JP2004526442A5 - - Google Patents
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- Publication number
- JP2004526442A5 JP2004526442A5 JP2002568777A JP2002568777A JP2004526442A5 JP 2004526442 A5 JP2004526442 A5 JP 2004526442A5 JP 2002568777 A JP2002568777 A JP 2002568777A JP 2002568777 A JP2002568777 A JP 2002568777A JP 2004526442 A5 JP2004526442 A5 JP 2004526442A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- dna polymerase
- polymerase
- molecule
- target nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 23
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 20
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 20
- 108020004707 nucleic acids Proteins 0.000 claims 20
- 102000039446 nucleic acids Human genes 0.000 claims 20
- 150000007523 nucleic acids Chemical class 0.000 claims 20
- 239000000523 sample Substances 0.000 claims 15
- 102000004190 Enzymes Human genes 0.000 claims 7
- 108090000790 Enzymes Proteins 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 6
- 230000003213 activating effect Effects 0.000 claims 5
- 102000003960 Ligases Human genes 0.000 claims 4
- 108090000364 Ligases Proteins 0.000 claims 4
- 230000001351 cycling effect Effects 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 239000011541 reaction mixture Substances 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 3
- 230000003321 amplification Effects 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 241000205160 Pyrococcus Species 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 230000000415 inactivating effect Effects 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 238000005382 thermal cycling Methods 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- HCGYMSSYSAKGPK-UHFFFAOYSA-N 2-nitro-1h-indole Chemical compound C1=CC=C2NC([N+](=O)[O-])=CC2=C1 HCGYMSSYSAKGPK-UHFFFAOYSA-N 0.000 claims 1
- FTBBGQKRYUTLMP-UHFFFAOYSA-N 2-nitro-1h-pyrrole Chemical compound [O-][N+](=O)C1=CC=CN1 FTBBGQKRYUTLMP-UHFFFAOYSA-N 0.000 claims 1
- 108020005196 Mitochondrial DNA Proteins 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- 241000205180 Thermococcus litoralis Species 0.000 claims 1
- 241000589500 Thermus aquaticus Species 0.000 claims 1
- 108020005202 Viral DNA Proteins 0.000 claims 1
- 108020000999 Viral RNA Proteins 0.000 claims 1
- 238000012197 amplification kit Methods 0.000 claims 1
- 239000013611 chromosomal DNA Substances 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000007789 sealing Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27143301P | 2001-02-27 | 2001-02-27 | |
| PCT/EP2002/002287 WO2002068683A2 (en) | 2001-02-27 | 2002-02-27 | Circular probe amplification (cpa) using energy-transfer primers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004526442A JP2004526442A (ja) | 2004-09-02 |
| JP2004526442A5 true JP2004526442A5 (cg-RX-API-DMAC10.html) | 2005-12-22 |
Family
ID=23035537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002568777A Pending JP2004526442A (ja) | 2001-02-27 | 2002-02-27 | エネルギー転移プライマーを用いる環状プローブ増幅（ｃｐａ） |
Country Status (13)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1381697T3 (da) | 2001-02-27 | 2009-06-08 | Virco Bvba | Cirkulær probe-amplifikation (CPA) af ringformede nukleinsyremolekyler |
| US7361489B2 (en) * | 2001-10-15 | 2008-04-22 | Mount Sinai School Of Medicine Of New York University | Nucleic acid amplification methods |
| JPWO2005028647A1 (ja) * | 2003-09-22 | 2006-11-30 | 国立大学法人京都大学 | 核酸プローブ、核酸チップ、標的核酸検出方法、薬剤スクリーニング方法、標的核酸検出装置及び遺伝子診断方法 |
| WO2005061735A2 (en) * | 2003-12-04 | 2005-07-07 | The Government Of The United States Of America As Represented By The Department Of Health Human Servicees | Strand-specific amplification |
| CA2564837A1 (en) * | 2004-05-04 | 2005-11-17 | Ventana Medical Systems, Inc. | Internal control in situ hybridization |
| WO2007044864A2 (en) * | 2005-10-11 | 2007-04-19 | Stratagene California | Target nucleic acid signal detection |
| US7897747B2 (en) * | 2006-05-25 | 2011-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby |
| EP2058396A4 (en) * | 2006-08-31 | 2010-06-30 | Toyo Seikan Kaisha Ltd | nucleic acid amplification |
| US7985557B2 (en) | 2007-05-23 | 2011-07-26 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
| WO2010114599A1 (en) * | 2009-04-01 | 2010-10-07 | Dx Terity Diagnostics Inc. | Chemical ligation dependent probe amplification (clpa) |
| US10066257B2 (en) * | 2010-03-29 | 2018-09-04 | Dxterity Diagnostics Incorporated | Methods and compositions for detecting target nucleic acids |
| US9354172B2 (en) * | 2011-12-20 | 2016-05-31 | Rarecyte, Inc. | Tube and reflective float systems for analyzing suspensions |
| EP3225698B1 (en) | 2011-09-06 | 2019-07-31 | Gen-Probe Incorporated | Closed nucleic acid structures |
| US9193994B2 (en) * | 2012-04-20 | 2015-11-24 | Samsung Electronics Co., Ltd. | Polynucleotide and use thereof |
| US10450595B2 (en) | 2013-03-15 | 2019-10-22 | Theranos Ip Company, Llc | Nucleic acid amplification |
| SG11201507261WA (en) | 2013-03-15 | 2015-10-29 | Theranos Inc | Nucleic acid amplification |
| WO2014145296A2 (en) | 2013-03-15 | 2014-09-18 | Theranos, Inc. | Nuclei acid amplification |
| AU2014233145A1 (en) | 2013-03-15 | 2015-09-17 | Theranos Ip Company, Llc | Nucleic acid amplification |
| CN105917235A (zh) | 2013-09-06 | 2016-08-31 | 赛拉诺斯股份有限公司 | 用于检测感染性疾病的系统和方法 |
| IL274464B2 (en) | 2013-12-11 | 2023-08-01 | Accuragen Holdings Ltd | Preparations and methods for the detection of rare sequence variants |
| US11859246B2 (en) | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| CN104232622B (zh) * | 2014-09-24 | 2016-09-14 | 中国人民解放军疾病预防控制所 | 一种用聚合酶螺旋反应恒温扩增核酸的方法及其应用 |
| US10808278B2 (en) | 2015-03-03 | 2020-10-20 | University Of Miami | Kits and methods for pathogen detection |
| JP2017006472A (ja) * | 2015-06-24 | 2017-01-12 | 株式会社 京都医療設計 | 脈管用塞栓材 |
| CN114807323A (zh) * | 2015-10-09 | 2022-07-29 | 安可济控股有限公司 | 用于富集扩增产物的方法及组合物 |
| EP3383994A4 (en) | 2015-12-03 | 2019-08-28 | Accuragen Holdings Limited | METHOD AND COMPOSITIONS FOR FORMING LIGATION PRODUCTS |
| CA3024630A1 (en) | 2016-05-16 | 2017-11-23 | Accuragen Holdings Limited | Method of improved sequencing by strand identification |
| WO2018035170A1 (en) | 2016-08-15 | 2018-02-22 | Accuragen Holdings Limited | Compositions and methods for detecting rare sequence variants |
| GB201621514D0 (en) | 2016-12-16 | 2017-02-01 | Q-Linea Ab | Padlock probe detection method |
| EP3607092B1 (en) * | 2018-01-12 | 2022-12-21 | Stem Arts Projects, LLC | Reaction condition composition for circularizing oligonucleotide probes |
| US11203782B2 (en) | 2018-03-29 | 2021-12-21 | Accuragen Holdings Limited | Compositions and methods comprising asymmetric barcoding |
| CN112601823A (zh) | 2018-06-12 | 2021-04-02 | 安可济控股有限公司 | 用于形成连接产物的方法和组合物 |
| US20240192204A1 (en) * | 2020-05-15 | 2024-06-13 | Universal Sequencing Technology Corporation | A device and assays for detection of pathogens |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4737462A (en) | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4996143A (en) | 1985-12-23 | 1991-02-26 | Syngene, Inc. | Fluorescent stokes shift probes for polynucleotide hybridization |
| US4925785A (en) | 1986-03-07 | 1990-05-15 | Biotechnica Diagnostics, Inc. | Nucleic acid hybridization assays |
| US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| DE3803275A1 (de) | 1988-02-04 | 1989-08-17 | Dornier Medizintechnik | Piezoelektrische stosswellenquelle |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| EP1067134B1 (en) | 1991-11-07 | 2004-07-28 | Nanotronics, Inc. | Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system |
| US5348853A (en) | 1991-12-16 | 1994-09-20 | Biotronics Corporation | Method for reducing non-specific priming in DNA amplification |
| US5438131A (en) * | 1992-09-16 | 1995-08-01 | Bergstrom; Donald E. | 3-nitropyrrole nucleoside |
| US5593840A (en) | 1993-01-27 | 1997-01-14 | Oncor, Inc. | Amplification of nucleic acid sequences |
| US5714320A (en) | 1993-04-15 | 1998-02-03 | University Of Rochester | Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides |
| US6096880A (en) | 1993-04-15 | 2000-08-01 | University Of Rochester | Circular DNA vectors for synthesis of RNA and DNA |
| US6077668A (en) | 1993-04-15 | 2000-06-20 | University Of Rochester | Highly sensitive multimeric nucleic acid probes |
| DK0862656T3 (da) * | 1995-11-21 | 2001-04-09 | Univ Yale | Unimolekylær segmentamplifikation og -detektering |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US6007994A (en) | 1995-12-22 | 1999-12-28 | Yale University | Multiparametric fluorescence in situ hybridization |
| US5912124A (en) | 1996-06-14 | 1999-06-15 | Sarnoff Corporation | Padlock probe detection |
| US6117635A (en) * | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5866336A (en) | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US6399304B1 (en) * | 1996-12-20 | 2002-06-04 | Roche Diagnostics Gmbh | Sequential activation of one or more enzymatic activities within a thermocycling reaction for synthesizing DNA molecules |
| US5916750A (en) | 1997-01-08 | 1999-06-29 | Biogenex Laboratories | Multifunctional linking reagents for synthesis of branched oligomers |
| JP4163386B2 (ja) | 1998-12-15 | 2008-10-08 | キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング | 環状化核酸プローブの増幅方法 |
| US6383752B1 (en) * | 1999-03-31 | 2002-05-07 | Hybridon, Inc. | Pseudo-cyclic oligonucleobases |
| ATE318932T1 (de) * | 1999-08-13 | 2006-03-15 | Univ Yale | Binär kodierte sequenzmarker |
| DK1381697T3 (da) | 2001-02-27 | 2009-06-08 | Virco Bvba | Cirkulær probe-amplifikation (CPA) af ringformede nukleinsyremolekyler |
-
2002
- 2002-02-27 DK DK02727349T patent/DK1381697T3/da active
- 2002-02-27 AU AU2002257605A patent/AU2002257605B2/en not_active Ceased
- 2002-02-27 MX MXPA03007786A patent/MXPA03007786A/es active IP Right Grant
- 2002-02-27 WO PCT/EP2002/002287 patent/WO2002068683A2/en not_active Ceased
- 2002-02-27 PT PT02727349T patent/PT1381697E/pt unknown
- 2002-02-27 JP JP2002568777A patent/JP2004526442A/ja active Pending
- 2002-02-27 CA CA2439477A patent/CA2439477C/en not_active Expired - Fee Related
- 2002-02-27 AT AT02727349T patent/ATE426041T1/de active
- 2002-02-27 US US10/469,099 patent/US20040067511A1/en not_active Abandoned
- 2002-02-27 ES ES02727349T patent/ES2322559T3/es not_active Expired - Lifetime
- 2002-02-27 DE DE60231606T patent/DE60231606D1/de not_active Expired - Lifetime
- 2002-02-27 EP EP02727349A patent/EP1381697B1/en not_active Expired - Lifetime
- 2002-02-27 NZ NZ528348A patent/NZ528348A/en not_active IP Right Cessation
-
2006
- 2006-12-12 US US11/609,436 patent/US7977053B2/en not_active Expired - Fee Related
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