ATE309339T1 - Thrombomodulin analoga und ihre pharmazeutische verwendung - Google Patents
Thrombomodulin analoga und ihre pharmazeutische verwendungInfo
- Publication number
- ATE309339T1 ATE309339T1 AT01948487T AT01948487T ATE309339T1 AT E309339 T1 ATE309339 T1 AT E309339T1 AT 01948487 T AT01948487 T AT 01948487T AT 01948487 T AT01948487 T AT 01948487T AT E309339 T1 ATE309339 T1 AT E309339T1
- Authority
- AT
- Austria
- Prior art keywords
- thrombomodulin
- analogas
- pharmaceutical use
- thrombin
- analogs
- Prior art date
Links
- 102000012607 Thrombomodulin Human genes 0.000 title abstract 3
- 108010079274 Thrombomodulin Proteins 0.000 title abstract 3
- 230000004913 activation Effects 0.000 abstract 2
- 102000003847 Carboxypeptidase B2 Human genes 0.000 abstract 1
- 108090000201 Carboxypeptidase B2 Proteins 0.000 abstract 1
- 101800004937 Protein C Proteins 0.000 abstract 1
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 1
- 101800001700 Saposin-D Proteins 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229960000856 protein c Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21367800P | 2000-06-21 | 2000-06-21 | |
| US09/880,484 US6632791B1 (en) | 2000-06-21 | 2001-06-12 | Thrombomodulin analogs for pharmaceutical use |
| PCT/US2001/019590 WO2001098352A2 (en) | 2000-06-21 | 2001-06-20 | Thrombomodulin analogs for pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE309339T1 true ATE309339T1 (de) | 2005-11-15 |
Family
ID=26908302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01948487T ATE309339T1 (de) | 2000-06-21 | 2001-06-20 | Thrombomodulin analoga und ihre pharmazeutische verwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6632791B1 (de) |
| EP (1) | EP1292673B1 (de) |
| JP (1) | JP4855627B2 (de) |
| AT (1) | ATE309339T1 (de) |
| AU (1) | AU2001269927A1 (de) |
| DE (1) | DE60114819T2 (de) |
| DK (1) | DK1292673T3 (de) |
| ES (1) | ES2256266T3 (de) |
| NO (1) | NO20026147L (de) |
| WO (1) | WO2001098352A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030118580A1 (en) * | 2001-11-09 | 2003-06-26 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and thrombomodulin polypeptides |
| US7579000B2 (en) | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
| HK1080372A1 (zh) * | 2002-05-01 | 2006-04-28 | Schering Aktiengesellschaft | 作为抗凝剂的新型组织因子目标抗体 |
| US8012693B2 (en) | 2003-12-16 | 2011-09-06 | 3M Innovative Properties Company | Analysis of chemically crosslinked cellular samples |
| US7833978B2 (en) | 2004-02-20 | 2010-11-16 | Emory University | Thrombomodulin derivatives and conjugates |
| EP1943332A4 (de) | 2005-10-14 | 2011-04-13 | Medimmune Inc | Zellpräsentation von antikörperbibliotheken |
| EP2120049A1 (de) | 2008-05-14 | 2009-11-18 | PAION Deutschland GmbH | Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern |
| WO2010006635A1 (en) * | 2008-07-16 | 2010-01-21 | Paion Deutschland Gmbh | Treatment of inflammatory bowel disease |
| US20110144024A1 (en) * | 2008-07-16 | 2011-06-16 | Paion Deutschland Gmbh | Prevention and treatment of radiation injury |
| US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
| JP2012529445A (ja) * | 2009-06-12 | 2012-11-22 | パイオン ドイチュラント ゲーエムベーハー | 線溶亢進を伴う凝固障害の処置 |
| EP2600891B1 (de) | 2010-08-05 | 2018-01-17 | Council of Scientific & Industrial Research | Proteinfusionskonstrukte mit thrombolyse- und gerinnungshemmenden eigenschaften |
| WO2014020183A1 (de) * | 2012-08-03 | 2014-02-06 | Ici Immunochemical Intelligence Gmbh | In-vitro-assay zur diagnose von störungen der hämostase |
| US9156904B2 (en) * | 2013-07-29 | 2015-10-13 | Blue Blood Biotech Corp. | Thrombomodulin variants and use thereof |
| WO2017189943A1 (en) * | 2016-04-28 | 2017-11-02 | Saint Louis University | Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466668A (en) | 1989-04-28 | 1995-11-14 | Schering Aktiengesellschaft | Superior thrombomodulin analogs for pharmaceutical use |
| US6063763A (en) | 1989-04-28 | 2000-05-16 | Schering Aktiengesellschaft | Protease-resistant thrombomodulin analogs |
| US5256770A (en) | 1990-04-09 | 1993-10-26 | Schering Ag | Oxidation resistant thrombomodulin analogs |
| AU4533093A (en) * | 1992-06-10 | 1994-01-04 | Michael John Morser | Mutants of the epidermal growth factor domains of human thrombomodulin |
-
2001
- 2001-06-12 US US09/880,484 patent/US6632791B1/en not_active Expired - Fee Related
- 2001-06-20 AU AU2001269927A patent/AU2001269927A1/en not_active Abandoned
- 2001-06-20 DE DE60114819T patent/DE60114819T2/de not_active Expired - Lifetime
- 2001-06-20 AT AT01948487T patent/ATE309339T1/de active
- 2001-06-20 ES ES01948487T patent/ES2256266T3/es not_active Expired - Lifetime
- 2001-06-20 WO PCT/US2001/019590 patent/WO2001098352A2/en not_active Ceased
- 2001-06-20 DK DK01948487T patent/DK1292673T3/da active
- 2001-06-20 EP EP01948487A patent/EP1292673B1/de not_active Expired - Lifetime
- 2001-06-20 JP JP2002504307A patent/JP4855627B2/ja not_active Expired - Fee Related
-
2002
- 2002-12-20 NO NO20026147A patent/NO20026147L/no not_active Application Discontinuation
-
2003
- 2003-05-14 US US10/438,648 patent/US6790828B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1292673A2 (de) | 2003-03-19 |
| ES2256266T3 (es) | 2006-07-16 |
| NO20026147L (no) | 2003-02-20 |
| DE60114819T2 (de) | 2006-08-10 |
| DK1292673T3 (da) | 2006-03-27 |
| DE60114819D1 (de) | 2005-12-15 |
| EP1292673B1 (de) | 2005-11-09 |
| AU2001269927A1 (en) | 2002-01-02 |
| NO20026147D0 (no) | 2002-12-20 |
| JP2004527452A (ja) | 2004-09-09 |
| WO2001098352A2 (en) | 2001-12-27 |
| US6632791B1 (en) | 2003-10-14 |
| US20030186883A1 (en) | 2003-10-02 |
| US6790828B2 (en) | 2004-09-14 |
| WO2001098352A3 (en) | 2002-08-01 |
| JP4855627B2 (ja) | 2012-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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