseases 0.000 description 2
- 229920000954 Polyglycolide Polymers 0.000 description 2
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- 206010072610 Skeletal dysplasia Diseases 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 238000000540 analysis of variance Methods 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 238000010322 bone marrow transplantation Methods 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229960001265 ciclosporin Drugs 0.000 description 2
- 208000018631 connective tissue disease Diseases 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 229930182912 cyclosporin Natural products 0.000 description 2
- 208000030172 endocrine system disease Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000002436 femur neck Anatomy 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 210000004349 growth plate Anatomy 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 238000010191 image analysis Methods 0.000 description 2
- 229960003444 immunosuppressant agent Drugs 0.000 description 2
- 230000001861 immunosuppressant effect Effects 0.000 description 2
- 229940124589 immunosuppressive drug Drugs 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 238000009940 knitting Methods 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 230000005577 local transmission Effects 0.000 description 2
- -1 methyl amyl amino Chemical group 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000002997 osteoclast Anatomy 0.000 description 2
- 206010036067 polydipsia Diseases 0.000 description 2
- 239000004633 polyglycolic acid Substances 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 201000003068 rheumatic fever Diseases 0.000 description 2
- 239000012852 risk material Substances 0.000 description 2
- 208000007056 sickle cell anemia Diseases 0.000 description 2
- 230000000391 smoking effect Effects 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 210000005065 subchondral bone plate Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 210000001694 thigh bone Anatomy 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229950003937 tolonium Drugs 0.000 description 2
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- PMXAPNNYCFBALB-UHFFFAOYSA-N (1-hydroxy-1-phosphono-3-pyrrolidin-1-ylpropyl)phosphonic acid Chemical group OP(=O)(O)C(P(O)(O)=O)(O)CCN1CCCC1 PMXAPNNYCFBALB-UHFFFAOYSA-N 0.000 description 1
- GUXHBMASAHGULD-SEYHBJAFSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=C(Cl)C=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O GUXHBMASAHGULD-SEYHBJAFSA-N 0.000 description 1
- UPMXNNIRAGDFEH-UHFFFAOYSA-N 3,5-dibromo-4-hydroxybenzonitrile Chemical compound OC1=C(Br)C=C(C#N)C=C1Br UPMXNNIRAGDFEH-UHFFFAOYSA-N 0.000 description 1
- LCSKNASZPVZHEG-UHFFFAOYSA-N 3,6-dimethyl-1,4-dioxane-2,5-dione;1,4-dioxane-2,5-dione Chemical group O=C1COC(=O)CO1.CC1OC(=O)C(C)OC1=O LCSKNASZPVZHEG-UHFFFAOYSA-N 0.000 description 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010061619 Deformity Diseases 0.000 description 1
- FMTDIUIBLCQGJB-UHFFFAOYSA-N Demethylchlortetracyclin Natural products C1C2C(O)C3=C(Cl)C=CC(O)=C3C(=O)C2=C(O)C2(O)C1C(N(C)C)C(O)=C(C(N)=O)C2=O FMTDIUIBLCQGJB-UHFFFAOYSA-N 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 241001653121 Glenoides Species 0.000 description 1
- 206010020100 Hip fracture Diseases 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 108090000573 Osteocalcin Proteins 0.000 description 1
- 102000004067 Osteocalcin Human genes 0.000 description 1
- 208000002804 Osteochondritis Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 208000008877 Shoulder Dislocation Diseases 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- DKJJVAGXPKPDRL-UHFFFAOYSA-N Tiludronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1 DKJJVAGXPKPDRL-UHFFFAOYSA-N 0.000 description 1
- UGEPSJNLORCRBO-UHFFFAOYSA-N [3-(dimethylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid Chemical compound CN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O UGEPSJNLORCRBO-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- DEGAKNSWVGKMLS-UHFFFAOYSA-N calcein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(CN(CC(O)=O)CC(O)=O)=C(O)C=C1OC1=C2C=C(CN(CC(O)=O)CC(=O)O)C(O)=C1 DEGAKNSWVGKMLS-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229960002286 clodronic acid Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 229960002398 demeclocycline Drugs 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 125000003963 dichloro group Chemical group Cl* 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000009547 dual-energy X-ray absorptiometry Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 208000020089 femoral neck fracture Diseases 0.000 description 1
- 229940126864 fibroblast growth factor Drugs 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000001215 fluorescent labelling Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000003208 gene overexpression Methods 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 208000012285 hip pain Diseases 0.000 description 1
- 238000011540 hip replacement Methods 0.000 description 1
- 210000004095 humeral head Anatomy 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 238000002639 hyperbaric oxygen therapy Methods 0.000 description 1
- 229940015872 ibandronate Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- LWRDQHOZTAOILO-UHFFFAOYSA-N incadronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)NC1CCCCCC1 LWRDQHOZTAOILO-UHFFFAOYSA-N 0.000 description 1
- 229950006971 incadronic acid Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000000450 navicular bone Anatomy 0.000 description 1
- PUUSSSIBPPTKTP-UHFFFAOYSA-N neridronic acid Chemical compound NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O PUUSSSIBPPTKTP-UHFFFAOYSA-N 0.000 description 1
- 229950010733 neridronic acid Drugs 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229960002378 oftasceine Drugs 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 230000001582 osteoblastic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229910021426 porous silicon Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 102000037983 regulatory factors Human genes 0.000 description 1
- 108091008025 regulatory factors Proteins 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229940089617 risedronate Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940019375 tiludronate Drugs 0.000 description 1
- 230000005944 tissue migration Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
未手术对照 | 手术对照 | 术后给药 | 术前术后给药 | |
XR头面积(%对照) | - | 63 | 79 | 85 |
BMD(g/cm2) | 0.11 | 0.07 | 0.11 | 0.12 |
BMC(g) | 0.017 | 0.006 | 0.012 | 0.015 |
Claims (23)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPR2907 | 2001-02-06 | ||
AUPR2907A AUPR290701A0 (en) | 2001-02-06 | 2001-02-06 | A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis |
AUPR4187A AUPR418701A0 (en) | 2001-04-03 | 2001-04-03 | A drug for use in bone grafting |
AUPR4187 | 2001-04-03 | ||
AUPR6654A AUPR665401A0 (en) | 2001-07-27 | 2001-07-27 | A drug and method for the treatment of osteonecrosis |
AUPR6654 | 2001-07-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1529604A CN1529604A (zh) | 2004-09-15 |
CN1233325C true CN1233325C (zh) | 2005-12-28 |
Family
ID=27158265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018225365A Expired - Fee Related CN1233325C (zh) | 2001-02-06 | 2001-12-13 | 治疗骨坏死和处理有发展为骨坏死危险的患者用的药物 |
Country Status (24)
Country | Link |
---|---|
US (2) | US7425549B2 (zh) |
EP (1) | EP1365769B1 (zh) |
JP (1) | JP2004527479A (zh) |
KR (1) | KR20030072399A (zh) |
CN (1) | CN1233325C (zh) |
AT (1) | ATE496624T1 (zh) |
AU (1) | AU2002221339B2 (zh) |
BR (1) | BR0116862A (zh) |
CA (1) | CA2435552C (zh) |
CY (1) | CY1111402T1 (zh) |
CZ (1) | CZ301361B6 (zh) |
DE (1) | DE60143964D1 (zh) |
DK (1) | DK1365769T3 (zh) |
HK (1) | HK1061797A1 (zh) |
HU (1) | HUP0303013A3 (zh) |
IL (1) | IL157201A (zh) |
MX (1) | MXPA03007029A (zh) |
NO (1) | NO20033446L (zh) |
NZ (1) | NZ527351A (zh) |
PL (1) | PL361909A1 (zh) |
SI (1) | SI1365769T1 (zh) |
SK (1) | SK9862003A3 (zh) |
WO (1) | WO2002062351A1 (zh) |
ZA (1) | ZA200305890B (zh) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002221339B2 (en) * | 2001-02-06 | 2006-04-27 | The Sydney Children's Hospitals Network (Randwick And Westmead) (Incorporating The Royal Alexandra Hospital For Children) | A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis |
WO2002080933A1 (en) * | 2001-04-03 | 2002-10-17 | The Royal Alexandra Hospital For Children | A drug for use in bone grafting |
CA2469779C (en) * | 2001-12-21 | 2008-02-12 | The Procter & Gamble Company | Method for the treatment of bone disorders |
WO2003095029A1 (en) * | 2002-05-10 | 2003-11-20 | F. Hoffmann-La Roche Ag | Bisphosphonic acid for the treatment and prevention of osteoporosis |
RU2315603C2 (ru) * | 2002-12-20 | 2008-01-27 | Ф.Хоффманн-Ля Рош Аг | Композиция с высокой дозой ибандроната |
PT1534305E (pt) | 2003-05-07 | 2007-02-28 | Osteologix As | Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis |
WO2005072747A1 (ja) * | 2004-02-02 | 2005-08-11 | Ono Pharmaceutical Co., Ltd. | 骨吸収抑制剤 |
ITMI20040218A1 (it) * | 2004-02-10 | 2004-05-10 | Abiogen Pharma Spa | Uso di neridronato sodico per promuovere la neoformazione ossea |
KR101165614B1 (ko) | 2004-02-26 | 2012-07-18 | 오스테올로지스 에이에스 | 괴사성 골 질환의 예방 또는 치료에 사용하기 위한스트론튬 함유 화합물 |
WO2006039721A2 (en) * | 2004-10-08 | 2006-04-13 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
US8012949B2 (en) * | 2004-10-08 | 2011-09-06 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS |
WO2006050493A2 (en) * | 2004-11-03 | 2006-05-11 | The Regents Of The University Of Michigan | Biodegradable implant for intertransverse process fusion |
US8071574B2 (en) * | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
KR20080111070A (ko) * | 2006-03-17 | 2008-12-22 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 비스포스포네이트 화합물 및 방법 |
US7833270B2 (en) * | 2006-05-05 | 2010-11-16 | Warsaw Orthopedic, Inc | Implant depots to deliver growth factors to treat osteoporotic bone |
US8062364B1 (en) | 2007-04-27 | 2011-11-22 | Knee Creations, Llc | Osteoarthritis treatment and device |
AU2010278860B2 (en) | 2009-07-31 | 2016-05-26 | Thar Pharma, Llc | Crystallization method and bioavailability |
US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
US9340565B2 (en) | 2010-11-24 | 2016-05-17 | Thar Pharmaceuticals, Inc. | Crystalline forms |
GB201200868D0 (en) * | 2012-01-19 | 2012-02-29 | Depuy Int Ltd | Bone filler composition |
US10022172B2 (en) | 2014-06-25 | 2018-07-17 | Spine Wave, Inc. | Minimally invasive posterolateral fusion |
CN105012995B (zh) * | 2015-06-04 | 2018-03-09 | 武汉维斯第医用科技股份有限公司 | 一种含促骨愈合药物的胶原蛋白海绵及其制备方法 |
WO2016204711A1 (en) | 2015-06-16 | 2016-12-22 | Spine Wave, Inc. | Instrument and system for placing graft, implant and graft material for minimally invasive posterolateral fusion |
KR20180102154A (ko) * | 2016-01-14 | 2018-09-14 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Llp2a-비스포스포네이트 화합물로 뼈괴사를 치료하는 방법 |
US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
AU2017204355B2 (en) | 2016-07-08 | 2021-09-09 | Mako Surgical Corp. | Scaffold for alloprosthetic composite implant |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0675723A4 (en) * | 1992-12-23 | 1998-08-05 | Merck & Co Inc | BIPHOSPHONATE / ESTROGEN THERAPY FOR TREATING AND PREVENTING BONE LOSS. |
US5403829A (en) * | 1993-03-24 | 1995-04-04 | Leiras Oy | Use of bisphosphonates in endo-osteal bone surgery |
US5646134A (en) | 1994-04-21 | 1997-07-08 | Merck & Co., Inc. | Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices |
US5476865A (en) * | 1994-07-06 | 1995-12-19 | Eli Lilly And Company | Methods of inhibiting bone loss |
CN1113440A (zh) | 1994-07-29 | 1995-12-20 | 孟照强 | 一种治疗骨伤的中药制剂及其制备方法 |
WO1996039974A1 (en) * | 1995-06-07 | 1996-12-19 | Implex Corporation | Femoral head core channel filling prosthesis |
US7041641B2 (en) * | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
US5843678A (en) * | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins |
US6316408B1 (en) * | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
EP1027076A2 (de) | 1997-10-29 | 2000-08-16 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Verwendung von vektoren wie adenoviren und/oder adeno-assoziierten viren und/oder retroviren und/oder herpes-simplex-viren und/oder liposomen und/oder plasmiden als vehikel für genetische information zur befähigung von säugetierzellen mittel, zur behandlung von knochenpathologien zu produzieren |
US6268367B1 (en) * | 1998-02-23 | 2001-07-31 | Zymogenetics, Inc. | Piperazine derivatives for treating bone deficit conditions |
AU6427599A (en) | 1998-10-15 | 2000-05-01 | Merck & Co., Inc. | Methods for stimulating bone formation |
NZ515541A (en) * | 1999-05-21 | 2003-03-28 | Novartis Ag | Pharmaceutical compositions comprising bisphosphonates to treat angiogenesis |
AU781068B2 (en) * | 1999-08-19 | 2005-05-05 | Sydney Children's Hospitals Network (Randwick and Westmead) (incorporating The Royal Alexandra Hospital for Children), The | Drug for treating fractures |
AUPQ232599A0 (en) | 1999-08-19 | 1999-09-09 | Royal Alexandra Hospital For Children, The | Drug for treating fractures |
US6482411B1 (en) | 1999-08-27 | 2002-11-19 | Board Of Regents, The University Of Texas System | Methods of reducing bone loss with CD40 ligand |
GB0029111D0 (en) | 2000-11-29 | 2001-01-10 | Novartis Ag | Organic compounds |
AU2002221339B2 (en) * | 2001-02-06 | 2006-04-27 | The Sydney Children's Hospitals Network (Randwick And Westmead) (Incorporating The Royal Alexandra Hospital For Children) | A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis |
AUPR553701A0 (en) * | 2001-06-07 | 2001-07-12 | Royal Alexandra Hospital For Children, The | A device for the delivery of a drug to a fractured bone |
-
2001
- 2001-12-13 AU AU2002221339A patent/AU2002221339B2/en not_active Ceased
- 2001-12-13 SI SI200130991T patent/SI1365769T1/sl unknown
- 2001-12-13 DK DK01273650.0T patent/DK1365769T3/da active
- 2001-12-13 EP EP01273650A patent/EP1365769B1/en not_active Expired - Lifetime
- 2001-12-13 DE DE60143964T patent/DE60143964D1/de not_active Expired - Lifetime
- 2001-12-13 US US10/470,924 patent/US7425549B2/en not_active Expired - Fee Related
- 2001-12-13 WO PCT/AU2001/001616 patent/WO2002062351A1/en active IP Right Grant
- 2001-12-13 SK SK986-2003A patent/SK9862003A3/sk unknown
- 2001-12-13 HU HU0303013A patent/HUP0303013A3/hu unknown
- 2001-12-13 CZ CZ20032408A patent/CZ301361B6/cs not_active IP Right Cessation
- 2001-12-13 CN CNB018225365A patent/CN1233325C/zh not_active Expired - Fee Related
- 2001-12-13 AT AT01273650T patent/ATE496624T1/de active
- 2001-12-13 BR BR0116862-2A patent/BR0116862A/pt not_active Application Discontinuation
- 2001-12-13 PL PL36190901A patent/PL361909A1/xx not_active IP Right Cessation
- 2001-12-13 NZ NZ527351A patent/NZ527351A/en not_active IP Right Cessation
- 2001-12-13 JP JP2002562358A patent/JP2004527479A/ja active Pending
- 2001-12-13 KR KR10-2003-7010328A patent/KR20030072399A/ko not_active Application Discontinuation
- 2001-12-13 MX MXPA03007029A patent/MXPA03007029A/es active IP Right Grant
- 2001-12-13 CA CA2435552A patent/CA2435552C/en not_active Expired - Fee Related
-
2003
- 2003-07-30 ZA ZA2003/05890A patent/ZA200305890B/en unknown
- 2003-07-31 IL IL157201A patent/IL157201A/en not_active IP Right Cessation
- 2003-08-04 NO NO20033446A patent/NO20033446L/no not_active Application Discontinuation
-
2004
- 2004-06-02 HK HK04103953.5A patent/HK1061797A1/xx not_active IP Right Cessation
-
2008
- 2008-08-13 US US12/191,264 patent/US7612050B2/en not_active Expired - Fee Related
-
2011
- 2011-04-20 CY CY20111100406T patent/CY1111402T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1365769A4 (en) | 2005-08-10 |
US7425549B2 (en) | 2008-09-16 |
CA2435552A1 (en) | 2002-08-15 |
SK9862003A3 (en) | 2004-02-03 |
AU2002221339B2 (en) | 2006-04-27 |
NO20033446D0 (no) | 2003-08-04 |
WO2002062351A1 (en) | 2002-08-15 |
DK1365769T3 (da) | 2011-05-16 |
DE60143964D1 (de) | 2011-03-10 |
CN1529604A (zh) | 2004-09-15 |
CZ301361B6 (cs) | 2010-01-27 |
KR20030072399A (ko) | 2003-09-13 |
HUP0303013A2 (hu) | 2003-12-29 |
HK1061797A1 (en) | 2004-10-08 |
JP2004527479A (ja) | 2004-09-09 |
BR0116862A (pt) | 2004-01-13 |
IL157201A (en) | 2010-04-29 |
CZ20032408A3 (cs) | 2004-06-16 |
PL361909A1 (en) | 2004-10-04 |
EP1365769A1 (en) | 2003-12-03 |
MXPA03007029A (es) | 2004-10-15 |
US7612050B2 (en) | 2009-11-03 |
NZ527351A (en) | 2005-01-28 |
CA2435552C (en) | 2010-04-27 |
SI1365769T1 (sl) | 2011-06-30 |
ATE496624T1 (de) | 2011-02-15 |
US20040097469A1 (en) | 2004-05-20 |
NO20033446L (no) | 2003-10-01 |
EP1365769B1 (en) | 2011-01-26 |
ZA200305890B (en) | 2005-01-26 |
CY1111402T1 (el) | 2015-08-05 |
US20090005347A1 (en) | 2009-01-01 |
HUP0303013A3 (en) | 2007-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1233325C (zh) | 治疗骨坏死和处理有发展为骨坏死危险的患者用的药物 | |
Zhang et al. | The effects of different doses of IGF-1 on cartilage and subchondral bone during the repair of full-thickness articular cartilage defects in rabbits | |
Kang et al. | Repairing defect and preventing collapse of femoral head in a steroid-induced osteonecrotic of femoral head animal model using strontium-doped calcium polyphosphate combined BM-MNCs | |
AU2002244520B2 (en) | A drug for use in bone grafting | |
Vandermeer et al. | Local administration of ibandronate and bone morphogenetic protein-2 after ischemic osteonecrosis of the immature femoral head: a combined therapy that stimulates bone formation and decreases femoral head deformity | |
AU2002221339A1 (en) | A drug for the treatment of osteonecrosis and for the management of patients at risk of developing osteonecrosis | |
AU2002244520A1 (en) | A drug for use in bone grafting | |
FR2705235A1 (fr) | Utilisation de particules d'un sel de calcium biocompatible et biorésorbable comme ingrédient actif dans la préparation d'un médicament destiné au traitement local des maladies déminéralisantes de l'os. | |
CN113749825B (zh) | 一种框架式骨关节假体及其制备方法和应用 | |
CN102844033A (zh) | 提高植入物骨结合的方法和组合物 | |
Tinsley et al. | Systemic administration of sclerostin antibody enhances bone morphogenetic protein-induced femoral defect repair in a rat model | |
CN1166316A (zh) | 组合疗法治疗骨质疏松症 | |
Kwon et al. | Locally delivered ethyl-2, 5-dihydroxybenzoate using 3D printed bone implant for promotion of bone regeneration in a osteoporotic animal model | |
Göker et al. | Combined effect of parathyroid hormone and strontium ranelate on bone healing in ovariectomized rats | |
CN1622826A (zh) | 用凝血酶肽衍生物刺激骨生长和软骨形成 | |
CN1151793C (zh) | 多发性骨髓瘤的骨病变治疗用医药组合物 | |
CN102068688A (zh) | 力生长因子及其e肽在制备治疗骨质疏松或骨缺损的药物及材料中的应用 | |
Zandi et al. | Histological assessment of the effects of teriparatide therapy on mandibular fracture healing: a preclinical study | |
CN110974940A (zh) | Ihh在制备预防或治疗生长板损伤的药物中的应用 | |
ES2362024T3 (es) | Fármaco para el tratamiento de osteonecrosis para la gestión de pacientes con riesgo de desarrollar osteonecrosis. | |
RU2284821C2 (ru) | Лекарственное средство для лечения остеонекроза и для лечения пациентов с риском развития остеонекроза | |
Casap et al. | Imperforate Titanium Shell Enclosing Recombinant Human Bone Morphogenetic Protein-2–Induced Bone Formation for High-Profile Dental Implants in Rabbit Tibia | |
JP5485704B2 (ja) | 骨吸収と骨形成の不均衡を是正するための方法ならびにキット及び組成物 | |
A Osman et al. | The effect of simvastatin drug on osteogenesis around titanium implant (radiographic and histomorphometric analysis) | |
Erickson | Engineering Biomaterials and Drug Delivery Systems to Promote Cartilage Tissue Regeneration for Physeal Injuries |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SYDNEY CHILDREN S HOSPITALS NETWORK CO. (RANDWICK Free format text: FORMER OWNER: ROYAL ALEXNDRA HOSPITAL FOR CHILDREN Effective date: 20110905 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20110905 Address after: New South Wales, Australia Patentee after: Sydney children's Hospital Network (Rand and West Meade) Address before: New South Wales, Australia Patentee before: Royal Alexndra Hospital For Children |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20051228 Termination date: 20121213 |