DK1292673T3 - Trombomodulinanaloger til farmaceutisk anvendelse - Google Patents

Trombomodulinanaloger til farmaceutisk anvendelse

Info

Publication number
DK1292673T3
DK1292673T3 DK01948487T DK01948487T DK1292673T3 DK 1292673 T3 DK1292673 T3 DK 1292673T3 DK 01948487 T DK01948487 T DK 01948487T DK 01948487 T DK01948487 T DK 01948487T DK 1292673 T3 DK1292673 T3 DK 1292673T3
Authority
DK
Denmark
Prior art keywords
pharmaceutical use
thrombomodulin
thrombin
analogs
thrombomodulin analogues
Prior art date
Application number
DK01948487T
Other languages
Danish (da)
English (en)
Inventor
David Light
Michael John Morser
Mariko Nagashima
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK1292673T3 publication Critical patent/DK1292673T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK01948487T 2000-06-21 2001-06-20 Trombomodulinanaloger til farmaceutisk anvendelse DK1292673T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21367800P 2000-06-21 2000-06-21
US09/880,484 US6632791B1 (en) 2000-06-21 2001-06-12 Thrombomodulin analogs for pharmaceutical use

Publications (1)

Publication Number Publication Date
DK1292673T3 true DK1292673T3 (da) 2006-03-27

Family

ID=26908302

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01948487T DK1292673T3 (da) 2000-06-21 2001-06-20 Trombomodulinanaloger til farmaceutisk anvendelse

Country Status (10)

Country Link
US (2) US6632791B1 (de)
EP (1) EP1292673B1 (de)
JP (1) JP4855627B2 (de)
AT (1) ATE309339T1 (de)
AU (1) AU2001269927A1 (de)
DE (1) DE60114819T2 (de)
DK (1) DK1292673T3 (de)
ES (1) ES2256266T3 (de)
NO (1) NO20026147L (de)
WO (1) WO2001098352A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030118580A1 (en) * 2001-11-09 2003-06-26 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and thrombomodulin polypeptides
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
AU2003225256B2 (en) * 2002-05-01 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Novel tissue factor targeted thrombomodulin fusion proteins as anticoagulants
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
US7833978B2 (en) 2004-02-20 2010-11-16 Emory University Thrombomodulin derivatives and conjugates
KR20080073293A (ko) 2005-10-14 2008-08-08 메디뮨 엘엘씨 항체 라이브러리의 세포 디스플레이
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
WO2010006635A1 (en) * 2008-07-16 2010-01-21 Paion Deutschland Gmbh Treatment of inflammatory bowel disease
EP2320936A1 (de) * 2008-07-16 2011-05-18 PAION Deutschland GmbH Prävention und behandlung von strahlenschäden
US20120165244A1 (en) * 2008-10-30 2012-06-28 Hua-Lin Wu Methods for binding lewis y antigen
US20120270789A1 (en) * 2009-06-12 2012-10-25 Paion Deutschland Gmbh Treatment of coagulopathy with hyperfibrinolysis
US9150844B2 (en) 2010-08-05 2015-10-06 Neeraj Maheshwari Protein fusion constructs possessing thrombolytic and anticoagulant properties
WO2014020183A1 (de) * 2012-08-03 2014-02-06 Ici Immunochemical Intelligence Gmbh In-vitro-assay zur diagnose von störungen der hämostase
US9156904B2 (en) * 2013-07-29 2015-10-13 Blue Blood Biotech Corp. Thrombomodulin variants and use thereof
WO2017189943A1 (en) * 2016-04-28 2017-11-02 Saint Louis University Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256770A (en) 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
US5466668A (en) 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
US6063763A (en) 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
AU4533093A (en) * 1992-06-10 1994-01-04 Michael John Morser Mutants of the epidermal growth factor domains of human thrombomodulin

Also Published As

Publication number Publication date
US20030186883A1 (en) 2003-10-02
US6632791B1 (en) 2003-10-14
NO20026147D0 (no) 2002-12-20
WO2001098352A3 (en) 2002-08-01
US6790828B2 (en) 2004-09-14
ATE309339T1 (de) 2005-11-15
ES2256266T3 (es) 2006-07-16
JP2004527452A (ja) 2004-09-09
WO2001098352A2 (en) 2001-12-27
AU2001269927A1 (en) 2002-01-02
DE60114819T2 (de) 2006-08-10
EP1292673A2 (de) 2003-03-19
JP4855627B2 (ja) 2012-01-18
NO20026147L (no) 2003-02-20
DE60114819D1 (de) 2005-12-15
EP1292673B1 (de) 2005-11-09

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