JP2004526701A - 神経系の損傷後疾患の処置のためのトリペプチド誘導体 - Google Patents

神経系の損傷後疾患の処置のためのトリペプチド誘導体 Download PDF

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Publication number
JP2004526701A
JP2004526701A JP2002562378A JP2002562378A JP2004526701A JP 2004526701 A JP2004526701 A JP 2004526701A JP 2002562378 A JP2002562378 A JP 2002562378A JP 2002562378 A JP2002562378 A JP 2002562378A JP 2004526701 A JP2004526701 A JP 2004526701A
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JP
Japan
Prior art keywords
alkyl
alkoxy
group
ile
residue derived
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Pending
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JP2002562378A
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English (en)
Japanese (ja)
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JP2004526701A5 (enExample
Inventor
ラパン,ジャン
ヴィッツマン,ハンス・クラウス
グリュメル,ジャン−マリー
ゴネラ,ジャック
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NeuroTell AG
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NeuroTell AG
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Application filed by NeuroTell AG filed Critical NeuroTell AG
Publication of JP2004526701A publication Critical patent/JP2004526701A/ja
Publication of JP2004526701A5 publication Critical patent/JP2004526701A5/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2002562378A 2001-02-05 2002-02-05 神経系の損傷後疾患の処置のためのトリペプチド誘導体 Pending JP2004526701A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10105040A DE10105040A1 (de) 2001-02-05 2001-02-05 Tripeptid-Derivate für die Behandlung von postläsionalen Krankheiten des Nervensystems
PCT/EP2002/001182 WO2002062372A2 (en) 2001-02-05 2002-02-05 Tripeptide derivatives for the treatment of postlesional diseases of the nervous system

Publications (2)

Publication Number Publication Date
JP2004526701A true JP2004526701A (ja) 2004-09-02
JP2004526701A5 JP2004526701A5 (enExample) 2005-12-22

Family

ID=7672833

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002562378A Pending JP2004526701A (ja) 2001-02-05 2002-02-05 神経系の損傷後疾患の処置のためのトリペプチド誘導体

Country Status (9)

Country Link
US (1) US7163922B2 (enExample)
EP (1) EP1390055B1 (enExample)
JP (1) JP2004526701A (enExample)
AT (1) ATE310529T1 (enExample)
AU (1) AU2002238532A1 (enExample)
DE (2) DE10105040A1 (enExample)
DK (1) DK1390055T3 (enExample)
ES (1) ES2250617T3 (enExample)
WO (1) WO2002062372A2 (enExample)

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU599809B2 (en) * 1987-05-20 1990-07-26 Zambon Group S.P.A. Isoxazoles with nootropic activity
CA1323301C (en) 1987-06-05 1993-10-19 Alan I. Faden Thyrotropin-releasing hormone analogs in cns injury
FR2622581B1 (fr) * 1987-11-03 1990-02-16 Inorgan Sa Rech Develop Pharm Nouveaux derives de l-proline, leur preparation et leurs applications biologiques
HU904967D0 (en) * 1988-04-22 1991-01-28 Hoechst Ag Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
DE4007869A1 (de) 1990-03-13 1991-09-19 Merck Patent Gmbh Aminosaeurederivate
JPH045240A (ja) 1990-04-20 1992-01-09 Taisho Pharmaceut Co Ltd 抗痴呆剤
JPH06504061A (ja) 1990-12-28 1994-05-12 コーテックス ファーマシューティカルズ インコーポレイテッド 神経変性の治療および予防におけるカルパイン阻害剤の使用
WO1992013549A1 (en) * 1991-02-07 1992-08-20 Research Corporation Technologies, Inc. Inhibition of cell proliferation by hydrophobic peptides
US6235929B1 (en) * 1991-12-27 2001-05-22 Georgia Tech Research Corporation Tripeptide α-ketoamides
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5834029A (en) * 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
EP0840614A1 (en) 1995-06-13 1998-05-13 Sanofi Winthrop, Inc. Calpain inhibitors for the treatment of neurodegenerative diseases
US5840838A (en) * 1996-02-29 1998-11-24 University Of Kentucky Research Foundation Process for enhancing the activity of amyloid β peptides
JP2001501930A (ja) 1996-10-04 2001-02-13 オークランド ユニサーヴィスィズ リミテッド 神経酵素の調節
JP4727770B2 (ja) * 1997-09-26 2011-07-20 カルピス株式会社 尿中カテコールアミン低下、尿中ノルアドレナリン低下、尿中ドーパミン低下及びFischer比低下の少なくとも1つの軽減剤
US6080848A (en) * 1998-05-01 2000-06-27 Incyte Pharmaceuticals, Inc. Human brain associated protein
US6379691B1 (en) * 1998-09-29 2002-04-30 Medtronic/Ave, Inc. Uses for medical devices having a lubricious, nitric oxide-releasing coating
AU1574701A (en) * 1999-10-22 2001-04-30 Wrair Walter Reed Army Institute Of Research A pharmaceutical composition containing pglu-glu-pro-nh2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
JP4633876B2 (ja) * 1999-11-11 2011-02-16 カルピス株式会社 トリペプチドの製造方法
WO2001068114A1 (en) 2000-03-10 2001-09-20 Monsanto Company Novel peptides with anti-hypertensive activity
DE10105041A1 (de) * 2001-02-05 2002-08-14 Tell Pharm Ag Hergiswil Tripeptide und Tripeptid-Derivate für die Behandlung neurodegenerativer Krankheiten
DE10105038B4 (de) * 2001-02-05 2005-07-07 Neurotell Ag Tripeptid-Derivate für die Behandlung von postläsionalen Krankheiten des Nervensystems

Also Published As

Publication number Publication date
ATE310529T1 (de) 2005-12-15
AU2002238532A1 (en) 2002-08-19
EP1390055A2 (en) 2004-02-25
EP1390055B1 (en) 2005-11-23
DK1390055T3 (da) 2006-01-09
US7163922B2 (en) 2007-01-16
DE60207550T2 (de) 2006-08-10
ES2250617T3 (es) 2006-04-16
WO2002062372A3 (en) 2004-01-08
DE10105040A1 (de) 2002-08-14
DE60207550D1 (de) 2005-12-29
US20050101539A1 (en) 2005-05-12
WO2002062372A2 (en) 2002-08-15

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