ATE309339T1 - Thrombomodulin analoga und ihre pharmazeutische verwendung - Google Patents
Thrombomodulin analoga und ihre pharmazeutische verwendungInfo
- Publication number
- ATE309339T1 ATE309339T1 AT01948487T AT01948487T ATE309339T1 AT E309339 T1 ATE309339 T1 AT E309339T1 AT 01948487 T AT01948487 T AT 01948487T AT 01948487 T AT01948487 T AT 01948487T AT E309339 T1 ATE309339 T1 AT E309339T1
- Authority
- AT
- Austria
- Prior art keywords
- thrombomodulin
- analogas
- pharmaceutical use
- thrombin
- analogs
- Prior art date
Links
- 102000012607 Thrombomodulin Human genes 0.000 title abstract 3
- 108010079274 Thrombomodulin Proteins 0.000 title abstract 3
- 230000004913 activation Effects 0.000 abstract 2
- 102000003847 Carboxypeptidase B2 Human genes 0.000 abstract 1
- 108090000201 Carboxypeptidase B2 Proteins 0.000 abstract 1
- 101800004937 Protein C Proteins 0.000 abstract 1
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 1
- 101800001700 Saposin-D Proteins 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229960000856 protein c Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21367800P | 2000-06-21 | 2000-06-21 | |
| US09/880,484 US6632791B1 (en) | 2000-06-21 | 2001-06-12 | Thrombomodulin analogs for pharmaceutical use |
| PCT/US2001/019590 WO2001098352A2 (en) | 2000-06-21 | 2001-06-20 | Thrombomodulin analogs for pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE309339T1 true ATE309339T1 (de) | 2005-11-15 |
Family
ID=26908302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01948487T ATE309339T1 (de) | 2000-06-21 | 2001-06-20 | Thrombomodulin analoga und ihre pharmazeutische verwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6632791B1 (de) |
| EP (1) | EP1292673B1 (de) |
| JP (1) | JP4855627B2 (de) |
| AT (1) | ATE309339T1 (de) |
| AU (1) | AU2001269927A1 (de) |
| DE (1) | DE60114819T2 (de) |
| DK (1) | DK1292673T3 (de) |
| ES (1) | ES2256266T3 (de) |
| NO (1) | NO20026147L (de) |
| WO (1) | WO2001098352A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030118580A1 (en) * | 2001-11-09 | 2003-06-26 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and thrombomodulin polypeptides |
| US7579000B2 (en) | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
| JP4567437B2 (ja) * | 2002-05-01 | 2010-10-20 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 抗凝固剤としての新規組織因子標的化されたトロンボモジュリン融合タンパク質 |
| US8012693B2 (en) | 2003-12-16 | 2011-09-06 | 3M Innovative Properties Company | Analysis of chemically crosslinked cellular samples |
| US7833978B2 (en) | 2004-02-20 | 2010-11-16 | Emory University | Thrombomodulin derivatives and conjugates |
| KR20080073293A (ko) | 2005-10-14 | 2008-08-08 | 메디뮨 엘엘씨 | 항체 라이브러리의 세포 디스플레이 |
| EP2120049A1 (de) | 2008-05-14 | 2009-11-18 | PAION Deutschland GmbH | Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern |
| WO2010006635A1 (en) * | 2008-07-16 | 2010-01-21 | Paion Deutschland Gmbh | Treatment of inflammatory bowel disease |
| EP2320936A1 (de) * | 2008-07-16 | 2011-05-18 | PAION Deutschland GmbH | Prävention und behandlung von strahlenschäden |
| US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
| AU2009347614A1 (en) * | 2009-06-12 | 2012-01-19 | Paion Deutschland Gmbh | Treatment of coagulopathy with hyperfibrinolysis |
| KR20130099027A (ko) | 2010-08-05 | 2013-09-05 | 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 | 혈전용해 및 응고억제 특성을 갖는 단백질 융합 구조물 |
| WO2014020183A1 (de) * | 2012-08-03 | 2014-02-06 | Ici Immunochemical Intelligence Gmbh | In-vitro-assay zur diagnose von störungen der hämostase |
| US9156904B2 (en) * | 2013-07-29 | 2015-10-13 | Blue Blood Biotech Corp. | Thrombomodulin variants and use thereof |
| WO2017189943A1 (en) * | 2016-04-28 | 2017-11-02 | Saint Louis University | Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466668A (en) | 1989-04-28 | 1995-11-14 | Schering Aktiengesellschaft | Superior thrombomodulin analogs for pharmaceutical use |
| US6063763A (en) | 1989-04-28 | 2000-05-16 | Schering Aktiengesellschaft | Protease-resistant thrombomodulin analogs |
| US5256770A (en) | 1990-04-09 | 1993-10-26 | Schering Ag | Oxidation resistant thrombomodulin analogs |
| WO1993025675A1 (en) * | 1992-06-10 | 1993-12-23 | Schering Aktiengesellschaft | Mutants of the epidermal growth factor domains of human thrombomodulin |
-
2001
- 2001-06-12 US US09/880,484 patent/US6632791B1/en not_active Expired - Fee Related
- 2001-06-20 WO PCT/US2001/019590 patent/WO2001098352A2/en not_active Ceased
- 2001-06-20 AT AT01948487T patent/ATE309339T1/de active
- 2001-06-20 AU AU2001269927A patent/AU2001269927A1/en not_active Abandoned
- 2001-06-20 JP JP2002504307A patent/JP4855627B2/ja not_active Expired - Fee Related
- 2001-06-20 DK DK01948487T patent/DK1292673T3/da active
- 2001-06-20 EP EP01948487A patent/EP1292673B1/de not_active Expired - Lifetime
- 2001-06-20 ES ES01948487T patent/ES2256266T3/es not_active Expired - Lifetime
- 2001-06-20 DE DE60114819T patent/DE60114819T2/de not_active Expired - Lifetime
-
2002
- 2002-12-20 NO NO20026147A patent/NO20026147L/no not_active Application Discontinuation
-
2003
- 2003-05-14 US US10/438,648 patent/US6790828B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK1292673T3 (da) | 2006-03-27 |
| EP1292673A2 (de) | 2003-03-19 |
| US20030186883A1 (en) | 2003-10-02 |
| ES2256266T3 (es) | 2006-07-16 |
| WO2001098352A2 (en) | 2001-12-27 |
| US6790828B2 (en) | 2004-09-14 |
| WO2001098352A3 (en) | 2002-08-01 |
| NO20026147D0 (no) | 2002-12-20 |
| DE60114819D1 (de) | 2005-12-15 |
| DE60114819T2 (de) | 2006-08-10 |
| US6632791B1 (en) | 2003-10-14 |
| EP1292673B1 (de) | 2005-11-09 |
| JP4855627B2 (ja) | 2012-01-18 |
| NO20026147L (no) | 2003-02-20 |
| AU2001269927A1 (en) | 2002-01-02 |
| JP2004527452A (ja) | 2004-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE309339T1 (de) | Thrombomodulin analoga und ihre pharmazeutische verwendung | |
| SE0001899D0 (sv) | New compounds | |
| TR200200768T2 (tr) | Yeni kuinüklidin türevleri ve bunu içeren ilaç bileşimleri | |
| YU12103A (sh) | Polimorfni oblici epotilonskog analoga | |
| ATE344029T1 (de) | Behandlung von typ ii diabetes mit dipeptidyl- peptidase-iv-hemmern | |
| NO20055863L (no) | W-karboksyarylsubstituerte difenylureaforbindelser som raf-kinaseinhibitorer | |
| CY1108085T1 (el) | Υποκατεστημενα παραγωγα 1,3-διφαινυλπροπ-2-εν-1-ονης παρασκευη και χρησης αυτων | |
| ATE408601T1 (de) | Fredericamycin-derivate | |
| ATE291024T1 (de) | Neue 4-aminofuropyrimidine und ihre verwendung | |
| ATE282607T1 (de) | Tryptase-inhibitoren | |
| ATE231849T1 (de) | Cyclopentabenzofuran-derivate und ihre verwendung | |
| NO975028L (no) | Piperazinoderivater som neurokininantagonister | |
| PT804465E (pt) | Novos inibidores da elastase | |
| PL368686A1 (en) | Novel aminobenzoephenones | |
| SE0300457D0 (sv) | Novel compounds | |
| UA86399C2 (ru) | Применение 2,5 дигидроксибензолсульфоновой кислоты для изготовления лекарства, которые применяют для лечения болезней, зависимых от ангиогенеза | |
| IS2849B (is) | Notkun á írbesartani til framleiðslunnar á lyfjum sem eru notuð til að fyrirbyggja eða meðhöndla lungnaháþrýsting | |
| NO20033413L (no) | Krystallmodifisering av et syklisk depsipeptid med forbedret aktivitet | |
| TR200001026T2 (tr) | Nötrofil elastaz inhibitörü olarak pirolopirolon türevleri. | |
| HUP0301523A2 (hu) | VEGF-peptidek és alkalmazásuk angiogenezis gátlására | |
| ATE261732T1 (de) | Pharmazeutische zusammensetzung, umfassend eukalyptus- und orangenöl | |
| GB0221169D0 (en) | Crystal | |
| BR0112123A (pt) | Composto | |
| ATE392213T1 (de) | Verwendung von gamma-gt inhibitoren zur behandlung von chronischen degenerativerkrankungen | |
| SE0101386D0 (sv) | New compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1292673 Country of ref document: EP |