DE60114819D1 - Thrombomodulin analoga und ihre pharmazeutische verwendung - Google Patents

Thrombomodulin analoga und ihre pharmazeutische verwendung

Info

Publication number
DE60114819D1
DE60114819D1 DE60114819T DE60114819T DE60114819D1 DE 60114819 D1 DE60114819 D1 DE 60114819D1 DE 60114819 T DE60114819 T DE 60114819T DE 60114819 T DE60114819 T DE 60114819T DE 60114819 D1 DE60114819 D1 DE 60114819D1
Authority
DE
Germany
Prior art keywords
pharmaceutical use
thrombomodulin
thrombomodulin analogue
thrombin
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60114819T
Other languages
English (en)
Other versions
DE60114819T2 (de
Inventor
David Light
John Morser
Mariko Nagashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of DE60114819D1 publication Critical patent/DE60114819D1/de
Publication of DE60114819T2 publication Critical patent/DE60114819T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE60114819T 2000-06-21 2001-06-20 Thrombomodulin analoga und ihre pharmazeutische verwendung Expired - Lifetime DE60114819T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21367800P 2000-06-21 2000-06-21
US213678P 2000-06-21
US09/880,484 US6632791B1 (en) 2000-06-21 2001-06-12 Thrombomodulin analogs for pharmaceutical use
US880484 2001-06-12
PCT/US2001/019590 WO2001098352A2 (en) 2000-06-21 2001-06-20 Thrombomodulin analogs for pharmaceutical use

Publications (2)

Publication Number Publication Date
DE60114819D1 true DE60114819D1 (de) 2005-12-15
DE60114819T2 DE60114819T2 (de) 2006-08-10

Family

ID=26908302

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60114819T Expired - Lifetime DE60114819T2 (de) 2000-06-21 2001-06-20 Thrombomodulin analoga und ihre pharmazeutische verwendung

Country Status (10)

Country Link
US (2) US6632791B1 (de)
EP (1) EP1292673B1 (de)
JP (1) JP4855627B2 (de)
AT (1) ATE309339T1 (de)
AU (1) AU2001269927A1 (de)
DE (1) DE60114819T2 (de)
DK (1) DK1292673T3 (de)
ES (1) ES2256266T3 (de)
NO (1) NO20026147L (de)
WO (1) WO2001098352A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030118580A1 (en) * 2001-11-09 2003-06-26 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and thrombomodulin polypeptides
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
AU2003225256B2 (en) * 2002-05-01 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Novel tissue factor targeted thrombomodulin fusion proteins as anticoagulants
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
US7833978B2 (en) 2004-02-20 2010-11-16 Emory University Thrombomodulin derivatives and conjugates
KR20080073293A (ko) 2005-10-14 2008-08-08 메디뮨 엘엘씨 항체 라이브러리의 세포 디스플레이
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
WO2010006635A1 (en) * 2008-07-16 2010-01-21 Paion Deutschland Gmbh Treatment of inflammatory bowel disease
EP2320936A1 (de) * 2008-07-16 2011-05-18 PAION Deutschland GmbH Prävention und behandlung von strahlenschäden
US20120165244A1 (en) * 2008-10-30 2012-06-28 Hua-Lin Wu Methods for binding lewis y antigen
US20120270789A1 (en) * 2009-06-12 2012-10-25 Paion Deutschland Gmbh Treatment of coagulopathy with hyperfibrinolysis
US9150844B2 (en) 2010-08-05 2015-10-06 Neeraj Maheshwari Protein fusion constructs possessing thrombolytic and anticoagulant properties
WO2014020183A1 (de) * 2012-08-03 2014-02-06 Ici Immunochemical Intelligence Gmbh In-vitro-assay zur diagnose von störungen der hämostase
US9156904B2 (en) * 2013-07-29 2015-10-13 Blue Blood Biotech Corp. Thrombomodulin variants and use thereof
WO2017189943A1 (en) * 2016-04-28 2017-11-02 Saint Louis University Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256770A (en) 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
US5466668A (en) 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
US6063763A (en) 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
AU4533093A (en) * 1992-06-10 1994-01-04 Michael John Morser Mutants of the epidermal growth factor domains of human thrombomodulin

Also Published As

Publication number Publication date
US20030186883A1 (en) 2003-10-02
US6632791B1 (en) 2003-10-14
NO20026147D0 (no) 2002-12-20
WO2001098352A3 (en) 2002-08-01
US6790828B2 (en) 2004-09-14
ATE309339T1 (de) 2005-11-15
ES2256266T3 (es) 2006-07-16
JP2004527452A (ja) 2004-09-09
WO2001098352A2 (en) 2001-12-27
AU2001269927A1 (en) 2002-01-02
DE60114819T2 (de) 2006-08-10
EP1292673A2 (de) 2003-03-19
DK1292673T3 (da) 2006-03-27
JP4855627B2 (ja) 2012-01-18
NO20026147L (no) 2003-02-20
EP1292673B1 (de) 2005-11-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE

R082 Change of representative

Ref document number: 1292673

Country of ref document: EP

Representative=s name: KOENIG SZYNKA TILMANN VON RENESSE PATENTANWAEL, DE