JP2004527452A5 - - Google Patents

Download PDF

Info

Publication number
JP2004527452A5
JP2004527452A5 JP2002504307A JP2002504307A JP2004527452A5 JP 2004527452 A5 JP2004527452 A5 JP 2004527452A5 JP 2002504307 A JP2002504307 A JP 2002504307A JP 2002504307 A JP2002504307 A JP 2002504307A JP 2004527452 A5 JP2004527452 A5 JP 2004527452A5
Authority
JP
Japan
Prior art keywords
thrombomodulin
analog
modified
native
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002504307A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004527452A (ja
JP4855627B2 (ja
Filing date
Publication date
Priority claimed from US09/880,484 external-priority patent/US6632791B1/en
Application filed filed Critical
Publication of JP2004527452A publication Critical patent/JP2004527452A/ja
Publication of JP2004527452A5 publication Critical patent/JP2004527452A5/ja
Application granted granted Critical
Publication of JP4855627B2 publication Critical patent/JP4855627B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2002504307A 2000-06-21 2001-06-20 医薬用途のためのトロンボモジュリン Expired - Fee Related JP4855627B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21367800P 2000-06-21 2000-06-21
US60/213,678 2000-06-21
US09/880,484 2001-06-12
US09/880,484 US6632791B1 (en) 2000-06-21 2001-06-12 Thrombomodulin analogs for pharmaceutical use
PCT/US2001/019590 WO2001098352A2 (en) 2000-06-21 2001-06-20 Thrombomodulin analogs for pharmaceutical use

Publications (3)

Publication Number Publication Date
JP2004527452A JP2004527452A (ja) 2004-09-09
JP2004527452A5 true JP2004527452A5 (enExample) 2008-08-07
JP4855627B2 JP4855627B2 (ja) 2012-01-18

Family

ID=26908302

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002504307A Expired - Fee Related JP4855627B2 (ja) 2000-06-21 2001-06-20 医薬用途のためのトロンボモジュリン

Country Status (10)

Country Link
US (2) US6632791B1 (enExample)
EP (1) EP1292673B1 (enExample)
JP (1) JP4855627B2 (enExample)
AT (1) ATE309339T1 (enExample)
AU (1) AU2001269927A1 (enExample)
DE (1) DE60114819T2 (enExample)
DK (1) DK1292673T3 (enExample)
ES (1) ES2256266T3 (enExample)
NO (1) NO20026147L (enExample)
WO (1) WO2001098352A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030118580A1 (en) * 2001-11-09 2003-06-26 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and thrombomodulin polypeptides
BR0304660A (pt) * 2002-05-01 2005-06-07 Schering Ag Anticorpos direcionados a fator de tecido como anticoagulantes
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
US7833978B2 (en) 2004-02-20 2010-11-16 Emory University Thrombomodulin derivatives and conjugates
CA2625619A1 (en) 2005-10-14 2007-04-26 Medimmune, Inc. Cell display of antibody libraries
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
US20110144024A1 (en) * 2008-07-16 2011-06-16 Paion Deutschland Gmbh Prevention and treatment of radiation injury
WO2010006635A1 (en) * 2008-07-16 2010-01-21 Paion Deutschland Gmbh Treatment of inflammatory bowel disease
US20120165244A1 (en) * 2008-10-30 2012-06-28 Hua-Lin Wu Methods for binding lewis y antigen
CA2764638A1 (en) * 2009-06-12 2010-12-16 Paion Deutschland Gmbh Treatment of coagulopathy with hyperfibrinolysis
JP6234224B2 (ja) 2010-08-05 2017-11-22 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ 血栓溶解及び抗凝固特性を有するタンパク質融合構築物
WO2014020183A1 (de) * 2012-08-03 2014-02-06 Ici Immunochemical Intelligence Gmbh In-vitro-assay zur diagnose von störungen der hämostase
US9156904B2 (en) * 2013-07-29 2015-10-13 Blue Blood Biotech Corp. Thrombomodulin variants and use thereof
WO2017189943A1 (en) * 2016-04-28 2017-11-02 Saint Louis University Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256770A (en) 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
US6063763A (en) 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
US5466668A (en) 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
AU4533093A (en) * 1992-06-10 1994-01-04 Michael John Morser Mutants of the epidermal growth factor domains of human thrombomodulin

Similar Documents

Publication Publication Date Title
JP2004527452A5 (enExample)
AU617126B2 (en) A polypeptide growth factor from milk
CA2529179A1 (en) Recombinant adeno-associated virus vector for treatment of alzheimer disease
EP0662827A4 (en) THERAPEUTIC AND DIAGNOSTIC METHODS AND COMPOSITIONS BASED ON NOTCH PROTEINS AND NUCLEIC ACIDS.
EP2875826A1 (en) Composition for preventing or treating sepsis
CA2165197A1 (en) Recombinant stratum corneum chymotryptic enzyme (scce)
EP1440980A3 (en) Peptide analogs of human myelin basic protein
WO2000024893A3 (en) Methods and compositions for the prevention and treatment of anemia
WO2003093299A3 (en) Insulin-associated peptides with effects on cerebral health
WO1997049373A3 (en) Treatment and prevention of hiv infection by administration of derivatives of human chorionic gonadotropin
AU6020099A (en) Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
KR880000463A (ko) 사슬 결합법
KR20200078413A (ko) 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체 및 인슐린을 포함하는 약학 조성물
WO2002002133A3 (en) Peptide composition for treatment of periodontal diseases and prevention of skin aging
MX9703642A (es) Metodos para el tratamiento de esclerosis multiple utilizando analogos de peptido en la posicion 91 de la proteina basica de mielina humana.
WO2004009625A3 (en) PEPTIDES AND PEPTIDE DERIVATIVES FOR THE TREATMENT OF α-SYNUCLEIN-RELATED DISEASES
AU2025220790A1 (en) Pharmaceutical composition for preventing or treating periodontal disease or luxated teeth
JP2002522508A5 (enExample)
FR2766191B1 (fr) Peptides anti-microbiens de crustaces
NZ508816A (en) Bactericidal/permeability-increasing protein (BPI) deletion analogs
JP2004538320A5 (enExample)
WO2002058589A3 (en) Agents and methods for promoting bone growth
JP2004521076A5 (enExample)
WO2000058466A3 (en) Protease resistant flint analogs
EP1243595A4 (en) BH4 FUSIONED POLYPEPTIDES